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Chinese Journal of Structural Chemistry 2006年第10期25卷 1260-1264页

作者： wang ying yan lian-he School of Chemical Engineering Nanjing University of Science and Technology Nanjing Jiangsu 210094 China

The title compound has been prepared and characterized by elemental analysis, infrared and FT-Raman spectra, and thermal analysis. The crystal and molecular structures of bis（N＇-ethyl-N-piperazinly-carbodithioato-S,S＇） nickel（Ⅱ） complex （Ni（S2CNC4H8NC2H5）2） were determined by X-ray diffraction methods. The crystal crystallizes in the triclinic system, space group PI^- with a = 0.66770（15）, b = 0.85066（12）, c = 0.8973（2） nm,α= 84.97（2）, β =78.71（2）,γ= 80.12（2）°, Mr = 437.34, V= 0.49160（17） nm^3, Z = 1, Dc = 1.477 g/cm^3, F（000） = 230, R = 0.0422 and wR = 0.1290. In the structure, the central Ni atom is coordinated in a slightly distorted square plane by four S atoms from two bidentate S2CNC4H8NC2H5 ligands with the four Ni-S bond distances in the range of 0.22065（10）～0.22076（9） nm. The IR and FT-Raman spectral data are in agreement with the structural data. Thermal analysis indicates that the title compound decomposes completely at the temperature of 799.88℃, leaving NiS.

关键词： crystal structure N-ethylpiperazine nickel complex FT-Raman

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin Ren ying Liu Juntang yan Congai Chen yanhui he Yuyu Shi Fafeng Cheng Qingguo wang Changxiang Li Xueqian wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

Electrode/Electrolyte Optimization‑Induced Double‑Layered Architecture for High‑Performance Aqueous Zinc‑(Dual)Halogen Batteries

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Nano-Micro Letters 2025年第3期17卷 121-137页

作者： Chengwang Zhou Zhezheng Ding Shengzhe ying Hao Jiang yan wang Timing Fang You Zhang Bing Sun Xiao Tang Xiaomin Liu School of Textiles and Clothing School of Chemistry and Chemical EngineeringQingdao UniversityQingdao 266071ShandongPeople’s Republic of China Centre for Clean Energy Technology School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyUltimoNSW 2007Australia School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007HenanPeople’s Republic of China

Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources,intrinsic safety,and high theoretical ***,the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical ***,a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid(ZEA)artificial film and ZnF2-rich solid electrolyte interphase(SEI)layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic *** ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer,therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal *** double-layered architecture not only modulates Zn2+flux and suppresses the zinc dendrite growth,but also blocks the direct contact between the metal anode and electrolyte,thus mitigating the corrosion from the active *** employing optimized metal anodes and electrolytes,the as-developed zinc-(dual)halogen batteries present high areal capacity and satisfactory cycling *** work provides a new avenue for developing aqueous zinc-(dual)halogen batteries.

关键词： Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual)halogen batteries

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu ying wang yan Sun Lingxiao Deng Melissa Walker Chen Chen heqiao Dai Qi Han ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Crystal Structure and Characterization of Bis(4-isoniazidylthioformyl) Disulfide Hydration Sodium Coordination Polymer:n[(4-Pyridyl-CONHNCS_2)_2^(2-)]·[Na_2(H_2O)_8^(2+)]_n

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Chinese Journal of Structural Chemistry 2006年第6期25卷 740-746页

作者： wang ying BEI Feng-Li yan lian-he School of Chemical Engineering Nanjing Universityof Science and Technology Nanjing 210094 China

The title compound has been prepared and characterized by elemental analysis, infrared spectra, NMR and thermal analyses, and its crystal structure was determined by X-ray diffraction method. The crystal crystallizes in the monoclinic system, space group C2/c with a = 2.3066（5）, b = 0.53320（ 11）, c = 2.3236（5） nm,β= 102.76（3）°, V = 2.7872（ 10） nm^3, Mr = 612.67, Z = 4, Dc = 1.460 g/cm^3, R = 0.0570 and wR = 0.1271. In the title compound, two 4-isoniazidylthioformyl units are bridged by S-S bond （0.2037（3） nm）. The Na ions are linked by O（4）, O（4A）, O（1） and O（1A） to form a one-dimensional hydration sodium coordination polymer. The Na ion is coordinated by a meridional arrangement of the six O atoms to assume a slightly distorted octahedron as a result of intermolecular hydrogen bonds. The thermal analytical data indicate that it decomposes completely at the temperature of 609.26 ℃.

关键词： crystal structure bridging isoniazide coordination polymer

Crystal Structure of Norfloxacin Methanol Solvate: C_(16)H_(18)FN_3O_3·CH_3OH·H_2O

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Chinese Journal of Structural Chemistry 2005年第12期24卷 1359-1362页

作者： wang ying SUN Li-Wei wang Wei yan lian-he Water Treatment Institute Nanjing University of Science and Technology Nanjing 210094 China

Norfloxacin methanol solvate （ 1 -ethyl-6-fluoro- 1,4-dihydro-4-oxo-7-（ 1 -piperazinyl）-3- quinoline carboxylic acid methanol solvate） has been prepared. The crystal and molecular structures of the title compound, C16H18FN3O3·CH3OH·H2O, were determined by X-ray diffraction method. The compound crystallizes in monoclinic, space group P21/c with a = 7.8660（16）, b = 22.525 （5）, c = 10.253（2）A, β= 108.31°, Mr = 369.39, V = 1724.7（6）A^3, Z = 4, Dc= 1.423 g/cm^3, F（000） = 784, R = 0.0557 and wR = 0.1224. The TGA analysis indicates that it decomposes completely at 723.75℃.

关键词： crystal structure norfloxacin methanol solvate

DimRouter： A Multi-Mode Router Architecture for Higher Energy-Proportionality of On-Chip Networks

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Journal of Computer Science & Technology 2018年第5期33卷 984-997页

作者： Shi-Qi lian ying wang Yin-he Han State Key Laboratory of Computer Architecture Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

In the dark silicon era, many independent components of many-core processors are becoming voluntarily inactive due to the constraint of power consumption on a chip. However, to keep network connectivity, the on-chip interconnection must still be kept activated and wastes considerable energy to avoid the isolation of these inactive components, harming the energy-proportionality of the whole processor chip. In this paper, we propose a novel design to provide more energy- proportional on-chip connection without damaging the network connectivity. To achieve this goal, we redesign the router architecture. The new architecture, DimRouter, supports three modes： normal, dark and dim. In the dim mode, only part of the router is active and provides flexible connection while the dark mode puts all router elements in the asleep state. Moreover, to maximize the number of dark routers, we also propose a reconfiguration algorithm based on degree-constrained Steiner Tree. The evaluation result under synthetic traffic shows that the new design can reduce the energy consumption up to 85% compared with the common design. For real application traffic, the new design can also save average 46% energy consumption with 4% performance improvement.

关键词： dark silicon energy-proportion power gating topology reconfiguration

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu ying wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Effects of impregnation sequence on the NH_(3)-SCR activity and hydrothermal stability of a Ce-Nb/SnO_(2) catalyst

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Journal of Environmental Sciences 2024年第4期138卷 450-457页

作者： ying Zhu Wenpo Shan Zhihua lian Jingjing Liu yan Zhang Hong he Center for Excellence in Regional Atmospheric Environment and Key Laboratory of Urban Pollutant Conversion Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control Ningbo Urban Environment Observation and Research StationInstitute of Urban EnvironmentChinese Academy of SciencesNingbo 315800China State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Hydrothermal stability is crucial for the practical application of deNO_(x)catalyst on diesel vehicles,for the selective catalytic reduction of NO_(x)with NH_(3)(NH_(3)-SCR).SnO_(2)-based materials possess superior hydrothermal stability,which is attractive for the development of NH_(3)-SCR *** this work,a series of Ce-Nb/SnO_(2)catalysts,with Ce and Nb loading on SnO_(2)support,were prepared by impregnation *** was found that,the NH_(3)-SCR activities and hydrothermal stabilities of the Ce-Nb/SnO_(2)catalysts significantly varied with the impregnation sequences,and the Ce-Nb(f)/SnO_(2) catalyst that firstly impregnated Nb and then impregnated Ce exhibited the best *** characterization results revealed that CeNb(f)/SnO_(2)possessed appropriate acidity and redox ***,the strong synergistic effect between Nb and Sn species stabilized the structure and maintained the dispersion of acid *** study may provide a new understanding for the effect of impregnation sequence on activity and hydrothermal stability and a new environmental-friendly NH_(3)-SCR catalyst with potential applications for NO_(x)removal from diesel and hydrogenfueled engines.

关键词： NO_(x)emission control NH_(3)-SCR Hydrothermal stability Ce-Nb/SnO_(2)catalyst Impregnation sequence

Component Optimization and Seepage Simulation Method of Resin Based Permeable Brick

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Journal of Renewable Materials 2020年第8期8卷 947-968页

作者： Xiaofu wang Xiong Zhang yan he Chunming lian Key Laboratory of Advanced Civil Engineering Materials of Education Ministry School of Material Science and TechnologyTongji UniversityShanghai201804China School of Civil Engineering Suzhou University of Science and TechnologySuzhou215011China China Construction Eighth Engineering Bureau Co. Ltd.Shanghai200122China

In order to solve the problem of urban surface runoff,it is necessary to study permeable brick *** test and DMA test were used to study the binder material of permeable brick,and a material with the best mechanical properties was selected as the binder of resin based permeable brick;The permeable brick with single gradation and continuous gradation and porosity of 0.1–0.5 gradient is constructed by 3D modeling *** particle composition and the seepage simulation results of permeable brick under different design parameters were analyzed;A resin-based permeable brick with micro-pores was prepared using the selected binder and desert sand with high roundness as aggregate,and compared with the simulation,its water permeability coefficient is 3.25×10-2 cm/s and the compressive strength is 36.19 *** the seepage simulation of permeable brick,it is known that with the increase of gradation width“value i”,the water permeability coefficient ***,in order to control the number of aggregate particles and obtain better seepage performance,the wide gradation of i≥4 and the design porosity of 0.3–0.4 should be *** study provides a research basis and a simulation method for the component optimization of resin based permeable brick.

关键词： Permeable brick epoxy resin aggregate sponge city