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Chloroplast proteostasis:A story of birth,life,and death

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Plant Communications 2023年第1期4卷 62-86页

作者： Lin-Lin Gao Zheng-Hui Hong yinsong wang Guo-Zhang Wu Shanghai Collaborative Innovation Center of Agri-Seeds School of Agriculture and BiologyShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Joint Center for Single Cell Biology School of Agriculture and BiologyShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China

Protein homeostasis(proteostasis)is a dynamic balance of protein synthesis and *** of the endosymbiotic origin of chloroplasts and the massive transfer of their genetic information to the nucleus of the host cell,many protein complexes in the chloroplasts are constituted from subunits encoded by both ***,the proper function of chloroplasts relies on the coordinated expression of chloroplast-and nucleus-encoded *** biogenesis and maintenance of chloroplast proteostasis are dependent on synthesis of chloroplast-encoded proteins,import of nucleus-encoded chloroplast proteins from the cytosol,and clearance of damaged or otherwise undesired“old”*** review focuses on the regulation of chloroplast proteostasis,its interactionwith proteostasis of the cytosol,and its retrograde control over nuclear gene *** also discuss significant issues and perspectives for future studies and potential applications for improving the photosynthetic performance and stress tolerance of crops.

关键词： chloroplast proteostasis interaction retrograde signaling stress

A multifunctional nanoparticle system combines sonodynamic therapy and chemotherapy to treat hepatocellular carcinoma

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Nano Research 2017年第3期10卷 834-855页

作者： Yang Liu Guoyun Wan Hua Guo Yuanyuan Liu Ping Zhou Hemei wang Dan wang Sipei Zhang yinsong wang Ning Zhang Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Medical University Tianjin 300060 China Research Center of Basic Medical Science & School of Pharmacy Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics) Tianjin Medical University Tianjin 300070 China

Hepatocellular carcinoma （HCC） is one of the most common and deadly malignancies worldwide. To date, the survival of patients with HCC has not improved because of the insensitivity of HCC to conventional treatments. Sonodynamic therapy （SDT） is a promising new approach that shows remarkable potential in the treatment of HCC. Here, we designed a simple, biocompatible, and multifunctional nanosystem that combines SDT and chemotherapy to treat HCC. This nanosystem, called HPDF nanoparticles, had a core-shell structure in which hematoporphyrin （HP） was complexed with doxorubicin （DOX） to form the hydrophobic core and the surface was coated with Pluronic F68 to form the hydrophilic shell. In HCC cells, HPDF nanoparticles in combination with ultrasonic irradiation （1.0 MHz, 1.5 W/cm2, 30 s） exhibited potent cytotoxicity, resulting from the synergistic effects of a large amount of reactive oxygen species generated from HP and DOX-induced DNA damage. Notabl~ HPDF nanoparticles in combination with ultrasonic irradiation significantly reversed drug resistance in Nanog-positive cancer stem cells （CSCs） in HCC. In nude mice bearing HCC tumors, HPDF nanoparticles efficiently accumulated in the tumors and reached the maximum levels within 6-8 h, post intravenous injection. HPDF nanoparticles, in combination with ultrasonic irradiation （1.0 MHz, 3 W/cm2, 5 min）, suppressed tumor growth, angiogenesis, and collagen deposition, considerably. In summary, our results show that HPDF nanoparticles can effectively combine SDT and chemotherapy to inhibit HCC growth and progression through multiple mechanisms in both cellular and animal models.

关键词： nanoparticle sonodynamic therapy chemotherapy combination treatment hepatocellular carcinoma

Cell Membrane-camouflaged Multi-functional Dendritic Large Pore Mesoporous Silica Nanoparticles for Combined Photothermal Therapy and Radiotherapy of Cancer

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Chemical Research in Chinese Universities 2022年第2期38卷 562-571页

作者： WU Liting XIN Yujia GUO Zhaoyang GAO Wei ZHU Yanpeng wang yinsong RAN Ruixue YANG Xiaoying Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics(Theranostics) School of PharmacyTianjin Medical UniversityTianjin 300070P.R.China

Combining photothermal therapy and radiotherapy(PTT-RT) with reducing tumor hypoxia acts as an important antitumor modality. However, it is a great challenge to realize photothermal therapy, radiotherapy and exogenous oxygen supply in one nanosystem. To realize a combination of the three functions, we fabricated a red blood cell membrane(RBCm)-camouflaged, red blood cell content(RBCc) and the copper sulfide(CuS) co-loaded dendritic large pore mesoporous silica nanoparticle(DLMSN/CuS/RBCc/ RBCm). The cell membrane coating endowed the nanoparticles with good stability in the physiological environment, and CuS allowed the nanoparticle exhibiting good photothermal and radiosensitization properties. RBCc loaded nanoparticle DLMSN/CuS/RBCc enhanced superior anti-tumor effect than DLMSN/CuS during combined PTT-RT therapy because the introduction of RBCc increased the exogenous oxygen supply. The in vitro study further demonstrated that the combination of photothermal therapy and radiotherapy induced superior antitumor efficacy than single therapy. Our work thus presents a unique multifunctional nanoscale platform favorable for combined PTT and RT.

关键词： Dendritic large pore mesoporous silica nanoparticle Photothermal therapy Radiosensitization Red blood cell membrane Oxygen carrying

Speciation of iron in atmospheric particulate matter by EXAFS

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Chinese Science Bulletin 2006年第18期51卷 2275-2280页

作者： wang yinsong LI Aiguo ZHANG Yuanxun XIE Yaning LI Delu LI Yan ZHANG Guilin Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China Institute of High Energy Physics Chinese Academy of Sciences Beijing 100039 China

The study on elemental speciation in atmospheric particulate matter (PM) is important for understanding the formation and origin of pollution and evaluating their toxicity. In this paper,the speci- ation of iron in atmospheric PM was investigated with extended X-ray absorption fine structure (EXAFS) spectra based on synchrotron radiation. The chemi- cal components of PM can be calculated by regres- sion analysis of EXAFS spectra. This is a non-destructive method. In order to have knowledge of the influence of chemical components on EXAFS spectra,we prepared a series of mixed reference samples,and proved the precision of method is good. The PM samples with different particle sizes and from different sampling sites were collected in Shanghai,China. The chemical components of the samples were calculated by regression analysis of EXAFS spectra. The results show that the iron in all PM samples mainly consist of Fe2O3,Fe3O4 and Fe2(SO4)3,but their proportions are different in dif- ferent samples. The changes of components among PM samples were observed preliminarily. The con- centrations of iron in the samples were determined by proton-induced X-ray emission (PIXE) technique. It is observed that the concentrations of iron in the sam- ples of iron and steel industrial district were much higher than those of other districts,and chemical components were also different from those of others.

关键词：大气悬浮微粒形成铁 EXAFS 回归分析

Leukocyte/platelet hybrid membrane-camouflaged dendritic large pore mesoporous silica nanoparticles co-loaded with photo/chemotherapeutic agents for triple negative breast cancer combination treatment

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Bioactive Materials 2021年第11期6卷 3865-3878页

作者： Tao Zhang Hui Liu Ling Li Zhaoyang Guo Jia Song Xiaoying Yang Guoyun Wan Rongshan Li yinsong wang Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics(Theranostics) The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical EpigeneticsDepartment of PharmaceuticsSchool of PharmacyTianjin Medical UniversityTianjin300070China The Key Laboratory of Biomedical Material School of Life Science and TechnologyXinxiang Medical UniversityXinxiang453003China

Triple-negative breast cancer(TNBC)is an aggressive subset of breast cancer and currently lacks effective therapeutic *** two main phototherapeutic methods,photothermal therapy(PTT)and photodynamic therapy(PDT)show many advantages in TNBC treatment,and their combination with chemotherapy can achieve synergistic therapeutic *** the present study,a biomimetic nanoplatform was developed based on leukocyte/platelet hybrid membrane(LPHM)and dendritic large pore mesoporous silicon nanoparticles(DLMSNs).A near infrared(NIR)fluorescent dye IR780 and a chemotherapeutic drug doxorubicin(DOX)were co-loaded into the large pores of DLMSNs to prepare DLMSN@DOX/IR780(DDI)nanoparticles(NPs),followed by camouflage with LPHM to obtain LPHM@DDI *** the mediation of LPHM,LPHM@DDI NPs showed an excellent TNBC-targeting ability and very high PTT/PDT performances in vitro and in *** NIR laser irradiation,LPHM@DDI NPs exhibited synergistic cytotoxicity and apoptosis-inducing activity in TNBC cells,and effectively suppressed tumor growth and recurrence in TNBC mice through tumor ablation and *** synergistic effects were sourced from the combination of PTT/PDT and ***,this study offers a promising biomimetic nanoplatform for efficient co-loading and targeted delivery of photo/chemotherapeutic agents for TNBC combination treatment.

关键词： Leukocyte/platelet hybrid membrane Dendritic large pore mesoporous silica nanoparticles Triple-negative breast cancer Phototherapy Chemotherapy

A Prediction Method for Wind Speed Based on the Correlation Analysis of Measured Data of Adjacent Wind Turbine

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A Prediction Method for Wind Speed Based on the Correlation ...

pH-responsive nanoparticles base on algal polysaccharides containing celecoxib and doxorubicin to collaborative treat breast cancer and resistance metastasis

2015年中国智能自动化学术会议

作者： yinsong wang Ziqing Su Tsinghua University

Wind speed prediction is very important for the control of wind power generation. Former studies for wind speed prediction are limited to measuring their own historical data to achieve the future wind speed prediction. Compared with this situation, this paper presents a prediction method to get the specified point’s wind speed predicting value from the adjacent point’s historical wind speed data. Using Pearson correlation coefficient to show the relativity between the adjacent measuring points, the method of regression analysis based on correlation coefficient is introduced, and we chose the wind speed data of ten points from an actual wind field to simulate and verify this method. Simulation result shows that this method can guarantee the accuracy of wind forecasting, and it can improve the redundancy and reliability of wind measuring equipments effectively.

关键词： Wind speed forecast Pearson correlation coefficient Regression equation Time-series model

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pH-responsive nanoparticles base on algal polysaccharides co...

Synchrotron radiation XRF microprobe investigation of elemental distribution in femoral head slice with osteoporosis

2018年第十二届中国药物制剂大会

作者：张韬 Hui Liu yinsong wang Tianjin Medical University

Objectives: In this study, a pH-responsive nanoparticle system（PB-DOX/CXB） based on algal polysaccharide（PSS） was designed for co-loading and targeted delivery of selective COX-2 inhibitor celecoxib（CXB） and chemotherapeutic agent doxorubicin（DOX）, thus hoping to exert their synergistic effects against breast cancer growth and metastasis. Not only high drug-loading capacity, excellent in vitro stability and good biocompatibility these nanoparticles had, they also notably improved the water-solubility of CXB. Meanwhile, the pH-responsive nanoparticles implemented drug targeting delivery in physiological environment and controlled release in slightly acidic environment（tumor microenvironment） to reach the purpose of synergistic kill cancer cells and effective resistance to cancer metastasis. Methods: PSS were modified with aldehyde groups and reacted with DOX to obtain the pH-responsive structure by the "Schiff base" reaction. Then, the nanoparticles（PB-DOX/CXB） were prepared in the alkaline solution by the precipitation. The structure of PB-DOX/CXB was confirmed by 1 H-NMR and FT-IR. The morphologies of PB-DOX/CXB nanoparticles were observed by the TEM, their sizes were determined by the dynamic laser scattering method, and their surface charge property were measured by the zeta potential detector. The loading contents and encapsulation efficiencies of DOX and CXB in nanoparticle crystals were detected by the UV spectroscopy. Its weak acid responsiveness in vitro was assessed by the drug release in phosphoric buffer salt solution with different pH values. And the thermal behaviors of various samples were detected by DSC. The cytotoxicity and the migration resistance of PB-DOX/CXB nanoparticles were evaluated in breast carcinoma 4 T1 using MTT assay and wound healing assay. The in vitro synergistic kill cancer cells efficiency of were assessed in breast carcinoma 4 T1 cell by apoptosis analysis. The tissue distributions of PBDOX/CXB nanoparticles were measured in 4 T1

关键词： chemotherapy pH-responsive nanoparticle algal polysaccharides celecoxib doxorubicin

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Chinese Science Bulletin 2001年第13期46卷 1138-1141页

作者： ZHANG Yuanxun CHENG Feng LI Deyi wang yinsong ZHANG Guilin XU Hongjie LIAO Wensheng TANG Tingling HUANG Yuying HE Wei Shanghai Institute of Nuclear Research Chinese Academy of SciencesShanghai 201800China Shanghai No.9 People’s Hospital University of Shanghai Second MedicineShanghai 200011China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100039China

This note deals with the scanning of femoral head slices from both normal and osteoporosis subjects using synchrotron radiation X-ray fluorescence (SRXRF) microprobe technique. The sample preparation and experimental apparatus are described in detail. The quantitative computerized tomography (QCT) of elemental distribution, such as Ca, P, K, Fe, Zn, Sr and Pb in bone slice tissue including cartilage, substantial compact and substantial spongy, is investigated. Combined with the correlation between P, K, Zn, Sr and Ca, the loss way of minerals and the physiological functions of some metal elements in bone are also discussed.

关键词： synchrotron radiation X-ray fluorescence microprobe inorganic elements osteoporosis.

一种基于自适应反演算法的火电单元机组协调控制策略

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中国电机工程学报 2018年第7期38卷 2070-2081页

作者：席嫣娜王印松河北省发电过程仿真与优化控制工程技术研究中心(华北电力大学)

为了克服火电单元机组的本质非线性和不确定性对控制系统品质的影响,解决它在大范围变工况时的协调控制问题,该文针对综合考虑锅炉-汽轮机-发电机动态特性的单元机组整体模型,计及系统参数的不确定性,基于自适应反演算法和协调无源性理... 详细信息

为了克服火电单元机组的本质非线性和不确定性对控制系统品质的影响,解决它在大范围变工况时的协调控制问题,该文针对综合考虑锅炉-汽轮机-发电机动态特性的单元机组整体模型,计及系统参数的不确定性,基于自适应反演算法和协调无源性理论,设计了一种非线性协调控制策略。首先经过适当简化处理,将机组整体模型分解为两个低阶子系统;在子系统Ⅰ中,利用反演法得到主蒸汽阀门开度控制器,然后基于协调无源性理论设计励磁控制器;在子系统Ⅱ中,通过逐步递推设计燃料控制器。同时,基于李雅普诺夫稳定性方法,交错设计了模型不确定参数的自适应律,并通过在其中引入充分光滑投影算子,避免了系统不匹配参数可能发生的漂移问题。在实际工程应用中,为了获得良好的调节品质,总结了该控制器参数的设定规律。最后,针对某600MW单元机组非线性模型的仿真分析及在火电单元机组全范围仿真机上的变负荷实验均表明,文中提出的协调控制策略不仅保证了闭环系统的渐近稳定,而且具有较强的负荷指令跟踪性能、抗干扰能力和鲁棒性。

关键词：火电单元机组整体模型自适应反演法协调无源性非线性控制充分光滑投影算子