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Phenanthrene perturbs hematopoietic development and causes hematopoietic defects in zebrafish

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Journal of Environmental Sciences 2025年第5期151卷 573-581页

作者： Lingyu ren Yue wang ying ren Guangke Li Nan Sang College of Environment and Resource Research Center of Environment and HealthShanxi UniversityTaiyuan 030006China

Phenanthrene(Phe)is one of the common polycyclic aromatic hydrocarbons in the environment,and recent studies show that it can cause cardiac developmental toxicity and ***,it is still unknown whether it can affect the hematopoietic development in aquatic *** address this question,zebrafish(Danio rerio)were chronically exposed to Phe at different *** found that Phe caused structural damage to the renal tubules in the kidney,induced malformed erythrocytes in peripheral blood,and decreased the proportion of myeloid cells in adult zebrafish,suggesting possible negative impacts that Phe posed to hematopoietic ***,using in situ hybridization technology,we found that Phe decreased the expression of primitive hematopoietic marker genes,specifically gata1 and pu.1,accompanied by an obstruction of primitive erythrocyte ***,Phe impaired definitive hematopoiesis,increased aberrations of the transient hematopoietic site(PBI),and reduced the generation of hematopoietic stem cells,ultimately influencing the number of erythrocytes and myeloid *** findings suggested that Phe could induce hematopoietic toxicity in zebrafish embryos and pose unknown ecological risks.

关键词： Phenanthrene Zebrafish Hematopoietic development Hematopoietic defect

Enhancement of bending toughness for Fe-based amorphous nanocrystalline alloy with deep cryogenic-cycling treatment

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China Foundry 2025年第1期22卷 99-107页

作者： Yi-ran Zhang dong Yang Qing-chun Xiang Hong-yu Liu Jing Pang ying-lei ren Xiao-yu Li Ke-qiang Qiu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China Qingdao Yunlu Advanced Material Technology Co. Ltd.Qingdao 266232ShandongChina

The effects of deep cryogenic-cycling treatment(DCT)on the mechanical properties,soft magnetic properties,and atomic scale structure of the Fe_(73.5)Si_(13.5)B_(9)Nb_(3)Cu_(1)amorphous nanocrystalline alloy were *** DCT samples were obtained by subjecting the as-annealed samples to a thermal cycling process between the temperature of the supercooled liquid zone and the temperature of liquid *** flat plate bending testing,hardness measurements,and nanoindentation experiment,it is found that the bending toughness of the DCT samples is improved and the soft magnetic properties are also slightly *** are attributed to the rejuvenation behavior of the DCT samples,which demonstrate a higher enthalpy of ***,DCT is an effective method to enhance the bending toughness of Fe-based amorphous nanocrystalline alloys without degrading the soft magnetic properties.

关键词： deep cryogenic-cycling treatment Fe-based amorphous nanocrystalline alloy bending toughness rejuvenation

Longitudinal landscape of immune reconstitution after acute SARS-CoV-2 infection at single-cell resolution

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Science Bulletin 2025年第3期70卷 323-327页

作者： Lili ren Yiwei Liu Yeming wang Chao Wu Li Guo Lan Chen Xinming wang Yan Xiao Lixue Huang Jingchuan Zhong Jiacheng Yao Lu Liu Hui Li ying wang Yongchao Ma Yichunzi Zhang Lin Di Tao dong Julian Knight Jianbin wang Yanyi Huang Bin Cao Xianwen ren Jianwei wang National Health Commission Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory National Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 102629China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China State Key Laboratory of Respiratory Health and Multimorbidity Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100029China Department of Pulmonary and Critical Care Medicine Institute of Respiratory Medicine of Chinese Academy of Medical ScienceNational Center for Respiratory MedicineCenter of Respiratory MedicineNational Clinical Research Center for Respiratory DiseasesChina-Japan Friendship HospitalBeijing 100029China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Biomedical Pioneering Innovation Center(BIOPIC) Beijing Advanced Innovation Center for Genomics(ICG)College of Chemistryand Peking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China MRC Human Immunology Unit MRC Weatherall Institute of Molecular MedicineRadcliffe Department of MedicineThe University of OxfordOxford OX39DSUK Chinese Academy of Medical Science(CAMS)Oxford Institute(COI) University of OxfordOxford OX39DSUK Wellcome Centre for Human Genetics University of OxfordOxford OX39DSUK School of Life Sciences Tsinghua-Peking Center for Life SciencesTsinghua UniversityBeijing 100084China Beijing Advanced Innovation Center for Structural Biology(ICSB) Tsinghua UniversityBeijing 100084China Chinese Institute for Brain Research(CIBR) Beijing 102206China Institute for Cell Analysis Shenzhen Bay LaboratoryShenzhen 518107China Tsinghua University-Peking University Joint Center for Life Sciences Beijing 100084China Biomedical Pioneering Innovation Center(BIOPIC) Peking UniversityBeijing 100871China Changping Laboratory Beijing 102206China

The long-term consequences of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,known as the post-acute sequelae of COVID-19(PASC),have been a growing concern.A significant proportion of COVID-19 patients experience persistent health issues even six to twelve months after recovering from acute infection[1],[2],[3],[4].Therefore,understanding the immune reconstitution process and identifying the molecular and cellular mechanisms underlying PASC is crucial.

关键词： landscape consequences acute

Micro-macro regulating heterogeneous interface engineering in 3D N-doped carbon fiber/MXene/TiO_(2) nano-aerogel for boosting electromagnetic wave absorption

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Nano Research 2025年第2期18卷 843-857页

作者： ying Li Chunlei dong Sijia wang dongyi Lei Binbin Yin Yifei Cui Yanru wang Ran Li School of Civil Engineering Qingdao University of TechnologyQingdao 266033China Cooperative Innovation Center of Engineering Construction and Safety in Shandong Blue Economic Zone Qingdao University of TechnologyQingdao 266033China Department of Architecture and Civil Engineering City University of Hong KongHong Kong 999077China

MXene,as a rising star among two-dimensional(2D)electromagnetic wave materials,faces urgent challenges in addressing its self-stacking issue and regulating its ***,a micro-macro collaborative design strategy was proposed to regulate heterogeneous interface engineering in MXene-based ***-based cotton was introduced as three dimensional(3D)framework for constructing a porous structure,TiO_(2) was in-situ generated and nitrogen atom was doped on Ti_(3)C_(2)T_(x) MXene to regulate its dielectric properties,a 3D N-doped carbon fiber/MXene/TiO_(2)(CMT)nano-aerogel was successful *** synergistic effects of diverse components and structural designs,porous frameworks and TiO_(2) lattice contraction can significantly adjust the density of the conductive network and create abundant heterogeneous interfaces,as well as the lattice defects induced by nitrogen atom doping can enhance polarization loss,ultimately leading to the excellent microwave absorption performance of 3D N-CMT *** optimized N-CMT 30%aerogel exhibited a minimum reflection loss(RLmin)of−72.56 dB and an effective absorption bandwidth(EAB)of 6.92 GHz at 2.23 ***,when the thickness was adjusted from 1 to 5 mm,the EAB of the N-CMT 30%aerogel reached 13.94 GHz,achieving coverage of 98% of the C-band and the entire X and Ku ***,the attenuation capabilities of the N-CMT aerogel were further confirmed through RCS simulations,whose RCS reduction value reaches up to 19.969 dB·m^(2).These results demonstrate that 3D N-CMT nano-aerogel relying on interface engineering design exhibits significant potential in the field of electromagnetic protection,providing an important reference for future efficient absorbers.

关键词： interface engineering electromagnetic wave absorption MXene micro-macro design nano-aerogel

Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling wang Jing ren Chenguang Zheng Jiajia Yang dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin ren ying Liu Juntang Yan Congai Chen Yanhui He Yuyu Shi Fafeng Cheng Qingguo wang Changxiang Li Xueqian wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo Le Tong Jianhong dong Ziwei Fan Mengxian Jia Juanqing Yue ying wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

Hemispheric asymmetries and network dysfunctions in adolescent depression:A neuroimaging study using resting-state functional magnetic resonance imaging

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World Journal of Psychiatry 2025年第2期15卷 100-108页

作者： ying Xiong ren-Qiang Yu Xing-Yu wang Shun-Si Liang Jie Ran Xiao Li Yi-Zhi Xu Department of Hematology Chongqing General HospitalChongqing UniversityChongqing 401147China Department of Radiology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Currently,adolescent depression is one of the most significant public health concerns,markedly influencing emotional,cognitive,and social *** advancements in distinguish the neurobiological substrates underlying depression,the intricate patterns of disrupted brain network connectivity in adolescents warrant further *** To elucidate the neural correlates of adolescent depression by examining brain network connectivity using resting-state functional magnetic resonance imaging(rs-fMRI).METHODS The study cohort comprised 74 depressed adolescents and 59 healthy controls aged 12 to 17 *** underwent rs-fMRI to evaluate functional connectivity within and across critical brain networks,including the visual,default mode network(DMN),dorsal attention,salience,somatomotor,and frontoparietal control *** Analyses revealed pronounced functional disparities within key neural circuits among adolescents with *** results demonstrated existence of hemispheric asymmetries characterized by enhanced activity in the left visual network,which contrasted the diminished activity in the right *** DMN facilitated increased activity within the left prefrontal cortex and reduced engagement in the right hemisphere,implicating disrupted self-referential and emotional processing ***,an overactive right dorsal attention network and a hypoactive salience network were identified,underscoring significant abnormalities in attentional and emotional regulation in adolescent *** The findings from this study underscore distinct neural connectivity disruptions in adolescent depression,underscoring the critical role of specific neurobiological markers for precise early diagnosis of adolescent *** observed functional asymmetries and network-specific deviations elucidate the complex neurobiological architecture of adolescent depression,supporting the development of targeted the

关键词： Adolescent depression Brain network connectivity Neuroimaging biomarkers Functional magnetic resonance imaging Default mode network Salience network Hemispheric asymmetry

A Multi-faceted View of the X-Ray Spectral Variability in Seyfert Galaxy Ark 120

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Research in Astronomy and Astrophysics 2025年第1期25卷 228-239页

作者： Lu-Xin ren Jun-Xian wang Jia-Lai Kang CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China School of Astronomy and Space Science University of Science and Technology of China

Utilizing a range of techniques including multi-band light curves,softness ratio analysis,structure functions,rms spectra,cross-correlation functions,and ratios of spectra from different intervals,we present a comprehensive study of the complex X-ray spectral variability in Seyfert 1 galaxy Ark 120,through re-analyzing its six XMM-Newton observations taken between 2003 and *** find a clear“softer-when-brighter”trend in the 2–10 ke V power-law component over long timescales,with this trend being timescale dependent,as it is much weaker on shorter timescales,similar to that previously detected in NGC ***,a rare“harder-when-brighter”trend is observed during one exposure,indicating dynamic changes in the spectral variability behavior of the power-law *** exceptional exposure,with the spectral variability indeed marked by a power-law pivoting at an unusually low energy of～2 ke V,suggests intricate variations in the thermal Comptonization processes within the ***,when the data below 2 ke V are included,we identify that the soft excess component adds significant complexity to the spectral variability,such as evidenced by a transition from“harder-when-brighter”to“softer-when-brighter”during another single *** extra complexity arises because the variability of the soft excess sometimes follows and sometimes does not follow the changes in the power-law *** findings underscore the necessity of applying multiple analytic techniques to fully capture the multifaceted spectral variability of AGNs.

关键词： galaxies: active galaxies: Seyfert X-rays: galaxies