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Gene deficiency or pharmacological inhibition of PDCD4-mediated FGR signaling protects against acute kidney injury

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Acta Pharmaceutica Sinica B 2021年第2期11卷 394-405页

作者： xu Jing Dandan Ren Fei Gao Ye chen Xiao Wu yue Han Qingsheng Han liang li xiaojie wang Wei Tang Yan Zhang Department of Pharmacology School of Basic Medical ScienceShandong UniversityJinan 250012China The Key Laboratory of Cardiovascular Remodeling and Function Research Department of CardiologyQilu Hospital of Shandong UniversityJinan 250012China Department of Microbiology School of Basic Medical ScienceShandong UniversityJinan 250012China Department of Clinical Laboratory the Second Hospital of Shandong UniversityJinan 250033China chengda Biology Co. Ltd.Shenyang 110179China

Recent studies have shown that programmed cell death 4(PDCD4)modulates distinct signal transduction pathways in different pathological *** acute and chronic immune responses elicited by ischemia contributing to the functional deterioration of the kidney,the contributions and mechanisms of PDCD4 in acute kidney injury(AKI)have remained *** two murine AKI models including renal ischemia/reperfusion injury(IRI)and cisplatin-induced AKI,we found that PDCD4 deficiency markedly ameliorated renal dysfunction and inflammatory responses in AKI ***,upregulation of PDCD4 was also confirmed in the kidneys from patients with biopsy confirmed acute tubular necrosis from a retrospective cohort ***,we found that overexpression of Fgr,a member of the tyrosine kinase family,dramatically aggravated renal injury and counteracted the protective effects of PDCD4 deficiency in AKI *** discovered that FGR upregulated NOTCH1 expression through activating *** importantly,we further found that systemic administration of ponatinib,a tyrosine kinase inhibitor,significantly ameliorated AKI in *** summary,we identified that PDCD4 served as an important regulator,at least in part,of FGR/NOTCH1-mediated tubular apoptosis and inflammation in AKI ***,our findings suggest that ponatinib-mediated pharmacologic targeting of this pathway had therapeutic potential for mitigating AKI.

关键词： Acute kidney injury Ischemiae-reperfusion injury PDCD4 Cell death Tyrosine kinase FGR NOTCH1 Inflammation

Tuning the selectivity of photoreduction of CO2 to syngas over Pd/layered double hydroxide nanosheets under visible light up to 600 nm

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Journal of Energy Chemistry 2020年第7期29卷 1-7,I0001页

作者： Xian wang Zelin wang Ya Bai ling Tan Yanqi xu xiaojie Hao Jikang wang Abdul Hanif Mahadi Yufei Zhao lirong Zheng Yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China Institute of High Energy Physics The Chinese Academy of SciencesBeijing 100049China Centre for Advanced Material and Energy Sciences Universiti Brunei DarussalamTungku LinkGadong BE1410Brunei Darussalam

Photocatalytic reduction of CO2 with H2 O to syngas is an effective way for producing high value-added chemical feedstocks such as methanol and light olefins in ***,the precise control of CO/H2 ratio from photocatalytic CO2 reduction reaction still poses a great challenge for the further ***,we prepared a series of highly efficient heterostructure based on highly dispersed palladium supported on ultrathin Co Al-layered double hydroxide(LDH).In conjunction with a Ru-complex sensitizer,the molar ratios of CO/H2 can be tuned from 1:0.74 to 1:3 under visible-light irradiation(λ>400 nm).More interestingly,the syngas can be obtained under light irradiation atλ>600 *** characterization and density functional theory calculations revealed that the remarkable catalytic activity can be due to the supported palladium,which improved the charge transfer ***,more H atoms were used to generate H2 on the supported palladium for further tunable CO/H2 *** work demonstrates a new strategy for harnessing abundant solar-energy to produce syngas from a CO2 feedstock.

关键词： Syngas CO2 reduction Layered double hydroxide Visible light

Salt and pH-dependent properties of native and mutant insulin

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Chinese Science Bulletin 2002年第6期47卷 464-466页

作者： MA Xiaohui li Chunhua LU Benzhuo chen Weizu wang Cunxin xu xiaojie Center for Biomedical Engineering Beijing Polytechnic UniversityBeijing 100022China Department of Astronomy and Applied Physics University of Science and Technology of ChinaHeifei 230026China College of Chemistry&Molecular Engineering Peking UniversityBeijing 100871China

A fast and effective model for predicting the salt and pH dependent properties of protein complexes is presented. It is based on the formal charge parameter sets of ionizable groups and applied in conjunction with the finite difference Poisson-Boltzmann (FDPB) method to calculate the electrostatic interactions. All simulations were performed on the native 2Zn insulin and its fast-acting mutants such as B9D (B9Ser→Asp), B9E (B9Aer→Glu), B9EB10D (B9Ser→ Glu, B10His→Asp), and B10D (B10His→Asp). The salt and pH dependent properties of these dimers were analyzed from the aspect of electrostatic interaction, and the theoretical basis of the fast-acting behavior of these mutants was explained. It is found that the results agree well with experimental observations.

关键词： formal charge electrostatic interaction insulin Pois-son-Boltzmann equation.

A 26.5–29.5-GHz Doherty PA with enhanced linearity and efficiency based on adaptive bias circuit for 5G MIMO arrays

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Science China(Information Sciences) 2024年第7期67卷 341-342页

作者： Long wang Jixin chen Debin HOU xiaojie xu Wei HONG State Key Laboratory of Millimeter Waves Southeast University Misic Microelectronics Co. Ltd.

Power amplifiers (PAs) play a crucial role in achieving key performance metrics such as efficiency, power, and ***, in the millimeter-wave frequency range, the performance of active devices rapidly deteriorates with increasing frequency. The typical Doherty architecture, through load modulation techniques, can achieve high back-off efficiency [1]. To enhance the linearity of the PA, adaptive bias circuits (ADBs) have been widely adopted [2, 3].

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Emerging open-channel droplet arrays for biosensing

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National Science Review 2023年第10期10卷 172-186页

作者： Yongchao Song lirong wang Tailin xu Guangyao Zhang xueji Zhang School of Biomedical Engineering Health Science CenterShenzhen University Intelligent Wearable Engineering Research Center of Qingdao Research Center for Intelligent and Wearable Technology College of Textiles and ClothingState Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao University

Open-channel droplet arrays have attracted much attention in the fields of biochemical analysis,biofluid monitoring,biomarker recognition and cell interactions,as they have advantages with regard to miniaturization,parallelization,high-throughput,simplicity and *** droplet arrays not only improve the sensitivity and accuracy of a biosensor,but also do not require sophisticated equipment or tedious processes,showing great potential in next-generation miniaturized sensing *** review summarizes typical examples of open-channel micro droplet arrays and focuses on diversified biosensing integrated with multiple signal-output approaches(fluorescence,colorimetric,surface-enhanced Raman scattering(SERS),electrochemical,etc.).The limitations and development prospects of open-channel droplet arrays in biosensing are also discussed with regard to the increasing demand for biosensors.

关键词： open-channel droplet wettable pattern mini-pillar platform liquid marbles multiple biosensing

Detrital Zircon U–Pb Geochronology and Provenance of Bayan Obo Group, Northern Margin of North China Craton: New Implications for the Position of NCC in Rodinia

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Acta Geologica Sinica(English Edition) 2019年第5期93卷 1397-1416页

作者： li Changhai liU Zhenghong xu Zhongyuan DONG xiaojie li Pengchuan SHI Qiang wang Shijie College of Earth Sciences Jilin UniversityChangchun 130001China Key Laboratory of Mineral Resources Evaluation in Northeast Asia Ministry of Natural ResourcesChangchun 130026China

The paleoposition of North China Craton in Rodinia has long been in controversial. This paper mainly focuses on the U-Pb geochronological studies of detrital zircons obtained from Bayan Obo Group exposed in the Shangdu area, Inner Mongolia, aiming to provide more information for interprating this problem. Based on the acquired data, this paper comes to the following conclusions. Firstly, the depositional age of Bayan Obo Group might be from Meso- to Neoproterozoic according to the zircons U-Pb dating results. The lower succession of this group, namely Dulahala and Jianshan formations deposited between 1800 and 1650 Ma. The Halahuogete and Bilute formations deposited between 1500 and 1350 Ma. For Baiyinbaolage and Hujiertu formations, their depositional age was 1250-900 Ma. Secondly, for the provenance of Bayan Obo Group, this paper believes detrital zircons with age of 2.51-2.71 Ga and 2.00-2.48 Ga were from Guyang, Xi Ulanbulang and Zhuozi area;the Khondalite Belt provided detrital zircons with age of 1.95-1.80 Ga;zircons with age of 1.60-1.75 Ga might come from granitic rocks in Miyun Area. The magmatism after 1.60 Ga was rarely recorded in the NCC, therefore those zircons with ages younger than 1.60 Ga might come from outside of NCC. The magmatism with the same age existed in Baltic, Amazonia and Laurentia. Based on previous paleomagnetic researches, this paper proposes that NCC might receive detritus from Baltic during 1560-1350 Ma and had affinity with Laurentia and Amazonia at ~0.9 Ga in Rodinia. Baltic, Amazonia and Laurentia might be potential provenances for non-NCC detritus in Bayan Obo Group.

关键词： North China Craton Precambria Bayan Obo Group detrital zircons Rodinia

A Self-sensing TSA-actuated Anthropomorphic Robot Hand

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Journal of Bionic Engineering 2024年第3期21卷 1174-1190页

作者： Chanchan xu Shuai Dong Yifan Ma Jingwei Zhan Yucheng wang xiaojie wang Institute of Intelligent Machines Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei230026China Institutes of Physical Science and Information Technology Anhui UniversityHefei230601China

This paper introduces a self-sensing anthropomorphic robot hand driven by Twisted String Actuators(TSAs).The use of TSAs provides several advantages such as muscle-like structures,high transmission ratios,large output forces,high efficiency,compactness,inherent compliance,and the ability to transmit power over ***,conventional sensors used in TSA-actuated robotic hands increase stiffness,mass,volume,and complexity,making feedback control *** address this issue,a novel self-sensing approach is proposed using strain-sensing string based on Conductive Polymer Composite(CPC).By measuring the resistance changes in the strain-sensing string,the bending angle of the robot hand's fingers can be estimated,enabling closed-loop control without external *** developed self-sensing anthropomorphic robot hand comprises a 3D-printed structure with five fingers,a palm,five self-sensing TSAs,and a 3D-printed *** studies validate the self-sensing properties of the TSA and the anthropomorphic robot ***,a real-time Virtual Reality(VR)monitoring system is implemented for visualizing and monitoring the robot hand's movements using its self-sensing *** research contributes valuable insights and advancements to the field of intelligent prosthetics and robotic end grippers.

关键词： Anthropomorphic robot hand Twisted string actuator Self-sensing Conductive polymer composite Virtual reality monitoring

Development of a stable attenuated double-mutant of tobacco mosaic virus for cross-protection

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Journal of Integrative Agriculture 2024年第7期23卷 2318-2331页

作者： xiaojie xu Shaoyan Jiang Chunju liu xujie Sun Qing Zhu Xiuzhai chen Pengchao Jiang Fenglong wang Yanping Tian Xiangdong li The Engineering Research Institute of Agriculture and Forestry Ludong UniversityYantai 264025China Laboratory of Plant Virology Department of Plant PathologyCollege of Plant ProtectionShandong Agricultural UniversityTai’an 271018China Weifang Tobacco Corporation Weifang 261031China linyi Tobacco Corporation Linyi 276000China Tobacco Research Institute Chinese Academy of Agricultural SciencesQingdao 266101China

Tobacco(Nicotiana tabacum)and tomato(Solanum lycopersicum)are two major economic crops in *** mosaic virus(TMV;genus Tobamovirus)is the most prevalent virus infecting both ***,some widely cultivated tobacco and tomato cultivars are susceptible to TMV and there is no effective strategy to control this ***-protection can be a safe and environmentally friendly strategy to prevent viral ***,stable attenuated TMV mutants are *** this study,we found that the substitutions in the replicase p126,arginine at position 196(R^(196))with aspartic acid(D),glutamic acid at position 614(E^(614))with glycine(G),serine at position 643(S^(643))with phenylalanine(F),or D at position 730(D^(730))with S,significantly reduced the virulence and replication of ***,only the mutation of S^(643) to F reduced the RNA silencing suppression activity of TMV p126.A double-mutant TMV-E614G-S643F induced no visible symptom and was genetically stable through six successive passages in tobacco ***,our results showed that TMV-E614G-S643F double-mutant could provide effective protection against the wild-type TMV infection in tobacco and tomato *** study reports a promising mild mutant for cross-protection to control TMV in tobacco and tomato plants.

关键词： cross-protection double-mutant p126 tobacco mosaic virus virulence

Switching Optimally Balanced Fe-N Interaction Enables Extremely Stable Energy Storage

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Energy & Environmental Materials 2023年第2期6卷 275-283页

作者： Zhenzhen Zhao Wei Zhang Miao liu Dong wang Xiyang wang lirong Zheng xu Zou Zizhun wang Dabing li Keke Huang Weitao Zheng Key Laboratory of Mobile Materials MOE and School of Materials Science&Engineeringand Electron Microscopy Centerand International Center of Future ScienceJilin UniversityChangchun 130012China State Key Laboratory of Chem/Bio-Sensing and Chemometrics Provincial Hunan Key Laboratory for Graphene Materials and DevicesCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Department of Mechanical and Mechatronics Engineering University of WaterlooWaterloo Canada Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China

The interaction between electrode materials and charge carriers is one of the central issues dominating underlying energy storage *** address the notoriously significant volume changes accompanying intercalation or formation of alloy/compounds,we aim to introduce and utilize a weak,reversible Fe-N interaction during the(de)intercalation of ammonium ions(NH_(4)^(+))within iron(Ⅲ)hexacyanoferrate(FeHCF),inspired by manipulating the electrostatic adsorption between N and Fe in the early stages of ammonia synthesis(Bosch-Harber Process,Chemical Engineering)and steel nitriding processes(Metal Industry).Such strategy of switching well-balanced Fe-N interaction is confirmed in between the nitrogen of ammonium ions and highspin Fe in FeHCF,as observed by using X-ray absorption *** resulting material provided an extremely stable energy storage(58 mAh g^(-1) after 10000 cycles at current density of 1 A g^(-1))as well as high-rate performance(23.6 mAh g^(-1) at current density of 10 A g^(-1)).

关键词： ammonium ion battery Iron(Ⅲ)hexacyanoferrate reversible Fe-N interaction stability