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Expression of Thioredoxin System Protein Induced by Silica in Rat Lung Tissue

Biomedical and Environmental Sciences 2022年第7期35卷 663-668页

作者： GUAN Yi LI Gai LIU Nan wang yong heng ZHOU Qiang CHANG Mei Yu ZHAO Lin Lin YAO San Qiao School of Public Health North China University of Science and TechnologyTangshan 063210HebeiChina North China University of Science and Technology Affiliated Hospital Tangshan 063000HebeiChina School of Pharmacy North China University of Science and TechnologyTangshan 063210HebeiChina Xinxiang Medical University Xinxiang 453003HenanChina

Silicosis,a potentially fatal global occupational disease, is characterized by progressive deterioration of pulmonary function and irreversible fibrosis resulting from crystalline silicon dioxide or silica inhalation.Extensive pieces of evidence[1-3]manifest that inhaled silica particles could directly or indirectly cause excess generation of reactive oxygen species(ROS),which plays a key role in the pathogenesis of silicosis.In order to maintain the cellular redox balance,the main function of thioredoxin(Trx)/thioredoxin reductase(TrxR)systems is to scavenge the ROS. TrxR, as a reductase of Trx currently known only,has the function of antioxidation and scavenging free radicals[4].In addition, recent in vitro studies demonstrate that Trx interacts directly with and inhibits the activity of apoptosis-regulating kinase-1(ASK-1)[5].The damaged cell of lung tissue caused by ROS may be an important link to ASK-1 triggered cell apoptosis.Zhu et al.[1] reported that silica could aggravate oxidative stress and promote the development of silicosis in rat lungs after silica exposure by downregulating the expression of TrxR and poor Trx activity. The specific mechanism of imbalance of reduction/oxidation status in silicosis is poorly understood.Our previous studies[6]demonstrated that oxidative stress in rats induced by silica leads to increased peroxiredoxins(Prxs) protein reactivity to resist oxidative stress, and Trx as an electron donor is functionally associated with Prxs. Hence, we propose a hypothesis that silica exposure may lead to the disturbance of the function of the Trx/TrxR system,contributing to further oxidative damage.

关键词： oxidative irreversible maintain

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Biotransformation ofα-asarone by Alternaria longipes CGMCC 3.2875

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Chinese Journal of Natural Medicines 2021年第9期19卷 700-705页

作者： ZOU Jian ZHANG Shuai ZHAO Huan wang yong-heng ZHOU Zheng-Qun CHEN Guo-Dong HU Dan LI Ning YAO Xin-Sheng GAO Hao Institute of Traditional Chinese Medicine&Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents ofTCM and New Drugs ResearchJinan UniversityGuangzhou 510632China College of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China College of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou 510632China

Biotransformation ofα-asarone by Alternaria longipes CGMCC 3.2875 yielded two pairs of new neolignans,(+)(7 S,8 S,7’S,8’R)iso-magnosalicin(1 a)/(-)(7 R,8 R,7’R,8’S)iso-magnosalicin(1 b)and(+)(7 R,8 R,7’S,8’R)magnosalicin(2 a)/(-)(7 S,8 S,7’R,8’S)magnosalicin(2 b),and four known metabolites,(±)acoraminol A(3),(±)acoraminol B(4),asaraldehyde(5),and 2,4,5-trimethoxybenzoic acid(6).Their structures,including absolute configurations,were determined by extensive analysis of NMR spectra,X-ray crystallography,and quantum chemical ECD calculations.The cytotoxic activity and Aβ_(42)aggregation inhibitory activity of all the compounds were evaluated.Compound 2 displayed significant anti-Aβ_(42)aggregation activity with an inhibitory rate of 60.81%(the positive control EGCG:69.17%).In addition the biotransformation pathway ofα-asarone by Alternaria longipes CGMCC 3.2875 was proposed.

关键词： Biotransformation α-Asarone Alternaria longipes CGMCC 3.2875 Anti-Aβ_(42)aggregation activity

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Construction of Naphthalenediimide Lanthanide(Ⅲ)-MOFs and Composites Incorporated Electron-Rich Pyrene Derivative as Multifunctional Fluorescence Sensing for Nitro Aromatic Compounds and Aldehydes

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Chinese Journal of Chemistry 2024年第3期42卷 283-293页

作者： Rong Huo Ting Zhang Guang Zeng Chen wang yong heng Xing Feng Ying Bai College of Chemistry and Chemical Engineering Liaoning Normal UniversityDalianLiaoning116029 China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning116023 China

The development of host-guest MOF luminescent composites has attracted considerable attention. However,it is still a challenge to reasonably design large scale conjugated polycarboxylic acids metal-organic framework (MOF) and modulate donor-acceptor interaction. Herein,a series of isostructural 3D porous lanthanide MOF [Ln_(2)(BINDI)0.5(NO_(3))(DMA)(H_(2)O)]∙DMA∙2.5H_(2)O (Ln = La (1),Ce (2),Pr (3) and Nd (4);H_(4)BINDI (N,N’-bis(5-isophthalic acid)-1,4,5,8-naphthalenediimide) were synthesized. Considering the electron-deficient performances of Ln-BINDI MOFs,D-A type composites Ln-MOFs (1—4@H_(4)TBAPy) were prepared via the incorporation of electron-rich H_(4)TBAPy (1,3,6,8-tetrakis(p-benzoic acid) pyrene),which more improved the luminescence performance of complexes 1—4 and can be used as fluorescence sensors for the detection of nitro compounds and aldehydes. High sensitivity of 1@H_(4)TBAPy towards pNBA,pNA PNP,DNP,and TNP could be achieved through hydrogen bond interactions between MOF and analytes,as well as the π-π interaction between H_(4)TBAPy and the naphthalene ring of BINDI,thus the fluorescence quenching efficiency of 1@H_(4)TBAPy was better than that of the complex 1. In addition,it is found that 1@H_(4)TBAPy has high selectivity and sensitivity to aromatic aldehyde SA,5-Mesal and HMBA. Such strategy to enhance the emission of NDI based Ln-BINDI MOFs,will open up an avenue to obtain more fluorescent MOFs for sensing.

关键词： Ln-MOF Pyrene molecule NACs Aldehydes Fluorescence sensing Carboxylate ligands Charge transfer Donor-acceptor systems

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Concise extraction and characterization of the pore-throat network in unconventional hydrocarbon reservoirs: A new perspective

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Petroleum Science 2024年第3期21卷 1474-1487页

作者： Shu-heng Du yong-Min Shi State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences School of Earth and Space Sciences Peking University

In this study, a new image-based method for the extraction and characterization of pore-throat network for unconventional hydrocarbon storage and exploitation is proposed. “Pore-throat solidity”, which is analogous to particle solidity, and a new method for automatic identification of pores and throats in tight sandstone oil reservoirs are introduced. Additionally, the “pore-throat combination” and “pure pore” are defined and distinguished by drawing the cumulative probability curve of the pore-throat solidity and by selecting an appropriate cutoff point. When the discrete grid set is recognized as a pore-throat combination, Legendre ellipse fitting and minimum Feret diameter are used. When the pore and throat grid sets are identified as pure pores, the pore diameter can be directly calculated. Using the new method, the analytical results for the physical parameters and pore radius agree well with most prior studies. The results comparing the maximum ball and the new model could also prove the accuracy of the latter's in micro and nano scales. The new model provides a more practical theoretical basis and a new calculation method for the rapid and accurate evaluation of the complex processes of oil migration.

关键词： Hydrocarbon exploitation Pore Throat Porous media Identification

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Changes of coastline and tidal flat and its implication for ecological protection under human activities: Take China’s Bohai Bay as an example

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China Geology 2024年第1期7卷 26-35页

作者： yong Li Ming-zheng Wen heng Yu Peng Yang Fei-cui wang Fu wang Tianjin Center China Geological SurveyMinistry of Natural ResourcesTianjin 300170China Key Laboratory of Coast Geo-environment China Geological SurveyMinistry of Natural ResourcesTianjin 300170China Tianjin Key Laboratory of Coast Geological Processes and Environmental Safety Tianjin 300170China Hebei University of Environmental Engineering Qinhuangdao 066102China Hebei Engineering Research Center for Ecological Restoration of seaward Rivers and Coastal Waters Qinhuangdao 066102China Department of Earth and Environment Boston UniversityBoston 02215USA

The change processes and trends of shoreline and tidal flat forced by human activities are essential issues for the sustainability of coastal area,which is also of great significance for understanding coastal ecological environment changes and even global changes.Based on field measurements,combined with Linear Regression(LR)model and Inverse Distance Weighing(IDW)method,this paper presents detailed analysis on the change history and trend of the shoreline and tidal flat in Bohai Bay.The shoreline faces a high erosion chance under the action of natural factors,while the tidal flat faces a different erosion and deposition patterns in Bohai Bay due to the impact of human activities.The implication of change rule for ecological protection and recovery is also discussed.Measures should be taken to protect the coastal ecological environment.The models used in this paper show a high correlation coefficient between observed and modeling data,which means that this method can be used to predict the changing trend of shoreline and tidal flat.The research results of present study can provide scientific supports for future coastal protection and management.

关键词： Shoreline Tidal flat Erosion deposition patterns Changing trend Ecological protection Human activity Linear regression model Inverse distance weighing method Prediction Bohai Bay

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Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation

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Current Medical Science 2024年第3期44卷 475-484页

作者： Min-shan LI Xiang-hong wang heng wang Department of Otolaryngology-Head and Neck Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Institute of Allergy and Clinical Immunology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Clinical Research Center for Nasal Inflammatory Diseases Wuhan430030China

Proton-activated G protein-coupled receptors(GPCRs),initially discovered by Ludwig in 2003,are widely distributed in various tissues.These receptors have been found to modulate the immune system in several inflammatory diseases,including inflammatory bowel disease,atopic dermatitis,and asthma.Proton-activated GPCRs belong to the G protein-coupled receptor family and can detect alternations in extracellular pH.This detection triggers downstream signaling pathways within the cells,ultimately influencing the function of immune cells.In this review,we specifically focused on investigating the immune response of proton-activated GPCRs under inflammatory conditions.

关键词： proton-activated G protein-coupled receptors inflammation immunomodulation disease

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Value iteration algorithm for continuous-time linear quadratic stochastic optimal control problems

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Science China(Information Sciences) 2024年第2期67卷 170-180页

作者： Guangchen wang heng ZHANG School of Control Science and Engineering Shandong University

In this study, we investigate a continuous-time infinite-horizon linear quadratic stochastic optimal control problem with multiplicative noise in control and state variables. Using the techniques of stochastic stability, exact observability, and stochastic approximation, a value iteration algorithm is developed to solve the corresponding generalized algebraic Riccati equation. Unlike the existing policy iteration algorithm, this algorithm does not rely on an initial stabilizing control. Further, this algorithm can also be used to compute policy evaluation steps that arise in the policy iteration algorithm. Herein, a simulation example is provided to validate the obtained results.

关键词： stochastic systems optimal control linear quadratic stochastic problem generalized algebraic Riccati equation value iteration algorithm

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Effectiveness of intravitreal ranibizumab for diabetic macular edema in vitrectomized versus non-vitrectomized eyes:a Meta-analysis

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 729-735页

作者： Yi-heng wang Qian Xu Jie Luan Department of Ophthalmology Zhongda HospitalSoutheast UniversityNanjing 210009Jiangsu ProvinceChina School of Medicine Southeast UniversityNanjing 210009Jiangsu ProvinceChina

AIM:To evaluate the effectiveness and safety of intravitreal ranibizumab(IVR)for diabetic macular edema(DME)in vitrectomized versus non-vitrectomized eyes.METHODS:The PubMed,EMBASE,Web of Science,Cochrane,EBSCO were comprehensively searched for studies comparing vitrectomized and non-vitrectomized eyes with DME.Clinical outcomes of best-corrected visual acuity(BCVA),central macular thickness(CMT),the mean number of intravitreal injection and adverse events were extracted and analyzed.RESULTS:Six studies involving 641 eyes were included.Final visual gain significantly improved and CMT significantly reduced in vitrectomized eyes at 6mo and 12mo visits(P<0.05).Although the mean reduction in CMT among non-vitrectomized eyes was significantly greater than in vitrectomized eyes at the 6mo[mean difference(MD)=53.57,95%confidence interval(CI):28.03 to 78.72,P<0.0001]and 12mo(MD=49.65,95%CI:19.58 to 79.72,P=0.01),no significant difference was detected in improvement in BCVA at either 6mo(MD=0.05,95%CI:-0.02 to 0.13,P=0.14)or 12mo(MD=0.03,95%CI:-0.04 to 0.09,P=0.43).Injection number of ranibizumab in non-vitrectomized eyes was significantly less than that in vitrectomized eyes during 6-month period(MD=0.60,95%CI:0.16 to 1.04,P=0.008),while there was no statistically significant difference between the two groups during 12mo of follow-up.CONCLUSION:Evidence from current study suggests that IVR was useful for both vitrectomized group and nonvitrectomized group with DME.Although less reduction in macular thickness is found in vitrectomized group,visual improvement between two groups is similar.

关键词： diabetic macular edema ranibizumab vitrectomized eye

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Science China Mathematics 2024年第2期67卷 405-430页

作者： Junzhuo Gao Lei wang heng Lian School of Statistics and Data Science&LPMC Nankai UniversityTianjin 300071China Department of Mathematics City University of Hong KongHong KongChina

In this paper, we consider the unified optimal subsampling estimation and inference on the lowdimensional parameter of main interest in the presence of the nuisance parameter for low/high-dimensionalgeneralized linear models (GLMs) with massive data. We first present a general subsampling decorrelated scorefunction to reduce the influence of the less accurate nuisance parameter estimation with the slow convergencerate. The consistency and asymptotic normality of the resultant subsample estimator from a general decorrelatedscore subsampling algorithm are established, and two optimal subsampling probabilities are derived under theA- and L-optimality criteria to downsize the data volume and reduce the computational burden. The proposedoptimal subsampling probabilities provably improve the asymptotic efficiency of the subsampling schemes in thelow-dimensional GLMs and perform better than the uniform subsampling scheme in the high-dimensional GLMs.A two-step algorithm is further proposed to implement, and the asymptotic properties of the correspondingestimators are also given. Simulations show satisfactory performance of the proposed estimators, and twoapplications to census income and Fashion-MNIST datasets also demonstrate its practical applicability.

关键词： A-optimality decorrelated score subsampling high-dimensional inference L-optimality massive data

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Granular Ionogel Particle Inks for 3D Printed Tough and Stretchable Ionotronics

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Research 2024年第1期2023卷 429-442页

作者： Yuan Yao Yue Hui Zhenhua wang Hehao Chen heng Zhu Nanjia Zhou Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024Zhejiang ProvinceChina Institute of Advanced Technology Westlake Institute for Advanced StudyHangzhou 310024Zhejiang ProvinceChina School of Chemical Engineering and Advanced Materials the University of AdelaideAdelaide 5005South AustraliaAustralia State Key Laboratory of Fluid Power&Mechatronic System Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceCenter for X-MechanicsDepartment of Engineering MechanicsZhejiang UniversityHangzhou 310027China

Ionogels have garnered great attention as promising soft conducting materials for the fabrication of flexible energy storage devices,soft actuators,and ionotronics.However,the leakage of the ionic liquids,weak mechanical strength,and poor manufacturability have greatly limited their reliability and applications.Here,we propose a new ionogel synthesis strategy by utilizing granular zwitterionic microparticles to stabilize ionic liquids.The ionic liquids swell the microparticles and physically crosslink microparticles via either electronic interaction or hydrogen bonding.Further introducing a photocurable acrylic monomer enables the fabrication of double-network(DN)ionogels with high stretchability(>600%)and ultrahigh toughness(fracture energy>10 kJ/m^(2)).The synthesized ionogels exhibit a wide working temperature of−60 to 90℃.By tuning the crosslinking density of microparticles and physical crosslinking strength of ionogels,we synthesize DN ionogel inks and print them into three-dimensional(3D)motifs.Several ionogelbased ionotronics are 3D printed as demonstrations,including strain gauges,humidity sensors,and ionic skins made of capacitive touch sensor arrays.Via covalently linking ionogels with silicone elastomers,we integrate the ionogel sensors onto pneumatic soft actuators and demonstrate their capacities in sensing large deformation.As our last demonstration,multimaterial direct ink writing is harnessed to fabricate highly stretchable and durable alternating-current electroluminescent devices with arbitrary structures.Our printable granular ionogel ink represents a versatile platform for the future manufacturing of ionotronics.

关键词： crosslinking utilizing gauge

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