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Neural Regeneration Research 2023年第9期18卷 2005-2010页

作者： Xin li Xuan-Kang wang Zhi-Jie Zhu Zhuo-Wen liang Peng-Hui li yang-Guang Ma Tan Ding Kun li Xiao-Shuang zuo Cheng ju Zhi-Hao zhang Zhi-Wen Song Hui-lin Quan Jia-wei zhang liang Luo Zhe wang Xue-Yu Hu Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina 2967 Hospital of People’s liberation Army Joint Logistic Support Force DalianLiaoning ProvinceChina

Increasing evidence indicates that mitochonarial lission imbalance plays an important role in derayed neuronal cell death. Our previous study round that photo biomodulation improved the motor function of rats with spinal cord ***,the precise mechanism remains *** investigate the effect of photo biomodulation on mitochondrial fission imbalance after spinal cord injury,in this study,we treated rat models of spinal co rd injury with 60-minute photo biomodulation(810 nm,150 mW) every day for 14 consecutive *** electron microscopy results confirmed the swollen and fragmented alte rations of mitochondrial morphology in neurons in acute(1 day) and subacute(7 and 14 days) *** biomodulation alleviated mitochondrial fission imbalance in spinal cord tissue in the subacute phase,reduced neuronal cell death,and improved rat posterior limb motor function in a time-dependent *** findings suggest that photobiomodulation targets neuronal mitochondria,alleviates mitochondrial fission imbalance-induced neuronal apoptosis,and thereby promotes the motor function recovery of rats with spinal cord injury.

关键词： low-level laser therapy mitochondria mitochondrial dynamics mitochondrial fission imbalance neuron photobiomodulation secondary injury spinal cord injury

Risk factors for depression in patients with chronic obstructive pulmonary disease

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World Journal of Psychiatry 2020年第4期10卷 59-70页

作者： Hui-Ming Yao Ren-Sen Xiao Ping-liang cao Xiao-Lei wang wei zuo wei zhang Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Second Department of Cardiovascular Medicine Jiangxi Provincial People's Hospital Affiliated to Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND The prevalence of depression in patients with chronic obstructive pulmonary disease(COPD)ranges from 10%to 42%,but the diagnosis of depression in patients with COPD is often unrecognized and *** depression has major implications for compliance with medical treatment,prolonged lengths of stay,increased frequency of hospital admissions,and increased consultations with primary care *** studies have attempted to identify risk factors for progression,prognosis and response to therapy in patients with ***,few studies have examined the risk factors for depression in patients with COPD,and some results remain *** To identify the potential risk factors to define patients with COPD who are at“high risk”of *** The clinical data of 293 patients with COPD were reviewed from January 2017 to December *** correlations between demographics,clinical characteristics and depression were *** risk factors for depression in patients with COPD were identified by multivariate logistic regression *** cutoff value,sensitivity and specificity of the independent correlation factors were calculated with a receiver operating characteristic *** Of the 293 patients included,65(22.18%)individuals were identified to have *** differences were detected between patients with and without depression in terms of body mass index(BMI),forced expiratory volume in 1 s(FEV1),and COPD assessment test(CAT)score(all P<0.05).Low BMI,low FEV1,and high CAT were independent risk factors for depression in patients with COPD and the cutoff values of BMI,FEV1,and CAT scores were 21.373 kg/m2,0.855 L and 12.5,*** Low BMI,low FEV1,and high CAT score were identified as independent risk factors for depression in patients with COPD.

关键词： Depression Chronic obstructive pulmonary disease Body mass index Forced expiratory volume in 1 second Chronic obstructive pulmonary disease assessment test scores Risk factors

Phospholipid membrane-decorated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy

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Acta Pharmaceutica Sinica B 2020年第11期10卷 2246-2257页

作者： junjing yin Haiqiang cao Hong wang Kaoxiang Sun Yaping li Zhiwen zhang School of Pharmacy Yantai UniversityYantai 264005China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Yantai Key Laboratory of Nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantai 264000China

Hypoxia is a serious impediment to current treatments of many malignant ***,an antioxidant enzyme,is capable of decomposing endogenous hydrogen peroxide(H2O2)into oxygen for tumor reoxygenation,but suffered from in vivo instability and limited delivery to deep interior hypoxic regions in ***,a deep-penetrated nanocatalase-loading DiIC18(5,DiD)and soravtansine(Cat@PDS)were provided by coating catalase nanoparticles with PEGylated phospholipids membrane,stimulating the structure and function of erythrocytes to relieve tumor hypoxia for enhanced chemophotodynamic *** intravenous administration,Cat@PDS preferentially accumulated at tumor sites,flexibly penetrated into the interior regions of tumor mass and remarkably relieved the hypoxic status in ***,the Cat@PDS+laser treatment produced striking inhibition of tumor growth and resulted in a 97.2%suppression of lung ***,the phospholipids membrane-coated nanocatalase system represents an encouraging nanoplatform to relieve tumor hypoxia and synergize the chemophotodynamic cancer therapy.

关键词： Photodynamic therapy Tumor hypoxia Catalase Tumor penetration Drug delivery Nanoparticle Tumor targeting Cancer metastasis Cancer therapy

Low-latitude hydroclimate changes related to paleomagnetic variations during the Holocene in coastal southern China

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Frontiers of Earth Science 2024年第2期18卷 324-335页

作者： Tingwei zhang Xiaoqiang yang Jian yin Qiong CHEN Jianfang HU Lu wang Mengshan ju Qiangqiang wang School of Earth Science and Engineering/Guangdong Provincial Key Laboratory of Geodynamics and Geohazards/Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Sun Yat-sen UniversityGuangzhou 510275China Institute of Cultural Heritage Shandong UniversityQingdao 266237China State Key Laboratory of Organic Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China College of Urban and Environmental Sciences Peking UniversityBeijing 100871China Institute of Oceanology Chinese Academy of SciencesQingdao 266071China

The variations in precipitation have displayed a complex pattern in different regions since the *** formation processes may have a significant impact on precipitation,especially during the tropical marine processes and summer monsoon which convey abundant water vapor to coastal southern China and inland ***,we use two 7500 year sedimentary records from the Pearl River Delta and the closed Maar Lake,respectively,in coastal southern China to reconstruct the mid-to-late-Holocene humidity variability and explore its possible relationship with cloud cover modulated by the Earth’s magnetic fields(EMF).Our proxy records document an apparent increase in wetness in coastal southern China between 3.0 and 1.8 kyr *** apparent increase in humidity appears to be consistent with the lower virtual axial dipole moments and,in turn,with a lower *** correlation suggests that the EMF might have been superimposed on the weakened monsoon to regulate the mid-to-late-Holocene hydroclimate in coastal southern China through the medium of galactic cosmic rays,aerosols,and cloud ***,further investigations are needed to verify this interaction.

关键词： hydroclimate variations Earth’s magnetic field coastal southern China the Holocene epoch

Targeting peptide-decorated biomimetic lipoproteins improve deep penetration and cancer cells accessibility in solid tumor

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Acta Pharmaceutica Sinica B 2020年第3期10卷 529-545页

作者： Tao Tan Yuqi wang jing wang Zhiwan wang Hong wang Haiqiang cao Jie li Yaping li Zhiwen zhang Siling wang School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Yantai Key Laboratory of Nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantai 264000China

The limited penetration of nanoparticles and their poor accessibility to cancer cell fractions in tumor remain essential challenges for effective anticancer ***,we designed a targeting peptide-decorated biomimetic lipoprotein(termed as BL-RD)to enable their deep penetration and efficient accessibility to cancer cell fractions in a tumor,thereby improving the combinational chemophotodynamic therapy of triple negative breast ***-RD was composed of phospholipids,apolipoprotein A1 mimetic peptide(PK22),targeting peptide-conjugated cytotoxic mertansine(RM)and photodynamic agents of DiIC18(5)(DiD).The counterpart biomimetic lipoprotein system without RM(termed as BL-D)was fabricated as *** BL-D and BL-RD were nanometer-sized particles with a mean diameter of less than 30 nm and could be efficiently internalized by cancer *** intravenous injection,they can be specifically accumulated at tumor *** comparing to the counterpart BLD,BL-RD displayed superior capability to permeate across the tumor mass,extravasate from tumor vasculature to distant regions and efficiently access the cancer cell fractions in a solid tumor,thus producing noticeable depression of the tumor *** together,BL-RD can be a promising delivery nanoplatform with prominent tumor-penetrating and cancer cells-accessing capability for effective tumor therapy.

关键词： lipoprotein Drug delivery Tumor penetration Nanoparticles Cancer therapy

Natural interface-mediated self-assembly of graphene-isolatednanocrystals for plasmonic arrays construction and personalized information acquisition

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Nano Research 2022年第10期15卷 9327-9333页

作者： Shen wang Tianhuan Peng Shengkai li linlin wang liang zhang Zhiwei yin Xin Xia Xinqi Cai Xiaoxu cao Long Chen Zhuo Chen weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of BiologyCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha 410082China Faculty of Science and Technology University of MacaoAvenida da UniversidadeTaipa 999078MacaoChina The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Hangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou 310022China Institute of Molecular Medicine(IMM) Renji HospitalShanghai Jiao Tong University School of Medicineand College of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

As Interface mediated self-assembly of nanocrystals provide excellent strategy for sensing,catalysis or photonics,the construction of innovative interfaces and development of versatile strategies for nanocrystal synthesis are urgently ***,latent fingerprints(LFPs),the most common markers for human identity,are used as naturally accessible interface for organization of graphene isolated nanocrystals(GINs).Excitingly,the selective adsorption of GINs on lipidic ridge provides a universal approach for the in-situ construction of the plasmonic *** system with intrinsic chrominance and Raman signal enables the high resolution colorimetric and surfaced-enhanced Raman spectroscopy(SERS)dual-mode imaging,which can detail the structures of the LFPs from 1st to 3rd level even the LFPs are ***,the interface can be constructed on diverse materials by a simple finger-pressing process and the densely packed arrays can serve as superior SERS substrate for label-free,non-invasive acquisition of molecule information especially residues in *** combination of chemical composition with detailed structures efficiently recognizes the human identity and could help link it to a crime ***,the LFPs can act as natural platform for interface mediated localized assembly and personalized information acquisition for forensic science or precise medicine.

关键词： interface self-assembly latent fingerprint personalized information acquisition

Performance Evaluation of a Novel and Effective Water-Soluble Aldehydes as Corrosion Inhibitor for Carbon Steel in Aggressive Hydrochloric Medium

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Journal of Renewable Materials 2022年第2期10卷 301-327页

作者： Yun wang Tiantian wang Bei wang wei chang Jiangli cao lihua Hu Minxu Lu Lei zhang University of Science and Technology Beijing Beijing100083China Wenzhou Hongfeng Electrical Alloy Co. Ltd.Wenzhou325603China CNOOC Research Institute Beijing100028China

A novel and effective water-soluble aldehydes(β-HA)as corrosion inhibitor was synthesized for N80 steel corro-sion in 15%HCl solution,and the corrosion inhibition performance was evaluated by using weight loss,electro-chemical measurements,scanning electron microscope(SEM),quantum chemical calculation and molecular dynamics simulation(MDS).The results show that synthesizedβ-HA showed excellent corrosion performance compared with MHB and PE for carbon steel in 15%HCl solution compared with MHB and PE,and the inhibi-tion efficiency increased with increasing concentration of the *** inhibition efficiency of β-HA at 8 mmol/L reached the maximum value 94.08%.The inhibitor acted as mixed-type inhibitor via blocking both the anodic and cathodic *** adsorption of inhibitors on N80 steel surface obeyed Langmuir adsorption isotherm,and the process contained chemisorption and ***ΔG ads of β-HA was−28.81 kJ·mol^(-1)der the standard atmospheric ***,the theoretical calculation parameters revealed stronger combination and higher interaction energy for inhibitor β-HA comparing with MHB and PE,further demonstrat-ing the correlation between the theoretical and experimental results.

关键词： Corrosion inhibitors n80 steel electrochemical adsorption molecular dynamics simulation

Risk Assessments for Type 1 Wild Poliovirus and Type 2 Vaccine-Derived Poliovirus Importation and Transmission—China,2023

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China CDC weekly 2024年第42期6卷 1098-1104,I0007,I0008页

作者： wei Kang Chunxiang Fan Yifan Song Zhaonan zhang Xiaoqi wang Miao wang jing Ma Mulei Chen Yuzhen yang Yi Wen Lei cao Lance Rodewald Fuzhen wang Zundong yin Ning Wen Hong yang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Education and Training of Chinese Center for Disease Control and Prevention BeijingChina

Introduction:All countries face the potential threat of imported polioviruses,including both wild type and circulating vaccine-derived *** response,we conducted a province-level assessment in China to evaluate the risk of importation and transmission of type 1 wild poliovirus(WPV1)and type 2 vaccine-derived poliovirus(VDPV2).Methods:Distinct risk assessment tools for WPV1 and VDPV2 were employed,incorporating three primary indicators—population immunity,poliovirus surveillance,and importation ***1 was assessed using 13 secondary indicators,whereas VDPV2 utilized 21 secondary *** used comprehensive provincial data from the preceding five ***(S-values)were derived from the secondary indicators’criteria and ratings,and used to classify the provincial-level administrative divisions(PLADs)into three risk categories:high,medium,and *** top 10%of PLADs were designated as highrisk,with the remaining provinces equally distributed into medium-and low-risk ***:In 2023,Xizang,Qinghai,and Xinjiang PLADs faced the highest risk of WPV1 importation and transmission;Xizang,Shaanxi,and Hainan PLADs were at the greatest risk for VDPV2 importation and ***:Risk assessment for VDPV2 importation and transmission has identified a distinct set of high-risk provinces compared to those identified by WPV1 risk *** and proactive response measures tailored to the specific risks should be implemented to maintain China’s polio-free status.

关键词： immunity maintain utilized

Development of a Decision Aid for Family Surrogate Decision Makers of Critically Ill Patients Requiring Renal Replacement Therapy in ICU:A User-Centered Design for Rapid Prototyping

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Chinese Medical Sciences Journal 2024年第2期39卷 91-101页

作者： Miao Zheng Yong-Hui zhang ying cao chang-lin yin li-Hua wang Department of Outpatient First Affiliated Hospital of Army Medical UniversityChongqing 400038China Department of Critical Care Medicine First Affiliated Hospital of Army Medical UniversityChongqing 400038China Administration Office First Affiliated Hospital of Army Medical UniversityChongqing 400038China

Objectives Renal replacement therapy(RRT)is increasingly adopted for critically ill patients diagnosed with acute kidney injury,but the optimal time for initiation remains unclear and prognosis is uncertain,leading to medical complexity,ethical conflicts,and decision dilemmas in intensive care unit(ICU)*** study aimed to develop a decision aid(DA)for the family surrogate of critically ill patients to support their engagement in shared decision-making process with *** Development of DA employed a systematic process with user-centered design(UCD)principle,which included:(i)competitive analysis:searched,screened,and assessed the existing DAs to gather insights for design strategies,developmental techniques,and functionalities;(ii)user needs assessment:interviewed family surrogates in our hospital to explore target user group's decision-making experience and identify their unmet needs;(iii)evidence syntheses:integrate latest clinical evidence and pertinent information to inform the content development of *** The competitive analysis included 16 relevant DAs,from which we derived valuable insights using existing *** decision needs were explored among a cohort of 15 family surrogates,revealing four thematic issues in decision-making,including stuck into dilemmas,sense of uncertainty,limited capacity,and delayed decision confirmation.A total of 27 articles were included for evidence *** decision making knowledge on disease and treatment,as delineated in the literature sourced from decision support system or clinical guidelines,were formatted as the foundational knowledge ***-one items of evidence were extracted and integrated into the content panels of benefits and risks of RRT,possible outcomes,and reasons to *** DA was drafted into a web-based phototype using the elements of *** platform could guide users in their preparation of decision-making through a sequential four-step process:identifying

关键词： decision aids renal replacement therapy intensive care units shared decision-making user-centered design surrogate

Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury

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Science Bulletin 2019年第16期64卷 1179-1194页

作者： Hua zhang Guodong Sun Xiaowei li Zhen Fu Chengbin Guo Guangchao cao Baocheng wang Qian wang Shuxian yang Dehai li Xichun Xia Peng li jing Zhu wei Zhou liangyan Zheng jingxia li Lei zhang Jianlei Hao libing Zhou Frederic Bornancin Zhizhong li Zhinan yin Yunfei Gao The First Affiliated Hospital Biomedical Translational Research Institute and School of PharmacyJinan UniversityGuangzhou 510632China Department of Orthopedics First Affiliated HospitalJinan UniversityGuangzhou 510632China Shandong Provincial Qianfoshan Hospital Shandong First Medical UniversityJinan 250014China Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhou 510632China Novartis Institutes for BioMedical Research CH-4002 BaselSwitzerland Department of Orthopedics Heyuan People’s Hospital(Heyuan Affiliated Hospital of Jinan University)Heyuan 517199China State Key Laboratory of Biotherapy Collaborative Innovation Center for BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Spinal cord injury(SCI) is a devastating traumatic injury that causes persistent, severe motor and sensory dysfunction. Immune responses are involved in functional recovery after SCI. Mucosa-associated lymphoid tissue lymphoma translocation 1(MALT1) has been shown to regulate the survival and differentiation of immune cells and to play a critical role in many diseases, but its function in lesion recovery after SCI remains unclear. In this paper, we generated KI(knock in) mice with a point mutation(C472 G) in the active center of MALT1 and found that the KI mice exhibited improved functional recovery after *** macrophages were recruited to the injury site in KI mice and these macrophages differentiated into anti-inflammatory macrophages. Moreover, macrophages from KI mice exhibited reduced phosphorylation of p65, which in turn resulted in decreased SOCS3 expression and increased pSTAT6 *** results were obtained upon inhibition of MALT1 paracaspase with the small molecule inhibitor‘‘MI-2' or the more specific inhibitor ‘‘MLT-827'. In patients with SCI, peripheral blood mononuclear cells(PBMC) displayed increased MALT1 paracaspase. Human macrophages showed reduced proinflammatory and increased anti-inflammatory characteristics following the inhibition of MALT1 paracaspase. These findings suggest that inhibition of MALT1 paracaspase activity in the clinic may improve lesion recovery in subjects with SCI.

关键词： Anti-inflammatory macrophage Pro-inflammatory macrophage Spinal cord injury NF-j B MALT1 paracaspase activity