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Artificial Water Channel Promoting Depolymerization of Actin Filaments to Trigger Cancer Cell Apoptosis

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Chinese Journal of Chemistry 2024年第12期42卷 1335-1340页

作者： Lei Zhang Yin-gui Cao Ting Fan Jjiatong Zhao yong-Hong Fu Qi Xiao Zhan-Ting Li Yunfeng wang Bo Xiao Jun-Li Hou Department of Chemistry Fudan University220 Handan RoadShanghai 200433China State Key Laboratory of Silkworm Genome Biology Cllege of SericultureTextileand Biomass Sciences InstitutionSouthwest UniversityChongqing400715China ENT Institute and Otorhinolaryngology Department of Eye&ENT Hospital Fudan UniversityShanghai 200031 Fudan International School 325 Guoquan RoadShanghai 200433China

Actin filaments play important physiological functions,which have become potential targets of antitumor *** chemicals to intervene their polymerization-depolymerization dynamics would generate new strategies for designing antitumor *** this report,an artificial water channel appending acetazolamide moiety,a ligand that can selectively bind to carbonic anhydrase IX,has been prepared.

关键词： Artificial water channel Actin depolymerization Cell apoptosis Nanostructures Molecular recognition Supramolecular chemistry

A hybrid physics-informed data-driven neural network for CO_(2) storage in depleted shale reservoirs

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Petroleum Science 2024年第1期21卷 286-301页

作者： Yan-Wei wang Zhen-Xue Dai gui-Sheng wang Li Chen Yu-Zhou Xia Yu-Hao Zhou College of Construction Engineering Jilin UniversityChangchun130026JilinChina Institute of Intelligent Simulation and Early Warning for Subsurface Environment Jilin UniversityChangchun130026JilinChina School of Energy Resources China University of GeosciencesBeijing100083China Department of Safety Environmental Protection and Quality ManagementShengli OilfieldSinopecDongying257000ShandongChina Key Laboratory of Thermo-Fluid Science and Engineering of MOE School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an710049ShaanxiChina College of Computer Science and Technology China University of Petroleum(East China)Qingdao266580ShandongChina Department of Physics University of FribourgFribourg1700Switzerland

To reduce CO_(2) emissions in response to global climate change,shale reservoirs could be ideal candidates for long-term carbon geo-sequestration involving multi-scale transport ***,most current CO_(2) sequestration models do not adequately consider multiple transport ***,the evaluation of CO_(2) storage processes usually involves laborious and time-consuming numerical simulations unsuitable for practical prediction and *** this paper,an integrated model involving gas diffusion,adsorption,dissolution,slip flow,and Darcy flow is proposed to accurately characterize CO_(2) storage in depleted shale reservoirs,supporting the establishment of a training *** this basis,a hybrid physics-informed data-driven neural network(HPDNN)is developed as a deep learning surrogate for prediction and *** incorporating multiple sources of scientific knowledge,the HPDNN can be configured with limited simulation resources,significantly accelerating the forward and inversion ***,the HPDNN can more intelligently predict injection performance,precisely perform reservoir parameter inversion,and reasonably evaluate the CO_(2) storage capacity under complicated *** validation and test results demonstrate that the HPDNN can ensure high accuracy and strong robustness across an extensive applicability range when dealing with field data with multiple noise *** study has tremendous potential to replace traditional modeling tools for predicting and making decisions about CO_(2) storage projects in depleted shale reservoirs.

关键词： Deep learning Physics-informed data-driven neural network Depleted shale reservoirs CO_(2)storage Transport mechanisms

Simultaneously enhanced energy storage performance and luminance resistance in (K_(0.5)Na_(0.5))NbO_(3) -based ceramics via synergistic optimization strategy

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Journal of Advanced Ceramics 2024年第1期13卷 34-43页

作者： Yu Huan Diyu gui Changxiao Li Tao Wei Lingzhi Wu Xinjian wang Xiaozhi wang Zhenxiang Cheng School of Materials Science and Engineering University of JinanJinan 250022China Yangtze Delta Region Transformation Center for Advanced Technological Achievements Suzhou 215000China Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education and International Center for Dielectric ResearchXi’an Jiaotong UniversityXi’an 710032China Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongInnovation CampusNorth Wollongong 2500Australia

The rapidly advancing energy storage performance of dielectric ceramics capacitors has garnered significant interest for applications in fast charge/discharge and high-power electronic *** the exceptional electrical properties in harsh environments can further promote their practical *** carriers can be excited under luminance irradiation,thereby leading to degradation of energy storage ***,a synergic optimization strategy is proposed to enhance energy storage properties and luminance resistance of(K_(0.5)Na_(0.5))NbO_(3)-base(KNN)***,the introduction of Bi(Zn0.5Ti0.5)O_(3) solid solution and La3+ions disrupts the long-range polar orders and enhances super paraelectric relaxation ***,doping La3+ions can increase the band gap and reduce oxygen vacancy concentration,resulting in excellent luminance ***,the viscous polymer process is employed to suppress the grain growth and promote chemical *** a result,ultrahigh recoverable energy storage density(Wrec)of 8.11 J/cm3 and high efficiency(η)of 80.98%are achieved under an electric field of 568 kV/***,the variations in Wrec andηare only 12.45%and 1.75%,respectively,under 500 W xenon lamp irradiation compared to the performance under a dark *** findings hold great potential in facilitating the practical application of dielectric ceramic capacitors in luminance irradiation environments.

关键词： potassium-sodium niobate energy storage performance illumination resistance oxygen vacancy viscous polymer processing

Thermal fatigue and wear of compacted graphite iron brake discs with various thermomechanical properties

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China Foundry 2024年第3期21卷 248-256页

作者： gui-quan wang Zhuo Xu Zhong-li Liu Xiang Chen Yan-xiang Li School of Nuclear Equipment and Nuclear Engineering Yantai UniversityYantai 264005ShandongChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

The increase in payload capacity of trucks has heightened the demand for cost-effective yet high performance brake *** this work,the thermal fatigue and wear of compacted graphite iron brake discs were investigated,aiming to provide an experimental foundation for achieving a balance between their thermal and mechanical *** graphite iron brake discs with different tensile strengths,macrohardnesses,specific heat capacities and thermal diffusion coefficients were produced by changing the proportion and strength of *** peak temperature,pressure load and friction coefficient of compacted graphite iron brake discs were analyzed through inertia friction *** morphology of thermal cracks and 3D profiles of the worn surfaces were also *** is found that the thermal fatigue of compacted graphite iron discs is determined by their thermal properties.A compacted graphite iron with the highest specific heat capacity and thermal diffusion coefficient exhibits optimal thermal fatigue *** of the matrix at low temperatures significantly weakens the function of alloy strengthening in hindering the propagation of thermal *** the reduced hardness,increasing the ferrite proportion can mitigate wear loss resulting from low disc temperatures and the absence of abrasive wear.

关键词： compacted graphite iron brake disc thermomechanical properties thermal fatigue wear

Lead Edge Status,Innovation Investment and Innovation Performance:an Empirical Study of User Innovation in China

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Lead Edge Status,Innovation Investment and Innovation Perfor...

Asymmetric reversible structural switching of a diene coordination polymer promoted by UV-visible light

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作者： GAO Zhong-yi wang yong-gui DONG Yi-ren School of Business Nanjing University

This study is to test the relationship between lead edge statuses（LES）,innovation investment and innovation *** have collected a large number of samples in *** our research we found that innovation investment played... 详细信息

关键词： Lead Edge Status Innovation Investment Mediator Innovation Performance

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Science China Chemistry 2024年第2期67卷 536-541页

作者： yong wang Qiaoqiao Zhang yong-yong Cao Qi Liu Brendan F.Abrahams Jian-Ping Lang College of Chemistry Chemical Engineering and MaterialsSoochow UniversitySuzhou215123China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032China College of Biological Chemical Science and EngineeringJiaxing UniversityJiaxing314001China School of Chemistry University of MelbourneVictoria3010Australia

In natural and artificial systems,reversible reactions are commonly asymmetric with respect to the time scale and nature of the stimuli which drive the forward and backward *** applications for which switching behavior is required,it is desirable that the reversible reaction goes as close to symmetric as possible;however,such systems are ***,we report an example of ultraviolet(UV)-visible light-regulated asymmetric reversible structural switching involving a diene-based coordination polymer,CP1 and its monocyclobutane product,*** is possible to cycle at least ten times through a forward [2+2] photocycloaddition reaction and the reverse,photocleavage reaction.A single cycle can be completed within a few *** transformation is accompanied by fast and distinct fluorescence changes,arising from optimisation of the reaction *** functional theory calculations allow rationalisation of the asymmetric reversible transformation between CP1 and CP1a rather than between CP1 and its dicyclobutane product *** work provides a clear illustration of reversible structural switching which approaches symmetric behaviour with respect to reaction rate and *** insights gained from this work also assist in the design of fast,reversible switching materials.

关键词： asymmetrical reversible structural switching coordination polymer photocycloaddition UV-visible light-controlled fluorescence switching

Modeling analysis of cobalt-based Fischer-Tropsch catalyst particles

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Chinese Journal of Chemical Engineering 2024年第6期70卷 82-92页

作者： Huashuai Wu Gang wang yong Yang yongwang Li College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China National Energy Research&Development Center for Coal to Liquid Fuels Synfuels China CompanyLimitedBeijing 101400China

The influences of particle size,shape,and catalyst distribution on the reactivity and hydrocarbon product selectivity of a cobalt-based catalyst for Fischer-Tropsch synthesis were investigated in the present work.A self-consistent kinetic model for Fischer-Tropsch reaction proposed here was found to correlate experimental data well and hence was used to describe the consumption rates of reactants and formation rates of hydrocarbon *** perturbed-chain statistical associating fluid theory equation of state was used to describe vapor-liquid equilibrium behavior associated with Fischer-Tropsch *** interaction between intraparticle diffusion and Fischer-Tropsch reaction was investigated in *** showed that in order to avoid the adverse influence of intraparticle diffusional limitations on catalyst reactivity and product selectivity,the use of small particles is *** eggshell spherical particles are shown to keep the original catalyst reactivity and enhance the selectivity of heavy hydrocarbon *** suitable layer thickness for a spherical particle with a diameter of 2 mm is nearly 0.15 *** the same outer diameter of 2 mm,the catalyst reactivity and heavy product selectivity of hollow cylindrical particles with a layer thickness of 0.25 mm are found to be larger than eggshell spherical *** the viewpoint of catalytic performance,hollow cylindrical particles are a better choice for industrial applications.

关键词： Fischer-Tropsch synthesis Kinetic modeling Vapor-liquid equilibria Numerical simulation Intraparticle diffusion Particle shapes

Fast Cross-Platform Binary Code Similarity Detection Framework Based on CFGs Taking Advantage of NLP and Inductive GNN

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Chinese Journal of Electronics 2024年第1期33卷 128-138页

作者： Jinxue PENG yong wang Jingfeng XUE Zhenyan LIU School of Computer Science and Technology Beijing Institute of Technology

Cross-platform binary code similarity detection aims at detecting whether two or more pieces of binary code are similar or not. Existing approaches that combine control flow graphs(CFGs)-based function representation and graph convolutional network(GCN)-based similarity analysis are the best-performing ones. Due to a large amount of convolutional computation and the loss of structural information, the use of convolution networks will inevitably bring problems such as high overhead and sometimes inaccuracy. To address these issues, we propose a fast cross-platform binary code similarity detection framework that takes advantage of natural language processing(NLP)and inductive graph neural network(GNN) for basic blocks embedding and function representation respectively by simulating extracting structural features and temporal features. GNN’s node-centric and small batch is a suitable training way for large CFGs, it can greatly reduce computational overhead. Various NLP basic block embedding models and GNNs are evaluated. Experimental results show that the scheme with long short term memory(LSTM)for basic blocks embedding and inductive learning-based Graph SAGE(GAE) for function representation outperforms the state-of-the-art works. In our framework, we can take only 45% overhead. Improve efficiency significantly with a small performance trade-off.

关键词： Training Semantics Process control Binary codes Feature extraction Natural language processing Graph neural networks

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Experimental and Numerical Investigation of Non-synchronous Blade Vibration Excitation in a Transonic Axial Compressor

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Journal of Thermal Science 2024年第2期33卷 602-610页

作者： wang Songbai WU Yadong CHEN yong CAO Zhipeng School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China AECC Sichuan Gas Turbine Establishment Chengdu610500China

The complex flow phenomenon of rotating instability(RI) and its induced non-synchronous vibration(NSV) have become a significant challenge as they continuously increase aerodynamic *** study aims to provide an understanding of the non-synchronous blade vibration phenomenon caused by the rotating instability of a transonic axial compressor *** this case,blade vibrations and non-synchronous excitation are captured by strain gauges and unsteady wall pressure transducer *** numerical simulations for a full-annulus configuration are used to obtain the non-synchronous flow *** results show that the first-stage rotor blade exhibits an NSV close to the first bending mode;NSV is accompanied by a sharp increase in pressure pulsation;amplitude can reach 20%,and unsteady aerodynamic frequency will lock in a structural mode frequency when the blade vibrates in a large-amplitude *** predicted NSV frequency aligns well with the experimental *** dominant mode of circumferential instability flow structure is approximately 47% of the number blades,and the cell size occupies 2-3 pitches in the circumferential *** full-annulus unsteady simulations demonstrate that the streamwise oscillation of the shedding and reattachment vortex structure is the main cause of NSV owing to the strong interaction between the tip leakage and separation vortices near the suction surface.

关键词： non-synchronous vibration transonic axial compressor rotor blade rotating instabilities unsteady flow