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Propofol Attenuates a-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke

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Neuroscience Bulletin 2020年第3期36卷 289-298页

作者： yuzhu wang Dan Tian Changwei Wei Victoria Cui Huan wang Yanbing Zhu Anshi Wu Yun Yue Department of Anesthesiology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Experimental and Translational Research Center Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Washington University School of Medicine St.LouisMIUSA

a-Synuclein is a soluble monomer abundant in the central nervous system. Aggregates of a-synuclein,consisting of higher-level oligomers and insoluble fibrils,have been observed in many chronic neurological diseases and are implicated in neurotoxicity and neurodegeneration.a-Synuclein has recently been shown to aggregate following acute ischemic stroke, exacerbating neuronal *** is an intravenous anesthetic that is commonly used during intravascular embolectomy following acute ischemic stroke. While propofol has demonstrated neuroprotective properties following brain injury, the mechanism of protection in the setting of ischemic stroke is unclear. In this study, propofol administration significantly reduced the neurotoxic aggregation of a-synuclein, decreased the infarct area, and attenuated the neurological deficits after ischemic stroke in a mouse model. We then demonstrated that the propofol-induced reduction of a-synuclein aggregation was associated with increased mammalian target of rapamycin/ribosomal protein S6 kinase beta-1 signaling pathway activity and reduction of the excessive autophagy occurring after acute ischemic stroke.

关键词： Propofol a-Synuclein Autophagy Stroke Neuroprotection

A Non-canonical Excitatory PV RGC–PV SC Visual Pathway for Mediating the Looming-evoked Innate Defensive Response

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Neuroscience Bulletin 2024年第3期40卷 310-324页

作者： Man Yuan Sen Jin Gao Tan Siyuan Song Yizong Liu Huadong wang Yin Shen Eye Center Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan430060China The Brain Cognition and Brain Disease Institute Shenzhen Key Laboratory of Viral Vectors for BiomedicineShenzhen Institute of Advanced TechnologyChinese Academy of Sciences(CAS)Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsNational Medical Products Administration Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsShenzhen Key Laboratory of Quality Control Technology for Virus-Based TherapeuticsGuangdong Provincial Medical Products AdministrationShenzhen518055China jan.and Dan Duncan Neurological Research Institute Baylor College of MedicineHouston77030USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Key Laboratory of Magnetic Resonance in Biological SystemsWuhan Center for Magnetic ResonanceInnovation Academy for Precision Measurement Science and TechnologyCASWuhan430071China Frontier Science Center of Immunology and Metabolism Medical Research InstituteWuhan UniversityWuhan430071China

Parvalbumin-positive retinal ganglion cells(PV+RGCs)are an essential subset of RGCs found in various ***,their role in transmitting visual information remains ***,we characterized PV+RGCs in the retina and explored the functions of the PV+RGC-mediated visual *** applying multiple viral tracing strategies,we investigated the downstream of PV+RGCs across the whole ***,we found that the PV+RGCs provided direct monosynaptic input to PV+excitatory neurons in the superficial layers of the superior colliculus(SC).Ablation or suppression of SC-projecting PV+RGCs abolished or severely impaired the flight response to looming visual stimuli in mice without affecting visual ***,using transcriptome expression profiling of individual cells and immunofluorescence colocalization for RGCs,we found that PV+RGCs are predominant glutamatergic ***,our findings indicate the critical role of PV+RGCs in an innate defensive response and suggest a non-canonical subcortical visual pathway from excitatory PV+RGCs to PV+SC neurons that regulates looming visual *** results provide a potential target for intervening and treating diseases related to this circuit,such as schizophrenia and autism.

关键词： Parvalbumin-positive retinal ganglion cell Innate fear Superior colliculus Excitatory-excitatory neuronal connection Looming-evoked defensive response Subcortical pathway

Propofol Protects Regulatory T Cells, Suppresses Neurotoxic Astrogliosis, and Potentiates Neurological Recovery After Ischemic Stroke

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Neuroscience Bulletin 2021年第5期37卷 725-728页

作者： yuzhu wang Dan Tian Yushang Zhao Mengyao Qu Yuhualei Pan Changwei Wei Yanbing Zhu Anshi Wu Department of Anesthesiology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Experimental and Translational Research Center Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

Dear Editor,Emergency intravascular thrombectomy is the best treatment for acute ischemic stroke [1]. However, it is controversial whether the use of general anesthesia during emergency intravascular thrombectomy affe... 详细信息

关键词： anesthesia acute intravascular

A cross-sectional study into the correlation of common household risk factors and allergic rhinitis in Taiwan's tropical environment

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亚太热带医药杂志：英文版 2017年第2期10卷 127-133页

作者： Yu-Hao wang Yu-Chieh wang Pi-Hsiung Wu Lan Hsu Chung-Yang wang Chung-Ren jan.Hsing-Hao Su Department of Microbiology and Immunology University of Rochester Department of Biology Wake Forest University Department of Otorhinolaryngology Head and Neck SurgeryKaohsiung Veterans General Hospital Department of Dermatology Kaohsiung Veterans General Hospital Anshing Clinic Department of Medical Education and Research Kaohsiung Veterans General Hospital

Objective:To discuss the effect of lesser-known potential risk factors,such as bedroom showers,on the prevalence of allergic ***:A cross-sectional,population-based study was performed using both survey and fungal culturing in southern *** were 998 participants enrolled in the survey,and 513 sets of fungal culture *** score for allergic rhinitis(SFAR) more than 7,the patient was defined to have allergic *** of allergic rhinitis were calculated as odds ratios for various predicted risk factors by logistic *** between predicted risk factors and fungal level were examined with linear ***:The adjusted odds ratio of frequently using bedroom shower to having allergic rhinitis was 1.572(95% confidence interval:1.090-2.265),and 0.962 for people with older age to have AR(95% confidence interval:0.949-0.976).As to the 24-hour fungal level,the standardized coefficient was 0.254 for frequent use of bedroom shower,and 0.106 for window open ***:Use of bedroom shower is a potential risk factor for allergic rhinitis development.

关键词： Allergic rhinitis Allergens Environment Fungi Indoor air quality

Velocity Selection of Atomic Beam by Laser

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Chinese Physics Letters 1995年第5期12卷 269-272页

作者： CAI Weiquan CHEN Hongxin LI Fusheng SHU Wei SUN Shundi wang yuzhu Joint Laboratory for Quantum Optics Shanghai Institute of Optics and Fine Mechanics and East China Normal University Shanghai Institute of Optics and Fine Mechanics Academia SinicaShanghai 201800

It is possible to deflect a group of atoms with a certain velocity from an effusive atomic beam if we use a properly detuned laser beam with a small angle off orthogonal to the atomic *** and initial experimental resu... 详细信息

关键词： beam Velocity properly

Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China:A nationwide retrospective study

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Virologica Sinica 2022年第5期37卷 637-645页

作者： Mengjia Liu Xinyu wang Linlin Zhang Guoshuang Feng Yueping Zeng Ran wang Zhengde Xie Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesLaboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing100045China Research Unit of Critical Infection in Children 2019RU016Chinese Academy of Medical SciencesBeijingChina Big Data Center Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing100045China Medical Record Management Office Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing100045China

Epstein-Barr virus(EBV)is very common,with the infection rate in adults over 90%*** mononucleosis(IM)is caused by primary infection with *** IM patients are generally considered to have a favorable prognosis,but a few patients will also develop *** with severe symptoms will require ***,the disease burden of children hospitalized with IM in China has been rarely *** this study,we included the Face sheets of discharge medical records from 27 member children's hospitals of Futang Research Center of Pediatric Development from jan.1st,2016 to Dec 31st,2020,and medical information such as gender,age,region,time of admission,length of stay and expenditure were *** were 24,120 IM cases,which accounted for 0.42%(24,120/5,693,262)of all hospitalized cases during this *** ratio of male to female was 1.48:*** for IM in the 4-6 years age group was the highest among inpatients of all age *** numbers increased year by year between 2016 and 2020,and the monthly hospitalization was generally high from Jul to Sep but reduced from jan.to Feb per ***/pneumonia and hepatic dysfunction were two common complications in hospitalized IM *** median length of stay was 8 days,and the median cost of hospitalization was 970.59 US *** study will help understand the epidemiological characteristics and disease burden of hospitalized children with IM in China.

关键词： Epstein-Barr virus(EBV) Infectious mononucleosis(IM) Children Epidemiological characteristics Disease burden

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北京地区高学历吸毒者的情况分析

中国药物依赖性杂志 2005年第6期14卷 437-439页

作者：张玉竹王振国北京市安康医院戒毒中心北京102406

目的:了解北京地区高学历吸毒者的情况,为采取有效防范措施提供依据。方法:自拟调查问卷对北京市安康医院戒毒中心2000年1月1日-2003年12月31日收治的戒毒人员中大专以上高学历者进行逐项登记,并对吸毒原因、毒品滥用等情况分析。结果:... 详细信息

目的:了解北京地区高学历吸毒者的情况,为采取有效防范措施提供依据。方法:自拟调查问卷对北京市安康医院戒毒中心2000年1月1日-2003年12月31日收治的戒毒人员中大专以上高学历者进行逐项登记,并对吸毒原因、毒品滥用等情况分析。结果:高学历吸毒者共计431例,占同期戒毒的4.52%,其中男265例(61.48%),女166例(38.52%)。婚姻状况:未婚289例(67.05%),已婚100例(23.20%);职业:以无业为主,219例(50.81%),其次为职员,73例(16.94%);吸毒主要原因:好奇264例(61.25%)、受他人(朋友)影响112例(25.99%);主要滥用毒品的种类:海洛因274例(63.57%)、“摇头丸”130例(30.16%);滥用方式:海洛因滥用者中烫吸155例(57.57%)、注射119例(43.43%),“摇头丸”均为口服,其中119例(91.54%)兑于酒或饮料中使用;大麻均为烟吸,“K粉”均为兑于饮料中使用。有86.92%(113/130)的“摇头丸”滥用者认为服用摇头丸不会成瘾。结论:高学历吸毒人群以未婚、无固定职业为主体,高学历者好奇心强,易受他人影响,对新型毒品(摇头丸)知识欠缺,有关部门应加强宣传教育。

关键词：高学历吸毒者情况分析北京

Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders

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Neuroscience Bulletin 2023年第3期39卷 491-502页

作者： Lijuan Zhang Yafei wang Taohui Liu Ying Mao Bo Peng Department of Neurosurgery Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical NeurobiologyMOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200040China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226001China

prominent immune cells in the central nervous system,microglia constantly monitor the environment and provide neuronal protection,which are important functions for maintaining brain *** the diseased brain,microglia are crucial mediators of neuroinflammation that regulates a broad spectrum of cellular *** this review,we summarize current knowledge on the multifunctional contributions of microglia to homeostasis and their involvement in *** further provide a comprehensive overview of therapeutic interventions targeting microglia in neurodegenerative ***,we propose microglial depletion and subsequent repopulation as promising replacement *** microglial replacement therapy is still in its infancy,it will likely be a trend in the development of treatments for neurodegenerative diseases due to its versatility and selectivity.

关键词： Microglia Neuroinflammation Multifunction Microglial replacement Neurodegeneration

人力资本对产业结构转型升级作用的实证分析——以云南省为例

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西部经济管理论坛 2018年第2期29卷 81-88页

作者：李君陈长瑶侯玉珠王若菲云南师范大学经济与管理学院云南师范大学MBA中心云南师范大学旅游与地理科学学院云南昆明650500

[目的/意义]目前对人力资本与产业结构关系的研究日益增加,但关于云南省区域产业结构与人力资本开发的研究较少。本文拟分析云南省人力资本水平对产业结构升级的影响,以期弥补云南省人力资源与产业结构关系研究的匮乏。[方法/过程]基于... 详细信息

[目的/意义]目前对人力资本与产业结构关系的研究日益增加,但关于云南省区域产业结构与人力资本开发的研究较少。本文拟分析云南省人力资本水平对产业结构升级的影响,以期弥补云南省人力资源与产业结构关系研究的匮乏。[方法/过程]基于云南省1995—2014年相关数据,构建人力资本与产业结构之间的协整方程和误差修正模型,从长期趋势和短期波动两个方面分析人力资本存量与结构对产业结构升级的影响,并采用脉冲响应分析及方差分解计量方法进行实证研究。[结果/结论]云南省人力资本水平与产业结构之间存在长期均衡关系和短期波动:长期内人力资本存量对产业结构升级的促进作用最大,短期内人力资本内部结构对产业结构升级的促进作用最大,高层次人才对产业结构升级作用显著,人力资本分布越公平越能促进产业结构升级。

关键词：云南省人力资本产业结构 VEC模型基尼系数