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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian wang Yun-Feng wang Fan Yang jian-Qin Liu Jie chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： Jin-Hui chen Zuo-Tang Liang Yu-Gang Ma xin-Li sheng Qun wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie chen Hai-Di Fan Wan wang Bin wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu xin-Yian Guo jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian xin Hua jianhong Dong Zheyu Fang Yuqing Liu Sibing chen Xiumin Xue Juanqing Yue Minyu Zhu Ying wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Intrinsic contractivity properties of Feynman-Kac semigroups for symmetric jump processes with infinite range jumps

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Frontiers of Mathematics in China 2015年第4期10卷 753-776页

作者： xin chen jian wang Department of Mathematics Shanghai Jiao Tong University Shanghai 200240 China School of Mathematics and Computer Science Fujian Normal University Fuzhou 350007 China

Let （Xt）t≥0 be a symmetric strong Markov process generated by non-local regular Dirichlet form （D, （D）） as follows：where J（x, y） is a strictly positive and symmetric measurable function on Rd × Rd. We study the intrinsic hypercontractivity, intrinsic supercontractivity, and intrinsic ultracontractivity for the Feynman-Kac semigroup

关键词： Symmetric jump process Levy process Dirichlet form Feynman-Kac semigroup intrinsic contractivity

Dynamic recrystallization behavior and microstructure evolution of high-performance Cu-3.28Ni-0.6Si-0.22Zn-O.11Cr-0.04P during hot compression

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Rare Metals 2021年第1期40卷 156-167页

作者： Chang-sheng wang Hua-Dong Fu jian-xin Xie Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation Institute for Advanced Materials and TechnologyBeijing 100083China

By means of isothermal compression at temperatures in the range of 650-900℃and strain rates in the range of 0.001-1 s^(-1),the dynamic recrystallization behavior and microstructural evolution of a Cu-3.28 Ni-0.6 Si-0.22 Zn-0.11 Cr-0.04 P(wt%)alloy designed by a machine learning method were investigated.A semiempirical constitutive equation,processing maps and an average activation energy were *** microstructure under different conditions and the effect of strain rate on the texture of the alloy at 800-900℃were *** results show that the suitable temperature is800-900℃;when the strain is less than 0.4,the appropriate strain rate is 0.01-0.5 s^(-1);and when the strain is greater than 0.4,the appropriate strain rate is below0.05 s^(-1).After deformation at 800℃,the main texture changed from{112}of copper to a uniform distribution with the increase in strain rate,but the sample did not have obvious texture after deformation at 850 and900℃.The above results can provide a reference for the selection of process parameters.

关键词： High-performance copper alloy Hot compression Dynamic recrystallization Processing map Texture evolution

Load Shedding Control Strategy in Power Grid Emergency State Based on Deep Reinforcement Learning

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CSEE Journal of Power and Energy Systems 2022年第4期8卷 1175-1182页

作者： jian Li sheng chen xinying wang Tianjiao Pu China Electric Power Research Institute Haidian DistrictBeijing 100192China

In viewing the power grid for large-scale new energy integration and power electrification of power grid equipment,the impact of power system faults is increased,and the ability of anti-disturbance is decreased,which makes the power system fault clearance more *** this paper,a load shedding control strategy based on artificial intelligence is proposed,this action strategy of load shedding,which is selected by deep reinforcement learning,can support autonomous voltage ***,the power system operation data is used as the basic data to construct the network training dataset,and then a novel reward function for voltage is *** value function,which conforms to the power grid operation characteristics,will act as the reward value for deep reinforcement learning,and the Deep Deterministic Policy Gradient algorithm(DDPG)algorithm,with the continuous action strategy,will be ***,the deep reinforcement learning network is continuously trained,and the load shedding strategy concerning the grid voltage control problem will be obtained in the power system emergency control situation,and this strategy action is input into the Pypower module for simulation verification,thereby realizing the joint drive of data and *** to the numerical simulation analysis,it shows that this method can effectively determine the accurate action selection of load shedding,and improve the stable operational ability of the power system.

关键词： Artificial intelligence deep reinforcement learning load shedding control power system emergency state

Sealing properties and structure optimization of packer rubber under high pressure and high temperature

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Petroleum Science 2019年第3期16卷 632-644页

作者： Wen-jian Lan Han-Xiang wang xin Zhang sheng-Shan chen College of Mechanical and Electronic Engineering China University of Petroleum

During hydraulic fracturing operations of low-permeability reservoirs,packers are the key component to ensure the success of multistage *** enable sections of the wellbore to be sealed off and separately fractured by hydraulic pressure,one at a time,while the remainder of the wellbore is not ***,reliable sealing properties of the packer rubber are required to meet the high-pressure and high-temperature(HPHT)conditions of reservoirs(such as 70 MPa and 170 ℃).In this study,the structures of the packer rubber with two different materials are optimized numerically by ABAQUS and validated by *** optimization process starts from the packer rubber with a conventional structure,and then,the weakest spots are identified by ABAQUS and improved by slightly varying its *** process is iterative,and the final optimized structure of a single rubber barrel with expanding back-up rings is *** the structure of three rubber barrels with metallic protective covers,both HNBR and AFLAS fail under HPHT *** the final optimized structure,the packer rubber made of AFLAS can work better under HPHT than that made of HNBR which ruptures after *** results show that the optimized structure of a single rubber barrel with expanding back-up rings and the material AFLAS are a good combination for the packer rubber playing an excellent sealing performance in multistage fracturing in horizontal wells.

关键词： Packer rubber Sealing property Structure optimization Hydrogenated nitrile-butadiene rubber (HNBR) AFLAS rubber

Data-Driven Control of Distributed Event-Triggered Network Systems

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IEEE/CAA Journal of Automatica Sinica 2023年第2期10卷 351-364页

作者： xin wang jian Sun Gang wang Frank Allgower Jie chen the National Key Laboratory of Autonomous Intelligent Unmanned Systems School of AutomationBeijing Institute of TechnologyBeijing 100081 the Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China IEEE the Institute for Systems Theory and Automatic Control University of StuttgartStuttgart 70550Germany the Department of Control Science and Engineering Tongji UniversityShanghai 201804 the National Key Laboratory of Autonomous Intelligent Unmanned Systems Beijing Institute of TechnologyBeijing 100081China

The present paper deals with data-driven event-triggered control of a class of unknown discrete-time interconnected systems(*** systems).To this end,we start by putting forth a novel distributed event-triggering transmission strategy based on periodic sampling,under which a model-based stability criterion for the closed-loop network system is derived,by leveraging a discrete-time looped-functional *** the model-based criterion with a data-driven system representation recently developed in the literature,a purely data-driven stability criterion expressed in the form of linear matrix inequalities(LMIs)is ***,the data-driven stability criterion suggests a means for co-designing the event-triggering coefficient matrix and the feedback control gain matrix using only some offline collected state-input ***,numerical results corroborate the efficacy of the proposed distributed data-driven event-triggered network system(ETS)in cutting off data transmissions and the co-design procedure.

关键词： Data-driven control distributed event-triggered network system(ETS) linear matrix inequalitie(LMI) looped-functional stability