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The rate of convergence of the Lax-Oleinik semigroup-degenerate fixed point case

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Science china Mathematics 2011年第3期54卷 545-554页

作者： wang KaiZhi1,2 & yan Jun1 1School of Mathematical Sciences and Key Lab of Mathematics for Nonlinear Science, fudan university, shanghai 2.043., china 2School of Mathematics, Jilin university, Changchun 130012, china 1. School of Mathematical Sciences and Key Lab of Mathematics for Nonlinear Science Fudan University Shanghai 200433 China2. School of Mathematics Jilin University Changchun 130012 China

For the standard Lagrangian in classical mechanics, which is defined as the kinetic energy of the system minus its potential energy, we study the rate of convergence of the corresponding Lax-Oleinik semigroup. Under the assumption that the unique global minimum point of the Lagrangian is a degenerate fixed point, we provide an upper bound estimate of the rate of convergence of the semigroup.

关键词： Hamiltonian system weak KAM theorem Lax-Oleinik semigroup

Amplification effect of intra-seasonal variability of soil moisture on heat extremes over Eurasia

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Advances in Climate Change Research 2024年第1期15卷 1-8页

作者： Yi-Nuo wang Zhi-yan ZUO Liang QIAO Kai-Wen ZHANG Mei-Yu CHANG Dong XIAO Zou-Xing LIN Huan wang Department of Atmospheric and Oceanic Sciences Institute of Atmospheric SciencesFudan UniversityShanghai 200438China CMA-FDU Joint Laboratory of Marine Meteorology Shanghai 200438China Key Laboratory of Cites Mitigation and Adaptation to Climate Change in shanghai China Meteorological AdministrationShanghai 200030China Collaborative Innovation Centeron Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 211800China shanghai Frontiers Science Center of Atmosphere-Ocean Interaction Shanghai 200123China college of Geography and Resources Science Sichuan Normal UniversityChengdu 610101China National Observations and Research Station for Wetland Ecosystems of the yangtze Estuary Shanghai 202183China Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081China

Drying soil has been conducive to a high frequency of extreme high-temperature events over many regions worldwide in recent ***,changes in the intraseasonal variability of soil moisture can also influence the likelihood of extremely high *** previous investigators have examined the association between extremely high temperatures and large-scale atmospheric circulation variability,the role of land-atmosphere coupling dominated by soil moisture variability in extremely high temperatures,particularly over the Eurasian continent,is not well *** this study,on the basis of the Land Surface,Snow,and Soil Moisture Model Intercomparison Project,we found that land-atmosphere feedback amplified the variability of soil moisture in most regions of Eurasia during summer from 1980 to *** amplification of soil moisture variability is closely correlated with more intensive intraseasonal variability of surface air temperature and more frequent occurrences of extreme high-temperature events,particularly in Europe,Siberia,Northeast Asia,and the Indochina *** correlation implies that increasing the intraseasonal variability of soil moisture results in a high likelihood of heat extremes during summer in most parts of Eurasia except Asian desert *** the intraseasonal timescale,the land-atmosphere coupling increases the variability of surface sensible heat flux and net long-wave radiation heating the atmosphere by intensifying the soil moisture variability,thus amplifying the variability of surface air temperature and enhancing the extreme high-temperature *** finding demonstrates the importance of changes in intraseasonal soil moisture variability for the increasing likelihood of heat extremes in summer.

关键词： Soil moisture Intraseasonal variability Land-atmosphere coupling Heat extremes

Response of warm season secondary pollutants to emissions and meteorology in the North china Plain region during 2.1.-2022

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Atmospheric and Oceanic Science Letters 2024年第4期17卷 58-64页

作者： Yueqi Gao Siyu wang Zhaolei Zhang Wenxuan Yu Shuai wang Shengqiang Zhu Peng wang yan Li Yele Sun Hongliang Zhang shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science&EngineeringFudan UniversityShanghaiChina Department of Atmospheric and Oceanic Sciences Fudan UniversityShanghaiChina shanghai Key Laboratory of Ocean-land-atmosphere Boundary Dynamics and Climate Change ShanghaiChina IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health Fudan UniversityShanghaiChina State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina college of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina Institute of Eco-Chongming ShanghaiChina

自2.1.年起中国空气质量虽改善,但华北平原(NCP)重污染仍存在且二次污染加剧,而人们对其成因和变化了解有限.本研究利用2.1.-2022年数据,借助CMAQ模型探讨此污染响应.结果显示,在2.1.-2022年间,PM_(2.5)浓度显著下降31%-37%,O_(3)和NO_... 详细信息

自2.1.年起中国空气质量虽改善,但华北平原(NCP)重污染仍存在且二次污染加剧,而人们对其成因和变化了解有限.本研究利用2.1.-2022年数据,借助CMAQ模型探讨此污染响应.结果显示,在2.1.-2022年间,PM_(2.5)浓度显著下降31%-37%,O_(3)和NO_(2)的年下降速率分别为1%和0.5%SIA和SOA也显著减少,每年分别减少9%和6%PM_(2.5)主要因排放减少而下降,而O_(3)则受气象影响而波动.硫酸盐和铵下降的主因是减排,而硝酸盐对气象变化敏感排放和气象变化对SOA的总体减少同样重要,但人为SOA对排放控制敏感生物SOA易受气象变化影响.研究强调了控制人为排放对缓解NCP地区夏季二次污染的重要性.

关键词： PM_(2.5) 二次污染物人为排放气象华北平原

Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells redeems palmitic acid-induced inflammation and reduction in nitric oxide bioavailability

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中国病理生理杂志 2012年第11期 2032-2033页

作者： TIAN Dai,QIU yan-yan,LI Xiao-bo,ZHI Xiu-ling,wang Xin-hong,YIN Lian-hua,NING yan-xia(Department of Physiology and Pathophysiology,shanghai Medical college,fudan university,shanghai 200032,china)

AIM:Endothelial dysfunction is a well documented evidence for onset of atherosclerosis and other cardiovascular ***-dogenic acute regulatory protein(StAR),one of the cholesterol transporters,plays an important role in maintenance of intracellular lipid ***,the effect of StAR in endothelial dysfunction is not completely *** acid(PA)has been

关键词： acid Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells redeems palmitic acid-induced inflammation and reduction in nitric oxide bioavailability

Evidence for distortion-induced local electric polarization in α-RuCl_(3)

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Science china(Physics,Mechanics & Astronomy) 2024年第9期67卷 165-173页

作者： Xinrun Mi De Hou Xiao wang Sabreen Hammouda Caixing Liu Zijian Xiong Han Li yan Liu Guiwen wang Aifeng wang Yisheng Chai yang Qi Wei Li Xiaoyuan Zhou Yixi Su DIKhomskii Mingquan He Zhigao Sheng Young Sun college of Physics Center of Quantum Materials and DevicesChongqing UniversityChongqing 401331China Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryHefei Institutes of Physical ScienceAnhuiChinese Academy of SciencesHefei 230031 China university of Science and Technology of china Hefei 230026China Jülich Centre for Neutron Scienceat Heinz Maier-Leibnitz Zentrum(JCNS-MLZ) Forschungszentrum Jülich GmbHGarching D-85747Germany School of Physics Beihang UniversityBeijing 100191China Analytical and Testing Center Chongqing UniversityChongqing 401331China State Key Laboratory of Surface Physics Department of PhysicsFudan UniversityShanghai 200433China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Ⅱ.Physikalisches Institut Universität zu KölnKöln D-50937Germany

The spin-orbit assisted Mott insulator α-RuCl_(3) is a prime candidate for material realization of the Kitaev quantum spin *** little attention has been paid to charge degrees of freedom,charge effects,such as electric polarization,may arise in this ***,we report distortion-induced local electric polarization in α-RuCl_(3) as evidenced by single-crystal X-ray diffraction,second harmonic generation(SHG)and dielectric *** SHG signal appears at room temperature and develops substantially in the Kitaev paramagnetic state when short-range spin correlations come into *** sizable pyroelectric currents in the Kitaev paramagnetic state,the absence of hysteresis in the polarization-electric field(P-E)points to the shortrange nature of electric *** localized electric polarization is likely the result of distortion-induced charge dimerization,achieved through virtual hopping-induced charge *** addition,the electric polarization is boosted by short-range spin correlations via spin-phonon coupling in the Kitaev paramagnetic *** results emphasize the importance of charge degrees of freedom in α-RuCl_(3),which establish a novel platform to investigate charge effects in Kitaev materials.

关键词： Mott insulator Kitaev quantum spin liquid electric polarization

Positron Emission Tomography Imaging of Synaptic Dysfunction in Parkinson’s Disease

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Neuroscience Bulletin 2024年第6期40卷 743-758页

作者： Jiaqi Niu yan Zhong Chentao Jin Peili Cen Jing wang Chunyi Cui Le Xue Xingyue Cui Mei Tian Hong Zhang Department of Nuclear Medicine and PET Center The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou310009China Institute of Nuclear Medicine and Molecular Imaging Zhejiang UniversityHangzhou310009China Key Laboratory of Medical Molecular Imaging of Zhejiang Province Hangzhou310009China college of Biomedical Engineering&Instrument Science Zhejiang UniversityHangzhou310014China Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou310014China Huashan Hospital and Human Phenome Institute Fudan UniversityShanghai200040China

Parkinson’s disease(PD)is one of the most common neurodegenerative diseases with a complex *** formed by abnormal deposition of alpha-synuclein(αSyn)lead to synapse dysfunction of the dopamine and non-dopamine *** loss of dopaminergic neurons and concomitant alterations in non-dopaminergic function in PD constitute its primary pathological *** emission tomography(PET),as a representative molecular imaging technique,enables the non-invasive visualization,characterization,and quantification of biological processes at cellular and molecular *** synaptic function with PET would provide insights into the mechanisms underlying PD and facilitate the optimization of clinical *** this review,we focus on the synaptic dysfunction associated with theαSyn pathology of PD,summarize various related targets and radiopharmaceuticals,and discuss applications and perspectives of PET imaging of synaptic dysfunction in PD.

关键词： Parkinson’s disease Positron emission tomography Synapse dysfunction Alpha-synuclein Dopamine system Non-dopamine system

Penpulimab,an anti-PD-1 antibody,for heavily pretreated metastatic nasopharyngeal carcinoma:a single-arm phase II study

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3056-3062页

作者： Xiaozhong Chen Wei wang Qingfeng Zou Xiaodong Zhu Qin Lin Yi Jiang yan Sun Liangfang Shen Lin wang Guorong Zou Xiaoyan Lin Shaojun Lin Minying Li Ying wang Ruilian Xu Rui Ao Rensheng wang Haifeng Lin Shuang Huang Tingting Xu Wenting Li Mengying Xia Yu Xia Zhongmin wang Baiyong Li Jingao Li Chaosu Hu Department of Radiation Oncology Cancer Hospital of the University of ChineseAcademy of Sciences(Zhejiang Cancer Hospital)HangzhouChina Gastroenterology and Urology Department II Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaChina Clinical Research Center for Gastrointestinal Cancer in Hunan Province ChangshaChina Department of Medical Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhouChina Department of Radiation Oncology Guangxi Medical University Affiliated Tumor Hospital&Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University)Ministry of Education&Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorGuangxi Medical UniversityNanningChina Department of Radiation Oncology Cancer CenterThe First Affiliated Hospital of Xiamen UniversityXiamenChina Department of Medical Oncology Cancer Hospital of Shantou University Medical CollegeShantouChina Department of Radiation Oncology Peking University Cancer Hospital&InstituteBeijingChina Department of Oncology Xiangya Hospital Central South UniversityChangshaChina Department of Medical Oncology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikouChina Department of Oncology The Affiliated Panyu Central Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Medical Oncology Fujian Medical University Union HospitalFuzhouChina Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhouChina Department of Radiation Therapy for Thoracic Tumors Zhongshan City People’s HospitalZhongshanChina Tumor Radiotherapy Center Chongqing University Cancer HospitalChongqing Cancer HospitalChongqing Cancer InstituteChongqingChina Department of Oncology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSo

Penpulimab is an anti-programmed cell death-1(PD-1)IgG1 antibody with no Fc gamma receptor(FcγR)binding activity,and thus theoretically reduced immune-related adverse events(irAEs)while maintaining *** single-arm,phase II trial conducted across 20 tertiary care centers in china enrolled adult patients with metastatic nasopharyngeal carcinoma(NPC)who had failed two or more lines of previous systemic *** received 200-mg penpulimab intravenously every 2 weeks(4 weeks per cycle)until disease progression or intolerable *** primary endpoint was objective response rate(ORR)per RECIST(version 1.1),as assessed by an independent radiological review *** secondary endpoints included progression-free survival(PFS)and overall survival(OS).One hundred thirty patients were enrolled and 125 were efficacy *** the data cutoff date(September 28,2022),1 patient achieved complete response and 34 patients attained partial *** ORR was 28.0%(95%CI 20.3–36.7%).The response was durable,with 66.8%still in response at 9 ***-three patients(26.4%)were still on *** median PFS and OS were 3.6 months(95%CI=1.9–7.3 months)and 22.8 months(95%CI=17.1 months to not reached),***(7.6%)patients experienced grade 3 or higher *** has promising anti-tumor activities and acceptable toxicities in heavily pretreated metastatic NPC patients,supporting further clinical development as third-line treatment of metastatic NPC.

关键词： metastatic nasopharyngeal supporting

Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1302-1316页

作者： Xinyuan Xu Qian Zhang Xufeng wang Jing Jin Chengwei Wu Li Feng Xiuyan yang Mingzhu Zhao Yingyi Chen Shaoyong Lu Zhen Zheng Xiaobing Lan Yi wang yan Zheng Xuefeng Lu Qiufen Zhang Jian Zhang State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at ShanghaiRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Medicinal Chemistry and BioinformaticsCenter Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan UniversityShanghai 200040China Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Basic Medicine and Medical CenterUniversity of Science and Technology of ChinaHefei 230026China Department of Assisted Reproduction Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China college of Pharmacy Ningxia Medical UniversityYinchuan 750004China Department of Pancreatic Surgery Shanghai General HospitalShanghai Key Laboratory of Pancreatic DiseaseInstitute of Pancreatic DiseaseShanghai Jiao Tong University School of MedicineShanghai 200080China

Pancreatic cancer,one of the most aggressive malignancies,has no effective treatment due to the lack of targets and drugs related to tumour ***6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic ***,highly selective and potency SIRT6 inhibitor that can be used in vivo is yet to be ***,we developed a noveSIRT6 allosteric inhibitor,compound 11e,with maximal inhibitory potency and an IC_(50) value of 0.98±0.13μmol/***,compound 11e exhibited significant selectivity against other histone deacetylases(HADC1-11 and SIRT1-3)at concentrations up to 100μmol/*** allosteric site and the molecular mechanism of inhibition were extensively elucidated by cocrystal complex structure and dynamic structural ***,we confirmed the antimetastatic function of such inhibitors in four pancreatic cancer cell lines as well as in two mouse models of pancreatic cancer liver *** our knowledge,this is the first study to reveal the in vivo effects of SIRT6 inhibitors on liver metastatic pancreatic *** not only provides a promising lead compound for subsequent inhibitor developmentargeting SIRT6 but also provides a potential approach to address the challenge of metastasis in pancreatic cancer.

关键词： SIRT6 Inhibitor Allosteric Selectivity Cocrystal Pancreatic cancer metastasis

Graphene enhances artemisinin production in the traditional medicinal plant Artemisia annua via dynamic physiological processes and miRNA regulation

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Plant Communications 2024年第3期5卷 31-46页

作者： Junfeng Cao Zhiwen Chen Luyao wang Ning yan Jialing Lin Lipan Hou Yongyan Zhao Chaochen Huang Tingting Wen Chenyi Li Saeed ur Rahman Zehui Liu Jun Qiao Jianguo Zhao Jie wang yannan Shi Wei Qin Tong Si Yuliang wang Kexuan Tang Frontiers Science Center for Transformative Molecules Joint International Research Laboratory of Metabolic and Developmental SciencesPlant Biotechnology Research CenterFudan-SJTU Nottingham Plant Biotechnology R&D CenterSchool of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Engineering Research Center of Coal-based Ecological Carbon Sequestration Technology of the Ministry of Education Key Laboratory of Graphene Forestry Application of National Forest and Grass AdministrationShanxi Datong UniversityDatong 037009China National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology/CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China Hainan Institute Zhejiang UniversityYongyou Industry ParkYazhou Bay Sci-Tech CitySanya 572000China college of Agriculture and Biotechnology Zhejiang UniversityHangzhou 310058China Shandong Provincial Key Laboratory of Dryland Farming Technology College of AgronomyQingdao Agricultural UniversityQingdao 266109China Institute of Millet Crops Hebei Academy of Agriculture&Forestry Sciences/Hebei Branch of China National Sorghum Improvement CenterShijiazhuang 050035China

We investigated the effects of graphene on the model herb Artemisia annua,which is renowned for produc-ing artemisinin,a widely used pharmacological *** growth and biomass were promoted when *** was cultivated with low concentrations of graphene,an effect which was attributed to a 1.4-fold increase in nitrogen uptake,a 15%–22%increase in chlorophyllfluorescence,and greater abun-dance of carbon cycling–related *** to 10 or 20 mg/L graphene resulted in a�60%increase in H2O2,and graphene could act as a catalyst accelerator,leading to a 9-fold increase in catalase(CAT)ac-tivity in vitro and thereby maintaining reactive oxygen species(ROS)***,graphene exposure led to an 80%increase in the density of glandular secreting trichomes(GSTs),in which artemisinin is biosynthesized and *** contributed to a 5%increase in artemisinin content inmature ***-estingly,expression of miR828 was reduced by both graphene and H2O2 treatments,resulting in induction of its target gene AaMYB17,a positive regulator of GST *** molecular and genetic assays showed that graphene-induced H2O2 inhibits micro-RNA(miRNA)biogenesis through Dicers and regulates the miR828–AaMYB17 module,thus affecting GST *** results suggest that graphene may contribute to yield improvement in *** via dynamic physiological processes together with miRNA regulation,and it may thus represent a new cultivation strategy for increasing yield capacity through nanobiotechnology.

关键词： Artemisia annua artemisinin glandular secreting trichomes GSTs miRNA graphene