检索结果-南通市图书馆

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue Yuejia Ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Depolymerization of actin cytoskeleton is involved in stomatal closure-induced by extracellular calmodulin in Arabidopsis

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2004年第5期47卷 454-460页

作者： XIAO Yumei1, chen Yuling1,2, HUANG Rongfeng3, chen Jia1 & wang xue-chen1 1. The National Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Bei-jing 100094, China 2. College of Life Sciences, Hebei Normal University, Shijiazhuang 050016, China 3. Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China 1. The National Key Laboratory of Plant Physiology and Biochemistry College of Biological Sciences China Agricultural University 100094 Beijing China 2. College of Life Sciences Hebei Normal University 050016 Shijiazhuang China 3. Biotechnology Research Institute Chinese Academy of Agricultural Sciences 100081 Beijing China

Extracellular calmodulin (CaM) plays significant roles in many physiological proc-esses,but little is known about its mechanism of regulating stomatal movements. In this paper, whether CaM exists in the guard cell walls of Arabidopsis and whether depolymerization of actin cytoskeleton is involved in extracellular CaM-induced stomatal closing are investigated. It is found that CaM exists in guard cell walls of Arabidopsis, and its molecular weight is about 17 kD. Bioassay using CaM antagonists W7-agarose and anti-CaM serum shows that the endogenous extracellular CaM promotes stomatal closure and delays stomatal opening. The long radial actin filaments in guard cells undergo disruption in a time-dependent manner during exogenous CaM-induced stomatal closing. Pharmacological experiments show that depolymerization of ac-tin cytoskeleton enhances the effect of exogenous CaMinduced stomatal closing and polym-erization reduces the effect. We also find that exogenous CaM triggers an increase in [Ca2+]cyt of guard cells. If [Ca2+]cyt increase is blocked with EGTA, exogenous CaM-induced stomatal closure is inhibited. These results indicate that extracellular CaM causes elevation of [Ca2+]cyt in guard cells, subsequently resulting in disruption of actin filaments and finally leading to guard cells closure.

关键词： Arabidopsis,stomatal movements,extracellular calmodulin,actin,Ca2+.

苗族初中生反刍思维在正念与消极情绪间的中介作用:基于Bootstrap法的潜变量建模分析

在线全文

学校读者我要写书评

暂无评论

中国特殊教育 2017年第9期 64-68,42页

作者：万里川杨雪王凡陈维贵州师范大学教育科学学院贵阳550001

应用潜变量建模的方法探讨反刍思维在苗族初中生正念与消极情绪间的内在关系。选用正念注意觉知量表,积极消极情绪量表以及反刍思维量表对920名苗族初中生进行调查。研究结果表明:(1)苗族初中生的正念与消极情绪显著负相关;(2)反刍思维... 详细信息

应用潜变量建模的方法探讨反刍思维在苗族初中生正念与消极情绪间的内在关系。选用正念注意觉知量表,积极消极情绪量表以及反刍思维量表对920名苗族初中生进行调查。研究结果表明:(1)苗族初中生的正念与消极情绪显著负相关;(2)反刍思维在苗族正念对消极情绪的影响中发挥完全中介作用,其中介效应占总效应的74.5%。因此,苗族初中生的正念通过反刍思维影响个体的消极情绪。

关键词：正念消极情绪反刍思维 Bootstrap法中介效应

聚合温度对丙烯腈／丙烯酸甲酯共聚物结构与性能的影响

在线全文

学校读者我要写书评

暂无评论

高分子材料科学与工程 2009年第11期25卷 33-36页

作者：于万永韩娜王学晨张兴祥改性与功能纤维天津市重点实验室天津工业大学功能纤维研究所天津300160

在不同聚合温度下,以水相沉淀聚合法合成了丙烯腈与丙烯酸甲酯共聚物。采用差示扫描量热分析(DSC)、元素分析(EA)、核磁共振波谱分析(NMR)等方法对聚合物的组成和结构进行了表征。结果表明,不同的聚合温度对丙烯腈与丙烯酸甲酯共聚物的... 详细信息

在不同聚合温度下,以水相沉淀聚合法合成了丙烯腈与丙烯酸甲酯共聚物。采用差示扫描量热分析(DSC)、元素分析(EA)、核磁共振波谱分析(NMR)等方法对聚合物的组成和结构进行了表征。结果表明,不同的聚合温度对丙烯腈与丙烯酸甲酯共聚物的热力学行为、组成及序列长度产生一定的影响。相同的单体投料比,随着聚合温度的升高,共聚物中丙烯腈的摩尔含量降低,丙烯腈的数均序列长度减小。

关键词：丙烯腈丙烯酸甲酯共聚物温度序列长度

在线全文

学校读者我要写书评

暂无评论

固体推进剂整形过程工艺安全性的有限元分析

火炸药学报 2009年第6期32卷 87-90页

作者：李军赵孝彬王晨雪关红波程立国程新丽王宁航天工业固体推进剂安全技术研究中心湖北襄樊441003

为分析固体推进剂整形过程中的危险点,采用热-机械耦合对固体推进剂整形过程进行了模拟分析,基于固体推进剂药柱的黏弹性本构关系,揭示了整形过程中由于整形刀具挤压、摩擦引起的温度变化规律,计算了危险点。结果表明,固体推进剂整形温... 详细信息

为分析固体推进剂整形过程中的危险点,采用热-机械耦合对固体推进剂整形过程进行了模拟分析,基于固体推进剂药柱的黏弹性本构关系,揭示了整形过程中由于整形刀具挤压、摩擦引起的温度变化规律,计算了危险点。结果表明,固体推进剂整形温度随整形速度的增加而增加,当整形速度为10mm/s时,整形温度最高可达65℃;当整形厚度为1.0、1.5和2.5mm时,整形过程中的最高温度变化不明显。固体推进剂整形过程中的危险点出现在刀刃刚刚经过的药屑面上,而非刀具的刀刃上。

关键词：材料科学固体推进剂整形工艺安全性有限元

水分胁迫度及时期对设施延迟栽培葡萄耗水和产量的影响

在线全文

学校读者我要写书评

暂无评论

农业工程学报 2017年第1期33卷 155-161页

作者：张芮王旺田吴玉霞牛黎莉王俊林薛燕翎陈娜娜王菲甘肃农业大学工学院兰州730070 甘肃农业大学生命科学技术学院兰州730070 甘肃农业大学园艺学院兰州730070 张掖市水务局节水灌溉试验中心张掖730916

为研究水分胁迫对葡萄耗水规律和产量的影响,2012—2014年在甘肃省张掖市水务局灌溉试验站连续开展3 a设施栽培葡萄水分胁迫试验,将葡萄划分为萌芽、新梢生长、开花、果实膨大、着色成熟5个生育阶段,各生育期分别设1个土壤含水率下限为... 详细信息

为研究水分胁迫对葡萄耗水规律和产量的影响,2012—2014年在甘肃省张掖市水务局灌溉试验站连续开展3 a设施栽培葡萄水分胁迫试验,将葡萄划分为萌芽、新梢生长、开花、果实膨大、着色成熟5个生育阶段,各生育期分别设1个土壤含水率下限为55%的田间持水率(field water holding capacity,FC)供水水平(中度水分胁迫)和1个土壤含水率下限为65%FC的供水水平(轻度胁迫),以下限为75%FC为对照,研究3种供水水平下葡萄日耗水强度、产量、水分利用效率等的变化。结果表明:1)3个试验年度设施栽培葡萄在果实膨大期日耗水强度均达到最高值,该阶段为设施葡萄需水临界期。2)水分胁迫对葡萄各生育期耗水强度有明显的影响,萌芽期中度水分胁迫降低该阶段耗水强度,但随后复水后耗水量迅速恢复并出现复水补偿增长效应;开花期时间较短,中度水分胁迫对耗水的影响在随后生育期(果实膨大期)才体现出来;着色成熟期中度水分胁迫也显著降低葡萄在胁迫时段的耗水强度;新梢生长期轻度水分胁迫显著影响葡萄日耗水强度。3)2012年萌芽期中度胁迫能提高葡萄产量、水分利用效率,提高效应随胁迫年度持续逐渐减小,2013和2014年产量与充分供水处理差异不显著。研究可为深入理解设施栽培葡萄的耗水特性和设施葡萄节水高效生产提供依据。

关键词：胁迫水果灌溉设施栽培葡萄日耗水强度产量水分利用效率

Co-production of hydrogen, oxygen, and electricity via an integrated solar-driven system with decoupled water electrolyzer and Na-Zn ion battery

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 621-627页

作者： Fei Lv Longjie Liu Jiazhe Wu Pengfei wang Lixia Pan Dengwei Jing Yubin chen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Combining water electrolysis and rechargeable battery technologies into a single system holds great promise for the co-production of hydrogen （H2） and ***,the design and development of such systems is still in its ***,an integrated hydrogen-oxygen （O2）-electricity co-production system featuring a bipolar membrane-assisted decoupled electrolyzer and a Na-Zn ion battery was established with sodium nickelhexacyanoferrate （NaNiHCF） and Zn2+/Zn as dual redox *** decoupled electrolyzer enables to produce H2and O2in different time and space with almost 100%Faradaic efficiency at 100 mA ***,the charged NaNiHCF and Zn electrodes after the electrolysis processes formed a Na-Zn ion battery,which can generate electricity with an average cell voltage of 1.75 V at 10 m A *** connecting Si photovoltaics with the modular electrochemical device,a well-matched solar driven system was built to convert the intermittent solar energy into hydrogen and electric energy with a solar to hydrogen-electricity efficiency of 16.7%,demonstrating the flexible storage and conversion of renewables.

关键词： Hydrogen Electricity Decoupled water electrolyzer Na-Zn ion battery Solar energy

Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda Zhang Weimin Yuan Zhixing Ling Yong chen Nanda Rea Arne Rau Zhiming Cai Huaqing cheng Francesco Coti Zelati Lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue Li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng wang Lei Yang Bing Zhang chen Zhang Shuang-Nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier Liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong Li Bifang Liu Mingjun Liu Xing Liu Yuan Liu Zhu Liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria Lian Tao Junfeng wang Song wang Tinggui wang Zhongxiang wang Qingwen Wu xuefeng Wu Dong Xu Yanjun Xu Suijian xue Yongquan xue Zijian Zhang Zipei Zhu Hu Zou Congying Bao Fansheng chen Houlei chen Tianxiang chen Wei chen Yehai chen Yifan chen chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin chengkui Li Junfei Li Longhui Li Maoshun Li Wei Li Zhengda Li Tianying Lian Congzhan Liu Heyang Liu Huaqiu Liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan Liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao wang Juan wang Lei wang Wenxin wang Yilong wang Yusa wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin xue Yulong xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan Zhang Mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Ziliang Zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University Department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of Physics and Astronomy University of Nevada Las Vegas South African Astronomical Observatory Department of Astronomy University of Cape Town Department of Physics University of the Free State Université Paris Cité CNRS Astroparticule et Cosmologie Université Paris Cité CEA Paris-Saclay IRFU/DAp-AIM Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen Department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research The University of Tokyo ESA/ESTEC Department of Astronomy School of Physics Huazhong University of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The University of Sydney Department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and Technology School of Astronomy and Space Sciences University of Science and Technology of China Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

3种仿刺参养殖池塘底质特性的研究

水产科学 2017年第1期36卷 29-35页

作者：刘冉吴雪王琛崔龙波烟台大学生命科学学院山东烟台264005

为研究3种仿刺参养殖池塘底质的特点,于2014年4—6月检测了砂质底、泥沙质底和泥质底仿刺参养殖池塘底泥的粒度组成、7项理化指标及8类细菌数量特点。试验结果显示,3种池塘底质分别属于含砾泥质砂质底、粉砂质砂质底和砂质粉砂质底;底... 详细信息

为研究3种仿刺参养殖池塘底质的特点,于2014年4—6月检测了砂质底、泥沙质底和泥质底仿刺参养殖池塘底泥的粒度组成、7项理化指标及8类细菌数量特点。试验结果显示,3种池塘底质分别属于含砾泥质砂质底、粉砂质砂质底和砂质粉砂质底;底泥pH值波动均不大;氧化还原电位的变化范围分别为-336.83^-233.83mV、-340.77^-310.30mV和-380.66^-369.77mV;硫化物含量分别为29.64~386.83μg/g、47.6~507.50μg/g和160.16~991.04μg/g;砂质底池塘总氮、总磷、有机碳含量较少,泥沙质底总氮含量超标严重,泥质底总磷含量超标,且有机碳含量远高于其他两种底质池塘。3种底质池塘底泥中氨化细菌、反硝化细菌的数量均远高于亚硝化细菌的数量,还原性物质大量积累;泥沙质底池塘弧菌和硫还原细菌数量较多。结果表明,3种底质池塘底泥所存在的共性问题是底泥氧化还原电位偏低,硫化物含量较高;其差异性体现在砂质底池塘各指标波动较大,泥沙质底池塘总氮含量超标,有害细菌滋生,泥质底池塘底泥总磷含量超标,有机碳含量较高。

关键词：仿刺参池塘底质