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Modeling the intracellular dynamics for Vif-APO mediated HIV-1 virus infection

Chinese Science Bulletin 2010年第22期55卷 2329-2340页

作者： wang yi1,2 & lai luhua1,3.1 center for theoretical biology, peking university, beijing 100871, china 2 School of Physics, peking university, beijing 100871, china 3 BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, peking university, beijing 100871, china center for theoretical biology Peking University Beijing 100871 China School of Physics Peking University Beijing 100871 China BNLMS State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

The viral infectivity factor (Vif) was found to be essential for controlling HIV-1 virus infectivity. It targets cellular antiviral proteins in APOBEC family (APO) to trigger its fast degradation and inhibits APO packaging into nascent virion. In the present study, we propose a mathematical model to quantitatively study the intracellular dynamics of these typical virus-host interactions. Four sets of published experimental data were compared with simulation results to justify the model. Systematic parameter sensitivity and perturbation analysis showed that parameters related to APO are crucial to the infectivity of newly synthesized HIV-1 virus. Interestingly, we discovered that the synthesis rate of the viral structure protein Gag and the required number per nascent virion are optimized to achieve high virion production with minimal level of packaged APO, and large portion of model parameters are beneficial to virus only within a relatively small range. Furthermore, minor variations in several parameters related to viral protein Tat, the activator of viral RNA synthesis, were found to induce switch-like behaviors on both incorporated Vif and APO. These findings may provide new insights for understanding the high mutation rate of HIV-1 virus and its latency, as well as help identify key targets for therapeutic design.

关键词：病毒感染载脂蛋白 HIV 细胞内动力学抗病毒蛋白建模介导

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Principle and application of three-band gradient difference vegetation index

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Science china Earth Sciences 2005年第2期48卷 241-249页

作者： TANG Shihao, ZHU Qijiang, wang Jindi, ZHOU Yuyu & ZHAO Feng Research center for Remote Sensing and GIS, Department of Geography, beijing Normal university, beijing 100875, china National Satellite Meteorological center, china Meteorological Administration, beijing 100081, china 1. Research center for Remote Sensing and GIS Department of Geography Beijing Normal University 100875 Beijing China 2. National Satellite Meteorological center China Meteorological Administration 100081 Beijing China

Vegetation index is a simple, effective and experiential measurement of terrestrial vegetation activity, and plays a very important role in qualitative and quantitative remote sensing. Aiming at shortages of current vegetation indices, and starting from the analysis of vegetation spectral characteristics, we put forward a new vegetation index, the three-band gradient difference vegetation index (TGDVI), and established algorithms to inverse crown cover fraction and leaf area index (lai) from it. theoretical analysis and model simulation show that TGDVI has high saturation point and the ability to remove the influence of background to some degree, and the explicit functional relation with crown cover fraction and lai can be established. Moreover, study shows that TGDVI also has the ability to partly remove the influence of thin cloud. Experiment in the Shunyi District, beijing, china shows that reasonable result can be reached using the vegetation index to retrieve lai. We also theoretically analyzed the reason why the normalized difference vegetation index (NDVI) owns the low saturation point, and show that it is determined by the definition of NDVI and the characteristic of vegetation spectra, and is unavoidable to some degree. Meanwhile, through model simulation, we also indicate that the relationship between simple ratio vegetation index (SR) and lai closes to a piecewise linear one instead of a linear one, which is mainly caused by the influence of background and different change rates of reflectance in red and infrared bands with lai increasing.

关键词： vegetation index, remote sensing, lai, crown cover fraction, remote sensing inversion.

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Measurement of the neutron-induced total cross sections of ^(nat)Pb from 0.3 eV to 20 MeV on the Back-n at CSNS

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Nuclear Science and Techniques 2024年第2期35卷 85-93页

作者： Jie-Ming Xue Song Feng Yong-Hao Chen Han yi Min Xiao Pin-Jing Cheng Xin-Xiang Li Rong Liu yi-Wei Yang Zi-Jie Han Da-Jun Zhao Hao-Qiang wang Bao-Qian Li Ji-Rong Zhao Lei-Xun Tang Wen Luo Bo Zheng School of Nuclear Science and Technology University of South ChinaHengyang 421001China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science center Dongguan 523803China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China

The neutron-induced total cross sections of natural lead have been measured in a wide energy range(0.3 eV-20 MeV)on the back-streaming white neutron beamline(Back-n)at the china Spallation Neutron *** energy was determined by the neutron total cross-section spectrometer using the time-of-flight technique.A fast multi-cell fission chamber was used as the neutron detector,and a 10-mm-thick high-purity natural lead sample was employed for the neutron transmission *** on-beam background was determined using Co,In,Ag,and Cd *** excitation function of ^(nat)Pb(n,tot)reaction below 20 MeV was calculated using the TALYS-1.96 nuclear-reaction modeling *** present results were compared with previous results,the evaluated data available in the five major evaluated nuclear data libraries(i.e.,ENDF/B-VIII.0,JEFF-3.3,JENDL-5,CENDL-3.2,and BROND-3.1),and the theoretical calculation *** agreement was found between the new results and those of previous experiments and with the theoretical curves in the corresponding *** measurement obtained the neutron total cross section of natural lead with good accuracy over a wide energy range and added experimental data in the resonance energy *** provides more reliable experimental data for nuclear engineering design and nuclear data evaluation of lead.

关键词： Neutron-induced total cross section Natural lead Time-of-flight TALYS-1.96 CSNS Back-n white neutron beamline

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Composition and structure of ceramic coatings prepared on pure titanium by alternating-current microarc oxidation

Composition and structure of ceramic coatings prepared on pu...

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International Symposium of Young Scholars on Mechanics and Material Engineering for Science and Experiments

作者： Wenbin Xue11^ Chao wang1 U] Ruyi ChenI1>2] Zhiwei Deng Yongchun lai Key Laboratory for Radiation Beam Technology and Materials Modification Institute of Low Energy Nuclear Physics beijing Normal university) beijing 100875 china m beijing Radiation center beijing 100875 china Key Laboratory for Radiation Beam Technology and Materials Modification Institute of Low Energy Nuclear Physics Beijing Normal University Beijing 100875 China

ISBN: (纸本)1880132796

＜正＞ A ceramic oxide coating of 30μm was prepared on TA2 pure titanium by alternating-current microarc oxidation in aluminate solution. Its microstructure and phase component were characterized by scanning electron microscopy, X-ray diffractometry, Raman spectroscopy. The Al, Ti, O concentration profiles across the coating were determined by energy dispersive spectroscope. The coating contains two layers, an outer layer and an internal layer. The outer layer is composed of a large amount of TiAl2O5 and a little rutile type TiO2 compounds. But the rutile content in the inner layer is much higher than in the outer layer while the TiAl2O5 content decreases obviously in the inner layer. All of these oxides derive from a rapid solidification of the local molten coating in microarc discharge zone.

关键词： Microarc oxidation pure titanium phase structure ceramic coating

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Graphitized Cu-β-cyclodextrin polymer driving an efficient dual-reaction-center Fenton-like process by utilizing electrons of pollutants for water purification

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Journal of Environmental Sciences 2023年第4期126卷 565-574页

作者： Weixiang Liao lai Lyu Diwang Chun Hu Tong Li Key Laboratory for Water Quality and Conservation of the Pearl River Delta Ministry of EducationInstitute of Environmental Research at Greater BayGuangzhou UniversityGuangzhou 510006China School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China

Excessive consumption of energy and resources is a major challenge in wastewater ***,a novel heterogeneous Fenton-like catalyst consisting of Cu-doped graphenelike catalysts (Cu-GCD NSs) was first synthesized by an enhanced carbothermal reduction of β-cyclodextrin (β-CD).The catalyst exhibits excellent Fenton-like catalytic activity for the degradation of various pollutants under neutral conditions,accompanied by low H_(2)O_(2)*** results of structural characterization and theoretical calculations confirmed that the dual reaction centers (DRCs) were constructed on Cu-GCD NSs surface through C-O-Cu bonds supported on zero-valent copper species,which play a significant role in the high-performance Fenton-like *** pollutants that served as electron donors were decomposed in the electron-poor carbon centers,whereas H_(2)O_(2)and dissolved oxygen obtained these electrons in the electron-rich Cu centers through C-O-Cu bonds,thereby producing more active *** study demonstrates that the electrons of pollutants can be efficiently utilized in Fenton-like reactions by DRCs on the catalyst surface,which provides an effective strategy to improve Fenton-like reactivity and reduce H_(2)O_(2)consumption.

关键词： Fenton-like Dual reaction centers Graphene-like carbon Nanoscale zero-valent copper Pollutants degradation

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Ultrafast and low-power optoelectronic infrared-to-visible upconversion devices

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Photonics Research 2019年第10期7卷 1161-1168页

作者： ZHAO SHI HE DING HAO HONG DALI CHENG KAMRAN RAJABI JIAN YANG YONGTIAN wang lai wang yi LUO KAIHUI LIU XING SHENG Department of Electronic Engineering and beijing National Research center for Information Science and Technology Tsinghua UniversityBeijing 100084China beijing Engineering Research center of Mixed Reality and Advanced Display School of Optics and PhotonicsBeijing Institute of TechnologyBeijing 100081China State Key Laboratory for Mesoscopic Physics Collaborative Innovation Center of Quantum Matterand School of PhysicsPeking UniversityBeijing 100871China

Photon upconversion with transformation of low-energy photons to high-energy photons has been widely studied and especially applied in biomedicine for sensing, stimulation, and imaging. Conventional upconversion materials rely on nonlinear luminescence processes, suffering from long decay lifetime or high excitation power. Here,we present a microscale, optoelectronic infrared-to-visible upconversion device design that can be excited at low power(1–100 mW∕cm^2). By manipulating device geometry, illumination position, and temperature, the device luminescence decay lifetime can be tuned from tens to hundreds of nanoseconds. Based on carrier transportation and circuit dynamics, theoretical models are established to understand the transient behaviors. Compared with other mechanisms, the optoelectronic upconversion approach demonstrates the shortest luminescence lifetime with the lowest required excitation power, owing to its unique photon–electron conversion process. These features are expected to empower the device with essential capabilities for versatile applications as high-performance light emitters.

关键词： optoelectronic lifetime visible

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Exploring light-cone distribution amplitudes from quantum computing

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Science china(Physics,Mechanics & Astronomy) 2023年第8期66卷 57-65页

作者： Tianyin Li Xingyu Guo Wai Kin lai Xiaohui Liu Enke wang Hongxi Xing Dan-Bo Zhang Shi-Liang Zhu Guangdong Provincial Key Laboratory of Nuclear Science Institute of Quantum MatterSouth China Normal UniversityGuangzhou 510006China Guangdong-Hong Kong Joint Laboratory of Quantum Matter Southern Nuclear Science Computing Center South China Normal University.Guangzhou 510006China Department of Physics and Astronomy University of CaliforniaLos Angeles 90095USA center of Advanced Quantum Studies Department of PhysicsBeijing Normal UniversityBejing 100875China center for High Energy Physics Peking UniversityBeijing 100871China Guangdong-Hong Kong Joint Laboratory of Quantum Matter Frontier Research Institute for PhysicsSouth China Normal UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials School of Physics and Telecommunication EngineeringSouth China Normal UniversityGuangzhou 510006China

Light-cone distribution amplitudes(LCDAs)are essential nonperturbative quantities for theoretical predictions of exclusive highenergy processes in quantum chromodynamics(QCD).We demonstrate the prospect of calculating LCDAs on a quantum computer by applying a recently proposed quantum algorithm,with staggered fermions,to the simulation of the LCDA in the(1+1)-dimensional Nambu-Jona-Lasinio(NJL)model on classical *** agreement between the result from the classical simulation of the quantum algorithm and that from exact diagonalization justifies the proposed quantum *** find that the resulting LCDA in the NJL model exhibits features shared with the LCDAs obtained from the QCD.

关键词： light-cone distribution amplitude quantum algorithm NJL model

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai yijian Cai yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing beijing Computational Science Research center Beijing beijing Conveyi LTD Beijing beijing Glass Research Institute Co. LtdBeijing beijing Institute of Technology Beijing beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Non-aqueous lithium bromine battery of high energy density with carbon coated membrane

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Journal of Energy Chemistry 2017年第4期26卷 639-646页

作者： Xiaoli Xi Xianfeng Li Chenhui wang Qinzhi lai Yuanhui Cheng Pengcheng Xu Huamin Zhang Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina university of Chinese Academy of Sciences Beijing 100039China Collaborative Innovation center of Chemistry for Energy Materials Dalian 116023LiaoningChina

Flow batteries with high energy density and long cycle life have been pursued to advance the progress of energy storage and grid application. Non-aqueous batteries with wide voltage windows represent a promising technology without the limitation of water electrolysis, but they suffer from low electrolyte concentration and unsatisfactory battery performance. Here, a non-aqueous lithium bromine rechargeable battery is proposed, which is based on Br;/Br;and Li;/Li as active redox pairs, with fast redox kinetics and good stability. The Li/Br battery combines the advantages of high output voltage（;.1 V）,electrolyte concentration（3.0 mol/L）, maximum power density（29.1 m W/cm;） and practical energy density（232.6 Wh/kg）. Additionally, the battery displays a columbic efficiency（CE） of 90.0%, a voltage efficiency（VE） of 88.0% and an energy efficiency（EE） of 80.0% at 1.0 m A/cm;after continuously running for more than 1000 cycles, which is by far the longest cycle life reported for non-aqueous flow batteries.

关键词： Non-aqueous Battery Lithium Bromine Energy-storage

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Designer uniform Li plating/stripping through lithium–cobalt alloying hierarchical scaffolds for scalable high-performance lithium-metal anodes

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Journal of Energy Chemistry 2021年第1期30卷 385-392,I0013页

作者： Xinhua Liu Xiaojuan Qian Weiqiang Tang Hui Luo Yan Zhao Rui Tan Mo Qiao Xinlei Gao Yang Hua Huizhi wang Shuangliang Zhao Chao lai Magda Titirici Nigel PBrandon Shichun Yang Billy Wub School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Imperial College London Sough Kensington CampusSW72AZLondonUnited Kingdom School of Chemistry and Materials Science Jiangsu Normal UniversityXuzhou 221116JiangsuChina State Key Laboratory of Chemical Engineering and School of Chemical Engineering East China University of Science and TechnologyShanghai 200237China

Lithium metal anodes are of great interest for advanced high-energy density batteries such as lithiumair, lithium-sulfur and solid-state batteries, due to their low electrode potential and ultra-high theoretical capacity. There are, however, several challenges limiting their practical applications, which include low coulombic efficiency, the uncontrollable growth of dendrites and poor rate capability. Here, a rational design of 3D structured lithium metal anodes comprising of in-situ growth of cobalt-decorated nitrogen-doped carbon nanotubes on continuous carbon nanofibers is demonstrated via *** porous and free-standing scaffold can enhance the tolerance to stresses resulting from the intrinsic volume change during Li plating/stripping, delivering a significant boost in both charge/discharge rates and stable cycling performance. A binary Co-Li alloying phase was generated at the initial discharge process, creating more active sites for the Li nucleation and uniform deposition. Characterization and density functional theory calculations show that the conductive and uniformly distributed cobalt-decorated carbon nanotubes with hierarchical structure can effectively reduce the local current density and more easily absorb Li atoms, leading to more uniform Li nucleation during plating. The current work presents an advance on scalable and cost-effective strategies for novel electrode materials with 3D hierarchical microstructures and mechanical flexibility for lithium metal anodes.

关键词： Li metal anode Mixed conductor interface 3D porous host Dendrite free Metal-carbon nanofibers

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