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Ag-doped CNT/HAP nanohybrids in a PLLA bone scaffold show significant antibacterial activity

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Bio-Design and Manufacturing 2024年第2期7卷 105-120页

作者： Cijun Shuai Xiaoxin Shi Kai wang yulong Gu Feng Yang Pei Feng State Key Laboratory of Precision Manufacturing for Extreme Service Performance College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013China College of Mechanical Engineering Xinjiang UniversityUrumqi 830017China

Bacterial infection is a major problem following bone implant ***,poly-l-lactic acid/carbon nanotube/hydroxyapatite(PLLA/CNT/HAP)bone scaffolds possess enhanced mechanical properties and show good ***,wesynthesizedsilver(Ag)-dopedCNT/HAP(CNT/Ag-HAP)nanohybrids via the partial replacing of calcium ions(Ca2+)in the HAP lattice with silver ions(Ag+)using an ion doping technique under hydrothermal ***ﬁcally,the doping process was induced using the special lattice structure of HAP and the abundant surface oxygenic functional groups of CNT,and involved the partial replacement of Ca2+in the HAP lattice by doped Ag+as well as the in situ synthesis of Ag-HAP nanoparticles on CNT in a hydrothermal *** result-ing CNT/Ag-HAP nanohybrids were then introduced into a PLLA matrix via laser-based powder bed fusion(PBF-LB)to fabricate PLLA/CNT/Ag-HAP scaffolds that showed sustained antibacterial *** then found that Ag+,which pos-sesses broad-spectrum antibacterial activity,endowed PLLA/CNT/Ag-HAP scaffolds with this activity,with an antibacterial effectiveness of 92.65%.This antibacterial effect is due to the powerful effect of Ag+against bacterial structure and genetic material,as well as the physical destruction of bacterial structures due to the sharp edge structure of *** addition,the scaffold possessed enhanced mechanical properties,showing tensile and compressive strengths of 8.49 MPa and 19.72 MPa,***,the scaffold also exhibited good bioactivity and cytocompatibility,including the ability to form apatite layers and to promote the adhesion and proliferation of human osteoblast-like cells(MG63 cells).

关键词： Ag-doped Carbon nanotube/hydroxyapatite(CNT/HAP) Antibacterial properties Bone scaffold

Origin of the Yueguang gold deposit in Xinhua, Hunan Province, South China: insights from fl uid inclusion and hydrogen–oxygen stable isotope analysis

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Acta Geochimica 2024年第2期43卷 235-254页

作者： Hongxin Fan Qiang wang yulong Yang Yao Tang Hao Zou College of Earth Sciences Chengdu University of TechnologyChengdu 610059China College of Earth Sciences Jilin UniversityJilin 130061China

The Yueguang gold deposit is located in Fengjia,Xinhua County,Hunan Province,South *** represents a recently discovered small-scale gold deposit situated in the southwestern region of the Jiangnan Orogenic Belt,west of the Baimashan granitic *** order to discern the characteristics of the ore-formingﬂuids,the underlying mineralization processes,and establish a foundation for the origin of the Yueguang gold depositﬂuid inclusion micro-thermometry,as well as quartz hydrogen and oxygen isotope analysis,have been carried out on samples obtained from various stages of *** hydrothermal miner-alization stages within the Yueguang gold deposit can be categorized into three stages:(i)the barren,pre-ore quartz-pyrite stage(Stage Ⅰ),the quartz-pyrite-gold stage(Stage Ⅱ),and the post-ore quartz-carbonate stage(Stage Ⅲ),with the second stage being the main mineralization ***ﬂuid inclusions identiﬁed in samples from the main min-eralization stage can predominantly be described with the NaCl–H_(2)O and CO_(2)–NaCl–H_(2)O *** inclusions display homogenization temperatures ranging from 158.8 to 334.9℃,and theﬂuid salinity ranges from 0.3%to 4.0%(wt.%NaCl equiv.).Laser Raman spectroscopy analysis of individual inclusions further reveals the presence of gas-phases such as CO_(2),CH_(4),and N_(2).Isotopic analysis indicatesδ^(18)Oﬂuid values ranging from 3.95 to 6.7‰ and δDH_(2)O values ranging from-71.9 to-55.7‰.These results indi-cate that the ore-formingﬂuid of the Yueguang gold deposit belongs to metamorphic hydrothermalﬂuids of middle-low temperature and low *** the process of ore formation,gold is transported in the form of Au(HS)2-complexes,with gold deposition being driven byﬂuid ***,the Yueguang gold deposit is categorized as an orogenic gold deposit dominated by metamorphic hydrother-malﬂ*** may become a new target for gold exploration in the Baimashan region,central Hunan Province.

关键词： Hunan province Yueguang gold deposit Fluid inclusions Hydrogen–oxygen isotopes Laser Raman Fluid immiscibility Orogenic gold deposit

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川渝卫生资源配置公平性分析

卫生软科学 2024年第1期38卷 58-63页

作者：王玉龙胡巧凤刘瑞峰张华敏陈建成都医学院公共卫生学院四川成都610500 重庆市九龙坡区疾病预防控制中心重庆500107

[目的]分析2016-2020年四川(川)、重庆(渝)卫生资源配置公平性,为川渝政府优化卫生资源配置提供参考。[方法]采用差别指数、集聚度评价川渝卫生资源配置公平性。[结果]四川、重庆按人口分布差别指数远小于按地理分布差别指数。成都平原... 详细信息

[目的]分析2016-2020年四川(川)、重庆(渝)卫生资源配置公平性,为川渝政府优化卫生资源配置提供参考。[方法]采用差别指数、集聚度评价川渝卫生资源配置公平性。[结果]四川、重庆按人口分布差别指数远小于按地理分布差别指数。成都平原、川南、重庆都市区5个卫生资源配置指标的HRAD均大于1.6,呈现地区按地理配置公平性过高;从人口配置公平性来看,除川西北外,其他区域HRAD/PAD值为1.0左右,公平性整体较好。除成都平原和重庆市区外,其他区域卫生人力资源公平性低于物力资源。[结论]川渝各区域的卫生资源参差不齐。经济欠发达地区的人口配置卫生资源公平性优于地理配置,且医疗人才资源匮乏。创新区域卫生资源协同体制机制,对有效推动川渝卫生健康资源共享、优势互补、均衡发展具有重要意义。

关键词：卫生资源公平性集聚度差别指数四川重庆

The biological functions and metabolic pathways of valine in swine

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Journal of Animal Science and Biotechnology 2024年第1期15卷 20-34页

作者： Chuni wang Yao Peng Yiru Zhang Juan Xu Sheng Jiang Leli wang yulong Yin Institute of Subtropical Agriculture Chinese Academy of SciencesChangshaChina Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation College of Life SciencesHunan Normal UniversityChangshaChina Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjinChina

Valine is an essential amino acid and a type of branched-chain amino acid. Due to the involvement of branchedchain amino acids in various metabolic pathways, there has been a surge of interests in valine nutrition and its role in animal physiology. In pigs, the interactions between valine and other branched-chain amino acids or aromatic amino acids are complex. In this review, we delve into the interaction mechanism, metabolic pathways, and biological functions of valine. Appropriate valine supplementation not only enhances growth and reproductive performances, but also modulates gut microbiota and immune functions. Based on past observations and interpretations, we provide recommended feed levels of valine for weaned piglets, growing pigs, gilts, lactating sows, barrows and entire males. The summarized valine nutrient requirements for pigs at different stages offer valuable insights for future research and practical applications in animal husbandry.

关键词： Additional dosage Biological function Metabolic pathway Pig Valine

Effects of urbanization and forest type on species composition and diversity,forest characteristics,biomass carbon sink,and their associations in Changchun,Northeast China:implications for urban carbon stock improvement

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Journal of Forestry Research 2024年第2期35卷 146-162页

作者： Yuanyuan wang Xinzhu Dai Xingling Chen Dan Zhang Guiqing Lin Yuanhang Zhou Tianyi wang yulong Cui Academy of Forestry Sciences of Changchun Bureau of Forestry and Landscaping of ChangchunChangchun 130117People’s Republic of China College of Landscape Architecture Changchun UniversityChangchun 130022People’s Republic of China Changchun South Lake Park Bureau of Forestry and Landscaping of ChangchunChangchun 130012People’s Republic of China

Differences in forest attributes and carbon sequestration of each organ and layer between broadleaved and conifer forests of central and outer urban areas are not well-defined,hindering the precise management of urban forests and improvement of *** clarify the effect of two forest types with different urbanization intensities,we determined differences in vegetation composition and diversity,structural traits,and carbon stocks of 152 plots(20 m×20 m)in urban park forests in Changchun,which had the largest green quantity and carbon density *** found that 1.1-fold thicker and healthier trees,and 1.6-to 2.0-fold higher,healthier,denser,and more various shrubs but with sparser trees and herbs occurred in the central urban forests(p<0.05)than in the outer *** conifer forests exhibited 30–70%obviously higher tree aboveground carbon sequestration(including stem and leaf)and 20%bigger trees,especially in the outer forests(p<0.05).In contrast,1.1-to 1.5-fold higher branch stocks,healthier and more diverse trees were found in broadleaved forests of both the inner and outer forests(p<0.05).Plant size and dominant species had similarly important roles in carbon stock improvement,especially big-sized woody plants and Pinus *** addition,a higher number of deciduous or needle species positively affected the broadleaved forest of the central urban area and conifer forest of the outer urban area,*** findings can be used to guide precise management and accelerate the improvement of urban carbon function in Northeast China in the future.

关键词： Species diversity Forest characteristics Biomass carbon sink Forest-type effect Urbanization effect Urban forests

Effects of pore size and dissolved organic matters on diffusion of arsenate in aqueous solution

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Journal of Environmental Sciences 2017年第2期29卷 190-196页

作者： yulong wang Shaofeng wang Xin wang Yongfeng Jia Key Laboratory of Pollution Ecology and Environmental Engineering Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China

Presented here is the influence of membrane pore size and dissolved organic matters on the diffusion coefficient（D） of aqueous arsenate, investigated by the diffusion cell method for the first time. The p H-dependent diffusion coefficient of arsenate was determined and compared with values from previous studies; the coefficient was found to decrease with increasing p H, showing the validity of our novel diffusion cell method. The D value increased dramatically as a function of membrane pore size at small pore sizes, and then increased slowly at pore sizes larger than 2.0 μm. Using the Exp Assoc model, the maximum D value was determined to be 11.2565 × 10^-6cm^2/sec. The presence of dissolved organic matters led to a dramatic increase of the D of arsenate, which could be attributed to electrostatic effects and ionic effects of salts. These results improve the understanding of the diffusion behavior of arsenate, especially the important role of various environmental parameters in the study and prediction of the migration of arsenate in aquatic water systems.

关键词： Arsenate Diffusion Pore p H Dissolved organic matters Migration

国医大师洪广祥从补益宗气论治慢性阻塞性肺病稳定期经验浅析

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中医药通报 2024年第2期23卷 9-12页

作者：张芬芬王玉龙谢荣芳黄春燕兰智慧江西中医药大学研究生院江西南昌330004 江西中医药大学附属医院江西南昌330006

国医大师洪广祥教授认为,慢性阻塞性肺病的基本病机为本虚标实,本虚为宗气虚,标实为痰浊、水饮及血瘀阻肺。宗气虚贯穿慢性阻塞性肺病发病的全过程,宗气虚不仅导致肺脾肾三脏虚损,还可导致痰瘀阻肺,是慢性阻塞性肺病发病的根本原因。洪... 详细信息

国医大师洪广祥教授认为,慢性阻塞性肺病的基本病机为本虚标实,本虚为宗气虚,标实为痰浊、水饮及血瘀阻肺。宗气虚贯穿慢性阻塞性肺病发病的全过程,宗气虚不仅导致肺脾肾三脏虚损,还可导致痰瘀阻肺,是慢性阻塞性肺病发病的根本原因。洪广祥教授认为治疗慢性阻塞性肺病重在补益宗气,并自创补元汤。文中从慢性阻塞性肺病的病因病机、宗气理论、治疗原则、治法方药等方面总结洪广祥教授的经验,并附验案1则。

关键词：慢性阻塞性肺病稳定期洪广祥补益宗气肺脾肾

空运中转医疗队配属航空兵场站医院保障模式探讨

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空军航空医学 2024年第3期41卷 273-275页

作者：杨海青王宇龙孟龙何皎桑崇铃王娇朱立强中部战区空军医院院办大同037006 中部战区空军医院烧伤整形科大同037006 中部战区空军医院训练康复科大同037006 中部战区空军医院信息科大同037006 中部战区空军医院呼吸内科大同037006 中部战区空军医院心理科大同037006 中部战区空军医院质量管理科大同037006

介绍空运中转医疗队配属航空兵场站医院3种保障模式,即空运中转医疗队独立开设空运医疗后送中转机构保障模式、空运中转医疗队与场站医院实施整建制融合式保障模式和空运中转医疗队组建模块化小分队支援式保障模式,并分析不同配属模式... 详细信息

介绍空运中转医疗队配属航空兵场站医院3种保障模式,即空运中转医疗队独立开设空运医疗后送中转机构保障模式、空运中转医疗队与场站医院实施整建制融合式保障模式和空运中转医疗队组建模块化小分队支援式保障模式,并分析不同配属模式的利弊,为全军卫勤力量建设提供参考。

关键词：空运中转医疗队场站医院保障模式

维得利珠单抗一线及后线治疗炎症性肠病的疗效比较

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胃肠病学和肝病学杂志 2024年第1期33卷 55-58页

作者：方洒吴开春时永全王玉龙韩霜陈敏西安交通大学附属红会医院消化内科陕西西安710054 空军军医大学第一附属医院消化内科

目的评估维得利珠单抗(Vedolizumab,VDZ)作为一线生物制剂治疗炎症性肠病(inflammatory bowel disease,IBD)患者的疗效和安全性。方法回顾性分析2021年2月至2022年5月空军军医大学第一附属医院使用VDZ治疗IBD患者的临床资料。比较既... 详细信息

目的评估维得利珠单抗(Vedolizumab,VDZ)作为一线生物制剂治疗炎症性肠病(inflammatory bowel disease,IBD)患者的疗效和安全性。方法回顾性分析2021年2月至2022年5月空军军医大学第一附属医院使用VDZ治疗IBD患者的临床资料。比较既往未使用生物制剂治疗的患者与既往使用生物制剂治疗患者使用VDZ的治疗效果。结果共32例使用VDZ治疗IBD患者纳入研究,其中VDZ为一线生物制剂组占43.8%(14/32),VDZ为后线生物制剂组占56.3%(18/32)。在第6周、14周、22周、52周时,两组临床应答率差异无统计学意义(P均>0.05);在22周、52周时,VDZ为一线生物制剂组临床缓解率均高于VDZ为后线生物制剂组(P0.05);在22周时,VDZ为一线生物制剂组内镜缓解率高于VDZ为后线生物制剂组(P=0.009)。随访期间仅VDZ为后线生物制剂组出现1例过敏性皮疹。结论 VDZ作为一线生物制剂在短期内对IBD具有较好的诱导临床及内镜缓解作用,安全性高。

关键词：维得利珠单抗炎症性肠病溃疡性结肠炎克罗恩病疗效安全性