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Oxidative Stress:Role in Acetamiprid-Induced Impairment of the Male Mice Reproductive System

Agricultural Sciences in China 2011年第5期10卷 786-796页

作者： ZHANG Jiao-jiao wang yi xiang Hai-yang LI Meng-xue LI Wen-hao MA Kai-ge wang Xian-zhong ZHANG Jia-hua College of Animal Science and Technology Southwest University Chongqing 400716 P.R.China

Acetamiprid has a wide range of influence on physiological functions in *** objective of this study was to examine the effect of acetamiprid on the reproductive function of male mice,and to study the role of oxidative stress in acetamiprid-induced damage to the *** adult Kunmin male mice （25-30 g） were divided into five groups （n=10 per group）,i.e.,control,blank,acetamiprid alone,acetamiprid and vitamin E,and vitamin E *** groups were treated for 35 *** results showed that acetamiprid significantly decreased the body weight and the weight of testosterone-responsive organs,such as the testis,epididymis,seminal vesicle,and ***,acetamiprid also significantly reduced the serum testosterone concentration,and decreased sperm count,viability,motility,and the intactness of the acrosome （P〈0.05 for each parameter）.The mice treated with acetamiprid had damaged seminiferous tubules and Leydig cells based on the histological structure of testes;there was degeneration of the mitochondria and endoplasmic reticulum of Leydig *** deleterious effects of acetamiprid may be mediated by increasing oxidative stress,as acetamiprid increased malondialdehyde and nitric oxide in the testes,reduced the activity of catalase,glutathione peroxidase,superoxide dismutase,and activated *** concentration of acetamiprid in the testes was lower than that in liver,so did the concentrations of liver function tests,including aspartate transaminase （AST）,alanine transaminase （ALT） and alkaline phosphatase （ALP）,which suggest that male reproductive function may be affected through the indirect action of its *** E significantly ameliorated the effects of *** conclude that acetamiprid damages male reproductive function through inducing oxidative stress in the testes.

关键词： acetamiprid oxidative stress reproductive function testis

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How do Notch Shape and Boundary Conditions Affect the Hydro-Mechanical Behavior of Fractured Geomaterials?Findings via the Darcy-Brinkman-Biot Approach

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Journal of Earth Science 2025年第1期36卷 351-356页

作者： yi-xiang wang Xiao-Pei Guo Ling Xu Shi-Feng Lu Department of Civil Engineering School of Human Settlements and Civil EngineeringXi'an Jiaotong UniversityXi'an 710049China China Construction Eighth Engineering Division Co. Ltd.Southwest BranchChengdu 610041China

0 INTRODUCTION Natural geomaterials,including soils and rocks,are invariably exposed to intricate stress conditions,in addition to water pressure,in various engineering contexts such as foundation treatment,mining,and *** geomaterials frequently contain numerous fractures,which significantly influence hydrological dynamics as water permeates through them,leading to processes like expansion and bifurcation(Shu et al.,2023;Tran and Jha,2021;Lei et al.,2017;wang et al.,2015).

关键词： bifurcation invar mining

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论彝族史诗《梅葛》的社会功能

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云南民族大学学报（哲学社会科学版） 2007年第6期24卷 43-48页

作者：王翼祥楚雄师范学院地方民族文化研究所云南楚雄675000

作为一部数百年来主要传唱于云南姚安、大姚、永仁、牟定地区的彝族史诗,《梅葛》具有多方面的功能。即敬神拜祖、驱鬼除秽、祈福纳吉的宗教功能;民族历史、传统文化的承载与传播功能;凝聚群体意识、规范个人行为的社会功能;悦神娱人、... 详细信息

作为一部数百年来主要传唱于云南姚安、大姚、永仁、牟定地区的彝族史诗,《梅葛》具有多方面的功能。即敬神拜祖、驱鬼除秽、祈福纳吉的宗教功能;民族历史、传统文化的承载与传播功能;凝聚群体意识、规范个人行为的社会功能;悦神娱人、男欢女爱的娱乐功能。多种功能相互关联,又相互渗透,并随着社会发展而变化。

关键词：《梅葛》宗教功能传播功能社会功能娱乐功能

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Nonspherical photonic scatterers and design criterion for efficient passive daytime radiative cooling

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Science China(Technological Sciences) 2025年第2期68卷 1-14页

作者： Xinping ZHANG Tairong KANG Fuqiang wang xiang LI Hongliang yi School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China College of New Energy Harbin Institute of Technology at WeihaiWeihai 264209China Construction Eco-Environmental Protection Technology Co. Ltd.Suzhou 215123China

Passive daytime radiative cooling(PDRC)exhibits efficient cooling performance to reduce global fossil energy consumption and has attracted enormous *** efficient PDRC technology for achieving daytime subambient cooling is supposed to exhibit ultra-high solar reflectivity and infrared emissivity within atmospheric windows,among which ultra-high solar reflectivity is the principal *** most PDRC technologies,spherical particles are selected as scatterers to achieve high solar reflectivity because the Mie scattering effect of spherical scatterers can provide a high scattering ***,the weak backward scattering of spherical scatterers remains a *** this study,several nonspherical scatterers with strong backward scattering are introduced and researched *** numerical analysis results indicate that pyramidal scatterers provide the strongest backward scattering and square/circular scatterers exhibit the highest scattering ***,by considering scattering efficiency and asymmetry factor comprehensively,a dimensionless evaluation parameter is proposed,which can be employed as a quantitative design criterion to achieve the optimal-object-oriented designing of superior *** work can provide an innovative strategy for designing efficient passive daytime radiative cooling materials.

关键词： radiative cooling nonspherical scatterers solar reflectivity backward scattering design criterion

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Evaluation of Glycosaminoglycan in the Lumbar Disc Using Chemical Exchange Saturation Transfer MR at 3.0 Tesla:Reproducibility and Correlation with Disc Degeneration

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Biomedical and Environmental Sciences 2016年第1期29卷 47-55页

作者： Deng Min Yuan Jing Chen Wei Tian Queenie Chan James F Griffith wang yi xiang Department of Imaging and Interventional Radiology Faculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalShatinNew TerritoriesHong Kong SAR 999077China Medical Physics and Research Department Hong Kong Sanatorium&HospitalHappy ValleyHong Kong SAR 999077China MR Clinical Science Philips Healthcare Greater ChinaHong Kong SAR 999077 China

Objective This study aims to explore the clinical applicability and relevance of giycosaminoglycan Chemical Exchange Saturation Transfer （gagCEST） for intervertebral disc. Methods 25 subjects ranging in age from 24 yrs to 74 yrs were enrolled, gagCEST was acquired using a single-slice TSE sequence on a 3T. Saturation used a continuous rectangular RF pulse with B1=0.8 I^T and a fixed duration time =1100 ms. Sagittal image was obtained firstly without saturation pulse, and then saturated images were acquired at 52 offsets ranging from ＋0.i25 to ＋_7 parts per million （ppm）. MR T2 relaxivity map was acquired at the identical location. Six subjects were scanned twice to assess scan-rescan reproducibility. Results GagCEST intraclass correlation coefficient （ICC） of six subjects was 0.759 for nucleus pulposus （NP） and 0.508 for annulus fibrosus （AF）. Bland-Altman plots showed NP had a mean difference of 0.10% （95% limits of agreement： -3.02% to 3.22%）; while that of AF was 0.34% （95% limits of agreement： -2.28% to 2.95%）. For the 25 subjects, gag CEST in NP decreased as disc degeneration increased, with a similar trend to T2 relaxivity. Gag CEST of AF showed a better correlation with disc degeneration than T2 relaxivity. Conclusion GagCEST in NP and AF decreased as disc degeneration increased, while gagCEST in AF showed a better correlation than T2 relaxivity.

关键词： Glycosaminoglycan Chemical Exchange Saturation Transfer (CEST) Reproducibility Discdegeneration

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Characteristics of Rat Lumbar Vertebral Body Bone Mineral Density and Differential Segmental Responses to Sex Hormone Deficiency:a Clinical Multidetector Computed Tomography Study

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Biomedical and Environmental Sciences 2012年第6期25卷 607-613页

作者： DENG Min wang yi xiang James F. GRIFFITH LU Gang Anil T AHUJA POON Wai S Department of Imaging and Interventional Radiology Prince of Wales Hospital the Chinese University of Hong Kong Shatin N.T. Hong Kong China Division of Neurosurgery Department of Surgery Prince of Wales Hospital the Chinese University of Hong Kong Shatin N.T. Hong Kong China

Objective To investigate sex hormone deficiency related osteoporosis and efficacy of different therapies. Methods Orchiectomized and ovariectomized rat models are used to investigate sex hormone deficiency related osteoporosis and efficacy of different therapies. A rat vertebral body can be longitudinally divided into central portion, which contain more trabecular bone, and para-endplate portions which contain more compact bone. In matured male and female Wistar and Sprague-Dawley rat lumbar spines, we investigated baseline bone mineral density （BMD） characteristics and the differential segmental responses in bone loss within the lumbar vertebral body post gonadal surgery with clinical multidetector computed tomography. Results Para-endplate sections had a higher BMD than central sections. The cephalad para-endplate sections had a higher BMD than the caudad para-endplate sections. Eight weeks after gonadal removal, there was more bone loss in central sections than para-endplate sections. The relative difference of bone loss between para-endplate and central sections was more apparent in male rats than in female rats. There was more bone loss in caudad sections than cephalad sections; this lead to a further increase of BMD difference between caudad para-endplate sections and cephalad para-endplate sections post gonadal surgery. Conclusion The approach described in this study provided a consistent way to study BMD change within predominantly compact bone portion and trabecular bone portion of the vertebral body.

关键词： Bone mineral density Quantitative computed tomography, Rat Vertebra Orchiectomy Ovariectomy Cortical bone Trabecular bone

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建立大鼠双膦酸盐相关颌骨骨坏死模型并初步分析其发病原因

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北京大学学报（医学版） 2014年第6期46卷 945-949页

作者：马泽云王衣祥北京大学口腔医学院.口腔医院特诊科北京100081 北京大学口腔医学院.口腔医院中心实验室北京100081

目的:建立大鼠双膦酸盐相关颌骨骨坏死(bisphosphonate-related osteonecrosis of the jaw,BRONJ)模型并初步分析其发病原因。方法:用帕米磷酸二钠、地塞米松加牙槽骨创伤(拔牙)的方法在大鼠体内建立了双膦酸盐相关颌骨骨坏死模型,并分... 详细信息

目的:建立大鼠双膦酸盐相关颌骨骨坏死(bisphosphonate-related osteonecrosis of the jaw,BRONJ)模型并初步分析其发病原因。方法:用帕米磷酸二钠、地塞米松加牙槽骨创伤(拔牙)的方法在大鼠体内建立了双膦酸盐相关颌骨骨坏死模型,并分析了CD4+和CD90+T淋巴细胞在双膦酸盐相关颌骨骨坏死发病过程中的变化。体外实验利用CCK-8法研究帕米磷酸二钠和地塞米松对人成骨肉瘤细胞MG-63和破骨前体细胞Raw 264.7的作用,初步分析双膦酸盐相关颌骨骨坏死的发病机制。结果:在牙槽骨创伤的前提下,成功地在帕米磷酸二钠和地塞米松联合用药组建立了大鼠BRONJ模型,流式细胞仪分析证实联合使用帕米磷酸二钠和地塞米松比单独应用这两种药物更能降低CD4+和CD90+T淋巴细胞在脾细胞中的比例。CCK-8实验证实帕米磷酸二钠能抑制MG-63及Raw264.7细胞的增殖,地塞米松能增强帕米磷酸二钠对抑制Raw 264.7细胞增殖的作用。结论:成功地建立了大鼠BRONJ模型,并证实了地塞米松可以增强双膦酸盐对破骨前体细胞抑制增殖作用;至少创伤、感染及地塞米松导致的免疫学反应等因素参与了BRONJ的发生和发展。

关键词：双膦酸盐相关颌骨骨坏死模型动物帕米磷酸二钠地塞米松免疫系统

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苦丁茶冬青治疗代谢综合征的临床研究

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时珍国医国药 2015年第4期26卷 914-916页

作者：王义相湖北省通山县中医医院 437600

目的研究苦丁茶冬青对代谢综合征(MS)患者的影响,并探讨其作用机制。方法将68例MS患者随机分为两组,对照组34例给予盐酸二甲双胍治疗;治疗组34例给予盐酸二甲双胍+苦丁茶提取液治疗。观察苦丁茶对MS患者治疗前后血脂、血糖、血压各指标... 详细信息

目的研究苦丁茶冬青对代谢综合征(MS)患者的影响,并探讨其作用机制。方法将68例MS患者随机分为两组,对照组34例给予盐酸二甲双胍治疗;治疗组34例给予盐酸二甲双胍+苦丁茶提取液治疗。观察苦丁茶对MS患者治疗前后血脂、血糖、血压各指标及血清内皮素(ET)、一氧化氮(NO)、血管紧张素II(Ang II)和糖化血红蛋白(HbA1c)水平的影响。结果治疗组能显著调节MS患者的血脂、血糖、血压各项指标,且治疗后血清ET、NO、Ang II、HbA1c水平均得到显著改善(P<0.05或P<0.01),与对照组比较具有显著性差异(P<0.05或P<0.01)。结论苦丁茶冬青可显著改善MS患者的各项指标和临床症状。

关键词：苦丁茶代谢综合征 ET NO Ang II HbA1c

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Formation and evolution of supercritical geofluid

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Science China Earth Sciences 2025年第1期68卷 39-51页

作者： Huaiwei NI yilin XIAO Xiaolin XIONG Xiandong LIU Chunxiao GAO yi-xiang CHEN Yunguo LI Wan-Cai LI Xuan GUO Yang-Yang wang Dong-Bo TAN Li ZHANG State Key Laboratory of Lithospheric and Environmental Coevolution University of Science and Technology of ChinaHefei230026China Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei230026China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou510640China School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China State Key Lab of Superhard Materials Jilin UniversityChangchun130012China

In this work,we provide a comprehensive review on the formation,evolution,properties,and effects of supercritical *** Earth's interior,enhanced miscibility between H_(2)O and silicate by the addition of special components or by the increase of pressure and temperature gives rise to supercritical geofluid with a significant amount of both H_(2)O and silicate *** formation of supercritical geofluid in magmatic-hydrothermal systems,typified by pegmatite system,is governed by meltfluid critical *** formation of supercritical geofluid in metamorphic systems,typified by subducted slab,is governed by the second critical end *** results suggest that the presence of boron and fluorine in pegmatite system makes it possible to form supercritical geofluid at crustal depths,but the release of supercritical geofluid from subducted slab is withheld until almost 100 km depth.A major presence of both H_(2)O and depolymerized structural units(monomers,dimers,etc.)endows supercritical geofluid with unique physical properties including low density,low elastic moduli,low viscosity,high diffusivity,and high electrical *** geofluid can effectively mobilize a variety of elements even including high field strength elements and heavy rare earth *** chemical signatures of supercritical geofluid can be inherited by metasomatized mantle and mantle-derived melts,and this could give an explanation of the oxidation of arc *** separation of supercritical geofluid through the mechanism of spinodal decomposition leads to formation of a melt *** fluid inclusions recovered from subduction zone rocks and pegmatites are possible relics of supercritical *** geofluid can cause electrical anomaly and low seismic velocity near the top of subducted slab,and can be linked with intermediate-focus *** geofluid may have played a crucial role in the formation of pegmatites and associ

关键词： Supercritical geofluid Miscibility Subduction zone Pegmatite

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尼古丁和牙龈卟啉单胞菌脂多糖影响单核细胞黏附血管内皮细胞的分子机制

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北京大学学报（医学版） 2015年第5期47卷 809-813页

作者：王衣祥安娜欧阳翔英北京大学口腔医学院.口腔医院中心实验室北京100081 北京大学口腔医学院.口腔医院综合二科北京100081 北京大学口腔医学院.口腔医院牙周科北京100081

目的:研究牙龈卟啉单胞菌和尼古丁影响动脉粥样硬化的初步分子机制。方法:在单核细胞U937细胞中,用CCK-8法检测尼古丁、牙龈卟啉单胞菌脂多糖(Porphyromonas gingivalis lipopolysaccharide,P.g-LPS)及二者联合对U937细胞增殖能力的影响... 详细信息

目的:研究牙龈卟啉单胞菌和尼古丁影响动脉粥样硬化的初步分子机制。方法:在单核细胞U937细胞中,用CCK-8法检测尼古丁、牙龈卟啉单胞菌脂多糖(Porphyromonas gingivalis lipopolysaccharide,P.g-LPS)及二者联合对U937细胞增殖能力的影响;实时定量荧光聚合酶链反应(Real-time PCR)检测尼古丁对P.g-LPS诱导炎症因子白细胞介素(interleukin,IL)-6能力的影响。在血管内皮细胞中,用Real-time PCR和蛋白印记杂交实验检测尼古丁、P.g-LPS及二者联合应用对单核细胞趋化因子(C-C模体)配体8[chemokine(C-C motif)ligand 8,CCL-8]和血管细胞黏附因子1(vascular cell adhesion molecule 1,Vcam-1)、非常晚期抗原4α(very late antigen 4 alpha,VLA4α)、肿瘤坏死因子受体超家族成员4(tumor necrosis factor receptor superfamily member 4,OX40)和其配体(OX40 ligand,OX40L)的表达的影响。同时,在尼古丁和P.g-LPS共同作用下,用黏附实验检测单核细胞与血管内皮细胞的黏附能力。结果:P.g-LPS并不影响尼古丁促进单核细胞系U937增殖的作用,100μmol/L尼古丁能抑制P.g-LPS诱导U937细胞产生IL-6的能力。在血管内皮细胞中,与对照和单一药物处理相比,尼古丁和P.g-LPS共同作用可以促进其表达CCL-8及Vcam-1、VLA4α、OX40和OX40L。黏附实验结果显示,尼古丁和P.g-LPS共同刺激可以明显提高单核细胞黏附血管内皮细胞的能力。结论:牙龈卟啉单胞菌和尼古丁可能通过上调CCL-8表达募集单核细胞到血管内皮损伤处,并通过增强黏附分子Vcam-1/VLA4α及OX40L/OX40的相互作用,促进单核细胞与血管内皮细胞黏附,参与动脉粥样硬化病损的启动和形成。

关键词：尼古丁牙龈卟啉单胞菌动脉粥样硬化细胞黏附分子

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