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CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ

Bone Research 2023年第2期11卷 427-441页

作者： Ruiqi Yu Hong Han Shuxian Chu Yijun Ding Shiqi Jin yufeng wang Wei Jiang Yuting Liu Yongxin Zou Molin wang Qiao Liu Gongping Sun Baichun Jiang Yaoqin Gong The Key Laboratory of Experimental Teratology of the Ministry of Education and Department of Genetics School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China The Key Laboratory of Liquid-Solid Structural Evolution and Processing of Materials of Ministry of Education and Institute of Liquid Metal and Casting Technology School of Materials Science and EngineeringShandong UniversityJinan 250012China The Key Laboratory of Experimental Teratology of the Ministry of Education and Department of Histology and Embryology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Dysregulated lineage commitment of mesenchymal stem cells(MSCs)contributes to impaired bone formation and an imbalance between adipogenesis and osteogenesis during skeletal aging and *** intrinsic cellular mechanism that regulates MSC commitment remains ***,we identified Cullin 4B(CUL4B)as a critical regulator of MSC ***4B is expressed in bone marrow MSCs(BMSCs)and downregulated with aging in mice and *** knockout of Cul4b in MSCs resulted in impaired postnatal skeletal development with low bone mass and reduced bone ***,depletion of CUL4B in MSCs aggravated bone loss and marrow adipose accumulation during natural aging or after *** addition,CUL4B deficiency in MSCs reduced bone ***,CUL4B promoted osteogenesis and inhibited adipogenesis of MSCs by repressing KLF4 and C/EBPδexpression,*** CUL4B complex directly bound to Klf4 and Cebpd and epigenetically repressed their ***,this study reveals CUL4B-mediated epigenetic regulation of the osteogenic or adipogenic commitment of MSCs,which has therapeutic implications in osteoporosis.

关键词： CUL4B impaired epigenetic

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融合多源数据的城镇空间演化研究——以京津冀为例

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北京理工大学学报 2022年第2期42卷 152-157页

作者：王雨枫中国海洋大学环境科学与工程学院山东青岛266100

为了解决传统研究手段在城镇空间演化探测方面的不足,响应中国土地精细化转型,并提升光学卫星及遥感技术在社会经济领域的深层次应用,基于京津冀城市群,运用城镇演化及产业转移等模型,分析1990—2020年其演化的时空特征.结果表明:(1)演... 详细信息

为了解决传统研究手段在城镇空间演化探测方面的不足,响应中国土地精细化转型,并提升光学卫星及遥感技术在社会经济领域的深层次应用,基于京津冀城市群,运用城镇演化及产业转移等模型,分析1990—2020年其演化的时空特征.结果表明:(1)演化强度整体表现出"上升-下降"趋势,呈现出环京津唐及石家庄-保定等演化热点;(2)北京、天津及唐山等综合发展呈下降趋势,石家庄、邯郸及邢台等呈上升趋势;(3)区域产业链在空间上表现出集聚与扩散趋势,中高端产业在首位城市集聚,中低端产业向周围城市转移.研究证明光学卫星在城镇发展监测方面具有巨大的潜力,可以对地区一体化发展的规划与决策提供一定的参考.

关键词： Landsat卫星城镇空间探测人口流动产业转移京津冀城市群

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京津冀地区耕地利用时空分异与影响机制分析

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农业机械学报 2022年第1期53卷 192-197,214页

作者：王雨枫王娟中国海洋大学环境科学与工程学院青岛266100 云南省城乡规划设计研究院昆明650228

京津冀地区耕地资源的不均衡分布使得社会经济发展的地域差异性突出,厘清其耕地时空异质性对于地区协调可持续发展有着重要意义。基于京津冀地区,采用耕地动态变化模型及地理探测器等方法对1990—2020年间其耕地空间分布演化与影响机制... 详细信息

京津冀地区耕地资源的不均衡分布使得社会经济发展的地域差异性突出,厘清其耕地时空异质性对于地区协调可持续发展有着重要意义。基于京津冀地区,采用耕地动态变化模型及地理探测器等方法对1990—2020年间其耕地空间分布演化与影响机制进行了探讨。结果表明:北京市率先进入工业化城镇建设,天津市次之,河北省滞后,相对的耕地变化动态度高值也先后出现。耕地分布集聚特征显著,呈现“东南密西北疏”的核密度格局。土地利用结构改变特征明显,面积净增长的主要有建设用地、林地及水域,面积净减少的主要有耕地、草地及未利用地。耕地流失主要表现出环北京及环渤海为中心的聚集式特征,且东部流失的热度比西部高,南部比北部高。社会经济及政策因素对耕地利用的影响力呈上升趋势,而自然因素的影响力呈下降趋势。本研究结果可为京津冀地区耕地保护、区域协调发展提供科学依据。

关键词：耕地分布土地利用转移时空演变影响机制京津冀地区

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浙江城市群人口与用地规模的时空分异结构演变研究

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武汉大学学报（信息科学版） 2022年第2期47卷 280-286页

作者：王雨枫王娟中国海洋大学环境科学与工程学院山东青岛266100 云南省城乡规划设计研究院云南昆明650000

结合夜间灯光与城市统计数据,应用城市位序-规模法则及人地异速生长模型,初步分析了浙江人口分布及人地关系,考虑到人口增长的特征,提出了加入滞后效应的修正模型,对浙江城市群长期的发展展开了动态研究。研究结果表明,浙江城市群结构... 详细信息

结合夜间灯光与城市统计数据,应用城市位序-规模法则及人地异速生长模型,初步分析了浙江人口分布及人地关系,考虑到人口增长的特征,提出了加入滞后效应的修正模型,对浙江城市群长期的发展展开了动态研究。研究结果表明,浙江城市群结构体系较为成熟,但是随着经济发展,城市首位度逐步提高,人口逐渐呈现聚集状态;浙江城市群中的杭州、宁波及温州城市发展呈现出立体型,而金华、嘉兴、丽水及台州城市发展呈现出扁平型;加入滞后项的异速模型能够明显提高拟合精度,其中平均增幅为6.47%,最高增幅为12.61%。研究结果证明了人口与土地开发的相关性,有利于省域层面的组织结构规划。

关键词：夜间灯光城区人口土地城市化位序-规模法则异速生长模型城市群时空分异结构

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Urban Color Planning of Xuzhou City

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Journal of Landscape Research 2017年第5期9卷 11-18,21页

作者： XIAO Bing wang yufeng JI Xiang Jiangsu Institute of Urban Planning and Design College of Architecture and Civil Engineering Xinyang Normal University School of Architecture and Design China University of Mining and Technology

Urban color planning will not only excavate historical context to strengthen urban difference and highlight urban individuality,thereby forming urban style and features that are easy to identify and perceive,but integrate natural landscape and control urban color,open space,green space system and architectural elements to crate a splendid visual *** to the concept of inheriting the historical context and culture,urban color planning of Xuzhou City fully taps the cultural potential of the historical and cultural resources,natural landscape resources and local customs and practices and carries out a practical exploration of urban color and urban style and features as well as the heritage and development of local culture through the urban color planning of"one centre,two axes,two belts,three sections",so as to provide a constructive reference for urban color planning of other cities in China.

关键词： Urban color planning Historical and cultural resources Color control system Color control benchmark Color recommendation and application

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Psychometric properties of the Caregiver Strain Questionnaire among Chinese parents of children with ADHD or ASD

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General Psychiatry 2021年第2期34卷 78-86页

作者： Runxu Yang Huizhi Zhou Jin Liu yufeng wang Yan Zhang Yanjiao wang Ruixiang Liu Xia Cao Dong Han Shuran Yang Jianzhong Yang Chuanyuan Kang Psychiatry Department Kunming Medical University First Affilliated HospitalKunmingYunnanChina Department of Psychosomatic Medicine Shanghai East HospitalTongji University School of MedicineShanghaiChina Psychiatry Department Peking University Sixth HospitalBeijingChina Psychiatry Department Kunming Medical University Second HospitalKunmingYunnanChina Department of Clinical Psychology The Second People's Hospital of Yunnan ProvinceKunmingChina Department of Science and Education Kunming Medical University Second HospitalKunmingYunnanChina

Background There is an urgent need in clinical practice to measure the stress of *** Caregiver Strain Questionnaire(CGSQ)was found to be useful to measure parenting stress,but it has not been validated among the Chinese *** To assess the reliability and construct validity of the Chinese version of CGSQ among Chinese *** From 2016 to 2017,266 parents(patient group)with a child having DSM-5-defined attention deficit hyperactivity disorder(ADHD)(n=107)or autism spectrum disorder(ASD)(n=159)and 268 parents of healthy children(control group)were recruited to the present study in Kunming,Yunnan *** the parents were asked to fill out the Chinese version of *** conducted exploratory factor analysis and confirmatory factor analysis(CFA)to verify construct validity of CGSQ in both patient and control ***’s α coefficient as an index of internal consistency was assessed for each *** days later,23 subjects filled out the scale ***-class correlation coefficient was calculated to evaluate the test-retest ***(1)Cronbach’s alpha of the global scale was 0.901 for the control group and 0.952 for the patient *** test-retest reliability for the whole scale was 0.890;(2)CFA indicated that the three-factor model had better fitting indices compared with the two-factor model in both ***,the fitting indices in the patient group were more favourable than those of the control group,withχ2/df=1.564,Goodness-of Fit Index=0.841,Comparative Fit Index=0.954,and root mean square error of approximation=0.065 for the patient group at three-factor model;(3)The caregiver strain of ASD parents was statistically higher than that of ADHD parents,and caregiver strain of ADHD parents was higher than that of control *** These findings provide initial evidence to support the construct validity and reliability of CGSQ as a parenting stress measurement tool for Chinese parents,especially

关键词： ASD indices filled

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The law of fracture propagation and intersection in zipper fracturing of deep shale gas wells

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Petroleum Exploration and Development 2024年第5期51卷 1316-1326页

作者： wang Qiang wang yufeng HU Yongquan ZHAO Jinzhou SONG Yi SHEN Cheng State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China Shale Gas Research Institute PetroChina Southwest Oil&Gas Field CompanyChengdu 610051China

In response to the unclear understanding of fracture propagation and intersection interference in zipper fracturing under the factory development model of deep shale gas wells,a coupled hydro-mechanical model for zipper fracturing considering the influence of natural fracture zones was established based on the finite element–discrete element *** reliability of the model was verified using experimental data and field monitoring pressure increase *** the deep shale gas reservoir in southern Sichuan as an example,the propagation and interference laws of fracturing fractures under the influence of natural fracture zones with different characteristics were *** results show that the large approaching angle fracture zone has a blocking effect on the forward propagation of fracturing fractures and the intersection of inter well *** pump shutdown,hydraulic fractures exhibit continued expansion behavior under net pressure *** high stress difference,as the approaching angle of the fracture zone increases,the response well pressure increase and the total length of the fractured fracture show a trend of first decreasing and then increasing,and first increasing and then decreasing,*** to small approach angle fracture zones,natural fracture zones with large approach angles require longer time and have greater difficulty to *** width of fractures and the length of natural fractures are negatively and positively correlated with the response well pressure increase,respectively,and positively and negatively correlated with the time required for intersection,the total length of hydraulic fractures,and fracturing efficiency,*** the displacement distance of the well increases,the probability of fracture intersection decreases,but the regularity between displacement distance and the response well pressure increase and the total length of fractures is not obvious.

关键词： thin sand-mud interbedded reservoir fracture penetration fracturing simulation experiment numerical simulation fracture penetration discrimination criterion fracturing performance evaluation

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Postural control and sensory information integration abilities of boys with two subtypes of attention deficit hyperactivity disorder： a case-control study

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Chinese Medical Journal 2014年第24期127卷 4197-4203页

作者： Ren Yuanchun Yu Lishen Yang Li Cheng Jia Feng Lei wang yufeng Department of Child Psychiatry Research Peking University Sixth Hospital Peking University Institute of Mental Health Key Laboratory of Ministry of HealthBeijing 100191 China Institute of Aviation Medicine of Air Force Beijing 100036 China Depression Treatment Center Beijing Anding Hospital Beijing 100124 China

Background Attention deficit hyperactivity disorder （ADHD） is one of the most commonly diagnosed psychiatric disorder in childhood. ADHD children with overlapping symptoms and signs of motor problems have more serious prognosis than that of children with ADHD only. However, the motor and sensory processing problems in children with ADHD have not been studied well. Few people adopt the technique of computerized dynamic posturography （CDP） in the study of ADHD, which is applied widely in clinical and laboratory research to objectively evaluate human＇s balance performance. This study aimed to assess the characteristics of postural control and sensory information processing of boys with two subtypes of ADHD by using CDP, so as to provide the proof for non-drug therapy of ADHD. Method From June 2003 to September 2004, a total of 73 boys （7-15 years of age） with ADHD and 73 normal developing boys matched by age and intelligence quotient from Peking University Institute of Mental Health were recruited in the study. The Sensory Organization Test was adopted to test the static balance performance under six sensory input conditions by SMART EquiTest 8.0 （NeuroCom） instrument. The sensory information from three sensory systems were available under condition 1, the visual inputs were removed or distorted under condition 2 or 3, the somatosensory inputs were in conflict with or without the visual inputs removed under condition 4 or 5, and both the visual and somatosensory inputs were in conflict under condition 6. The indexes of equilibrium score, somatosensory, vestibular, and visual ratios, and strategy scores were analyzed to indicate the subjects＇ postural control ability. Results ADHD boys had significantly lower composite equilibrium score （CES） than the normal group （P 〈0.05）. Under condition 1 and conditions 3-6, the equilibrium scores （ES） of the ADHD group were significantly lower （all P 〈0.05） than those of the control. Significantly lower visual and vestibular ratios

关键词： postural balance sensory integration attention deficit hyperactivity disorder subtypes childhood

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海洋浮标的非接触式电能与数据传输

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仪器仪表学报 2010年第11期31卷 2615-2621页

作者：张强王玉峰天津科技大学计算机科学与信息工程学院天津300222

提出一种新的基于电磁感应原理的非接触式海洋浮标电能与数据传输系统,设计了新型传输缆与电磁耦合器,建立了传输系统的数学模型,提出了优化传输效率的方法,在理论上提出并证明了降低传输缆电感的方法。实验表明该系统能够为水下仪器设... 详细信息

提出一种新的基于电磁感应原理的非接触式海洋浮标电能与数据传输系统,设计了新型传输缆与电磁耦合器,建立了传输系统的数学模型,提出了优化传输效率的方法,在理论上提出并证明了降低传输缆电感的方法。实验表明该系统能够为水下仪器设备提供一定的电能功率,双向数据传输波形失真较小。水下钢缆上的设备安装方便,可以随时、随地安装或拆除,钢缆生产与仪器挂载两道工艺完全分离。解决了为每个浮标系统特别定制钢缆的问题,降低浮标生产和投放成本。

关键词：电磁耦合浮标非接触电能传输双向数据传输

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苯乙烯生产工艺的节能优化和经济分析

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化学工程 2024年第7期52卷 88-94页

作者：王玉枫中石化上海工程有限公司上海200120

在中石化自主研发的苯乙烯生产工艺中,乙苯脱氢反应需要加入大量过热蒸汽作为脱氢介质,水蒸气和乙苯流量的比值是影响脱氢反应的一个重要因素。随着低水比催化剂工业应用取得进展,可以减少进入反应器的蒸汽量,而降低水比的关键就在于减... 详细信息

在中石化自主研发的苯乙烯生产工艺中,乙苯脱氢反应需要加入大量过热蒸汽作为脱氢介质,水蒸气和乙苯流量的比值是影响脱氢反应的一个重要因素。随着低水比催化剂工业应用取得进展,可以减少进入反应器的蒸汽量,而降低水比的关键就在于减少乙苯/苯乙烯塔顶冷凝器共沸蒸出的乙苯和蒸汽的量。控制恒沸蒸发量后,会导致乙苯/苯乙烯塔塔顶物料携带的热量不能完全回收。为合理利用这部分热量,对原工艺流程进行优化、热量进行耦合。此次节能优化主要涉及9台换热器,其中2台为新增。优化过程中还降低了预分塔塔压,提高了尾气压缩机出口温度。经过优化,可减少综合能耗11.364 kg标油(以1 t苯乙烯计),静态投资回收期约为2个月。

关键词：苯乙烯乙苯脱氢尾气压缩机降膜再沸器节能优化

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