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chemistry of trichosanthin Ⅶ.The chemical cleavage of the tryptophanyl peptide bond in trichosanthin

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Acta Chimica sinica(English Edition) 1988年第4期 372-376页

作者： LUO Guang-Xiang ZHANG Li-Qing GU Zi-Wei QIAN Rui-Qing wang yu shanghai institute of organic chemistry,academia sinica,shanghai

The single tryptophan residue of trichosanthin was cleaved by the use of BNPS-skatolereaction with STIG2 peptide fregment which was obtained from the tryptic digestion of *** separation,the N-terminal sequence of tryptophanyl C-side peptide was deter-mined by use of manual DABITC-PITC double coupling sequencing method as follows:-Leu-Ala-Leu-Ser-Lys-Gln-Ile-Gln-Ile-Ala-.

关键词： ST The chemical cleavage of the tryptophanyl peptide bond in trichosanthin

Studies on nucleic acid chemistry——Ⅶ. Synthesis of four oligoribonucleotides of dihydrouridine (D) loop of yeast alanine transfer RNA

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Chinese Journal of chemistry 1986年第4期4卷 358-369页

作者： YANG Bing-Hui HUANG Jian-Hua ZHOU Feng-Yi BAO Jian-Shao LAO Xia-Fei WU Lian-Fen SHEN Nan-Zhen wang Shu-Ju YANG Zai-Wan LU Ren-Rong TU Chuan-Zhong wang yu shanghai institute of organic chemistry, academia sinica, shanghai shanghai institute of organic chemistry Academia Sinica Shanghai

This article described the preparation and the protection of 3'-DMP and dihydrouridine（Dr） as well as the synthesis of four oligoribonucleotides composed of them. DMP and Dr were obtained by hydrogenation of 3'-UMP and Ur under acidic conditions inthe presence of platinum dioxide. They were monomethoxytritylated and benzoylated to （MeOTr）-Dbzpand （MeOTr） Dbz2, respectively. The latter was converted to Dbz2by demonomethoxytrityla-tion. The oligoribonucleotides containing DMP or Dr-ApGpD, DpApG, ApGpDpC and ApGpDp-CpGpG were synthesized via phosphodiester approach and DCC was used as condensing *** was also synthesized via phosphotriester approach and TPST, MSTe, MSNI and MSNTwere used as condensing reagents for a preliminary comparison of the coupling yields. These synthetic oligoribonucleotides were checked for purity and nucleotide sequences as *** and DpApG had been used for enzymatic synthesis of *** had been in turn successfully used for the total syntheses of the 5'-half molecule and the wholemolecule of yeast alanine t--RNA.

关键词： Studies on nucleic acid chemistry Synthesis of four oligoribonucleotides of dihydrouridine acid

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分枝杆菌石蜡油发酵液中的支链脂肪酸

化学学报 1988年第1期46卷 87-89页

作者：周乐黄敬坚王大琛汪猷中国科学院上海有机化学研究所上海中国科学院上海生物工程实验基地

作者从上海土壤中分离到一株以石蜡油为碳源的分枝杆菌Mycobacteium sp.A-3,并从该菌石蜡油发酵液中分离到石油醚可溶酸和石油醚不溶酸.石油醚可溶酸主要为饱和脂肪酸,石油醚不溶酸主要为3,5,7-三羟基取代的十五、十六、十七烷酸的混合... 详细信息

作者从上海土壤中分离到一株以石蜡油为碳源的分枝杆菌Mycobacteium sp.A-3,并从该菌石蜡油发酵液中分离到石油醚可溶酸和石油醚不溶酸.石油醚可溶酸主要为饱和脂肪酸,石油醚不溶酸主要为3,5,7-三羟基取代的十五、十六、十七烷酸的混合物.本文报道两个支链饱和脂肪酸的结构鉴定.石油醚可溶酸经逆流分溶法分离,得两种主要成份1和2,它们都为无色液体,比旋光为正,高锰酸钾不饱和性检定阴性.经元素分析、中和当量和碳甲基测定,提示分别为含有两个

关键词：石蜡油石油醚溶剂油比旋光分枝杆菌可溶酸甲基庚酸庚酸甲酯结构鉴定逆流分溶法壬酸饱和脂肪酸发酵液中和当量无色液体气相层析二硝基苯

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chemistry of trichosanthin *** main amino acid sequence of proposed principle primary structure of trichosanthin

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Chinese Journal of chemistry 1984年第1期2卷 86-88页

作者： GU Zi-Wei QIAN Rui-Qing JIN Shan-Wei QIAN Wei-Wei XU Shan-Zhen ZHANG Li-Qing ZHANG Xiu-Lan YAO yue-Zhen LIU Yong-Fu ZHU Shi-Qin CAO Bo-Sheng wang Shao-Fu wang Qiang-Hua ZHANG Wei-Jun LIU Yin-Zeng FU Yao-Hong wang yu shanghai institute of organic chemistry,academia sinica,shanghai shanghai institute of organic chemistry Academia Sinica Shanghai

In previous paper1-3were reported the physical and chemical properties,the deter-mination of the N-terminal amino acid sequence and the CNBr degradation fragment CBaof trichosanthin（TR）which is the active principle isolated from Chinese folk-medicine,TianHua Fen,traditionally used as abortificient and also for other OBS and GYN *** is a simple protein consisting of a single polypeptide chain of 224 amino acid（a.a.）

关键词： Li In acid IV

Total synthesis of cis-shisool

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Chinese Journal of chemistry 1990年第1期8卷 75-83页

作者： wang,Zhi-Qin LAI,Chun-Qiu shanghai institute of organic chemistry,academia sinica,shanghai 200032 shanghai institute of organic chemistry Academia Sinica Shanghai 200032

This paper describes the total sythesis of cis-shisool through intermediate 3,which was derived from the Diels-Alder adduct 4(or 5).The structure of the isomers produced by the Diels-Alder reaction of cyclohexadiene and crotonate has been elucidated by means of GC and ***- tion of 12 with Zn-CH_2Br_2-TiCl_4 or Ph_3P=CH_2 retains the stereochemistry of the carbon atom ad- jacent to the carbonyl group.

关键词： Total synthesis of cis-shisool cis

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Studies on fluoroalkylation and fluoroalkoxylation *** of aromatics with perfluoroalkyl iodides in the presence of copper

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Acta Chimica sinica(English Edition) 1985年第4期3卷 362-368页

作者： CHEN Qing-yun YANG Zhen-yu shanghai institute of organic chemistry,academia sinica,shanghai shanghai institute of organic chemistry Academia Sinica Shanghai

Perfluoroalkyl iodide RfI[Rf=（CF2）nO（CF2）2SO2F,n=2,（a）;n=4,（b）;（CF2）4Cl,（c）]reacted with substituted benzene C6H5Y（Y=alkyl,OCH3,CF3,F,Cl,Br,I）in the presence of copperin acetic anhydride to give the corresponding mixture of isomeric disubstituted benzene（RfC6H4Y）.The conversion and yield depend on both the amount of copper used and nature of *** explanation is that the reaction may involve a free radical *** perfluoroalkyl radicalcan be trapped by cyclohexene,isopropylbenzene and *** DMSO in place of acetic an-hydride as a solvent the reaction takes a different course,it is believed that the reaction in DMSOproceeds through a perfluoroalkylcopper intermediate.

关键词： Studies on fluoroalkylation and fluoroalkoxylation 2.Perfluoroalkylation of aromatics with perfluoroalkyl iodides in the presence of copper

Studies on sulfinatodehalogenation Ⅸ. Synthesis and reaction of secondary perfluoroalkyl iodides

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Chinese Journal of chemistry 1986年第3期4卷 266-272页

作者： HUANG Wei-yuan wang Wei shanghai institute of organic chemistry, academia sinica, shanghai shanghai institute of organic chemistry Academia Sinica Shanghai

Several derivatives of secondary perfluoroalkyl iodides such as CF3CFI（CF2）2O（CF2）2SO2F（3）, CF3CFI（CF2）2O（CF2）2SO3Na （4）, CF3CFI（CF2）_nCl （n=2, 7a; n=4, 7b） and CF3（CF2）2-OCFICF3（8） were synthesized using known methods, their reaction with sodium dithionite wasstudied and various olefins were added into the reaction system as radical traps to yield the 1:1radical adducts.

关键词： CFI Pr AB SO OC Synthesis and reaction of secondary perfluoroalkyl iodides

Studies on fluoroalkylation and fluoroalkoxylation——8. Palladium(0)-catalyzed addition reaction of fluoroalkyl iodides with alkynes

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Chinese Journal of chemistry 1986年第4期4卷 370-375页

作者： CHEN Qing-yun YANG Zhen-yu shanghai institute of organic chemistry, academia sinica, shanghai shanghai institute of organic chemistry Academia Sinica Shanghai

Fluoroalkyl iodide RFI [RF=（CF2）_nCl, n=2, 4, 6; CF3（CF2）_n, n=1, 3; H（CF2）4lreacted with alkyne （CH≡CC4H9; CH≡CSiMe3; CH≡CC6H5） in the presence of catalytic amountsof tetrakis （triphenylphosphine） palladium （0） to give a mixture of E and Z-fluoroalkylated *** reaction could not be catalyzed by dichloro--bis （triphenylphosphine）palladium （Ⅱ） and fluoro-alkyl complex of palladium （Ⅱ）. 2-Nitro-2--nitrosopropane partly suppressed the reaction. Itis believed that the reaction proceeds through a free radical intermediate rather than fluoroalkyl complexof palladium （Ⅱ）.

关键词： Palladium catalyzed addition reaction of fluoroalkyl iodides with alkynes Studies on fluoroalkylation and fluoroalkoxylation

Palladium catalyzed reaction of allylic geminal diacetates with nucleophiles

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Chinese Journal of chemistry 1988年第3期6卷 262-267页

作者： HUANG yu-Jin LU Xi-Yan*, shanghai institute of organic chemistry, academia sinica, shanghai shanghai institute of organic chemistry Academia Sinica Shanghai

The influence of ligands on the palladium catalyzed reaction of allylic-1,1-diol diacetate（1） with sodium dimethyl malonate was studied. When PPh3was used as the ligand, the malonateanion was found to attack the carbonyl carbon atom, but it would attack the allylic carbon atomwhile dppe was used as the ligand. The properties of nucleophiles also influence the position of *** suitable choice of the nucleophiles and ligands, dialkylated products can be obtained from 1.

关键词： Palladium catalyzed reaction of allylic geminal diacetates with nucleophiles