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王阳明心学涵育时代新人的价值:“三重向度”

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中国文化与管理 2024年第1期 157-168,274页

作者：王艺润季海菊范杰玉江苏开放大学马克思主义学院江苏开放大学党委宣传部宣传与理论教育科

“时代新人”是党在新时代“培养什么人”的高度概括,是实现中华民族伟大复兴的先锋力量。作为中国传统文化的精华,王阳明心学蕴含着丰富的育人价值,其涵育新人的逻辑架构可概括为“三重向度”:价值向度,王阳明心学的智慧与精髓是涵育... 详细信息

“时代新人”是党在新时代“培养什么人”的高度概括,是实现中华民族伟大复兴的先锋力量。作为中国传统文化的精华,王阳明心学蕴含着丰富的育人价值,其涵育新人的逻辑架构可概括为“三重向度”:价值向度,王阳明心学的智慧与精髓是涵育时代新人的力量来源;理论向度,“心即理”“知行合一”“致良知”“天地万物一体之仁”的当代发展为涵育时代新人提供哲理支撑;实践向度,文化滋养、实践锤炼、构建协同育人格局是涵育时代新人的有效路径。

关键词：王阳明心学涵育 “三重向度”

A Mode-switching Strategy of Droop Control for VSC-MTDC Systems Considering Maximum DC Voltage Regulation Capability

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 903-912页

作者： Yizhen wang Fengliang Qiu Zhongguan wang yirun Ji Zhengguang Chen Chengshan wang Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin 300072China Electric Power Research Institute of State Grid JiBei Electric Power Co.Ltd. Beijing 100045China State Grid Corporation of China Beijing 100031China IEEE

To achieve the goal of carbon neutrality,renewable energy integration through a voltage source converter based multi-terminal direct current(VSC-MTDC)system has been identified as a promising *** tackle the significant DC voltage over-limit problem in a VSC-MTDC system during disturbances,this paper proposes a mode-switching strategy of droop control considering maximum DC voltage regulation *** close relationship between node injection powers and node DC voltages in the MTDC system is elaborated,and the most effective regulation approach of local injection power for limiting DC voltage deviation is *** operating point trajectories of different droop control explains that the DC voltage deviation can be minimized by fully utilizing the capacity of ***,the mode-switching strategy with the maximum DC voltage regulation capability is realized by the switching between the voltage droop control and the constant maximum power *** addition,a mode recovery process and a smooth switching method are developed to make converters regain the capability of maintaining DC voltage and reduce power fluctuation during mode switching,***,three cases are investigated to verify the effectiveness of the proposed mode-switching *** with simulation results of the conventional droop control and the DC voltage deviation-dependent droop control,better performance of transient and steady-state DC voltage deviation is achieved through the proposed strategy.

关键词： Droop control maximum DC voltage regulation capability mode-switching VSC-MTDC

Acupuncture on Intracellular Ionic Distribution inMuscle Injury and Its Mechanism

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北京体育大学学报 1995年第S2期18卷 35-42页

作者： QU Zhuqing LU Dinghou wang yirun (36 years old, PhD. lecturer)

While delayed structural alterations of muscles(DSAM) induced by strenuous exercises have always been one of the commoest findings in sports-related muscle injuries, its pathogenesis remains unidentified. And although acupuncture at Ashi points has proved its efficacy in halting the progress of DASM and speeding up its recovery, we know very little about the underlying mechanism. This paper presents our work on these problems by using amphibian DSAM models created by electrostimulation, and such research tools as electromicroscopy, enzymology, the fluores cence indicator, Fura 2, and electron probe microanalysis (EPMA). Our results indicate:1) As revealed by EPMA, cytoplasmic Ca continued to rbe,reaching 3.07 and 5. 33 mmol/kg dry wt. 3 and 6hrs afterelectrostimlation respectively. Analysis of regions with variousstructural alterations showed rise of Ca concentration inparallel with severity of myofibrillar injury. Testing with Fura 2also demonstrated obvious increase of free Ca++ in cytoplasm 3 hrs after electrostimulation. All these showed a positive correlation between DSAM and the increase of intracellular Ca++.2) Further study to explore the possible mechanisms underlying the increase of cytoplasmic Ca++ revealed two sources. During the initial rise of cytoplasmic Ca, a decline of sarcoplasmic reticulum Ca content was found, suggesting the contribution of sarcoplasmic reticulum Ca. However, no further decline was noted despite continued rise of cytoplasmic Ca, which, then, could only be accounted for by extracellular contribution.3) In skeletal muscles after long-term exhaustive stimulation and in those with delayed structural alterations,the inereased cytoplasmic Ca was quickly lowered by acupuncture, down to lpretest level 10 minutes after acupuncture. Meanwhile,no marked change in sarcoplasmic reticulum Ca content and in enzymic activity of Ca, Mg-ATPase was found, indicating no contribution on their part to the quick lowering of cytoplasmic Ca. But a rapid

关键词： Acupuncture Delayed Structural Alterations of Muscle (DSAM) Electron Probe Microanalysis (EPMA) Fura 2 Ca++, Calcium Pump Na-Ca Exchange Sarcoplasmic Reticulum (SR)

Substance P Promotes Proliferation of Adult Pancreatic Ductal Cells

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Substance P Promotes Proliferation of Adult Pancreatic Ducta...

Chemical constituents from Xiaoaiping injection

中国生理学会内分泌代谢、比较生理与应激生理学术会议

作者： Nan Zhang Di Gao Qian Shen yirun wang Yudan Liu 沙磊 Department of Neuroendocrine Pharmacology School of PharmacyChina Medical University

The neogenesis of p-cells is initiated from the exocrine component such as ductal epithelium *** substance P（SP） and calcitonin gene-related peptide（CGRP） released from primary sensory nerves innervate islets,acini and pancreatic ***:The aim of this study was to investigate the effects of SP and CGRP on the proliferation and differentiation of cells derived from rat pancreatic ***:Primary ductal cells at the third passage（P3） were *** identification of P3 cells were confirmed with flow cytometry analysis and immunostaining by CK19（the ductal cell marker）.Proliferation of ductal cells was verified by CCK-8 assay and Ki67 *** of cells was determined by flow cytometry analysis and ***:SP but not CGRP promotes cell viability and proliferation of the ductal ***,SP at concentrations as low as 10 μM possessed the ability to promote pancreatic ductal cells ***,NK-1 receptor antagonist L-703,606 blocked the SP-induced stimulation of proliferation,indicating that the promotion effects of SP on proliferation of ductal cells via NK-1 *** or CGRP does not have the ability of pro-differentiation of pancreatic ductal cells towards ***:Our results suggested that SP but not CGRP promotes proliferation of ductal cells,and SP does not promote cell differentiation towards P-cells.

关键词： Substance P calcitonin gene-related peptide pancreatic ductal cells proliferation differentiation

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Journal of Chinese Pharmaceutical Sciences 2014年第4期23卷 251-255页

作者：王艺润赵明波唐丽屠鹏飞中央民族大学生命与环境科学学院北京100081 北京大学医学部药学院天然药物及仿生药物国家重点实验室北京100191

Xiaoaiping injection is a single-prescription of Marsdenia tenacissima. One new compound, tenacigenoside L （1）, along with ten known compounds were isolated from the CHCl3-soluble fraction of Xiaoaiping injection extract by silica gel, ODS, Sephadex LH-20 and semi-preparative HPLC chromatography. The new compound was characterized as 3-O-β-D-oleandropyranosyl- 17β-tenacigenin B. The ten known compounds were identified as tenacigenin B （2）, 17β-tenacigenin B （3）, marsdenoside F （4）, tenacissoside G （5）, tenacissoside I （6）, tenacissoside H （7）, marsdenoside D （8）, tenacigenin A （9）, marsdenoside I （10）, and tenacigenin C （11）. The structures of 11 compounds were elucidated on the basis of extensive analyses of spectroscopic data including MS, 1D NMR and 2D NMR, and comparison of their spectroscopic data with those reported in the literatures.

关键词： Xiaoaiping injection Marsdenia tenacissima Polyoxypregnane glycoside

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循环老化三元锂离子电池热失控气体毒性研究

北京航空航天大学学报 2024年第6期50卷 1761-1769页

作者：张青松曲奕润中国民航大学民航热灾害防控与应急重点实验室天津300300

为研究高能量密度锂离子电池循环老化过程中热失控特性变化及释放气体的毒性危害,对不同循环老化程度的三元锂离子电池进行热滥用实验,利用气体传感器阵列,基于有效剂量分数模型对热失控气体毒性危害进行定量分析。结果表明,高镍含量三... 详细信息

为研究高能量密度锂离子电池循环老化过程中热失控特性变化及释放气体的毒性危害,对不同循环老化程度的三元锂离子电池进行热滥用实验,利用气体传感器阵列,基于有效剂量分数模型对热失控气体毒性危害进行定量分析。结果表明,高镍含量三元锂离子电池循环性能差,200次循环老化后,电池健康状态低于70%。老化电池更容易进入热失控状态,热失控反应更剧烈但释放能量少,释放气体燃烧效率低。在密闭空间内,电池热失控释放窒息性气体危害性比刺激性气体更高,150次循环老化电池的窒息性气体毒性累积效应比新鲜电池早638 s达到临界值1。随老化程度增加,最终电池的刺激性气体毒性即时效应与气体致死毒性即时效应降低,与新鲜电池相比,100次循环老化后,电池的刺激性气体毒性即时效应降低0.34,气体致死毒性即时效应降低0.19。研究结果可为老化电池安全性评估及热失控预警提供数据支撑。

关键词：三元锂离子电池热失控循环老化气体传感器阵列气体毒性分析

TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca^(2+) -Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression

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Research 2024年第1期2023卷 351-368页

作者： Cheng Zhong Jing Yang Yiyin Zhang Xiaoxiao Fan Yang Fan Ning Hua Duguang Li Shengxi Jin yirun Li Peng Chen Yongle Chen Xiaobo Cai Yi Zhang Linhua Jiang Wei Yang Peilin Yu Hui Lin Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouP.R.China Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital Zhejiang University School of MedicineHangzhou 310000P.R.China Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province Xinxiang Medical University453003 XinxiangHenanP.R.China School of Biomedical Sciences Faculty of Biological SciencesUniversity of LeedsLS29JT LeedsUK Department of Toxicology and Department of Medical Oncology of Second Affiliated Hospital Zhejiang University School of MedicineHangzhouP.R.China Zhejiang Engineering Research Center of Cognitive Healthcare Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310020P.R.China College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhou 310058P.R.China

Hepatic ischemia–reperfusion(IR)injury is a serious clinical problem that complicates liver resection and *** recent advances in understanding of the pathophysiology of hepatic IR injury,effective interventions and therapeutics are still ***,we examined the role of transient receptor potential melastatin 2(TRPM2),a Ca^(2+)-permeable,non-selective cation channel,in mediating hepatic IR *** data showed that TRPM2 deficiency attenuated IR-induced liver dysfunction,inflammation,and cell death in ***,RNA sequencing analysis indicated that TRPM2-induced IR injury occurs via ferroptosis-related ***,as a ferroptosis inducer,(1S,3R)-RSL3 treatment induced mitochondrial dysfunction in hepatocytes and a TRPM2 inhibitor suppressed ***,TRPM2-mediated calcium influx caused mitochondrial calcium accumulation via the mitochondrial Ca^(2+)-selective uniporter and increased the expression level of arachidonate 12-lipoxygenase(ALOX12),which results in mitochondrial lipid peroxidation during hepatic IR ***,hepatic IR injury-induced ferroptosis was obviously relieved by a TRPM2 inhibitor or calcium depletion,both in vitro and in ***,these findings demonstrate a crucial role for TRPM2-mediated ferroptosis in hepatic IR injury via increased Ca^(2+)-induced ALOX12 expression,indicating that pharmacological inhibition of TRPM2 may provide an effective therapeutic strategy for hepatic IR injury-related diseases,such as during liver resection and transplantation.

关键词： TRPM2 Lipid Hepatic

Swarm intention identification via dynamic distribution probability image

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Chinese Journal of Aeronautics 2024年第10期37卷 380-392页

作者： Yinhan wang Jiang wang Shaoming HE Fei wang Qi wang School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China

In the realm of decision-making for defense and security applications,it is paramount to swiftly and accurately identify the intentions of incoming *** identification methods predominantly focus on single-target applications and overlook the perturbations introduced by measurement *** this study,we propose a novel concept:the Dynamic Distribution Probability(DDP)image,which is constructed using the estimated state and its covariance *** grayscale pixel value within the image signifies the probability of the presence of the agent within the *** proposed identification scheme integrates the use of Extended Kalman Filter(EKF),Convolutional Neural Network(CNN),Back Propagation(BP)network,and Gated Recurrent Unit(GRU)***,the DDP image is processed through a CNN to distill the formation characteristics,and the estimated swarm state from EKF is inputted into a BP network to deduce the kinematic *** outputs from both networks are summed and subsequently channeled into a GRU network to capture temporal *** numerical simulations and flight experiments are presented to demonstrate the robust anti-noise capability of the proposed scheme compared with conventional methods,as well as its superior training efficiency.

关键词： Intention Identification Kalman filters Convolutional neural networks Swarm intelligence

循证护理在50例妊娠高血压孕妇中的应用研究

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上海医药 2020年第19期41卷 42-44页

作者：祁健施政王奕闰方小莉宁波市妇女儿童医院北院日间手术病区浙江宁波315031 宁波市妇女儿童医院北院妇一病区浙江宁波315031 宁波市妇女儿童医院妇三科浙江宁波315012

目的:观察循证护理在妊娠高血压孕妇中的应用效果,为临床诊疗提供依据。方法:选取妊娠高血压孕妇100例随机分为对照组(n=50,常规护理)和观察组(n=50,循证护理)。对比两组护理前后焦虑、抑郁、生活质量评分、收缩压、舒张压变化和出院时... 详细信息

目的:观察循证护理在妊娠高血压孕妇中的应用效果,为临床诊疗提供依据。方法:选取妊娠高血压孕妇100例随机分为对照组(n=50,常规护理)和观察组(n=50,循证护理)。对比两组护理前后焦虑、抑郁、生活质量评分、收缩压、舒张压变化和出院时满意率。结果:护理后,两组焦虑、抑郁评分、舒张压、收缩压均降低,且观察组显著低于对照组(P<0.05);两组躯体功能、心理功能、社会功能、物质生活等评分均高于护理前,且观察组评分均显著高于对照组(P<0.05);观察组孕妇的满意率显著高于对照组(94.0%vs 80.0%,P<0.05)。结论:循证护理干预妊娠高血压孕妇具有明显的效果,能够有效缓解孕妇负性情绪,减轻孕妇痛苦,提高孕妇生活质量及满意率。

关键词：妊娠高血压孕妇循证护理生活质量负性情绪