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miR-93-5p Transferred by Exosomes Promotes the Proliferation of Esophageal Cancer Cells via Intercellular Communication by Targeting PTEN

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Biomedical and Environmental Sciences 2018年第3期31卷 171-185页

作者： LIU Meng xin LIAO Juan XIE Ming GAO Zhi Kui wang Xiang hu zhang ying SHANG Mu He YIN Li Hong PU Yue Pu LIU Ran Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Nanjing 210009 Jiangsu China Hangzhou First People's Hospital Hangzhou 310000 Zhejiang China North China Petroleum Bureau General Hospital Renqiu 062552 Hebei China

Objective To investigate the relationship between plasma miR-93-5p and the risk of esophageal cancer, as well as the influence of miR-93-5p on the biological function of esophageal cancer cells,exerted through *** The expression of plasma miR-93-5p in esophageal cancer patients and healthy controls was analysed by real-time quantitative PCR. The influence of miR-93-5p on the risk and prognosis of esophageal carcinoma was analyzed by conditional logistic regression and survival analysis. The effect of miR-93-5p on the biological function of recipient cells was investigated by establishing an in vitro donor cell co-culture model. The target gene of miR-93-5p was validated by luciferase reporter assay and Western *** Upregulation of plasma miR-93-5p expression significantly increases the risk of esophageal cancer and is associated with poor prognosis. miR-93-5p transferred by exosomes promotes the proliferation of recipient esophageal cancer cells and affects the expression of PTEN and its downstream proteins p21 and cyclin *** Our study provides a reference for the identification of biomarkers for the diagnosis and prognosis of esophageal cancer.

关键词： Exosomes miR-93-5p Esophageal cancer Plasma biomarker

The Impact of Lipid-metabolizing Genetic Polymorphisms on Body Mass Index and Their Interactions with Soybean Food Intake: A Study in a Chinese Population

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Biomedical and Environmental Sciences 2014年第3期27卷 176-185页

作者： wang Jin Wei TANG Xun LI Na WU Yi Qun LI Shuai LI Jin QIN Xue ying zhang Zong xin hu Yong hua CHEN Da Fan Department of Epidemiology and Biostatistics School of Public HealthPeking University Health Science Center Fangshan District Bureau of Health The First Hospital of Fangshan District

Objective To evaluate the association of known polymorphisms in the lipid metabolic pathway with body mass index （BMI）, and estimate their interactions with soybean food intake. Methods A community-based cross-sectional survey was conducted in a Chinese Han population. BMI, soybean food intake, and single nucleotide polymorphisms of rs599839, rs3846662, rs3846663, rs12916, rs174547, rs174570, rs4938303, and rs1558861 were measured in 944 subjects. A multivariate logistic regression was used to analyze the association of the studied polymorphisms with BMIs. The expectation-maximization algorithm was employed to evaluate the extent of linkage disequilibrium between pairwise polymorphisms. The gene-environment interaction was assessed in the general multifactor dimensionality reduction model. Results The polymorphisms of rs3846662 and rs3846663 were associated with 10% highest BMIs when comparing to the 10% lowest values both in individuals and haplotype-based association tests. Although no statistically significant gene-environment interactions were found, people with the haplotype composed of C allele in rs3846662 and T allele in rs3846663 and low frequency of soybean intake had significantly hisher risk to overweight and obesity as compared with those with the haplotype consisting of T allele in rs3846662 and C allele in rs3846663 and highly frequent soybean food intake, with an odds ratio of 1.64 （95% confidence interval： 1.15-2.34, P〈0.01） after adjusting for the common confounders. Conclusion Our study has sugsested that rs3846662 and rs3846663 may be the potential candidate polymorphisms for obesity, and their effect on the pathogenesis could be mediated by the frequency of soybean food intake.

关键词： Body mass index Lipid metabolism Genetic epidemiology Haplotypes Gene-environment interaction

Incidence and Risk Factors of the Upper-Limb Musculoskeletal Disorders Among Occupational Groups in Key Industries—China,2018–2021

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China CDC weekly 2022年第50期4卷 1123-1130页

作者： Ning Jia Meibian zhang huadong zhang Ruijie Ling Yimin Liu gang Li Yan Yin hua Shao Hengdong zhang Bing Qiu Dongxia Li Dayu wang Qiang Zeng Rugang wang Jianchao Chen Danying zhang Liangying Mei xinglin Fang Yongquan Liu Jixiang Liu Chengyun zhang Tianlai Li Jun Qi Qing Xu ying Qu Xueyan zhang xin Sun Zhongxu wang National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and PreventionBeijing MunicipalityChina Chongqing Center for Disease Control and Prevention Chongqing MunicipalityChina hubei Provincial Hospital of Integrated Chinese&Western Medicine Wuhan CityHubei ProvinceChina Guangzhou Twelfth People’s Hospital Affiliated to Guangzhou Medical University Guangzhou CityGuangdong ProvinceChina Liaoning Provincial Health Service Center Shenyang CityLiaoning ProvinceChina Shanghai Center for Disease Control and Prevention Shanghai MunicipalityChina Shandong Academy of Occupational Health and Occupational Medicine Jinan CityShandong ProvinceChina Jiangsu Provincial Center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina Civil Aviation Medical Center Civil Aviation Administration of ChinaBeijing MunicipalityChina Guizhou Province Occupational Disease Prevention and Control Hospital Guiyang CityGuizhou ProvinceChina Tianjin Occupational Disease Prevention and Control Hospital Tianjin MunicipalityChina Tianjin Center for Disease Control and Prevention Tianjin MunicipalityChina Beijing Center for Disease Control and Prevention Beijing MunicipalityChina Fujian Province Occupational Disease and Chemical Poisoning Prevention and Control Center Fuzhou CityFujian ProvinceChina Guangdong Province Hospital for Occupational Disease Prevention and Treatment Guangzhou CityGuangdong ProvinceChina hubei Provincial Center for Disease Control and Prevention Wuhan CityHubei ProvinceChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Institute of Occupational Medicine of Jiangxi Nanchang CityJiangxi ProvinceChina Ningxia hui Autonomous Region Center for Disease Control and Prevention Yinchuan CityNingxia ProvinceChina Sichuan Provincial Center for Disease Control and Prevention Chengdu CitySichuan ProvinceChina Shanxi Provincial Center for Disease Control and Prevention Xian CityShanxi ProvinceChin

What is already known about this topic?The burden of illness and economic losses due to upper-limb work-related musculoskeletal disorders(UL-WMSDs)is high;thus,they have become a major global public health *** present,the epidemiological characteristics of UL-WMSDs in China's occupational population are still *** is added by this report?The incidence of UL-WMSDs among key occupational groups in China is 22.5%,with distinct occupational *** are the implications for public health practice?This study has primarily determined the occurrence and potential risk factors of UL-WMSDs in key industries in China and provided data support for recommending prevention and control of the occurrence of such diseases in key industries in China,and in facilitating the addition into the China’s List of Legal Occupational Diseases.

关键词： Upper prevention skeletal

Circulating MicroRNA-21 is Downregulated in Patients with Metabolic Syndrome

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Biomedical and Environmental Sciences 2016年第5期29卷 385-389页

作者： HE Qing Fang wang Li xin ZHONG Jie Ming hu Ru ying FANG Le wang Hao GONG Wei Wei zhang Jie PAN Jing YU Min Zhejiang Provincial Center for Disease Prevention and Control Hangzhou 310052 Zhejiang China

The microRNA-21 （miR-21） is known to play a major role in cancer progression; however, its function in the cardiovascular system appears to be even more complex and conflicting. To characterize miR-21 expression in the plasma of individuals with or without metabolic syndrome （MetS）, 58 MetS cases and 96 non-MetS controls were investigated.

关键词： RNA Circulating MicroRNA-21 is Downregulated in Patients with Metabolic Syndrome HDLC BMI FBG NAFLD Met SBP

Multi-genome evolutionary study of the ABC1 gene family and identification of the pleiotropic effects of OsABC1-13 in rice development

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The Crop Journal 2024年第4期12卷 1022-1030页

作者： Fuying Ma Mingyu Liu Peiwen Yan Shicong He Jian hu xinwei zhang Fuan Niu Jinhao Cui xinyu Yuan Xiaoyun xin Liming Cao Jinshui Yang ying wang Xiaojin Luo State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology(Ministry of Education) School of Life SciencesFudan UniversityShanghai 200433China Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Department of Ecology and Evolutionary BiologySchool of Life SciencesFudan UniversityShanghai 200433China Institute of Crop Breeding and Cultivation Shanghai Academy of Agricultural SciencesShanghai 200241China Ministry of Education Key Laboratory of Crop PhysiologyEcology and Genetic Breeding College of AgronomyJiangxi Agricultural UniversityNanchang 330045JiangxiChina

In four rice genomes,85 ABC1-family genes were identified by comparative genomics,evolution,genetics,and ***,OsABC1-13,was shown by knockdown and knockout experiments to affect plant height,grain size,and photosynthet... 详细信息

关键词： Multi-genome analysis Activity of bc1 complex gene Photosynthesis Biomass Osabc1-13 Haplotype

Direct sunlight exposure reduces hair cortisol levels in rhesus monkeys(Macaca mulatta)

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Zoological Research 2019年第6期40卷 583-586页

作者： Xiao-Li Feng He-Long Che Xi Ning Xue-ying Ba Juan-Li Jing-Fang zhang Yun wang Zheng-Fei hu xin-Tian hu Xiao-Feng Ren School of Basic Medical Sciences Kunming Medical UniversityKunming Yunnan 650500China Key Laboratory of Animal Models and human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Department of General Surgery 908th Hospital of Chinese PLA Joint Logistic Support ForceYingtan Jiangxi 335000China Kunming Primate Research Center of the Chinese Academy of Sciences Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming Yunnan 650204China

DEAR EDITOR,Major depressive disorder (MDD), commonly known as depression, is a mental disease characterized by a core symptom of low mood. It lasts at least two weeks (Badamasi et al., 2019;wang et al., 2019) and is frequently accompanied by low self-esteem, loss of interest in routinely enjoyable activities, low energy, and unexplained pain (huey et al., 2018;Park et al., 2012;Post & Warden, 2018;Rice et al., 2019;Xiao et al., 2018). Approximately 2%–8% of adults with MDD commit suicide (Richards & O'Hara, 2014;Strakowski & Nelson, 2015), and around half of suicidal individuals suffer depression or other mood disorders (Bachmann, 2018).

关键词： rhesus monkeys hair cortisol levels

Large inverse and normal magnetocaloric effects in HoBi compound with nonhysteretic first-order phase transition

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Chinese Physics B 2022年第7期31卷 539-543页

作者： Yan zhang You-Guo Shi Li-Chen wang xin-Qi Zheng Jun Liu Ya-Xu Jin Ke-Wei zhang Hong-Xia Liu Shuo-Tong Zong Zhi-gang Sun Ji-Fan hu Tong-Yun Tong Bao-Gen Shen School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Institute of Physics Chinese Academy of SciencesBeijing 100190China Laboratory of Magnetic and Electric Functional Materials and Applications The Key Laboratory of Shanxi ProvinceTaiyuan 030024China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

HoBi single crystal and polycrystalline compounds with Na Cl-type structure are successfully obtained,and their magnetic and magnetocaloric properties are studied in *** temperature increasing,Ho Bi compound undergoes two magnetic transitions at 3.7 K and 6 K,*** transition temperature at 6 K is recognized as an antiferromagneticto-paramagnetic(AFM–PM)transition,which belongs to the first-order magnetic phase transition(FOMT).It is interesting that the Ho Bi compound with FOMT exhibits good thermal and magnetic ***,a large inverse and normal magnetocaloric effect(MCE)is found in Ho Bi single crystal in the H||[100]direction,and the positive?SMpeak reaches 13.1 J/kg·K under a low field change of 2 T and the negative?S_(M)peak arrives at-18 J/kg·K under a field change of5 *** excellent properties are expected to be applied to some magnetic refrigerators with special designs and functions.

关键词： magnetocaloric effect antiferromagnetic rare-earth compounds

Anticancer Activity of Diosgenin and Its Molecular Mechanism

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Chinese Journal of Integrative Medicine 2023年第8期29卷 738-749页

作者： REN Qun-li wang Qian zhang xin-qun wang Miao hu huan TANG Jun-jie YANG Xiong-tong RAN ying-hui LIU huan-huan SONG Zhi-xing LIU Jian-guo LI Xiao-lan Special Key Laboratory of Microbial Resources and Drug Development of Guizhou Higher Education Institution Zunyi Medical UniversityZunyiGuizhou Province(563000)China School of Stomatology Zunyi Medical UniversityZunyiGuizhou Province(563000)China Institute of Life Sciences Zunyi Medical UniversityZunyiGuizhou Province(563000)China Zheng'an County People's Hospital ZunyiGuizhou Province(563000)China School of Basic Medicine Zunyi Medical UniversityZunyiGuizhou Province(563000)China

Diosgenin, a steroidal sapogenin, obtained from Trigonella foenum-graecum, Dioscorea, and Rhizoma polgonati, has shown high potential and interest in the treatment of various cancers, such as oral squamous cell carcinoma, laryngeal cancer, esophageal cancer, liver cancer, gastric cancer, lung cancer, cervical cancer, prostate cancer, glioma, and leukemia. This article aims to provide an overview of the in vivo, in vitro,and clinical studies reporting the diosgenin’s anticancer effects. Preclinical studies have shown promising effects of diosgenin on inhibiting tumor cell proliferation and growth, promoting apoptosis, inducing differentiation and autophagy, inhibiting tumor cell metastasis and invasion, blocking cell cycle, regulating immunity and improving gut microbiome. Clinical investigations have revealed clinical dosage and safety property of diosgenin. Furthermore, in order to improve the biological activity and bioavailability of diosgenin, this review focuses on the development of diosgenin nano drug carriers, combined drugs and the diosgenin derivatives. However, further designed trials are needed to unravel the diosgenin’s deficiencies in clinical application.

关键词： diosgenin steroidal sapogenin anticancer molecular mechanism biological activity

Gefitinib(an EGFR tyrosine kinase inhibitor)plus anlotinib(an multikinase inhibitor)for untreated,EGFR-mutated,advanced non-small cell lung cancer(FL-ALTER):a multicenter phase III trial

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Signal Transduction and Targeted Therapy 2024年第9期9卷 4091-4102页

作者： hua-Qiang Zhou Ya-Xiong zhang gang Chen Qi-Tao Yu hua zhang Guo-Wu Wu Di Wu ying-Cheng Lin Jun-Fei Zhu Jian-hua Chen Xiao-hua hu Bin Lan Ze-Qiang Zhou Hai-Feng Lin Zi-Bing wang Xiao-Lin Lei Suo-Ming Pan Li-Ming Chen Jian zhang Tian-Dong Kong Ji-Cheng Yao xin Zheng Feng Li Li zhang Wen-Feng Fang Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Medical Oncology of Respirotary Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530021China Department of Urogenital Oncology the First People’s Hospital of FoshanFoshan 52800China Department of Medical Oncology Meizhou People’s Hospital(Huangtang Hospital)Meizhou 514031China Department of Respiratory and Critical Care Medicine Shenzhen people’s HospitalShenzhen 518020China Department of Medical Oncology of Respirotary Cancer Hospital of Shantou University Medical CollegeShantou 515031China Department of Respiratory and Critical Care Medicine Taizhou Central HospitalTaizhou 318000China Department of Medical Oncology Hunan Provincial Cancer HospitalChangsha 410031China Department of Medical Oncology the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Cardiothoracic Surgery Shantou Central HospitalShantou 515031China Department of Oncology the 2nd People’s Hospital of ShenzhenShenzhen 518025China Department of Medical Oncology the Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216China Department of Immunotherapy Henan Cancer HospitalZhengzhou 450003China Department of Oncology Affiliated Hospital of Panzhihua UniversityPanzhihua 617099China Department of Radiotherapy Yuebei People’s HospitalShaoguan 512099China Department of Oncology the First Affiliated Hospital of Shantou University Medicine CollegeShantou 515041China Department of Oncology ZhuJiang Hospital of Southern Medical University(The Second Clinical Medical College)Guangzhou 510280China Department of Respiratory Oncology the Third People’s Hospital of ZhengzhouZhengzhou 450001China Shanghai OrigiMed Co. LtdShanghaiChina

Dual inhibition of vascular endothelial growth factor and epidermal growth factor receptor(EGFR)signaling pathways offers the prospect of improving the effectiveness of EFGR-targeted *** this phase 3 study(***:NCT04028778),315 patients with treatment-naïve,EGFR-mutated,advanced non-small cell lung cancer(NSCLC)were randomized(1:1)to receive anlotinib or placebo plus gefitinib once daily on days 1–14 per a 3-week *** the prespecified final analysis of progression-free survival(PFS),a significant improvement in PFS was observed for the anlotinib arm over the placebo arm(hazards ratio[HR]=0.64,95%CI,0.48–0.80,P=0.003).Particularly,patients with brain metastasis and those harboring EGFR amplification or high tumor mutation load gained significant more benefits in PFS from gefitinib plus *** incidence of grade 3 or higher treatment-emergent adverse events was 49.7%of the patients receiving gefitinib plus anlotinib versus 31.0%of the patients receiving gefitinib plus *** plus gefitinib significantly improves PFS in patients with treatment-naïve,EGFR-mutated,advanced NSCLC,with a manageable safety profile.

关键词： cancer lung treatment