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Influence of Bath Composition on Magnetic Properties of Electrodeposited Co-Pt-W Thin Films

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Journal of Iron and Steel Research International 2007年第4期14卷 65-68页

作者： GE Hong-liang WEI Guo-ying WU Qiong ZHOU Qiao-ying wang xin-yan College of Material Science and Engineering China Jiliang University Hangzhou 310018 Zhejiang China

Effect of bath composition （[Co^2＋]/[-Pt^Ⅳ ] and [-WO4^2- ], [cit^-]） and pH on the magnetic properties of electrodeposited Co-Pt-W thin films has been investigated. Electrodeposited Co-Pt-W thin films exhibited strong perpendicular magnetic anisotropy when the ratio of [-Co^2＋ ] to [-Pt^Ⅳ ] was 10 ; cathode current efficiency and perpendicular magnetic anisotropy showed little variations when [WO4^2- ] was lower than 0. 1 mol/L, but perpendicular magnetic anisotropy had strengthened when [WO4^2-] was over 0. 1 mol/L, which could be explained by the fact that the hydrogen evolution could produce pores as magnetic domain pinnings; citrate as complexing reagent can promote the polarization of [Co^2＋] and [Pt^Ⅳ]. As a result, the equilibrium electrode potentials of cobalt and platinum moved to negative direction, which led to the co-deposition of Co, Pt, and W. It was also found out that the as-deposited Co- Pt-W hard magnetic thin films were very homogeneous, smooth, and had the maximum coercivity for the bath pH 8. 5 and the concentration of citrate 0. 26 mol/L.

关键词： electrodeposition Co-Pt-W thin film magnetic property bath composition

Association between Pre-pregnancy Body Mass Index and Offspring Neuropsychological Development from 1 to 24 Months of Age: A Birth Cohort Study in China

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Biomedical and Environmental Sciences 2019年第10期32卷 730-738页

作者： CAO Lu Jia LIN Hong yan LIANG Xuan CHEN Yong Jie LIU Yu yan ZHENG Yu Zhi wang xin yan LI Wen yan Jing HUANG Guo Wei Department of Nutrition and Food Science School of Public HealthTianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjin 300070China Department of Epidemiology and Statistics School of Public HealthTianjin Medical UniversityTianjin 300070China Department of Social Medicine and Health Administration School of Public HealthTianjin Medical UniversityTianjin 300070China

Objective To explore the interactions between pre-pregnancy body mass index(BMI) and age on offspring neuropsychological development from 1 to 24 months in *** In this birth cohort study, a total of 2,253 mother-child pairs were enrolled in Tianjin, China,between July 2015 and May 2018. The China Developmental Scale for Children was used to assess developmental quotient(DQ) of children aged from 1 to 24 *** Mixed-models analysis revealed significant age × pre-pregnancy BMI interactions for total DQ and five neurobehavioral domains(gross motor, fine motor, adaptive, language, and social;P < 0.001).Age × pre-pregnancy BMI ≥ 25 kg/m^2 was associated with a negative effect on total DQ and five neurobehavioral domains, as compared to pre-pregnancy BMI < 25 kg/m^2(P < 0.01). Multiple comparisons showed pre-pregnancy BMI ≥ 25 kg/m^2 of mothers had a positive effect on child total DQ at the age of 1 month but a negative effect at 24 months(P < 0.05).Conclusions This study supported the age × pre-pregnancy BMI interaction on offspring neuropsychological development. It also revealed a short-term positive impact of high pre-pregnancy BMI on neuropsychological development at 1 month of age, but a long-term negative effect(from 1 to24 months).

关键词： Pre-pregnancy BMI Neuropsychological development Offspring The first 1,000 days Birth cohort study

Involvement of CD4^＋CD25^＋ regulatory T cells in the pathogenesis of polycythaemia vera

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Chinese Medical Journal 2008年第18期 1781-1786页

作者： ZHAO Wen-bo LI Ying LIU xin ZHANG Ling-yan wang xin Department of Hematology Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China

Background Regulatory T cells （mreg） have been shown to play an important role in the regulation of hematopoietic activity. However, there is no information about the effect of Treg cells in the pathogenesis of polycythaemia vera （PV）. Methods In this study, we investigated the percentage and function of Treg cells in the peripheral blood of 21 PV patients and 25 healthy donors, mreg cells were identified and characterized as CD4^＋CD25^＋FOXP3^＋ by flow cytometry. The suppressive activity of CD4^＋CD25^＋ Treg cells was assessed by the proliferation and cytokine secretion of the co-cultured CD4^＋CD25^- fractions. Results The results showed that the percentage of Treg cells in the peripheral blood of PV patients significantly increased compared to healthy controls （（10.93±4.02）% vs （5.86±1.99）%, P 〈0.05）. Moreover, the mRNA and protein expression of FOXP3 was higher in CD4^＋CD25^＋ Treg cells. Coordinately, when co-cultured with the activated CD4^＋CD25^- cells, the CD4^＋CD25^＋ Treg cells showed enhanced suppressive function in PV. Yet, the underlying mechanism for the increased frequency and function of CD4^＋CD25^＋ Treg cells is still to be clarified. Conclusion Treg cells expansion might account for the abnormal T cell immunity in PV patients and thus contribute to the pathogenesis of PV.

关键词： polycythaemia vera regulatory T cells pathogenesis

Study on yan-xin wang’s medication experience and regularity in treating Insomnia from the liver based on data mining

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TMR Integrative Medicine 2023年第17期7卷 1-9页

作者： yan-yan Chen yan-xin wang Man Wen Zheng Yu Jing-Jing Wu First Clinical Medical College Anhui University of Chinese MedicineHefei 230031China Department of Neurology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031China

Background:Professor yan-xin wang has been committed to the use of traditional Chinese medicine formulas to treat insomnia from the liver for many years,and has achieved excellent clinical *** order to better inherit yan-xin wang’s academic *** purpose of this study is to use clinical data to explore the clinical experience of ***-xin wang in the application of Chinese medicine to treat insomnia patients from the liver,explore the compatibility and medication rules of traditional Chinese medicine,and give more clinical treatment ideas for ***:The general data and prescription information of insomnia patients treated with Chinese herbal medicine by ***-xin wang from January 1,2021,to December 31,2021,were summarized according to the inclusion and exclusion criteria,and the data were subjected to frequency statistics and drug association rules,complex network diagram analysis and cluster ***:A total of 159 patients and prescriptions were included in the study,of which 81.1%were women and 18.9%were men,containing 128 herbs;the highest frequency of use was 91.8%for Bupleuri *** Chinese herbs were used more than 70%of the time,namely Bupleuri Radix,Scutellariae Radix,oyster shell,Glycyrrhizae Radix,Os Draconis,and Ziziphi Spinosae *** top 20 herbs in terms of frequency of use were analyzed in terms of the four Qi,five flavours,and their *** four Qi were mainly calm and warm,the five flavours were mainly bitter and acrid,followed by sweet,and the attributions were mainly to the liver,spleen,and heart *** Chinese medicine association rules set the confidence level>80%and the support level>10%,resulting in 10 two-herb and three-herb associations with the highest confidence level,such as Os Draconis is associated with oyster shell,Platycodonis Radix is associated with Achyranthis Bidentatae Radix,Scutellariae Radix is associated with Bupleuri Radix,Os Draconis,Bupleuri Radix is associated

关键词： data mining insomnia liver-based treatment medication patterns

LINE-1 family member GCRG123 gene is up-regulated in human gastric signet-ring cell carcinoma

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World Journal of Gastroenterology 2008年第5期14卷 758-763页

作者： Gang-Shi wang Meng-Wei wang Ben-yan Wu xin-yan yang Wei-Hua wang Wei-Di You Department of Gerontal Gastroenterology General Hospital of Chinese PLA Beijing 100853 China

AIM： To analyze the expression profiles of a human gastriccancer-related gene, GCRG123, in human gastric signetring cell carcinoma tissues, and to perform bioinformatics analysis on GCRG123.METHODS： In situ hybridization was used to explore the GCRG123 expression pattern in paraffin-embedded gastric tissues, including 15 cases of signet-ring cell carcinoma, 15 of intestinal-type adenocarcinoma, and 15 of normal gastric mucosa. Northern blotting was used to analyze the differences in GCRG123 expression between stomach signet-ring cell carcinoma and intestinal-type adenocarcinoma tissues. Online software, including BLAST, Multalin and BLAT, were applied for bioinformatics analysis. National Center for Biotechnology Information （NCBI） and the University of California Santa Cruz （UCSC） databases were used for the analyses.RESULTS： The in situ hybridization signal appeared as blue precipitates restricted to the cytoplasm. Ten out of 15 cases of gastric signet ring cell carcinoma, normal gastric mucosal epithelium and pyloric glands showed high GCRG123 expression. Low GCRG123 expression was observed in gastric intestinal-type adenocarcinoma and normal gastric glands. Northern blotting revealed that GCRG123 was up-regulated in signet-ring cell carcinoma tissue but down-regulated in intestinal-type adenocarcinoma tissue. BLAST and Multalin analyses revealed that the GCRG123 sequence had 92% similarity with the ORF2 sequence of human long interspersed nuclear element retrotransposons （LINE-1, L1）. BLAT analysis indicated that GCRG123 mapped to all chromosomes. GCRG123 was found to integrate in the intron-17 and -23 of Rb, 5＇ flanking region of IL-2 and clotting factor Ⅸ genes.CONCLUSION： GCRG123, an active member of the Lt family, was up-regulated in human gastric signet-ring cell carcinoma.

关键词： Stomach Signet-ring cell carcinoma GCRG123 LINE-1 In situ hybridization Bioinformatics

Improved Performance in Differentiating Benign from Malignant Sinonasal Tumors Using Diffusion-weighted Combined with Dynamic Contrast-enhanced Magnetic Resonance Imaging

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Chinese Medical Journal 2015年第5期128卷 586-592页

作者： xin-yan wang Fei yan Hui Hao Jian-xing Wu Qing-Hua Chen Jun-Fang Xian Department of Radiology Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Radiology Beijing Tongren Hospital Capital Medical University Beijing 100730 China Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Capital Medical University Beijing 100069 China

Background：Differentiating benign from malignant sinonsal lesions is essential for treatment planning as well as determining the patient＇s prognosis,but the differentiation is often difficult in clinical *** study aimed to determine whether the combination of diffusion-weighted （DW） and dynamic contrast-enhanced magnetic resonance imaging （DCE-MRI） can improve the performance in differentiating benign from malignant sinonasal ***：This retrospective study included 197 consecutive patients with sinonasal tumors （116 malignant tumors and 81 benign tumors）.All patients underwent both DW and DCE-MRI in a 3-T magnetic resonance *** different settings ofb values （0,700 and 0,1000 s/mm^2） and two different strategies of region of interest （ROI） including whole slice （WS） and partial slice （PS） were used to calculate apparent diffusion coefficients （ADCs）.A DW parameter with WS ADCsb0.1000 and two DCE-MRI parameters （time intensity curve [TIC] and time to peak enhancement [Tpeak]） were finally combined to use in differentiating the benign from the malignant tumors in this ***：The mean ADCs of malignant sinonasal tumors （WS ADCsb0,1000=1.084 × 10^-3 mm^2/s） were significantly lower than those of benign tumors （WS ADCsb0,1000=1.617 × 10^-3 mm^2/s,P 〈 0.001）.The accuracy using WS ADCsb0,1000 alone was 83.7% in differentiating the benign from the malignant tumors （85.3% sensitivity,81.2% specificity,86.4% positive predictive value [PPV],and 79.5% negative predictive value [NPV]）.The accuracy using DCE with Tpeak and TIC alone was 72.1% （69.1% sensitivity,74.1% specificity,77.5% PPV,and 65.1% NPV）.Using DW-MRI parameter was superior than using DCE parameters in differentiation between benign and malignant sinonasal tumors （P 〈 0.001）.The accuracy was 87.3% （90.5% sensitivity,82.7% specificity,88.2% PPV,and 85.9% NPV） using DW-MRI combined with DCE-MRI,which was superior than that using DCE-MRI alone or using DW-MRI alone （both P 〈 0.001） in d

关键词： Diffusion-weighted Dynamic Contrast-enhanced Magnetic Resonance Imaging Nasal Cavity Neoplasm, Paranasal Sinus

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交会对接模拟系统姿态位置耦合有限时间控制

控制与决策 2017年第10期32卷 1789-1795页

作者：黄成王岩周乃新哈尔滨工业大学控制科学与工程系哈尔滨150001

针对航天器交会对接模拟系统的姿态同步和位置跟踪控制问题,在存在外界扰动和系统不确定性的情况下,基于改进的快速非奇异终端滑模面和改进的自适应律,采用双闭环控制结构分别设计内环和外环有限时间姿态位置耦合控制器.所提出的自适应... 详细信息

针对航天器交会对接模拟系统的姿态同步和位置跟踪控制问题,在存在外界扰动和系统不确定性的情况下,基于改进的快速非奇异终端滑模面和改进的自适应律,采用双闭环控制结构分别设计内环和外环有限时间姿态位置耦合控制器.所提出的自适应律不仅能有效地抑制扰动和不确定性且能保证控制器是连续的.李雅普诺夫理论推导和仿真结果表明,所提出的控制方法能保证系统内环和外环跟踪误差的有限时间稳定性和准确收敛性.

关键词：交会对接姿态位置耦合有限时间收敛终端滑模

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四川若尔盖大骨节病区水环境致病因素

地球科学（中国地质大学学报） 2010年第5期35卷 867-872页

作者：甘义群郭欣欣王焰新中国地质大学环境学院湖北武汉430074 中国地质大学生物地质与环境地质教育部重点实验室湖北武汉430074

为了从水环境的角度阐述大骨节病的成因机制,以大骨节病高发的四川省若尔盖县为研究区,系统采集了作为饮用水源的地下水和地表水样38件,测试了其化学成分,发现水中的常规组分和微量组分都偏低,且饮用地表水较地下水更容易患病.通过水化... 详细信息

为了从水环境的角度阐述大骨节病的成因机制,以大骨节病高发的四川省若尔盖县为研究区,系统采集了作为饮用水源的地下水和地表水样38件,测试了其化学成分,发现水中的常规组分和微量组分都偏低,且饮用地表水较地下水更容易患病.通过水化学特征分析,表明水环境中多种组分含量异常是导致病发的重要因素,并从水动力和水化学方面解释了其组分含量异常的原因.采用因子分析的方法,结合当地的区域水文地质条件,进一步揭示了大骨节病发生机制与饮用水中P、F、Se和Mn4种组分的含量密切相关,饮用水中这4种组分含量越低,大骨节病的发病率就越高.

关键词：大骨节病水文地球化学因子分析若尔盖致病因素

当代中国马克思主义哲学研究范式转换的基础与原则

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河北学刊 2007年第6期27卷 7-10页

作者：庄友刚苏州大学哲学系江苏苏州215123

　　在当代,尤其是在当代中国,马克思主义哲学研究范式的转换与创新成为理论界的热点话题,马克思主义哲学研究中各种新的范式被不断提出来重新阐释和建构马克思主义哲学.……

关键词：马克思主义哲学研究范式转换与创新