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Investigation of diagnosis and treatment of hemolysis-elevated liver enzymes-low platelet counts （HELLP） syndrome： clinical analysis of 59 cases

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Chinese Medical Journal 2010年第10期123卷 1273-1277页

作者： wang yong-qing wang jing ye rong-hua zhao yang-yu Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China

Background Hemolysis-elevated liver enzymes-low platelet counts （HELLP） syndrome is a clinical condition occurring in middle and late stage pregnancy. It is characterized by hemolysis, elevated liver enzymes and low platelet counts. This study involves the analysis of the diagnosis, clinical characteristics and treatment of 59 cases of HELLP syndrome as well as the clinical classification, method of delivery and gestational age at delivery. Methods Clinical data from 59 cases of HELLP syndrome occurring from January 2000 to December 2009 were analyzed retrospectively. Thirty-five cases were classified as complete HELLP syndrome and 24 cases were considered partial HELLP syndrome. Results Twenty-six of the 59 analyzed patients （44%） with complete HELLP syndrome showed rapid onset, severe signs, symptoms, and complications in addition to a poor clinical outcome. Complications included multiple organ dysfunction syndrome （MODS） occurring in 18 cases, eclampsia （3 cases）, placental abruption （3 cases）, and perinatal death （4 cases）. The remaining 33 cases （24 with partial and 9 with complete HELLP） were characterized by less severe signs, symptoms, complications and progression of the condition. Two of these cases were complicated with MODS （6.1%）, and 1 with perinatal death （3.0%）.Twelve non-radical-type cases received conservative treatment. The remaining 4 patients had recurring HELLP syndrome （6.78%）. Conclusions HELLP syndrome is classified as the radical type and non-radical-type according to clinical characteristics and outcome. Classification of HELLP syndrome cases according to clinical features can help in the monitoring and treatment of the disease. Active termination of pregnancy should be considered for radical-type cases. Non-radical-type cases can undergo conservative treatment with close monitoring in an attempt to improve perinatal outcome without increasing maternal morbidity.

关键词： HELLP syndrome severe preeclampsia diagnosis treatment

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A case of severe preeclampsia diagnosed as post-partum hemolytic uremic syndrome

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Chinese Medical Journal 2012年第6期125卷 1189-1192页

作者： wang yong-qing wang jing JIANG yuan-hui ye rong-hua zhao yang-yu Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China Department of Obstetrics and Gynecology Maternal and Child Health Hospital of Haidian District Beijing 100080 China

Post-partum hemolytic uremic syndrome （PHUS） is a severe thrombotic microangiopathy clinically characterized by hemolytic anemia, renal dysfunction, and low platelets after birth with rapid progression and poor prognosis. Here, we reported a rare case of severe preeclampsia diagnosed as hemolytic uremic syndrome after birth. The patient was diagnosed with PHUS and underwent intermittent plasma exchange with supportive treatment including glucocorticoid injections and transfusion of suspended red blood cells. After these treatments, the patient experienced no apparent remission and chronic renal dysfunction occurred on her. PHUS is a severe emergency with acute onset, rapid progress, and poor prognosis. Early detection, diagnosis, and treatment can significantly improve the prognosis.

关键词： preeclampsia hemolytic uremic syndrome thrombotic microangiopathy end-stage renal disease

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Patient with antiphospholipid syndrome accompanied by pre-eclampsia who developed hellp syndrome and eclampsia after abortion

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Chinese Medical Journal 2012年第22期125卷 4142-4144页

作者： wang yong-qing NIU Ji-hong wang Jia-lue ye rong-hua zhao yang-yu Peking Univ Dept Obstet & Gynecol Hosp 3 Beijing 100191 Peoples R China

Antiphospholipid syndrome （APS） refers to a group of clinical symptoms and signs caused by antiphospholipid antibody （aPLA）. We reported a rare case of poor outcome of a pregnant woman with APS. The pregnant woman had APS, hemolytic anemia, elevated liver function and low platelet count （HELLP） syndrome, and eclampsia and had a poor outcome from a second pregnancy. She was treated with antispasmodics, sedatives, and anti-hypertensive agents, along with anticoagulant therapy and infusion of immunoglobulin. APS during pregnancy often makes pregnancy even more complex and risky. Obstetricians should carry out anticoagulation treatment throughout the perinatal period.

关键词： antiphospholipid syndrome pre-eclampsia, eclampsia

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A case of aggravation of hemolytic anemia, elevated liver enzymes and low platelet count syndrome after delivery

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Chinese Medical Journal 2011年第8期124卷 1261-1263页

作者： JIANG yuan-hui wang yong-qing wang jing ye rong-hua Department of Obstetrics and Gynecology Peking UniversityThird Hospital Beijing 100191 China

Background Hemolytic anemia, elevated liver enzymes and low platelet count （HELLP） syndrome is a severe obstetric complication which usually resolves in most patients after *** We report a rare case of aggravation of HELLP syndrome after *** The patient underwent the treatment for HELLP syndrome,.including glucocorticoid therapy. The symptoms of HELLP syndrome reappeared and became more severe than before the termination of pregnancy. The patient also had severe and persistent hypoproteinemia, hyponatremia and *** HELLP syndrome is an acute and critical obstetric syndrome which can have heterogeneous presentations and variable prognosis. We should be fully aware of the diverse clinical characteristics of this condition.

关键词： HELLP syndrome hypocalcemia hyponatremia hypoproteinemia

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Development and validation of a score predicting mortality for older patients with mitral regurgitation

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Journal of Geriatric Cardiology 2023年第8期20卷 577-585页

作者： De-jing FENG yun-qing ye Zhe LI Bin ZHANG qing-rong LIU Wei-Wei wang Zhen-Yan zhao Zheng ZHOU qing-Hao zhao Zi-Kai yu Hai-Tong ZHANG Zhen-Ya DUAN Bin-Cheng wang Jun-Xing LV Shuai GUO Run-Lin GAO Hai-Yan XU yong-Jian WU on behalf of the China-DVD and China-VHD study investigators Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina

OBJECTIVE To develop and validate a user-friendly risk score for older mitral regurgitation(MR)patients,referred to as the Elder-MR *** The China Senile Valvular Heart Disease(China-DVD)Cohort Study functioned as the development cohort,while the China Valvular Heart Disease(China-VHD)Study was employed for external *** included patients aged 60 years and above receiving medical treatment for moderate or severe MR(2274 patients in the development cohort and 1929 patients in the validation cohort).Candidate predictors were chosen using Cox’s proportional hazards model and stepwise selection with Akaike’s information *** Eight predictors were identified:age≥75 years,body mass indexyed satisfactory performance in predicting one-year mortality in both the development cohort(C-statistic=0.73,95%CI:0.69-0.77,Brier score=0.06)and the validation cohort(C-statistic=0.73,95%CI:0.68-0.78,Brier score=0.06).The Elder-MR score ranges from 0 to 15 *** a one-year follow-up,each point increase in the Elder-MR score represents a 1.27-fold risk of death(HR=1.27,95%CI:1.21-1.34,Pyear mortality in the validation cohort(C-statistic=0.71 vs.0.70,net reclassification improvement=0.320,P<0.01;integrated discrimination improvement=0.029,P<0.01).CONCLUSIONS The Elder-MR score may serve as an effective risk stratification tool to assist clinical decision-making in older MR patients.

关键词： patients mitral score

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Chinese physicians' perceptions of fecal microbiota transplantation

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World Journal of Gastroenterology 2016年第19期22卷 4757-4765页

作者： rong-rong Ren Gang Sun yun-Sheng yang Li-hua Peng Shu-Fang wang Xiao-Hong Shi jing-Quan zhao yong-Ling Ban Fei Pan Xue-Hong wang Wei Lu Jian-Lin Ren Ying Song Jiang-Bin wang Qi-Ming Lu Wen-yuan Bai Xiao-Ping Wu Zi-Kai wang Xiao-Mei Zhang ye Chen Institute of Digestive Diseases Chinese PLA General Hospital Chinese PLA Medical Academy Medical College of Nankai University Department of Traditional Chinese Medicine The First People’s Hospital of Hangzhou City Department of Respiratory The People’s Hospital of Dongying City Department of Gastroenterology Affiliated Hospital of Qinghai University Department of Gastroenterology First Central Hospital of Tianjin Department of Gastroenterology Affiliated Hospital of Xiamen University Department of Gastroenterology Xi’an Central Hospital Department of Gastroenterology China-Japan Union of Jilin University Department of Gastroenterology the People’s Hospital of Gansu Department of Gastroenterology the Second Hospital of Hebei Medical University Department of Gastroenterology the Second Xiangya Hospital of Central South University Department of Gastroenterology Nanfang Hospital Southern Medical University

AIM: To explore Chinese physicians' perceptions towards fecal microbiota transplantation(FMT) and to provide information and an assessment of FMT development in ***: A self-administered questionnaire was developed according to the FMT practice guidelines and was distributed to physicians in hospitals via Internet Research Electronic Data Capture(REDcap) software and electronic mails to assess their attitudes toward and knowledge of FMT. The questionnaire included a brief introduction of FMT that was followed by 20 questions. The participants were required to respond voluntarily, under the condition of anonymity and without compensation. Except for the fill-in-the-blank questions, all of the other questions were required in the REDcap data collection systems, and the emailed questionnaires were completed based on ***: Up to December 9, 2014, 844 eligible questionnaires were received out of the 980 distributed questionnaires, with a response rate of 86.1%. Among the participants, 87.3% were from tertiary hospitals, and there were 647(76.7%) gastroenterologists and 197(23.3%) physicians in other departments(nongastroenterologists). Gastroenterologists' awareness of FMT prior to the survey was much higher than non-gastroenterologists'(54.3 vs 16.5%, P < 0.001); however, acceptance of FMT was not statistically different(92.4 vs 87.1%, P = 0.1603). Major concerns of FMT included the following: acceptability to patients(79.2%), absence of guidelines(56.9%), and administration and ethics(46.5%). On the basis of understanding, the FMT indications preferred byphysicians were recurrent Clostridium difficile infection(86.7%), inflammatory bowel disease combined with Clostridium difficile infection(78.6%), refractory ulcerative colitis(70.9%), ulcerative colitis(65.4%), Crohn's disease(59.4%), chronic constipation(43.7%), irritable bowel syndrome(39.1%), obesity(28.1%) and type 2 diabetes(23.9%). For donor selection, the majority of physicians preferred

关键词： Fecal microbiota transplantation Chinese physicians Gastroenterologists Perception Survey

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Discovery of a wild,genetically pure Chinese giant salamander creates new conservation opportunities

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Zoological Research 2022年第3期43卷 469-480页

作者： jing Chai Chen-Qi Lu Mu-rong Yi Nian-hua Dai Xiao-Dong Weng Ming-Xiao Di yong Peng yong Tang qing-hua Shan Kai wang huan-Zhang Liu Hai-Peng zhao Jie-Qiong Jin Ru-Jun Cao Ping Lu Lai-Chun Luo Robert W.Murphy Ya-Ping Zhang jing Che State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Institute of Biological Resources Jiangxi Academy of SciencesNanchangJiangxi 330096China Jiangxi Jiulingshan National Nature Reserve Jing’anJiangxi 330600China Sam Noble Oklahoma Museum of Natural History&Department of Biology University of OklahomaNorman 73072USA The Key Laboratory of Biodiversity and Conservation of Aquatic Organisms Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China School of Life Science Henan UniversityKaifengHenan 475001China jing’an County Bureau of Agriculture and Rural Affairs Jing’anJiangxi 330600China Centre for Biodiversity and Conservation Biology Royal Ontario MuseumTorontoOntario M5S 2C6Canada yunnan Key Laboratory of Biodiversity and Ecological Security of Gaoligong Mountain Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of the Chinese Academy of SciencesKunmingYunnan 650204China

Effective conservation of threatened biota relies on accurate assessments and scientific *** an unfortunate example,Chinese giant salamanders(Andrias,CGS)remain critically endangered in *** conservation efforts,e.g.,commercial propagation and releasing of millions of likely non-indigenous or interspecific hybrids,have further compromised conservation *** information on wild populations of CGS poses a significant conservation *** 18-month long field monitoring,we now report the discovery of a wild population of CGS in a closed nature reserve in Jiangxi Province,*** assessments reveal its genetic distinctiveness and do not detect genetic admixture with other *** on morphological and molecular evidences,we describe this CGS as a new species Andrias jiangxiensis *** is the only known species of CGS today with a genetically pure,reproducing,in situ *** discovery emphasizes the important role that closed nature reserves play in protecting species,and the necessity of integrating long-term field monitoring and genetic *** sets a new pathway for discovering and conserving endangered species,especially for those biotas that are similarly being extirpated by anthropogenic translocations and overexploitation.

关键词： Conservation Human translocation Genetic homogenization Field monitoring Taxonomy

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A chromosome-scale genome sequence of pitaya (Hylocereus undatus) provides novel insights into the genome evolution and regulation of betalain biosynthesis

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Horticulture Research 2021年第1期8卷 2260-2274页

作者： Jian-ye Chen Fang-fang Xie Yan-ze Cui Can-bin Chen wang-jin Lu Xiao-di Hu qing-zhu hua jing zhao Zhi-jiang Wu Dan Gao Zhi-ke Zhang Wen-kai Jiang qing-ming Sun Gui-bing Hu yong-hua Qin State Key Laboratory for Conservation and Utilization of Subtropical Agrobioresources/Guangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables/Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(South China) Ministry of Agriculture and Rural Affairs/Lingnan Guangdong Laboratory of Modern AgricultureCollege of HorticultureSouth China Agricultural University510642 GuangzhouGuangdongChina Novogene Bioinformatics Institute 100083 BeijingChina Horticulture Research Institute Guangxi Academy of Agricultural Sciences530007 NanningGuangxiChina Institute of Fruit Tree Research Guangdong Academy of Agricultural Sciences/Key Laboratory of South Subtropical Fruit Biology and Genetic Resource Utilization(MOA)/Guangdong Province Key Laboratory of Tropical and Subtropical Fruit Tree Research510640 GuangzhouChina

Pitaya(Hylocereus)is the most economically important fleshy-fruited tree of the Cactaceae family that is grown worldwide,and it has attracted significant attention because of its betalain-abundant ***,the lack of a pitaya reference genome significantly hinders studies focused on its evolution,as well as the potential for genetic improvement of this ***,we employed various sequencing approaches,namely,PacBio-SMRT,Illumina HiSeq paired-end,10×Genomics,and Hi-C(high-throughput chromosome conformation capture)to provide a chromosome-level genomic assembly of‘GHB’pitaya(***,2n=2x=22 chromosomes).The size of the assembled pitaya genome was 1.41 Gb,with a scaffold N50 of~127.15 *** total,27,753 protein-coding genes and 896.31Mb of repetitive sequences in the *** genome were *** has undergone a WGT(whole-genome triplication),and a recent WGD(whole-genome duplication)occurred after the gamma event,which is common to the other species in Cactaceae.A total of 29,328 intact LTR-RTs(~696.45Mb)were obtained in ***,of which two significantly expanded lineages,Ty1/copia and Ty3/gypsy,were the main drivers of the expanded genome.A high-density genetic map of F1 hybrid populations of‘GHB’×‘Dahong’pitayas(***)and their parents were constructed,and a total of 20,872 bin markers were identified(56,380 SNPs)for 11 linkage *** importantly,through transcriptomic and WGCNA(weighted gene coexpression network analysis),a global view of the gene regulatory network,including structural genes and the transcription factors involved in pitaya fruit betalain biosynthesis,was *** data present a valuable resource for facilitating molecular breeding programs of pitaya and shed novel light on its genomic evolution,as well as the modulation of betalain biosynthesis in edible fruits.

关键词： evolution expanded linkage

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GRB 220408B:A Three-episode Burst from a Precessing Jet

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Research in Astronomy and Astrophysics 2023年第11期23卷 214-224页

作者： Zijian Zhang Yi-Han Iris Yin Chenyu wang Xiangyu Ivy wang Jun yang Yan-Zhi Meng Zi-Ke Liu Guo-Yin Chen Xiaoping Fu huaizhong Gao Sihao Li Yihui Liu Xiangyun Long yong-Chang Ma Xiaofan Pan yuanze Sun Wei Wu Zirui yang Zhizhen ye Xiaoyu yu Shuheng zhao Xutao Zheng Tao Zhou qing-Wen Tang Qiurong Yan rong Zhou Zhonghai wang hua Feng Ming Zeng Bin-Bin Zhang School of Astronomy and Space Science Nanjing UniversityNanjing 210093China School of Physics Nanjing UniversityNanjing 210093China Department of Astronomy Tsinghua UniversityBeijing 100084China Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityMinistry of EducationNanjing 210093China School of Information Engineering Nanchang UniversityNanchang 330031China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Department of Health Physics China Institute for Radiation ProtectionTaiyuan 300000China Key Laboratory of Radiation Physics and Technology of Ministry of Education College of Physics of Sichuan UniversityChengdu 610065China School of Artificial Intelligence Nanjing UniversityNanjing 210093China Key Laboratory of Particle and Radiation Imaging Tsinghua UniversityMinistry of EducationBeijing 100084China Department of Computer Science and Technology Nanjing UniversityNanjing 210093China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210093China College of Engineering and Applied Sciences Nanjing UniversityNanjing 210093China Department of Physics School of Physics and Materials ScienceNanchang UniversityNanchang 330031China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China

Jet precession has previously been proposed to explain the apparently repeating features in the light curves of a few gamma-ray bursts(GRBs).In this paper,we further apply the precession model to a bright GRB 220408B by examining both its temporal and spectral consistency with the predictions of the *** one of the recently confirmed GRBs observed by our GRID CubeSat mission,GRB 220408B is noteworthy as it exhibits three apparently similar emission ***,the similarities are reinforced by their strong temporal correlations and similar features in terms of spectral evolution and spectral *** analysis demonstrates that these features can be well explained by the modulated emission of a Fast-Rise-Exponential-Decay(FRED)shape light curve intrinsically produced by a precessing jet with a precession period of 18.4_(-0.2)~(+0.2)s,a nutation period of11.1_(-0.2)~(+0.2)s and viewed *** study provides a straightforward explanation for the complex yet similar multiepisode GRB light curves.

关键词： gamma-rays:general (stars:)gamma-ray burst:individual(GRB 220408B) stars:jets

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3-to 24-month Follow-up on COVID-19 with Pulmonary Tuberculosis Survivors after Discharge:Results from a Prospective,Multicenter Study

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Biomedical and Environmental Sciences 2022年第12期35卷 1091-1099页

作者： wang jing Ya ZONG Xing yu WU Gui Hui QI yuan Lin LI Hui Zhen JI Xin yu TONG Lin ZHANG Lei yang Ming Bo yang Pu ye LI Ji Ke XIAO Fu rong ZHANG Lin Song HU yun Hong LIU Hong De XU Shou Fang SUN Sheng WU Wei MAO Ya LI Min qing HOU Hao hua GONG zhao yuan GUO yang JIAO Li Wen QIN Jin wang Ding Yi wang Fang GUAN Li LIN Gang MA Yan wang Yan Ping SHI Nan Nan Community Health Service Management Center Dongcheng DistrictBeijing 100700China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Public Health Clinical Center of Chengdu Chengdu 610066SichuanChina Yiyuan TCM Hospital Zibo 256199ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Xi’an Eighth Hospital Xi’an 710000ShaanxiChina Harbin Infectious Disease Hospital Harbin 150000HeilongjiangChina Hospital(T.C.M)Affiliated to Southwest Medical University Luzhou 646000SichuanChina Xingtai Hospital of Chinese Medicine Xingtai 054000HebeiChina Shijiazhuang Fifth Hospital Shijiazhuang 050000HebeiChina Jiamusi Infectious Disease Hospital Jiamusi 154000HeilongjiangChina Chengde Hospital of Traditional Chinese Medicine Chengde 067040HebeiChina Hanzhong Central Hospital Hanzhong 723000ShaanxiChina Ankang Hospital of Traditional Chinese Medicine Ankang 725000ShaanxiChina Department of Traditional Chinese medicine Dazhou Central HospitalDazhou 635000SichuanChina China National Medicines Corporation Ltd Beijing 100077China Beijing University of Chinese Medicine Beijing 101121China Infectious Disease Hospital of Heilongjiang Province Harbin 150030HeilongjiangChin

Objective Coronavirus disease 2019(COVID-19)and tuberculosis(TB)are major public health and social issues *** long-term follow-up of COVID-19 with pulmonary TB(PTB)survivors after discharge is *** study aimed to comprehensively describe clinical outcomes,including sequela and recurrence at 3,12,and 24 months after discharge,among COVID-19 with PTB *** From January 22,2020 to May 6,2022,with a follow-up by August 26,2022,a prospective,multicenter follow-up study was conducted on COVID-19 with PTB survivors after discharge in 13 hospitals from four provinces in *** outcomes,including sequela,recurrence of COVID-19,and PTB survivors,were collected via telephone and face-to-face interviews at 3,12,and 24 months after *** Thirty-two COVID-19 with PTB survivors were *** median age was 52(45,59)years,and 23(71.9%)were *** them,nearly two-thirds(62.5%)of the survivors were moderate,three(9.4%)were severe,and more than half(59.4%)had at least one comorbidity(PTB excluded).The proportion of COVID-19 survivors with at least one sequela symptom decreased from 40.6%at 3 months to 15.8%at 24 months,with anxiety having a higher proportion over a *** and amnesia recovered at the 12-month follow-up,while anxiety,fatigue,and trouble sleeping remained after ***,one(3.1%)case presented two recurrences of PTB and no re-positive COVID-19during the follow-up *** The proportion of long symptoms in COVID-19 with PTB survivors decreased over time,while nearly one in six still experience persistent symptoms with a higher proportion of *** recurrence of PTB and the psychological support of COVID-19 with PTB after discharge require more attention.

关键词： COVID-19 Pulmonary tuberculosis Long-term Sequela Recurrence Re-positive

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