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Treatment with β-sitosterol ameliorates the effects of cerebral ischemia/reperfusion injury by suppressing cholesterol overload, endoplasmic reticulum stress, and apoptosis

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Neural Regeneration Research 2024年第3期19卷 642-649页

作者： Xiuling Tang Tao Yan Saiying wang Qingqing Liu Qi Yang Yongqiang Zhang Yujiao Li Yumei Wu Shuibing Liu yulong Ma Le Yang Precision Pharmacy&Drug Development Center Department of PharmacyTangdu HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Clinical Pharmacy Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu ProvinceChina Department of Pharmacology School of PharmacyAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Anesthesiology The First Medical Center of Chinese PLA General HospitalBeijingChina Department of Anatomy Histology and Embryology and K.K.Leung Brain Research CentreAir Force Medical UniversityXi’anShaanxi ProvinceChina

β-Sitosterol is a type of phytosterol that occurs naturally in *** studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic *** we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced *** investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic *** addition,β-sitosterol showed high affinity for NPC1L1,a key transporter of cholesterol,and antagonized its *** conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways.

关键词： apoptosis blood-brain barrier β-sitosterol cerebral ischemia/reperfusion injury cholesterol overload cholesterol transport endoplasmic reticulum stress ischemic stroke molecular docking NPC1L1

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Printing strategies for scaling-up perovskite solar cells

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National Science Review 2021年第8期8卷 69-92页

作者： yulong wang Changyu Duan Pin Lv Zhiliang Ku Jianfeng Lu Fuzhi Huang Yi-Bing Cheng Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory State Key Laboratory of Silicate Materials for Architectures Wuhan University of Technology State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Department of Materials Science and Engineering Monash University

Photovoltaic technology offers a sustainable solution to the problem of soaring global energy ***, metal halide perovskite solar cells(PSCs) have attracted worldwide interest because of their high power conversion efficiency of 25.5% and great potential in becoming a disruptive technology in the photovoltaic industry. The transition from research to commercialization requires advancements of scalable deposition methods for both perovskite and charge transporting thin films. Herein, we share our view regarding the current challenges to fabrication of PSCs by printing techniques. We focus particularly on ink technologies, and summarize the strategies for printing uniform, pinhole-free perovskite films with good crystallinity. Moreover, the stability of perovskite solar modules is discussed and analyzed. We believe this review will be advantageous in the area of printable electronic devices.

关键词： printing technology perovskite solar cells ink large-area crystallization module stability

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G Bytes Data Hiding Method Based on Cluster Chain Structure

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Wuhan University Journal of Natural Sciences 2013年第5期18卷 443-448页

作者： NIU Xiaopeng LI Qingbao wang Wei wang yulong State Key Laboratory of Mathematical Engineering and Advanced Computing PLA Information Engineering University

Protecting the security of sensitive information has become a matter of great concern to everyone. Data hiding technique solves the problem to some extent, but still, some shortcomings remain for researching. To improve the capability of hiding huge data file in disk with high efficiency. In this paper, we propose a novel approach called CryptFS, which is achieved by utilizing the file access mechanism and modifying the cluster chain structure to hide data. CryptFS can quickly hide data file with G bytes size in less than 0.1s. The time used for hiding and recovering data is irrelevant to the size of data file, and the reliability of the hidden file is high, which will not be overlaid by new created file and disk defragment.

关键词： data hiding file system cluster chain index entry efficiency robustness

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Chemical construction and anti-HCoV-OC43 evaluation of novel 10,12-disubstituted aloperine derivatives as dual cofactor inhibitors of TMPRSS2 and SR-B1

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Chinese Chemical Letters 2024年第5期35卷 201-206页

作者： yulong Shi Fenbei Chen Mengyuan Wu Xin Zhang Runze Meng Kun wang Yan wang Yuheng Mei Qionglu Duan Yinghong Li Rongmei Gao Yuhuan Li Hongbin Deng Jiandong Jiang Yanxiang wang Danqing Song Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Pharmacy Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272000China

Thirty-one new 10,12-disubstituted aloperine derivatives were subtly constructed through a selective oxidation on the 10-α-C-H induced by sulfonyl and a nucleophilic substitution with the stereoselectivity and *** them,compound 6b displayed a moderate anti-human coronavirus OC43(HCoV-OC43)potency and blocked the viral entry stage through a host mechanism of *** chemoproteomic techniques,both transmembrane serine protease 2(TMPRSS2)and scavenger receptor class B type 1(SR-B1)proteins,which act as host cofactors of viral entry,were identified to be the direct targets of 6b against ***,6b may deactivate the TMPRSS2 by inducing a change in protein conformation,rather than binding to its catalytic center,thus suppressing the viral membrane ***,our study provided key scientific data for the development of aloperine derivatives into a new class of antiviral candidates against humanβ-coronavirus,including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).

关键词： Aloperine SARS-CoV-2 TMPRSS2 SR-B1 Synthesis

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Effects of COL1A1 and SYTL2 on inflammatory cell infiltration and poor extracellular matrix remodeling of the vascular wall in thoracic aortic aneurysm

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Chinese Medical Journal 2024年第9期137卷 1105-1114页

作者： Xinsheng Xie Ye Yuan yulong Huang Xiang Hong Shichai Hong Gang Chen Yihui Chen Yue Lin Weifeng Lu Weiguo Fu Lixin wang Department of Vascular Surgery Zhongshan Hospital(Xiamen)Fudan UniversityXiamenFujian 361015China Department of Vascular Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Vascular Surgery Institute of Fudan University Fudan UniversityShanghai 200032China

Background:Thoracic aortic aneurysm(TAA)is a fatal cardiovascular disease,the pathogenesis of which has not yet been *** study aimed to identify and validate the diagnostic markers of TAA to provide a strong theoretical basis for developing new methods to prevent and treat this ***:Gene expression profiles of the GSE9106,GSE26155,and GSE155468 datasets were acquired from the Gene Expression Omnibus(GEO)*** expressed genes(DEGs)were identified using the"limma"package in *** absolute shrinkage and selection operator(LASSO),support vector machine-recursive feature elimination(SVM-RFE),random forest,and binary logistic regression analyses were used to screen the diagnostic marker ***-sample gene set enrichment analysis(ssGSEA)was used to estimate immune cell infiltration in ***:A total of 16 DEGs were *** enrichment and functional correlation analyses showed that DEGs were mainly associated with inflammatory response pathways and collagen-related *** type I alpha 1 chain(COL1A1)and synaptotagmin like 2(SYTL2)were identified as diagnostic marker genes with a high diagnostic value for *** expression of COL1A1 and SYTL2 was considerably higher in TAA vascular wall tissues than in the corresponding normal tissues,and there were significant differences in the infiltration of immune cells between TAA and normal vascular wall ***,COL1A1 and SYTL2 expression were associated with the infiltration of immune cells in the vascular wall ***-cell analysis showed that COL1A1 in TAA was mainly derived from fibroblasts and SYTL2 mainly from cluster of differentiation(CD)8+T *** addition,single-cell analysis indicated that fibroblasts and CD8+T cells in TAA were significantly higher than those in normal arterial wall ***:COL1A1 and SYTL2 may serve as diagnostic marker genes for *** upregulation of SYTL2 and COL1A1 may be involved in the inflammat

关键词： Bioinformatics Thoracic aortic aneurysm Immune response Single cell analysis Machine learning

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Sequential dual-locking strategy using photoactivated Pt(Ⅳ)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3251-3265页

作者： Jun Li Qiang Zhang Hao Yang Wenli Lu yulong Fu Yingcai Xiong Xuan wang Tianming Lu Yanlin Xin Zejuan Xie Weichao Chen Guoqiang wang Yuanyuan Guo Ruogu Qi School of Medicine Nanjing University of Chinese MedicineNanjing 210023China Key Laboratory of Mesoscopic Chemistry of Ministry of Education Institute of Theoretical and Computational ChemistrySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Laboratory for Manufacturing Low Carbon and Functionalized Textiles College of Textiles&ClothingQingdao UniversityQingdao 266071China

Selective activation of Pt(Ⅳ)prodrugs within tumors has emerged as a promising strategy in tumor *** progress has been made with photo-and ultrasound-activated Pt(Ⅳ)prodrugs,concerns remain over the non-specific activation of photosensitizers(PS)and the potential for phototoxicity and chemical *** this study,a sequential dual-locked Pt(Ⅳ)nano-prodrug that can be activated by both the acidic tumor microenvironment and light was *** Pt(Ⅳ)prodrug was prepared by conjugating PS-locked Pt(Ⅳ)to a polymeric core,which was then chelated with metallo iron to lock its photoactivity and form a metallo-nano *** acidic tumor microenvironment conditions,the metallo-nano prodrug undergoes dissociation of iron,triggering a reduction process in oxaliplatin under light irradiation,resulting in the activation of both chemotherapy and photodynamic therapy(PDT).Additionally,the prodrug could induce metallo-triggered ferroptosis and polarization of tumorassociated macrophages(TAM),thereby enhancing tumor *** dual-lock strategy employed in a nanoparticle delivery system represents an expansion in the application of platinum-based anticancer drugs,making it a promising new direction in cancer treatment.

关键词： Dual-locking Pt(Ⅳ)reduction Chemotherapy Photodynamic therapy Ferroptosis Macrophage polarization Medicinal inorganic chemistry Metals in medicine

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A Novel Fast Terminal Sliding Mode Control Method Based on Immersion and Invariance for Course Control of USV

A Novel Fast Terminal Sliding Mode Control Method Based on I...

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第36届中国控制会议

作者： XUE Wentao ZHANG Chen LI Jianzhen wang yulong School of Electronics and Information Jiangsu University of Science and Technology

ISBN: (纸本)9781538629185

The course control of an unmanned surface vehicle（USV） with water-jet-propelled is addressed using a novel fast terminal sliding mode control approach based on system immersion and manifold invariant（FTSMC-I＆I）.The control scheme can ensure all error signals globally exponentially converge to origin in finite-time by the novel fast terminal sliding mode *** addition,I＆I method is applied to design an adaptive disturbance estimator in order to improve estimation accuracy and convergence speed with respect to parametric uncertainties and disturbances that are encountered in sailing ***,an additional compensation item is introduced into the adaptive law to keep the estimation error manifold invariant and *** a result,the estimation error of disturbances tends to zero and its dynamic process can be *** is shown that the proposed method can guarantee the asymptotical stability and the finite time convergence of the system from Lyapunov stability *** with the backstepping adaptive sliding mode control,the proposed control method can achieve higher precision and better robustness in the presence of practical input limits.

关键词： Unmanned surface vehicle Terminal sliding mode Immersion and invariant theory Adaptive law

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数字化时代高职院校教材建设的逻辑、特征与策略

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职教论坛 2022年第8期38卷 41-47页

作者：王玉龙浙江金融职业学院

职业教育数字化改革作为高职院校深化人才培养模式、提高教育教学质量的主要力量,加快信息技术对高职院校教材的改造升级,需要高职院校准确理解教材国家事权、类型特色的内在要求以及在服务发展和“三教”改革中的现实价值。在数字化背... 详细信息

职业教育数字化改革作为高职院校深化人才培养模式、提高教育教学质量的主要力量,加快信息技术对高职院校教材的改造升级,需要高职院校准确理解教材国家事权、类型特色的内在要求以及在服务发展和“三教”改革中的现实价值。在数字化背景下,高职院校教材应彰显价值引领、内容科学、职教特色、资源立体等特征,选择适宜教材建设的发展策略,通过完善教材管理体系、持续优化教材内容、丰富教材呈现形式、构建教材评价标准、加强教材理论研究、提高教材建设质量,进而推动高职院校教育教学改革。

关键词：数字化时代高职院校 “三教”改革教材建设

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DEEPEYE: Link Prediction in Dynamic Networks Based on Non-negative Matrix Factorization

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Big Data Mining and Analytics 2018年第1期1卷 19-33页

作者： Nahla Mohamed Ahmed Ling Chen yulong wang Bin Li Yun Li Wei Liu College of Information Engineering Yangzhou University College of Mathematical Sciences Khartoum University State Key Lab of Novel Software Tech Nanjing University College of Agriculture Yangzhou University

A Non-negative Matrix Factorization(NMF)-based method is proposed to solve the link prediction problem in dynamic graphs. The method learns latent features from the temporal and topological structure of a dynamic network and can obtain higher prediction results. We present novel iterative rules to construct matrix factors that carry important network features and prove the convergence and correctness of these algorithms. Finally, we demonstrate how latent NMF features can express network dynamics efficiently rather than by static representation,thereby yielding better performance. The amalgamation of time and structural information makes the method achieve prediction results that are more accurate. Empirical results on real-world networks show that the proposed algorithm can achieve higher accuracy prediction results in dynamic networks in comparison to other algorithms.

关键词： dynamic network link prediction matrix factorization

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Modulating Crystallinity and Miscibility via Side-chain Variation Enable High Performance All-Small-Molecule Organic Solar Cells

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Chinese Journal of Chemistry 2021年第8期39卷 2147-2153页

作者： Yang wang Qunping Fan yulong wang Jin Fang Qi Liu Lei Zhu Jinjing Qiu Xia Guo Feng Liu Wenyan Su Maojie Zhang Laboratory of Advanced Optoelectronic Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China Department of Chemistry City University of Hong KongKowloon 999077Hong KongChina Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Siyuan LaboratoryDepartment of PhysicsJinan UniversityGuangzhouGuangdong 510632China

Side-chain engineering as one of the most important molecular design strategies has been widely used to improve photovoltaic effi-ciency of active layer ***,a series of acceptor-n-donor-n-acceptor typed small molecule(SM)-donors(SL1,SL2,SL3,and SL4),on the basis of high-performance SM-donor BTTzR(SL1)with thiazolo[5,4-d]thiazole as the n-bridging units and 3-butylrho-danine as the terminal electron-withdrawing groups,were designed and synthesized to study the effect of the side-chain substitu-tions of BDT-T on the photovoltaic performanee.

关键词： Organic solar cells Small molecule donor Substituent effects Aggregation Solvent effects

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