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Global Burden of Cardiovascular Disease Attributable to High Temperature in 204 Countries and Territories from 1990 to 2019

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Biomedical and Environmental Sciences 2023年第3期36卷 222-230页

作者： HONG Le yaN Miao Miao ZHANG Yun Quan wang Kai wang ya qi LUO Si qi wang Fang Department of Epidemiology and Biostatistics School of Public HealthWuhan University of Science and TechnologyWuhan 430065HubeiChina Department of Biostatistics School of Public HealthXuzhou Medical UniversityXuzhou 221004JiangsuChina

Objective This study aimed to estimate spatiotemporal variations of global heat-related cardiovascular disease(CVD)burden from 1990 to *** Data on the burden of heat-related CVD were derived from the Global Burden of Disease Study *** and disability-adjusted life years(DALYs)were used to quantify heat-induced CVD *** calculated the age-standardized mortality rate(ASMR)and DALY rate(ASDR)per 100,000population to compare this burden across *** linear models were applied to evaluate estimated annual percentage changes(EAPC)for temporal trends from 1990 to *** correlation between the socio-demographic index(SDI)and age-standardized rate was measured using the Spearman rank *** Heat-induced CVD caused approximately 90 thousand deaths worldwide in *** ASMR and ASDR of heat-related CVD in 2019 were 1.17[95%confidence interval(CI):0.13-1.98]and 25.59(95%CI:2.07-44.17)per 100,000 population,*** burden was significantly increased in middle and low-SDI regions and slightly decreased in high-SDI regions from 1990 to *** showed an upward trend,with the most considerable increase in low-latitude *** observed a negative correlation between SDI and EAPC in ASMR(rs=-0.57,P<0.01)and ASDR(rs=-0.59,P<0.01)among204 *** Heat-attributable CVD burden substantially increased in most developing countries and tropical regions.

关键词： High temperature Cardiovascular disease Global disease burden Climate change

Dynamic Framed Slotted ALOHA Algorithm Used in RFID System

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南京邮电大学学报（自然科学版） 2010年第1期30卷 26-32页

作者： wang ya-qi JIANG Guo-ping College of Automation Nanjing University of Posts and Telecommunications Nanjing 210003China

In radio frequency identification(RFID) systems,one of the most widely used anti-collision algorithms is the dynamic framed slotted ALOHA(DFSA)algorithm which usually uses two methods,one is tag estimation method (TEM) which estimates the number of tags around the reader,and the other is dynamic slot allocation (DSA) method which is the method to dynamically allocate the frame size according to the number of *** can achieve optimal system performance when the frame size is equal to the number of *** the number of tags becomes large,DFSA is not practical to increase the frame size infinitely,thus the application of DFSA algorithm is *** this paper a TEM method and a DSA method are proposed from two novel aspects respectively in order to use DFSA algorithm more effectively,and the analysis and comparison are given ***,the improved DFSA algorithm is proposed to solve the problem of DFSA *** the number of tags is large,if the improved DFSA algorithm is applied,the system efficiency that can be attained is not less than 50%.

关键词： ALOHA 通信网网络安全 RFID

Adjuvant Effects of Recombinant Plasmids of Porcine IL-4 and IFN-γ to Cysticercosis cellulosae Vaccines in Mice and Pigs

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Agricultural Sciences in China 2010年第1期9卷 130-137页

作者： JING Zhi-zhong DOU Yong-xi MENG Xue-lian CHEN Guo-hua wang Pei-ya LUO qi-hui YUAN Gai-ling ZHENG ya-dong CAI Xue-peng Key Laboratory of Animal Parasitology of Gansu Province/Key Laboratory of Veterinary Public Health Ministry of Agriculture/State Key Laboratory of Veterinary Etiological Biology/Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou 730046. P.R.China

To investigate the adjuvant potential of porcine IL-4 and IFN-γ in mice and pigs, the genes of porcine IL-4 and IFN-γ were cloned and the recombinant mammalian expression plasmids were constructed for in vivo expression of the cytokines. Adjuvant effects of recombinant expression plasmids of IL-4 and IFN-γ （pcDNA-IL-4, pcDNA-IFN-γ） co-administrated with Cysticercus cellulosae crude antigen or TSOL18 recombinant protein antigen have been carried out in mice and pigs, respectively. We have demonstrated that recombinant plasmids of the cytokines as an adjuvant could induce stronger immune response in mice and pigs. With the C. cellulosae parasite antigen, porcine pcDNA-IL-4 induced higher specific antibody of immunized mice than pcDNA-IFN-γ. But pcDNA-IFN-γ is significantly stronger than that of no adjuvant or empty plasmids with the antigen control group. For the TSOL18 recombinant protein antigen vaccine, pcDNA-IL-4 still had a stronger ability to enhance specific antibody in swine than pcDNA-IFN-γ （P 〈 0.01）, but the immune protective rate was lower in challenged pigs （only 68.7%）. Although pcDNA-IFN-γ showed lower specific antibody, the protection rate was very high （91%） than other group （P 〈 0.01）. This study indicated that the recombinant expression plasmids of porcine IL-4 and IFN-γ display stronger adjuvant effects to C. cellulosae vaccine, further research should be carried out for understanding of the interaction mechanism.

关键词： porcine cytokines Cysticercosis cellulosae adjuvant effect immunity response

IGF-1 Accelerates Cell Aging by Inhibiting POLD1 Expression

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Biomedical and Environmental Sciences 2022年第11期35卷 981-991页

作者： HOU Yu Li wang Yi Fei SONG qiao ZHANG Xiao Min LIU Jing wang ya qi CUI Yu Ting FU Jing Xuan FENG Zi Yi ZHANG Chi wang Pei Chang Department of Clinical Laboratory Xuanwu HospitalNational Clinical Research Center for Geriatric DiseasesCapital Medical UniversityBeijing 100053China Clinical Laboratory Diagnostics Capital Medical UniversityBeijing 100053China

Objective The individual cascades of the insulin-like growth factor-1(IGF-1)signaling pathway and the molecular mechanism of aging have not been fully *** the current study,we explored the effect of DNA polymerase delta 1(POLD1)on the IGF-1 signaling pathway in cell *** First,we analyzed the relationship between IGF-1 and POLD1 expression in *** investigate the effect of IGF-1 on POLD1 expression and aging,the 2BS cells were incubated with youngage or old-age human serum,IGF-1 protein,or ***,the effect of IGF-1 on aging was examined in the 2BS cells with increased or decreased POLD1 expression to clarify the molecular *** In this study,we found that IGF-1 expression increased and POLD1 expression decreased with aging in human serum and hippocampal tissues of SAMP8 mice,and a negative relationship between IGF-1 and POLD1 expression was ***,the cells cultured with old-age human serum or IGF-1 showed lower POLD1 expression and more pronounced senescence characteristics,and the effect could be reversed by treatment with linsitinib or overexpression of POLD1,while the effect of linsitinib on cell aging could be reversed with the knockdown of *** Taken collectively,our findings demonstrate that IGF-1 promotes aging by binding to IGF-1R and inhibiting the expression of *** findings offer a new target for anti-aging strategies.

关键词： Insulin-like growth factor-1 DNA polymerase delta 1 Aging Linsitinib

TREM2:A Novel Potential Biomarker of Alzheimer's Disease

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Biomedical and Environmental Sciences 2021年第9期34卷 719-724页

作者： ZHANG Xiao Min LIU Jing CAO Min yaNG Ting Ting wang ya qi HOU Yu Li SONG qiao CUI Yu Ting wang Pei Chang Department of Clinical Laboratory Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Clinical Laboratory the Hospital of Shunyi District BeijingBeijing 101300China

Alzheimer’s disease(AD)is the most common type of neurodegenerative dementia worldwide[1].Deposition of extracellular amyloid proteinβ(Aβ)-producing amyloid plaques and intracellular tau aggregation-comprising neur... 详细信息

关键词： Alzheimer Aβ tau

Synthesis,Crystal Structure and Catalytic Activity Palladium(Ⅱ)Complexes Containing Bulky Azole Ligands

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Chinese Journal of Structural Chemistry 2020年第9期39卷 1669-1674,1556页

作者： ZHANG Meng-yao ZHANG Ying-Ying ZHANG Hui-Xin wang Shen wang ya-qi ZENG Yong-Fei LIU Gui-yan Tianjin Key Laboratory of Structure and Performance for Functional Molecules Key Laboratory of Inorganic-organic Hybrid Functional Material Chemistry(Tianjin Normal University)Ministry of EducationCollege of ChemistryTianjin Normal UniversityTianjin 300387China

Bulky azole ligands in combination with PdCl2 provide three new palladium(II)*** these complexes,as pre-catalysts,have high catalytic efficiency for the Suzuki-Miyaura cross-coupling reactions of sterically hindered aryl chlorides and good to high yields are obtained with low catalysts loadings(0.1 mol%)under mild conditions in air.

关键词： palladium(II)complexes crystal structure catalytic activity Suzuki-Miyaura cross-coupling sterically hindered aryl chlorides

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考虑网络流量的无标度网络病毒免疫策略研究

物理学报 2011年第6期60卷 6-13页

作者：王亚奇蒋国平南京邮电大学控制与智能技术研究中心南京210003 南京邮电大学自动化学院南京210003

考虑网络交通流量对病毒传播行为的影响,基于平均场理论研究无标度网络上的病毒免疫策略,提出一种改进的熟人免疫机理.理论分析表明,在考虑网络交通流量影响的情况下,当免疫节点密度较小时,随机免疫几乎不能降低病毒的传播速率,而对网... 详细信息

考虑网络交通流量对病毒传播行为的影响,基于平均场理论研究无标度网络上的病毒免疫策略,提出一种改进的熟人免疫机理.理论分析表明,在考虑网络交通流量影响的情况下,当免疫节点密度较小时,随机免疫几乎不能降低病毒的传播速率,而对网络实施目标免疫则能够有效抑制病毒的传播,并且选择度最大的节点进行免疫与选择介数最大的节点进行免疫的效果基本相同.研究还发现,对于网络全局信息未知的情况,与经典熟人免疫策略相比,所提出的免疫策略能够获得更好的免疫效果.通过数值仿真对理论分析进行了验证.

关键词：无标度网络病毒传播交通流量免疫策略

Fabrication of Negative Charged Poly(Ethylene glycol)-diacrylate Hydrogel as a Bone Tissue Engineering scaffold

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世界最新医学信息文摘 2016年第18期16卷 1-4页

作者： wang ya-qi LIU Jie TAN Fei XIE Wei Department of Prosthodontics The affiliated hospital of Qingdao universityQingdao University

Objective To improve the cell attachment of PEGDA hydrogel,the SMAS small molecule was used to modify the PEGDA *** charged hydrogel would show improved cell attachment and enhanced protein adsorption caused by enhancement of electrostatic *** In this study,a series of charged hydrogels were produced by adding different concentrations of charged small molecule monomer into the PEGDA ***,we investigate the physicochemical and biological characteristics of charged hydrogels,including FTIR,swelling ratio,contact angle,cell *** The results indicate that the charged monomer had been successfully incorporated into PEGDA ***,the protein adsorption of the hydrogel increased with increasing concentration of charge ***,compared to PEGDA hydrogel,the cell attachment significantly improved on the charged *** The charged hydrogel would be a promising scaffold candidate for bone tissue engineering.

关键词： Tissue engineering Charged hydrogel Charge

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风险社会视域下全球治理的不确定性探析

东北亚论坛 2022年第3期31卷 44-59,127页

作者：王亚琪南开大学周恩来政府管理学院天津300350

当前,全球各领域风险积聚联动,不确定性显著上升,全球治理体系变革的必要性凸显。本文引入风险社会理论范式,提出全球治理的不确定性是在人类活动的全球性和现代社会制度的高度复杂性共同催生的全球风险下,既有治理体系的风险认知和管... 详细信息

当前,全球各领域风险积聚联动,不确定性显著上升,全球治理体系变革的必要性凸显。本文引入风险社会理论范式,提出全球治理的不确定性是在人类活动的全球性和现代社会制度的高度复杂性共同催生的全球风险下,既有治理体系的风险认知和管控机制失灵,进而引发的各治理领域中不可有效预测、缺少规律性和必然性的状态和趋势的总和。具有来源人为化、作用方式制度化和影响范围超时空延伸的主要特征。以国际关系学科的不确定性研究视角审视,全球治理的不确定性不仅源于行为体有限理性,而且应被阐释为全球风险在体系层次引发的复杂系统效应。为有效消减全球治理的不确定性,应变革基于工具理性的规则治理理念,重塑国家在全球治理中的角色定位,以共同发展为导向建设包容型治理体系,构建全球共同风险下的命运共同体。

关键词：全球治理不确定性风险风险社会世界秩序人类命运共同体