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Adaptive Robust Servo Control for Vertical Electric Stabilization System of Tank and Experimental Validation

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Defence Technology（防务技术） 2024年第1期31卷 326-342页

作者： Darui lin Xiuye wang Yimin wang Guolai yang School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094China

A tracking stability control problem for the vertical electric stabilization system of moving tank based on adaptive robust servo control is *** paper mainly focuses on two types of possibly fast timevarying but bounded uncertainty within the vertical electric stabilization system:model parameter uncertainty and uncertain ***,the vertical electric stabilization system is constructed as an uncertain nonlinear dynamic system that can reflect the practical mechanics transfer process of the ***,the dynamical equation in the form of state space is established by designing the angular tracking ***,the comprehensive parameter of system uncertainty is designed to estimate the most conservative effects of ***,an adaptive robust servo control which can effectively handle the combined effects of complex nonlinearity and uncertainty is *** feasibility of the proposed control strategy under the practical physical condition is validated through the tests on the experimental *** paper pioneers the introduction of the internal nonlinearity and uncertainty of the vertical electric stabilization system into the settlement of the tracking stability control problem,and validates the advanced servo control strategy through experiment for the first time.

关键词： Adaptive robust servo control Experimental validation Nonlinearity compensation System uncertainty Vertical electric stabilization system

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Dynamics modeling and optimal control for multi-information diffusion in Social Internet of Things

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Digital Communications and Networks 2024年第3期10卷 655-665页

作者： Yaguang lin Xiaoming wang Liang wang Pengfei Wan School of Computer Science Shaanxi Normal UniversityXi'an710119China

As an ingenious convergence between the Internet of Things and social networks,the Social Internet of Things(SIoT)can provide effective and intelligent information services and has become one of the main platforms for people to spread and share ***,SIoT is characterized by high openness and autonomy,multiple kinds of information can spread rapidly,freely and cooperatively in SIoT,which makes it challenging to accurately reveal the characteristics of the information diffusion process and effectively control its *** this end,with the aim of exploring multi-information cooperative diffusion processes in SIoT,we first develop a dynamics model for multi-information cooperative diffusion based on the system dynamics theory in this ***,the characteristics and laws of the dynamical evolution process of multi-information cooperative diffusion are theoretically investigated,and the diffusion trend is *** this basis,to further control the multi-information cooperative diffusion process efficiently,we propose two control strategies for information diffusion with control objectives,develop an optimal control system for the multi-information cooperative diffusion process,and propose the corresponding optimal control *** optimal solution distribution of the control strategy satisfying the control system constraints and the control budget constraints is solved using the optimal control ***,extensive simulation experiments based on real dataset from Twitter validate the correctness and effectiveness of the proposed model,strategy and method.

关键词： Social Internet of Things Information diffusion Dynamics modeling Trend prediction Optimal control

TCP-1,a novel peptide to diagnose early colon cancer

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Chinese Chemical Letters 2024年第3期35卷 226-233页

作者： Hang Yu Baoying Wen Min Huang Ru Feng Libin Pan Manyi Xu Hao lin lin Cong Sen Zhang yan Li Chi-Hin Cho Chongjing Zhang Xiaoguang Chen yan wang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical SciencesBeijing 100050China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong KongChina

A nine cyclic peptide(TCP-1)showed excellent specificity for colon ***-1 binds with human tumor tissues at early stages and mice tumor with diameters of 1-4 mm,suggesting that TCP-1 may be used for early diagnosis of colon *** mechanism of the targeted binding of TCP-1 to colon cancer was also studied using immunoprecipitation,LC-MS and *** screening and identifying of the possible binding target proteins of TCP-1,keratin,typeⅡcytoskeletal 5 was speculated to be the specific binding target protein of TCP-1 in human tumor *** studies were conducted to investigate the target-mediated drug disposition of the new tumor-specific peptide by LC-MS/*** tissue distribution study showed that TCP-1 was found only in colon tumors(the target site)in tumor mice did not bind to any other *** TCP-1 to tumor markedly increased its removal rate from blood circulation but mildly extended its staying time in *** tumor mice,a lower AUC of TCP-1(reduced by almost 35%)and 2-fold higher clearance were found compared to that of normal *** proposed metabolic pathway of TCP-1 in the kidney was also determined using LC-MS^(n)-*** high specificity and low toxicity of the peptide may be caused by its extremely tight binding to the *** applications for future clinical use,including MRI and PET/CT were also explored,and this research may promote the development of colon cancer diagnostic technology research and provide new ideas and technical routes for tumor diagnostic technology.

关键词： Colon cancer TCP-1 Peptide Cytokeratin 5 Pharmacokinetics/pharmacodynamics(PK/PD)

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Amplification effect of intra-seasonal variability of soil moisture on heat extremes over Eurasia

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Advances in Climate Change Research 2024年第1期15卷 1-8页

作者： Yi-Nuo wang Zhi-yan ZUO Liang QIAO Kai-Wen ZHANG Mei-Yu CHANG Dong XIAO Zou-Xing lin Huan wang Department of Atmospheric and Oceanic Sciences Institute of Atmospheric SciencesFudan UniversityShanghai 200438China CMA-FDU Joint Laboratory of Marine Meteorology Shanghai 200438China Key Laboratory of Cites Mitigation and Adaptation to Climate Change in Shanghai China Meteorological AdministrationShanghai 200030China Collaborative Innovation Centeron Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 211800China Shanghai Frontiers Science Center of Atmosphere-Ocean Interaction Shanghai 200123China College of Geography and Resources Science Sichuan Normal UniversityChengdu 610101China National Observations and Research Station for Wetland Ecosystems of the yangtze Estuary Shanghai 202183China Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081China

Drying soil has been conducive to a high frequency of extreme high-temperature events over many regions worldwide in recent ***,changes in the intraseasonal variability of soil moisture can also influence the likelihood of extremely high *** previous investigators have examined the association between extremely high temperatures and large-scale atmospheric circulation variability,the role of land-atmosphere coupling dominated by soil moisture variability in extremely high temperatures,particularly over the Eurasian continent,is not well *** this study,on the basis of the Land Surface,Snow,and Soil Moisture Model Intercomparison Project,we found that land-atmosphere feedback amplified the variability of soil moisture in most regions of Eurasia during summer from 1980 to *** amplification of soil moisture variability is closely correlated with more intensive intraseasonal variability of surface air temperature and more frequent occurrences of extreme high-temperature events,particularly in Europe,Siberia,Northeast Asia,and the Indochina *** correlation implies that increasing the intraseasonal variability of soil moisture results in a high likelihood of heat extremes during summer in most parts of Eurasia except Asian desert *** the intraseasonal timescale,the land-atmosphere coupling increases the variability of surface sensible heat flux and net long-wave radiation heating the atmosphere by intensifying the soil moisture variability,thus amplifying the variability of surface air temperature and enhancing the extreme high-temperature *** finding demonstrates the importance of changes in intraseasonal soil moisture variability for the increasing likelihood of heat extremes in summer.

关键词： Soil moisture Intraseasonal variability Land-atmosphere coupling Heat extremes

Penpulimab,an anti-PD-1 antibody,for heavily pretreated metastatic nasopharyngeal carcinoma:a single-arm phase II study

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3056-3062页

作者： Xiaozhong Chen Wei wang Qingfeng Zou Xiaodong Zhu Qin lin Yi Jiang yan Sun Liangfang Shen lin wang Guorong Zou Xiaoyan lin Shaojun lin Minying Li Ying wang Ruilian Xu Rui Ao Rensheng wang Haifeng lin Shuang Huang Tingting Xu Wenting Li Mengying Xia Yu Xia Zhongmin wang Baiyong Li Jingao Li Chaosu Hu Department of Radiation Oncology Cancer Hospital of the University of ChineseAcademy of Sciences(Zhejiang Cancer Hospital)HangzhouChina Gastroenterology and Urology Department II Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaChina Clinical Research Center for Gastrointestinal Cancer in Hunan Province ChangshaChina Department of Medical Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhouChina Department of Radiation Oncology Guangxi Medical University Affiliated Tumor Hospital&Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University)Ministry of Education&Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorGuangxi Medical UniversityNanningChina Department of Radiation Oncology Cancer CenterThe First Affiliated Hospital of Xiamen UniversityXiamenChina Department of Medical Oncology Cancer Hospital of Shantou University Medical CollegeShantouChina Department of Radiation Oncology Peking University Cancer Hospital&InstituteBeijingChina Department of Oncology Xiangya Hospital Central South UniversityChangshaChina Department of Medical Oncology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikouChina Department of Oncology The Affiliated Panyu Central Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Medical Oncology Fujian Medical University Union HospitalFuzhouChina Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhouChina Department of Radiation Therapy for Thoracic Tumors Zhongshan City People’s HospitalZhongshanChina Tumor Radiotherapy Center Chongqing University Cancer HospitalChongqing Cancer HospitalChongqing Cancer InstituteChongqingChina Department of Oncology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSo

Penpulimab is an anti-programmed cell death-1(PD-1)IgG1 antibody with no Fc gamma receptor(FcγR)binding activity,and thus theoretically reduced immune-related adverse events(irAEs)while maintaining *** single-arm,phase II trial conducted across 20 tertiary care centers in China enrolled adult patients with metastatic nasopharyngeal carcinoma(NPC)who had failed two or more lines of previous systemic *** received 200-mg penpulimab intravenously every 2 weeks(4 weeks per cycle)until disease progression or intolerable *** primary endpoint was objective response rate(ORR)per RECIST(version 1.1),as assessed by an independent radiological review *** secondary endpoints included progression-free survival(PFS)and overall survival(OS).One hundred thirty patients were enrolled and 125 were efficacy *** the data cutoff date(September 28,2022),1 patient achieved complete response and 34 patients attained partial *** ORR was 28.0%(95%CI 20.3–36.7%).The response was durable,with 66.8%still in response at 9 ***-three patients(26.4%)were still on *** median PFS and OS were 3.6 months(95%CI=1.9–7.3 months)and 22.8 months(95%CI=17.1 months to not reached),***(7.6%)patients experienced grade 3 or higher *** has promising anti-tumor activities and acceptable toxicities in heavily pretreated metastatic NPC patients,supporting further clinical development as third-line treatment of metastatic NPC.

关键词： metastatic nasopharyngeal supporting

Clinical analysis of colistin sulfate in the treatment of pneumonia caused by carbapenem-resistant Gram-negative bacteria

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World Journal of Clinical Cases 2024年第13期12卷 2173-2181页

作者： Hai-Chang Xu yan Cui Xue-Ying wang Hai-Bo Wu Wei Li Dan wang Na lin lin lin Ying-Hui Zhang Department of Intensive Care Medicine The General Hospital of the Northern Theater Command of the People's Liberation Army of ChinaShenyang 110016Liaoning ProvinceChina

BACKGROUND Multidrug-resistant Gram-negative bacteria,exacerbated by excessive use of antimicrobials and immunosuppressants,are a major health *** To study the clinical efficacy and safety of colistin sulfate in the treatment of carbapenem-resistant Gram-negative bacilli-induced pneumonia,and to provide theoretical reference for clinical diagnosis and *** This retrospective analysis involved 54 patients with Gram-negative bacilli pneumonia admitted to intensive care unit of The General Hospital of the Northern Theater Command of the People's Liberation Army of China from August 2020 to June *** bacteriological culture,the patients'airway secretions were collected to confirm the presence of Gram-negative *** patients were divided into the experimental and control groups according to the medication *** research group consisted of 28 patients who received polymyxin sulfate combined with other drugs through intravenous,nebulization,or intravenous combined with nebulization,with a daily dosage of 1.5–3.0 million *** control group consisted of 26 patients who received standard dosages of other antibiotics(including sulbactam sodium for injection,cefoperazone sodium sulbactam for injection,tigecycline,meropenem,or vaborbactam).RESULTS Of the 28 patients included in the research group,26 patients showed improvement,treatment was ineffective for two patients,and one patient died,with the treatment efficacy rate of 92.82%.Of the 26 patients in the control group,18 patients improved,treatment was ineffective for eight patients,and two patients died,with the treatment efficacy rate of 54.9%;significant difference was observed between the two groups(P<0.05).The levels of white blood cell(WBC),procalcitonin(PCT),and C-reactive protein(CRP)in both groups were significantly lower after treatment than before treatment(P<0.05),and the levels of WBC,PCT,and CRP in the research group were significantly lower than those in the control group

关键词： Colistin sulfate Extensively drug-resistant Pneumonia Intravenous combined with nebulization Sepsis Nephrotoxicity Neurotoxicity

Pixels from two-dimensional vermiculite mineral

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National Science Review 2024年第6期11卷 98-99页

作者： yan wang Manish Chhowalla Materials Science & Metallurgy University of Cambridge

Vermiculite is a common mica-like mineral that is used in a wide variety of applications such as an additive to garden soil, building insulation, and lightweight concrete aggregate [1]. Its layered structure can be exfoliated down to very thin layers. The optical and electronic properties of vermiculite were thought to be unremarkable.

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LncFASA promotes cancer ferroptosis via modulating PRDX1 phase separation

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Science China(Life Sciences) 2024年第3期67卷 488-503页

作者： Xiao Fan Fangzhou Liu Xiang wang Ying wang Yu Chen Chengyu Shi Xinwan Su Manman Tan Qingfeng yan Jinrong Peng Jianzhong Shao yan Xiong Aifu lin MOE Laboratory of Biosystem Homeostasis and Protection College of Life SciencesZhejiang UniversityHangzhou 310058China Key Laboratoryof Cancer Prevention and Intervention China National Ministry of EducationHangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310058China Key Laboratory for Cell and Gene Engineering of Zhejiang Province Hangzhou 310058China Department of Central Laboratory the First People's Hospital of HuzhouHuzhou 313000China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Affiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006China MOE Key Laboratory for Molecular Animal Nutrition College of Animal SciencesZhejiang UniversityHangzhou 310058China Department of Orthopedic Surgery the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310000China Breast Center of the First Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310003China International School of Medicine International Institutes of MedicineThe 4th Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China

Ferroptosis, a unique type of non-apoptotic cell death resulting from iron-dependent lipid peroxidation, has a potential physiological function in tumor suppression, but its underlying mechanisms have not been fully elucidated. Here, we report that the long non-coding RNA(lncRNA) LncFASA increases the susceptibility of triple-negative breast cancer(TNBC) to ferroptosis. As a tumor suppressor, LncFASA drives the formation of droplets containing peroxiredoxin1(PRDX1), a member of the peroxidase family, resulting in the accumulation of lipid peroxidation via the SLC7A11-GPX4 axis. Mechanistically, LncFASA directly binds to the Ahpc-TSA domain of PRDX1, inhibiting its peroxidase activity by driving liquid-liquid phase separation, which disrupts intracellular ROS homeostasis. Notably, high LncFASA expression indicates favorable overall survival in individuals with breast cancer, and LncFASA impairs the growth of breast xenograft tumors by modulating ferroptosis. Together, our findings illustrate the crucial role of this lncRNA in ferroptosis-mediated cancer development and provide new insights into therapeutic strategies for breast cancer.

关键词： long non-coding RNA peroxiredoxin liquid-liquid phase separation ferroptosis breast cancer

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Granular collapse in fluids:Dynamics and flow regime identification

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Particuology 2024年第9期92卷 30-41页

作者： Hu Tang Bisong lin Dengming wang Department of Mechanics and Engineering Science School of Civil Engineering and MechanicsKey Laboratory of Mechanics on Disaster and Environment in Western China of Ministry of EducationLanzhou UniversityLanzhou730000China

The collapse of granular material in fluids is a prevalent phenomenon in both natural and industrial processes,displaying a notable sensitivity to initial configuration of the *** study is specifically oriented towards falling process of collapsing material under various fluid conditions,employing the computational fluid dynamics-discrete element method(CFD-DEM)to primarily investigate the dynamics and scaling laws of deposit morphology of collapsed *** a comprehensive analysis of particle sedimentation in fluids,we introduce a refined inertial characteristic time for granular collapse within the inertial ***,we propose modifications to conventional fluid-particle density ratio and Reynolds number,aiming to enhance the accuracy of depicting collapse dynamics and identifying flow regimes across diverse column heights and fluid ***,we construct a phase diagram of flow regimes using modified dimensionless numbers,emphasizing the role of column height in transition between viscous and inertial *** parameters demonstrate enhanced relevance in governing the collapse of immersed granular columns,thereby contributing to a more nuanced understanding of fluid-particle interations in dense granular flows under different regimes.

关键词： Immersed granular material Collapse Dynamic Flow regime Computational fluid dynamics-discrete element method