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针刺参与缺血性脑卒中二级预防的研究进展

针刺研究 2024年第6期49卷 625-633页

作者：周菁付渊博宋玉强王璟霏谢媛王一战杜鑫赵冰骢首都医科大学附属北京中医医院针灸科北京100010 针灸神经调控北京市重点实验室北京100010

由于缺血性脑卒中(IS)复发率高,预防IS复发具有重要意义,循证而有效的二级预防策略是当前干预IS的重要手段,针刺对IS二级预防相关危险因素均具有积极作用。本文从针刺对IS二级预防主要危险因素,即高血压(控制IS后血压水平,预防血管等组... 详细信息

由于缺血性脑卒中(IS)复发率高,预防IS复发具有重要意义,循证而有效的二级预防策略是当前干预IS的重要手段,针刺对IS二级预防相关危险因素均具有积极作用。本文从针刺对IS二级预防主要危险因素,即高血压(控制IS后血压水平,预防血管等组织结构、内分泌因子及中枢神经系统等不同维度失调后造成的不良影响)、高胆固醇血症(降低血清总胆固醇、甘油三酯和低密度脂蛋白胆固醇含量,提高高密度脂蛋白胆固醇含量)、糖尿病(调节脂肪组织分泌功能,激活胰岛素信号转导通路,保护胰腺β细胞功能,调节中枢神经系统功能)、吸烟(降低血液内啡肽水平,调节中枢神经系统兴奋性,缓解戒烟症状,减少吸烟者对吸烟的依赖)、睡眠呼吸暂停综合征(调节局部肌肉功能和神经系统兴奋性,减轻扁桃体肿胀)、肥胖(降低血糖和血脂,增加褐色/白色脂肪比例,减轻瘦素抵抗,抑制食欲,调节脂肪组织的存在形式)6大方面的作用机制角度,对当前相关研究进展进行综述。结果显示,针刺对于IS危险因素的调节机制多与神经-内分泌系统密切相关,且可同时兼顾多种危险因素的多个靶点。针刺疗法作为一种重要的二级预防干预手段,具有良好的疗效、安全性及重要的临床推广价值。

关键词：针刺缺血性脑卒中二级预防危险因素

中西医结合治疗椎基底动脉扩张延长症合并缺血性卒中1例

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中国中西医结合杂志 2024年第3期44卷 369-372页

作者：王一战姬旭陈鹏刘慧林刘清泉王鑫郭妍刘宏伟首都医科大学附属北京中医医院针灸中心北京100010 北京中医医院顺义医院脑病科北京101399

椎基底动脉扩张延长症(vertebrobasilar dolichoectasia,VBD)是一种以椎动脉颅内段和(或)基底动脉显著扩张、延长、迂曲为特征,属于少见的不可逆的颅内血管病变。VBD合并缺血性脑卒中综合预后不良,现代医学在治疗上存在争议,常规剂量的... 详细信息

椎基底动脉扩张延长症(vertebrobasilar dolichoectasia,VBD)是一种以椎动脉颅内段和(或)基底动脉显著扩张、延长、迂曲为特征,属于少见的不可逆的颅内血管病变。VBD合并缺血性脑卒中综合预后不良,现代医学在治疗上存在争议,常规剂量的抗血小板聚集或抗凝治疗,可能增加脑出血风险[1]。本例患者运用中西医结合的治疗方式,日常生活能力明显改善,正常回归社会,取得满意疗效,现报道如下。病例简介患者男,45岁,因“突发右侧肢体力弱伴语言不利17 h”于2022年10月4日就诊于北京中医医院急诊。患者17 h前(2022年10月3日21时)安静状态下出现右侧肢体力弱,行走右偏,语言欠流利,未重视及就诊。后上述症状进展加重,右侧肢体抬举费力,行走拖沓、语言含糊明显,右侧口角下垂,于北京中医医院急诊完善脑MRI结果提示:(1)左侧桥脑脑梗死(急性期)可能性大;(2)基底动脉延长扩张症可能(图1)。

关键词：北京中医医院椎基底动脉扩张延长症口角下垂缺血性卒中安静状态颅内血管病变日常生活能力预后不良

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不同植物对体外瘤胃发酵产气量和甲烷产量的影响

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饲料研究 2024年第10期47卷 93-98页

作者：刘尚王占义李琪宁玉娜刘海洋张梓婷李宏宇王成杰内蒙古农业大学草原与资源环境学院内蒙古呼和浩特010018 内蒙古农业大学草地资源教育部重点实验室内蒙古呼和浩特010018

试验旨在研究不同植物对体外瘤胃总产气量(GP)和甲烷(CH_(4))产量的影响。试验以11种植物的枝叶为材料,进行体外发酵培养,测定体外发酵24 h后的GP和CH_(4)产量。结果表明:在4种灌木、半灌木牧草中,紫丁香的GP最高;在多年生牧草中,紫花... 详细信息

试验旨在研究不同植物对体外瘤胃总产气量(GP)和甲烷(CH_(4))产量的影响。试验以11种植物的枝叶为材料,进行体外发酵培养,测定体外发酵24 h后的GP和CH_(4)产量。结果表明:在4种灌木、半灌木牧草中,紫丁香的GP最高;在多年生牧草中,紫花苜蓿、黄花苜蓿、百脉根、野大豆GP显著高于野豌豆、沙打旺和野艾蒿(P<0.05);紫丁香和冷蒿的CH_(4)产量低于达乌里胡枝子和百里香。紫丁香和野豌豆能够减少CH_(4)产量,提高微生物蛋白(MCP)含量。紫丁香、黄花苜蓿和野豌豆的总皂苷、生物碱含量与GP呈正相关,与CH_(4)呈负相关。研究表明,紫丁香、野豌豆和黄花苜蓿可以作为优质的饲料添加剂,调控反刍家畜瘤胃产气特征。

关键词：体外发酵产气量甲烷

“调神”思想在针灸临床中的运用概况及规律探讨

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针刺研究 2024年第8期49卷 867-874页

作者：曾宇涵付渊博李彬袁芳赵冰骢王一战宋玉强李柏洁沈琳博首都医科大学附属北京中医医院针灸科针灸神经调控北京市重点实验室北京100010

“神”在疾病治疗过程中所发挥的积极作用一直受到中医学者的重视,“调神”被认为是中医疗法的核心精髓所在。针灸调神作为一种身心并治的治疗手段,与当前的生物-心理-社会医学模式不谋而合。近年来,大量临床研究证实了针灸调神法的确... 详细信息

“神”在疾病治疗过程中所发挥的积极作用一直受到中医学者的重视,“调神”被认为是中医疗法的核心精髓所在。针灸调神作为一种身心并治的治疗手段,与当前的生物-心理-社会医学模式不谋而合。近年来,大量临床研究证实了针灸调神法的确切疗效。本文梳理近10年针灸调神法在精神心理疾病、神经系统疾病和消化系统疾病中的临床应用情况,简要总结多种针灸调神疗法的研究进展,探求通督调神法、疏肝调神法和“调神针法”的理论内涵,分析针灸调神的主要选穴规律,并为进一步完善针灸调神法的临床应用理论依据提出发展方向。

关键词：针灸调神临床应用

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Reducing the voltage loss of Y-series acceptor based organic solar cells via ternary/quaternary strategies

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Chinese Chemical Letters 2024年第2期35卷 70-86页

作者： Pengyu zhang Zhiyang zhang Heng Sun Jie Li yi Chen Jiang wang Chuanlang zhan Key Laboratory of Advanced Materials Chemistry and Devices (AMC&DLab) of the Department of Education of Inner Mongolia Autonomous Region Inner Mongolia Key Laboratory of Green CatalysisCollege of Chemistry and Environment ScienceInner Mongolia Normal UniversityHuhehot 010022China

In recent years, with the emergence of non-fullerene fused-ring acceptors, power conversion efficiencies (PCEs) of organic solar cells (OSCs) have exceeded 19%.However, compared to inorganic or perovskite photovoltaic cells, a higher voltage loss has become one of the key factors limiting further improvement in the PCEs of *** ternary/quaternary strategy has been identified as a feasible and effective way to obtain high-efficiency *** this review, a brief outline is given of the key roles that guest materials played in reducing voltage losses in solar cell devices and a brief look at the future material design and the design of ternary/quaternary systems.

关键词： Organic solar cell Ternary/quaternary strategy Open-circuit voltage Voltage loss Non-radiative recombination loss

Establishment of NaLuF_(4):15%Tb-based low dose X-PDT agent and its application on efficient antitumor therapy

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 599-610页

作者： yi Tian Zhiguang Fu Xiaosheng Zhu Chunjing zhan Jinwei Hu Li Fan Chaojun Song Qian Yang Yu wang Mei Shi Department of Radiation Oncology Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China Department of Oncology Air Force Medical CenterPLAThe Fourth Military Medical UniversityBeijing 100142China Department of Tumor Radiotherapy Air Force Medical CenterPLAThe Fourth Military Medical UniversityBeijing 100142China Department of Gastroenterology Air Force Hospital of Southern Theater CommandGuangzhou 510062China Department of Pharmaceutical Chemistry and Analysis School of PharmacyThe Fourth Military Medical UniversityXi’an 710032China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China Institue of Materia Medica School of PharmacyThe Fourth Military Medical UniversityXi’an 710032China

X-ray excited photodynamic therapy(X-PDT)is the bravo answer of photodynamic therapy(PDT)for deep-seated tumors,as it employs X-ray as the irradiation source to overcome the limitation of light penetration ***,high X-ray irradiation dose caused organ lesions and side effects became the major barrier to X-PDT *** address this issue,this work employed a classic-al co-precipitation reaction to synthesize NaLuF_(4):15%Tb^(3+)(NLF)with an average particle size of(23.48±0.91)nm,which was then coupled with the photosensitizer merocyanine 540(MC540)to form the X-PDT system NLF-MC540 with high production of singlet *** system could induce antitumor efficacy to about 24%in relative low dose X-ray irradiation range(0.1-0.3 Gy).In vivo,when NLF-MC540 irradiated by 0.1 Gy X-ray,the tumor inhibition percentage reached 89.5%±5.7%.The therapeutic mechanism of low dose X-PDT was found.A significant increase of neutrophils in serum was found on the third day after *** immunohistochemical staining of tumor sections,the Ly6G^(+),CD8^(+),and CD11c^(+)cells infiltrated in the tumor microenvironment were *** the bilat-eral tumor model,the NLF-MC540 with 0.1 Gy X-ray irradiation could inhibit both the primary tumor and the distant tumor ***-tected by enzyme linked immunosorbent assay(ELISA),two cytokines IFN-γand TNF-αin serum were upregulated 7 and 6 times than negative control,*** by enzyme linked immune spot assay(ELISPOT),the number of immune cells attributable to the IFN-γand TNF-αlevels in the group of low dose X-PDT were 14 and 6 times greater than that in the negative control group,***,it conclude that low dose X-PDT system could successfully upregulate the levels of immune cells,stimulate the secretion of cy-tokines(especially IFN-γand TNF-α),activate antitumor immunity,and finally inhibit colon tumor growth.

关键词： X-ray excited photodynamic therapy singlet oxygen low dose X-Ray irradiation efficient antitumor therapy anti-tumor immunity

Experimental investigation of engineered geopolymer composite for structural strengthening against blast loads

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Defence Technology（防务技术） 2024年第2期32卷 496-509页

作者： Shan Liu Chunyuan Liu yifei Hao yi zhang Li Chen zhan Li Key Laboratory of Coast Civil Structure Safety of Ministry of Education Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Prefabricated Buildings and Intelligent Construction Hebei University of TechnologyTianjin 300400China Institute of Defense Engineering AMSPLABeijing 100850China Engineering Research Center of Safety and Protection of Explosion&Impact of Ministry of Education Southeast UniversityNanjing 211189JiangsuChina State Key Laboratory of Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of the PLANanjing 210007JiangsuChina

The recent increase in blast/bombing incidents all over the world has pushed the development of effective strengthening approaches to enhance the blast resistance of existing civil *** geopolymer composite(EGC)is a promising material featured by eco-friendly,fast-setting and strain-hardening characteristics for emergent strengthening and ***,the fiber optimization for preparing EGC and its protective effect on structural elements under blast scenarios are *** this study,laboratory tests were firstly conducted to evaluate the effects of fiber types on the properties of EGC in terms of workability,dry shrinkage,and mechanical properties in compression,tension and *** experimental results showed that EGC containing PE fiber exhibited suitable workability,acceptable dry shrinkage and superior mechanical properties compared with other types of *** that,a series of field tests were carried out to evaluate the effectiveness of EGC retrofitting layer on the enhancement of blast performance of typical *** tests include autoclaved aerated concrete(AAC)masonry walls subjected to vented gas explosion,reinforced AAC panels subjected to TNT explosion and plain concrete slabs subjected to contact *** was found that EGC could effectively enhance the blast resistance of structural elements in different *** AAC masonry walls and panels,with the existence of EGC,the integrity of specimens could be maintained,and their deflections and damage were significantly *** plain concrete slabs,the EGC overlay could reduce the diameter and depth of the crater and spallation of specimens.

关键词： Engineered geopolymer composites Fiber optimization Strengthening material Blast resistance Masonry wall Reinforced AAC panel Plain concrete slab

A highly reduced Mo_(74) polyoxometalate featuring high proton conductivity accessed by building block strategy

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Science China Chemistry 2024年第3期67卷 862-868页

作者： Shi-yi Liu Xue-Xin Li Wei-Chao Chen Kui-zhan Shao Xin-Long wang Chao Qin Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Department of ChemistryNortheast Normal UniversityChangchun 130024China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China

Highly reduced polyoxometalates(POMs) are predicted to be used as rather high energy density materials;however,it still suffers from the limited cluster species and reduction *** we demonstrate that it is possible to employ the building block strategy to generate a highly reduced polyoxomolybdate(C_(2)H_(8)N)_(14)(NH_(4))_(4)H_(14)[Mo_(48)-ⅤMo_(26)ⅥO_(202)(OH)_(12)(SO_(4))_(6)]·46H_(2)O(Mo_(74)).The fundamental Mo-based{Mo_x}(x=4,5,and 6) building blocks,which are templated by tetra-coordinated anions{MoO_(4)}or{SO_(4)},not only lay foundation for the formation of Mo_(74) featuring an unprecedented reduction ratio of 65%,but also give rise to SBBs-mediated(secondary building blocks) supramolecular dense packing interactions among the isolated Mo_(74) clusters that are favorable for proton ***,high proton conductivity(2.04×10^(-2)S cm^(-1)) had been realized at 50℃ and 90% relative humidity,revealing one of the well-known POMs-based crystalline proton conducting *** result highlights that this building block approach possesses great potential in producing highly reduced POM systems that can achieve controllable reduced ratio and desirable properties.

关键词： polyoxometalate building block molybdenum highly reduced state proton conduction

Enhanced memristor performance via coupling effect of oxygen vacancy and ferroelectric polarization

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Journal of Materials Science & Technology 2024年第4期171卷 139-146页

作者： Zhi Yun Yue Zhi Dong zhang zhan Jie wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

As a new type of nonvolatile memory,the resistive memristor has broad application prospects in in-formation storage and neural computing based on its excellent resistive switching(RS)*** present,it is still a great challenge to improve both ferroelectric polarization and leakage current to achieve a high RS on/offratio of ferroelectric ***,epitaxial Pb(Zr_(0.40)Ti_(0.60))O_(3)(PZT)thin films with low content Ca doping were deposited on the Nb:SrTiO_(3)substrate to prepare PCZT/NSTO het-erostructures and their RS behaviors were *** research findings show that compared with pure PZT film,the ferroelectric polarization of 1-mol%-Ca-doped PZT film is slightly improved,while the leak-age current is increased by three orders of ***,the RS on/offratio reaches 2.5×10^(5),about three orders of magnitude higher than pure PZT *** theoretical analysis reveals that the RS behavior of PCZT/NSTO heterostructures is controlled by the PCZT/NSTO interfacial barrier and the space charge-limited current *** results demonstrate that the ferroelectricity and electricity of ferroelectric thin films can be improved simultaneously by doping low-content Ca ions to increase the RS performance,which provides a good reference for the development of high-performance ferroelectric memristor devices.

关键词： Ferroelectric memristor Ca-doped PZT Ferroelectric polarization Oxygen vacancies Resistive switching