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Innovative Design and Additive Manufacturing of Regenerative Cooling Thermal Protection System Based on the Triply Periodic Minimal Surface Porous Structure

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Computer Modeling in Engineering & Sciences 2020年第5期123卷 495-508页

作者： xinglong wang Cheng wang Xin Zhou Mingkang Zhang Peiyu Zhang Lei wang Science and Technology on Plasma Dynamics Laboratory Air Force Engineering UniversityXi’an710038China Basic Department Air Force Engineering UniversityXi’an710051China School of Mechanical&Automotive Engineering South China University of TechnologyGuangzhou510640China

The new regenerative cooling thermal protection system exhibits the multifunctional characteristics of load-carrying and heat exchange cooling,which are fundamental for the lightweight design and thermal protection of hypersonic *** periodic minimal surface(TPMS)is especially suitable for the structural design of the internal cavity of regenerative cooling structures owing to its excellent structural *** this study,test pieces were manufactured using Ti6Al4V lightweight *** designed three types of porous test pieces,and the interior was filled with a TPMS lattice(Gyroid,Primitive,I-WP)with a porosity of 30%.All porous test pieces were manufactured via selective laser melting technology.A combination of experiments and finite element simulations were performed to study the selection of the internal cavity structure of the regenerative cooling thermal protection ***,the relationship between the geometry and mechanical properties of a unit cell is established,and the deformation mechanism of the porous unit cell is *** the three types of porous test pieces,the weight of the test piece filled with the Gyroid unit cell was reduced by 8.21%,the average tensile strength was reduced by 17.7%compared to the solid test piece,while the average tensile strength of the Primitive and I-WP porous test pieces were decreased by 30.5%and 33.3%,*** with the other two types of unit cells,Gyroid exhibited better mechanical conductivity *** deformation process was characterised by stretching,shearing,and twisting,while the Primitive and I-WP unit cells underwent tensile deformation and tensile and shear deformation,*** finite element predictions in the study agree well with the experimental *** results can provide a basis for the design of regenerative cooling thermal protection system.

关键词： Triply periodic minimal surface(TPMS) regenerative cooling thermal protection system selective laser melting mechanical properties fracture analysis

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A local spectrum enhancement-based method and its application in incipient fault diagnosis of rotating machinery

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International Journal of Mechanical System Dynamics 2023年第2期3卷 162-172页

作者： Jiancong Shi Baoming Xu xinglong wang Jun Zhang School of Mechanical Engineering and Automation Fuzhou UniversityFuzhouChina

Incipient faults of gears and rolling bearings in rotating machineries are very difficult to identify using traditional envelope analysis *** address this challenge,this paper proposes an effective local spectrum enhancement‐based diagnostic method that can identify weak fault frequencies in the original complicated raw *** this purpose,a traversal frequency band segmentation technique is first proposed for dividing the raw signal into a series of subfrequency ***,the proposed synthetic quantitative index is constructed for selecting the most informative local frequency band(ILFB)containing fault features from the divided subfrequency ***,an improved grasshopper optimization algorithmbased stochastic resonance(SR)system is developed for enhancing weak fault features contained in the selected most ILFB with less computation ***,the enhanced weak fault frequencies are extracted from the output of the SR system using a common spectrum *** experiments on a laboratory planetary gearbox and an open bearing data set are used to verify the effectuality of the proposed *** diagnostic results demonstrate that the proposed method can identify incipient faults of gears and bearings in an effective and accurate ***,the advantages of the proposed method are highlighted by comparison with other methods.

关键词： fault diagnosis frequency band segmentation adaptive stochastic resonance improved grasshopper optimization algorithm synthetic quantitative index

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AI-assisted food enzymes design and engineering:a critical review

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Systems Microbiology and Biomanufacturing 2023年第1期3卷 75-87页

作者： xinglong wang Penghui Yang Beichen Zhao Song Liu Science Center for Future Foods Jiangnan University1800 Lihu RoadWuxi 214122JiangsuChina School of Biotechnology Jiangnan University1800 Lihu RoadWuxi 214122JiangsuChina

Food enzymes are basic components used for food *** catalysis,food enzymes can function as removing allergy,enriching absorbable nutrients,improving food texture,and adjusting *** enzymes work in various conditions,which brought out the need for engineering these enzymes with harsh environment tolerance and higher catalytic *** intelligence(AI)has recently provided solutions for structural modeling,finding modification hot spots,and guiding mutations toward specific needs,which greatly benefit enzyme ***-based tools showed great advantages in cutting down the computational time,enabling higher prediction accuracy,and providing trainable models suited for wide *** this review,we describe the functions and uses of food enzymes,as well as their utility *** necessity and advantages of using AI-based tools in enzyme engineering,and the differences between using traditional and AI-based tools are mainly *** AI-based tools for enzyme engineering were introduced and described their *** perspective of using AI tools and the future challenges were discussed.

关键词： Artificial intelligence Deep learning Protein rational design Protein thermostability Protein activity

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Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis

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Translational Neurodegeneration 2015年第1期4卷 105-110页

作者： Zhen Jiang Wenzhang wang George Perry Xiongwei Zhu xinglong wang Department of Pathology Case Western Reserve UniversityClevelandOHUSA College of Sciences University of Texas at San AntonioSan AntonioTXUSA

Amyotrophic lateral sclerosis(ALS)is the most common motor neuron disease characterized by progressive loss of motor neurons in the brainstem and spinal ***,there is no cure or effective treatment for ALS and the cause of disease is unknown in the majority of ALS *** mitochondria dysfunction is one of the earliest features of *** are highly dynamic organelles that undergo continuous fission,fusion,trafficking and turnover,all of which contribute to the maintenance of mitochondrial *** mitochondrial dynamics have been repeatedly reported in ALS and increasing evidence suggests altered mitochondrial dynamics as possible pathomechanisms underlying mitochondrial dysfunction in ***,we provide an overview of mitochondrial dysfunction and dynamic abnormalities observed in ALS,and discuss the possibility of targeting mitochondrial dynamics as a novel therapeutic approach for ALS.

关键词： ALS Mitochondrial dysfunction Mitochondrial dynamics Mitochondrial fission and fusion Mitochondrial trafficking Mitochondrial biogenesis and mitophagy

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Revisiting Al-Ni-Zr bulk metallic glasses using the 'cluster-resonance' model

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Chinese Science Bulletin 2011年第36期56卷 3902-3907页

作者： LI FengWei QIANG JianBing wang YingMin wang Qing DONG xinglong DONG Chuang Key Laboratory of Materials Modification of Ministry of Education Dalian University of Technology Dalian 116024 China

Six series of alloys,namely,Ni3Zr6Alx,Ni3Zr7Alx,Ni4Zr9Alx,Ni3Zr8Alx,Ni3Zr9Alx and Ni3Zr10Alx (x=1,1.5,2,3) were designed in this work and the bulk metallic glass (BMG) formation of these compositions was investigated by copper mold suction casting. A centimeter-scale BMG sample was obtained for the Ni4Zr9Al2 (Al13.3Ni26.7Zr60 in atomic percent) composition. The thermal glass parameters for this BMG were determined to be ΔTx = 68 K,Trg = 0.579,and γm = 0.689. Using the 'cluster-resonance' model for glass formation an optimal BMG composition was determined using the cluster formula [Ni3Zr9](Al2Ni1).

关键词：大块金属玻璃共振集群 BMG 玻璃形成锆镍铝

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One-pot Synthesis of 1,5-Diaza-2,6-cyclooctadiene-3,7-dicarboxylates Through a Multiple-component Reaction

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Chemical Research in Chinese Universities 2014年第3期30卷 387-389页

作者： LI Yufeng wang xinglong LI Wei WU Zhengguang SHI Jie MA Hongfei College of Science Nanjing Tech University Nanjing 211816 P. R. China

Methyl propiolate, formaldehyde, and various acyclic amines were assembled in one-pot into a series of 1,5-diaza-2,6-cyclooctadiene-3,7-dicarboxylates in moderate to good yields. This multiple-component reaction benef... 详细信息

关键词： Multiple-component reaction Methyl propiolate 1,5-Diaza-2,6-cyclooctadiene-3,7-dicarboxylate

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Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass

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Neuroscience Bulletin 2014年第2期30卷 243-252页

作者： David J. Bonda xinglong wang Hyoung-Gon Lee Mark A. Smith George Perry Xiongwei Zhu Department of Pathology Case Western Reserve University UTSA Neurosciences Institute and Department of Biology University of Texas at San Antonio

Considerable debate and controversy surround the cause（s） of AIzheimer＇s disease （AD）. To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD.

关键词： Alzheimer's disease amyloid-beta free radicals mitochondria mitochondrial dynamics oxidativestress

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Rationalizing the isolation distance needed for field trials involving genetically modified rapeseed (Brassica napus L.) in China

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Chinese Science Bulletin 2013年第13期58卷 1558-1567页

作者： ZHAO XiangXiang TANG Tang CHEN GuiMin LIU FuXia wang xinglong BU CuiPing LU ChangMing Key Laboratory of Oil Crop Biology of Ministry of Agriculture Oilcrops Research InstituteChinese Academy of Agricultural Sciences Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake Huaiyin Normal University

The isolation distance required for field trials of genetically modified (GM) rapeseed varies widely worldwide, with a 50-400 m distance in most nations contrasting with a minimum 1000-m isolation distance in China. The goal of this study was to evaluate the relevance of current regulations in China regarding the isolation distance needed for GM rapeseed trials. A pollen flow experiment was conducted based on the design of concentric circles, with the GM plants in a 20-m diameter circle at the centre, surrounded by non-GM plants to a distance 60 m from the perimeter of the circle containing GM plants. The rate of pollen flow was the highest at the isolation distance of 0.5 m, where it ranged from 2.3091% to 2.6711%. The general pattern of the pollen flow rate (y) with distance (x) was well described by the equation y = 1.3936x-0.9136 (R 2 = 0.9950). The long-distance pollen flow tested at the isolation distance of 800 m was 0.0018%, which agrees with the theoretical prediction. The results suggested that 300 m, rather than 1000 m, is a reasonable distance to ensure a tolerable threshold of pollen flow (less than 0.01%) under conditions of winter rapeseed production in China.

关键词：转基因油菜籽隔离距离现场试验中国转基因植物花粉流世界范围田间试验

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Influential Node Ranking and Invulnerability of Air Traffic Cyber Physical System

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Transactions of Nanjing University of Aeronautics and Astronautics 2021年第2期38卷 288-297页

作者： wang xinglong HE Min College of Air Traffic Management Civil Aviation University of ChinaTianjin 300300P.R.China

To ensure flight safety,the complex network method is used to study the influence and invulnerability of air traffic cyber physical system(CPS)*** to the rules of air traffic management,the logical coupling relationship between routes and sectors is analyzed,an air traffic CPS network model is constructed,and the indicators of node influence and invulnerability are *** K-shell algorithm is improved to identify node influence,and the invulnerability is analyzed under random and selective *** Airspace in Eastern China as an example,its influential nodes are sorted by degree,namely,K-shell,the improved K-shell(IKS)and betweenness *** invulnerability of air traffic CPS under different attacks is *** show that IKS can effectively identify the influential nodes in the air traffic CPS network,and IKS and betweenness centrality are the two key indicators that affect the invulnerability of air traffic CPS.

关键词： complex network air traffic cyber physical system improved K-shell algorithm influential node ranking invulnerability

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Posttranslational modifications of α-tubulin in alzheimer disease

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Translational Neurodegeneration 2015年第1期4卷 59-67页

作者： Fan Zhang Bo Su Chunyu wang Sandra L.Siedlak Siddhartha Mondragon-Rodriguez Hyoung-gon Lee xinglong wang George Perry Xiongwei Zhu Department of Pathology Case Western Reserve UniversityClevelandOH 44121USA Department of Neurosurgery Shandong Provincial HospitalShandong UniversityJinan 250012China Department of Neurobiology Shandong UniversityJinan 250012China Department of Neurology the Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Departamento de Neurobiología del Desarrollo y Neurofisiología Instituto de NeurobiologíaUniversidad Nacional Autónoma de México QuerétaroQuerétaro MéxicoD.F.Mexico The University of Texas at San Antonio One UTSA CircleSan AntonioTX 78249USA 2103 Cornell Road ClevelandOH 44106USA

Background:In Alzheimer disease(AD),hyperphosphorylation of tau proteins results in microtubule destabilization and cytoskeletal *** prior ultra-morphometric studies documented a clear reduction in microtubules in pyramidal neurons in AD compared to controls,however,this reduction did not coincide with the presence of paired helical *** latter suggests the presence of compensatory mechanism(s)that stabilize microtubule dynamics despite the loss of tau binding and *** are composed of tubulin dimers which are subject to posttranslational modifications that affect the stability and function of ***:In this study,we performed a detailed analysis on changes in the posttranslational modifications in tubulin in postmortem human brain tissues from AD patients and age-matched controls by immunoblot and ***:Consistent with our previous study,we found decreased levels ofα-tubulin in AD *** of tubulin with various posttranslational modifications such as polyglutamylation,tyrosination,and detyrosination were also proportionally reduced in AD brain,but,interestingly,there was an increase in the proportion of the acetylatedα-tubulin in the remainingα-*** distribution was changed from predominantly in the processes to be more accumulated in the cell *** number of processes containing polyglutamylated tubulin was well preserved in AD *** there was a cell autonomous detrimental effect of NFTs on tubulin,this is likely a gradual and slow process,and there was no selective loss of acetylated or polyglutamylated tubulin in NFT-bearing ***:Overall,we suggest that the specific changes in tubulin modification in AD brain likely represent a compensatory response.

关键词： Acetylation Alzheimer disease Polyglutamylation Tau Tubulin

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