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Research on the cuttings discharge in air cushion chamber of slurry shield based on CFD-DEM coupling method Author links open overlay panel

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Particuology 2024年第8期91卷 88-105页

作者： Han wang Wantao ding Weimin Yang Chengzhen wang Wenduan Yu Zhicheng wang School of Qilu Transportation Shandong UniversityJinan250002China China Railway 14th Bureau Group Co. LtdJinan250101China

The rapid discharge of cuttings from the air cushion chamber is crucial for the construction safety and excavation efficiency of the slurry *** studies have mainly focused on the transport characteristics of cuttings in the slurry discharge pipe,while the complete process of cuttings entering the slurry discharge pipe from the air cushion chamber until they are discharged was often *** on the CFD-DEM coupling method and combined with actual engineering,this paper established a numerical model that can more completely reflect the cuttings discharge process during slurry shield tunneling,and the effects of the slurry velocity at slurry gate and scouring pipes,inclination angle of slurry discharge pipe,cuttings diameter and shape coefficient were investigated by analyzing the variation in the mass flow rate,mass of discharged cuttings,and discharged *** results revealed that increasing the slurry velocity can promote the discharge of *** keep the discharged rate at a high level,it is recommended that the slurry velocity at the slurry gate should be greater than 0.15 m/*** the inclination angle of the discharge pipe is conducive to the rapid discharge of *** with large diameter or small shape coefficient are more prone to accumulate in the air cushion chamber and cause clogging *** research results not only help to improve engineers'understanding of cuttings discharge in slurry shield,but also provide practical guidance for formulating relevant construction measures.

关键词： Slurry shield CFD-DEM coupling method Cuttings discharge Aircushion chamber Slurry discharge pipe

Endogenous biosynthesis of docosahexaenoic acid(DHA)regulates fish oocyte maturation by promoting pregnenolone production

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Zoological Research 2024年第1期45卷 176-188页

作者： yi Li Xuehui Li ding Ye Ru Zhang Chengjie Liu Mudan He Houpeng wang Wei Hu Yonghua Sun State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyInnovation Academy for Seed DesignChinese Academy of SciencesWuhanHubei 430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hubei Hongshan Laboratory WuhanHubei 430070China

Omega-3 polyunsaturated fatty acids(n-3 PUFAs),particularly docosahexaenoic acid(22:6n-3,DHA),play crucial roles in the reproductive health of vertebrates,including ***,the underlying mechanism related to this phenomenon remains largely *** this study,we employed two zebrafish genetic models,i.e.,elovl2^(-/-)mutant as an endogenous DHAdeficient model and fat1(omega-3 desaturase encoding gene)transgenic zebrafish as an endogenous DHA-rich model,to investigate the effects of DHA on oocyte maturation and *** show that the elovl2^(-/-)mutants had much lower fecundity and poorer oocyte quality than the wild-type controls,while the fat1 zebrafish had higher fecundity and better oocyte quality than wildtype *** deficiency in elovl2^(-/-)embryos led to defects in egg activation,poor microtubule stability,and reduced pregnenolone *** study revealed that DHA promoted pregnenolone synthesis by enhancing transcription of cyp11a1,which encodes the cholesterol side-chain cleavage enzyme,thereby stabilizing microtubule assembly during *** turn,the hypothalamic-pituitary-gonadal axis was enhanced by *** conclusion,using two unique genetic models,our findings demonstrate that endogenously synthesized DHA promotes oocyte maturation and quality by promoting pregnenolone production via transcriptional regulation of cyp11a1.

关键词： Docosahexaenoic acid Oocyte maturation Oocyte quality Pregnenolone Microtubule

Improving constraint onΩ_(m)from SDSS using marked correlation functions

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 207-224页

作者： Limin Lai Jiacheng ding Xiaolin Luo yizhao Yang Zihan wang Keshi Liu Guanfu Liu Xin wang yi Zheng Zhaoyu Li Le Zhang Xiao-Dong Li School of Physics and Astronomy Sun Yat-sen University Zhuhai CampusZhuhai 519082China Department of Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Department of Astronomy Tsinghua UniversityBeijing 100084China CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area SYSUZhuhai 519082China Peng Cheng Laboratory Shenzhen 518000China

Large-scale structure(LSS)surveys will increasingly provide stringent constraints on our cosmological ***,the density-marked correlation function(MCF)has been introduced,offering an easily computable density-correlation *** have demonstrated that MCFs offer additional,independent constraints on cosmological models beyond the standard two-point correlation(2PCF).In this study,we apply MCFs for the first time to SDSS CMASS data,aiming to investigate the statistical information regarding clustering and anisotropy properties in the Universe and assess the performance of various weighting schemes in MCFs,and finally obtain constraints onΩ_(m).Upon analyzing the CMASS data,we observe that,by combining different weights(α=[-0.2,0,0.2,0.6]),the MCFs provide a tight and independent constraint on the cosmological parameterΩ_(m),yieldingΩ_(m)=0.293±0.006 at the 1σlevel,which represents a significant reduction in the statistical error by a factor of 3.4 compared to that from *** constraint is consistent with recent findings from the small-scale clustering of BOSS galaxies(Zhai et ***.J.948,99(2023))within the 1σ***,we also find that our estimate is lower than the Planck measurements by about 2.6σ,indicating the potential presence of new physics beyond the standard cosmological model if all the systematics are fully *** method outlined in this study can be extended to other surveys and datasets,allowing for the constraint of other cosmological ***,it serves as a valuable tool for forthcoming emulator analysis on the Chinese Space Station Telescope(CSST).

关键词： large scale structure of universe dark energy cosmological parameters marked weighted correlation function

High-precision nondestructive evaluation of a thermal barrier coating based on perovskite quantum dot anion exchange

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Nano Research 2024年第5期17卷 4582-4592页

作者： Tao Han Shufang ding Zifan wang Sirong Jiang Pengjiang Jing Tianshang yi Yaqi Chen Chunzhi Jiang Xiaofeng Zhang Microelectronics and Optoelectronics Technology Key Laboratory of Hunan Higher Education School of Physics and Electronic Electrical EngineeringXiangnan UniversityChenzhou 423000China National Engineering Laboratory for Modern Materials Surface Engineering Technology&The Key Lab of Guangdong for Modern Surface Engineering Technology Guangdong Institute of New MaterialsGuangdong Academy of SciencesGuangzhou 510650China

Thermal barrier coatings(TBCs)in gas turbine engines are used in expressly harsh environments;thus,assessing TBC integrity status is critical for safety and ***,traditional periodic maintenance involves visual inspections of the TBCs,requiring the gas turbine to be decommissioned and partially *** importantly,tiny defects or internal damages that easily cause coating failure cannot be *** this work,a new nondestructive evaluation(NDE)technique of TBCs based on quantum dot(QD)anion exchange is first explored *** exchanging anions between the Cl ions and the CsPbBr_(3) QDs,the degrees of salt corrosion of the TBCs are *** resultant NDE technique shows that the colour of the TBCs obviously changes from green to blue,accompanied by a large blueshift(~100 nm)of the photoluminescence(PL)peak *** addition,the relationship between the PL peak position and coating thermophysical properties indicates that the precision of this NDE technique may easily identify theμm-level of the thermal growth oxide(TGO)changes inside the TBCs.

关键词： thermal barrier coatings nondestructive evaluation CsPbBr_(3)quantum dot anion exchange thermal growth oxide

Efficacy and safety of Huzhang Granule,a compound Chinese herbal medicine,for acute gouty arthritis:A double-blind,randomized controlled trial

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Journal of Integrative Medicine 2024年第3期22卷 270-278页

作者： Hao wang Si-ting Chen Xiao-jie ding Le Kuai Liang Hua Xin Li yi-fei wang Ming Zhang Bin Li Rui-ping wang Mi Zhou Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai 201203China Department of Dermatology the Affiliated Hospital of Jiangxi University of Chinese MedicineNanchang 330000Jiangxi ProvinceChina Shanghai Skin Disease Hospital School of MedicineTongji UniversityShanghai 200443China Institute of Dermatology School of MedicineTongji UniversityShanghai 200443China

Background:Acute gouty arthritis(AGA)is an inflammatory joint disease with a high *** medical interventions,including nonsteroidal anti-inflammatory drugs,colchicine and glucocorticoids,can have serious adverse *** Granule(HZG),a compound Chinese herbal medicine,has been used to treat AGA for more than 30 years with satisfactory effects and no significant adverse ***,the efficacy and safety of HZG in AGA patients remains ***:The present investigation was designed to examine the efficacy and safety profile of HZG in managing AGA ***,setting,participants and interventions:The current study was conducted as a noninferiority,randomized controlled clinical trial on 180 eligible enrolled *** were randomly assigned into the HZG and etoricoxib *** were administered for 5 d,during which the HZG group received HZG and placebo etoricoxib,while the etoricoxib group received etoricoxib and placebo HZG in the same ratio(1:1).Main outcome measures:The primary outcome was pain experienced by the patient in the gout-afflicted joint from days 2 to 5 of the treatment *** pain level was measured via a visual analogue scale,ranging from 0 mm to 100 *** secondary outcomes comprised joint tenderness and swelling,reduction of inflammatory biomarkers,and the patient’s and investigator’s global evaluations of therapeutic ***:The mean reduction in pain was-51.22 mm(95%confidence interval[CI],[-53.42,-49.03]mm)for the HZG and-52.00 mm(95%CI,[-54.06,-49.94]mm)for the etoricoxib *** mean difference between the two groups was 0.78 mm(95%CI,[-2.25,3.81]mm).All additional efficacy endpoints,covering decreased inflammation and pain relief,yielded compelling proof of *** in the HZG group exhibited a comparatively lower rate of adverse events compared to those in the etoricoxib group(4.44%vs 13.33%;P≤0.05).Conclusion:HZG and etoricoxib groups demons

关键词： Acute gouty arthritis Huzhang Granule Randomized controlled trial Blind

Ore Geology,H-O-C Isotopes and 40Ar-39Ar Dating of the Wutonggou Iron Deposit,Eastern Tianshan,NW China:Implications for the Source,Timing,and Genesis of Hydrothermal Mineralization in a Sedimentary Iron Deposit

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Journal of Earth Science 2024年第4期35卷 1170-1185页

作者： Chun-Long wang yi-Tian wang State Key Laboratory of Geological Processes and Mineral Resources Collaborative Innovation Center for Exploration of Strategic Mineral ResourcesSchool of Earth ResourcesChina University of GeosciencesWuhan430074China MNR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing100037China

The Wutonggou iron deposit is located in the well-known iron metallogenic belt in the eastern Tianshan,NW China,and has been regarded as a sedimentary iron *** hydrothermal overprinting could play indispensable roles in the formation of high-grade iron ores in sedimentary iron deposits,previous studies mainly focused on sedimentary-related iron mineralization,while the nature and contribution of hydrothermal fluids are poorly ***,an integrated study of ore geology,H-O-C isotopes and^(40)Ar-^(39)Ar dating,is conducted on the Wutonggou deposit,in order to reveal the features,source,and timing of hydrothermal *** studied deposit includes two mining sections namely the Jianshan and ***δ^(18)O values of early magnetite from the Jianshan section range from+3.0‰to+5.8‰that nearly consistent with classic magmatic magnetite,while increase to 6.3‰-8.0‰in the late *** from the two sections shows comparable H-O isotopic compositions and identical fractionation trends,and is plotted in or periphery to the primary magmatic water *** from the two sections are broadly similar in carbon and oxygen isotopic compositions,and siderite from the Wutonggou section is plotted in the same ***,comparable stable isotopic compositions and evolution trends indicate similar magmatic fluids contributed hydrothermal iron mineralization in the two mining ***,water-rock interactions of varying degrees generated distinct mineralization styles in the Jianshan and Wutonggou sections,and caused the isotopic fractionation in late *** extracted from a hydrothermal siderite ore yielded a^(40)Ar-^(39)Ar plateau age of 299.5±2.0 Ma,indicates the timing of hydrothermal iron mineralization is corresponding to the emplacement of vicinity *** together,the hydrothermal mineralization in the Wutonggou iron deposit was the product of remobilization and upgrading of early sedimentary iron ores,a

关键词： iron deposits H-O-C isotopes 40Ar-39Ar dating sedimentary iron deposits Wutonggou iron deposit eastern Tianshan

Unconditionally stable Crank-Nicolson algorithm with enhanced absorption for rotationally symmetric multi-scale problems in anisotropic magnetized plasma

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Journal of Systems Engineering and Electronics 2024年第1期35卷 65-73页

作者： WEN yi wang Junxiang XU Hongbing School of Automatic Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Beijing Institute of Aerospace Systems Engineering Beijing 100076China

Large calculation error can be formed by directly employing the conventional Yee’s grid to curve *** order to alleviate such condition,unconditionally stable CrankNicolson Douglas-Gunn(CNDG)algorithm with is proposed for rotationally symmetric multi-scale problems in anisotropic magnetized *** the CNDG algorithm,an alternative scheme for the simulation of anisotropic plasma is proposed in body-of-revolution *** perfectly matched layer(CPML)formulation is proposed to efficiently solve the open region *** example is carried out for the illustration of effectiveness including the efficiency,resources,and *** the results,it can be concluded that the proposed scheme shows considerable performance during the simulation.

关键词： anisotropic magnetized plasma body-of-revolution(BOR) Crank-Nicolson Douglas-Gunn(CNDG) finite-difference time-domain(FDTD) perfectly matched layer(PML) rotationally symmetric multi-scale problems

Boswellic acids: a review on its pharmacological properties, molecular mechanism and bioavailability

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Traditional Medicine Research 2024年第10期9卷 64-74页

作者： Na Cui Ming-Jie Li yi-Wen wang Qian Meng Ya-Jun Shi yi ding Department of Pharmacy 3201 HospitalHanzhong 723000China Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’an 710032China School of Pharmacy Shaanxi University of Traditional Chinese medicineXianyang 712046China

Boswellic acids is a general term for a series of pentacyclic triterpenoid compounds that are isolated from the oleogin resin of the Boswellia genus and serve as the main active *** exhibits a wide range of biological activities,such as anti-inflammatory,anti-cancer,antibacterial,antiviral,hepatoprotective,neuroprotective,anti-diabetic,and anti-thrombotic *** a result,it has gained significant recognition among practitioners of traditional Chinese and Indian *** biological effects may be associated with multiple molecular targets and signal transduction ***,the poor pharmacokinetic properties of the substance lead to lower bioavailability,which affects its *** address this issue,scientists have proposed a number of strategies,such as solid dispersions,phytosome®technologies,and novel drug delivery *** article aims to provide a comprehensive overview for boswellic acids on the phytochemistry,molecular mechanisms,potential therapeutic applications,and strategies to improve bioavailability.

关键词： boswellic acids molecular mechanism pharmacological properties bioavailability

Dynamic COVID Zero Strategy triggered a significant increase of chlorine-based disinfectant

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 73-80页

作者： Xuhao wang Mai Su Chunyan wang yi Liu School of Environment Tsinghua UniversityBeijing 100084China

Chlorine-based disinfectants(CBDs)have been widely used to prevent and control the spread of the COVID-19,which may lead to the formation of carcinogenic *** China,strict disinfection strategies by local governments/communities or volunteering by residents have been implemented to meet the Dynamic COVID Zero(DCZ)***,the amount of CBDs used has not been *** author proposed an urban-scale disinfectant consumption estimation(ALICE)model to quantify weekly CBD *** results show that the CBD consumption for the urban region of Beijing during the DCZ strategy was 3704.0 t(0.43 kg/(cap-yr)),equivalent to a monthly increase of 15 g/cap(70.5%)in CBD consumption compared with that in *** to the scenario analysis,a stricter strategy with a shorter response time toward new cases will decrease the total CBD consumption by 1.2% compared with the baseline estimation.A more precise prevention strategy with a smaller delineation of risk area and a less stringent strategy with a longer response time will lower the total CBD consumption by 0.42% and 0.35%,***,the more precise prevention strategy will reduce CBD consumption of close off and lockdown area(COLD area)by 16.9%,and the stricter strategy will reduce this consumption by 37.7%.This study highlights the impact of pandemic prevention and control strategies on chlorine-based disinfectant consumption and some implications for future environmental pollution and risk assessments.

关键词： COVID-19 Dynamic COVID Zero Strategy Disinfectants consumption Bottom-up approach Scenario analysis