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Study of NMR porosity for terrestrial formation in China

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Science China(Physics,Mechanics & Astronomy) 2006年第3期49卷 313-320页

作者： wang xiaowen XIAO Lizhi XIE Ranhong ZHANG Yuanzhong Faculty of Natural Resource and Information Technology China University of Petroleum Beijing 102249 China Faculty of Natural Resource and Information Technology China University of Petroleum Beijing 102249 China Faculty of Natural Resource and Information Technology China University of Petroleum Beijing 102249 China Faculty of Natural Resource and Information Technology China University of Petroleum Beijing 102249 China

NMR logging is an effective method for porosity measurement. NMR-derived porosity only comes from the pore fluid and is, in principle, not affected by rock matrix. However, it is found that the difference between NMR-derived and conventional log-derived porosities is often between 2 to 6 pu, which is unacceptable, in terrestrial formation in China. In the paper, the theory of NMR porosity was reviewed. The influence factors on NMR porosity error were analyzed based on NMR core measurements. More than 30 core samples with a wide range of porosities including sandstone, limestone and artificial ceramic were chosen for the conventional and NMR porosity measurements. The current NMR data acquisition method was studied based on laboratory NMR core meas- urements and found to be not good for terrestrial formation. A new NMR data acquisition method suiting for terrestrial formation in China was proposed and much improved the accuracy of NMR porosity measurement. It is suggested that the analysis of core samples from different regions should be carried out before logging in order to obtain accurate NMR porosity.

关键词： NMR logging,terrestrial formation,porosity

三和散加减方联合八段锦治疗便秘型肠易激综合征肝郁气滞证的临床疗效

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中国中西医结合消化杂志 2024年第2期32卷 145-150页

作者：王晓雯牛明了张龙江万家鑫李勇骑余湘浩河南中医药大学第二临床医学院郑州450002 河南省中医院河南中医药大学第二附属医院肛肠科

目的:观察三和散加减方联合八段锦治疗便秘型肠易激综合征(IBS-C)肝郁气滞证的临床疗效。方法:收集2022年10月—2023年6月门诊收治的80例符合纳入标准的IBS-C患者,将其随机分为对照组和观察组,每组40例。对照组口服枸橼酸莫沙必利分散片... 详细信息

目的:观察三和散加减方联合八段锦治疗便秘型肠易激综合征(IBS-C)肝郁气滞证的临床疗效。方法:收集2022年10月—2023年6月门诊收治的80例符合纳入标准的IBS-C患者,将其随机分为对照组和观察组,每组40例。对照组口服枸橼酸莫沙必利分散片,观察组给予三和散加减方。2组均辅助配合八段锦,疗程4周。记录治疗前后患者肠易激综合征(IBS)中医证候评分、每周自发排便数(CSBM)、IBS严重程度积分表(IBS-SSS)、汉密尔顿焦虑、抑郁量表评分(HAMA、HAMD)、生活质量量表(IBS-QOL)、脑肠肽[5羟色氨(5-HT)、血管活性肽(VIP)、P物质(SP)]水平和复发情况。结果:观察组的总有效率为94.74%(36/38),明显优于对照组的74.36%(29/39)(P<0.05);治疗后,2组患者的CSBM频率、IBS-SSS、HAMA、HAMD、IBS-QOL评分及血清5-HT、VIP、SP水平均优于治疗前(P<0.05),且观察组优于对照组;观察组复发率为16.67%(6/36),明显低于对照组的48.28%(14/29)(P<0.01)。结论:三和散加减方联合八段锦治疗肝郁气滞证IBS-C具有减轻患者临床症状、调整脑肠肽、改善情绪、降低复发率等作用。

关键词：便秘型肠易激综合征三和散八段锦焦虑抑郁脑肠肽

Risk Prediction Model for Surgical Treatment of Ruptured Corpus Luteum in the Ovary

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Yangtze Medicine 2023年第2期7卷 63-75页

作者： Yuqi Qiu Sufei wang Yong Chen Wenrong He xiaowen wang Department of Obstetrics and Gynecology The First Affiliated Hospital of Yangtze University Jingzhou China

Objective: To explore the related factors of surgical treatment of patients with corpus luteum rupture and establish a risk prediction model of surgical treatment of corpus luteum rupture. Methods: 222 patients with corpus luteum rupture treated in Jingzhou First People’s Hospital from January 2015 to March 2022 were analyzed retrospectively, including 45 cases of surgery and 177 cases of conservative treatment. The training set and validation set were randomly assigned according to 7:3. We collected the basic information, laboratory and ultrasonic examination data of 222 patients. Logistic regression analysis was used to determine the independent risk factors and combined predictors of surgical treatment of corpus luteum rupture. The risk prediction model was established and the nomogram was drawn. The discrimination and calibration of the prediction model were verified and evaluated by receiver operating characteristic (ROC) curve, calibration curve and Hosmer-Lemeshow goodness of fit test;Decision curve analysis (DCA) was used to evaluate the clinical effectiveness of the prediction model. Results: Univariate logistic regression showed that whole abdominal pain (OR: 2.314, 95% CI: 1.090 - 4.912), abdominal muscle tension (OR: 2.379, 95% CI: 1.112 - 5.089), adnexal mass ≥ 4 cm (OR: 3.926, 95% CI: 1.771 - 8.266), hemoglobin Conclusion: The nomogram prediction model containing three predictive variables (hemoglobin, depth of pelvic effusion under ultrasound and cervical lifting pain) can be used to predict the risk of surgical treatment in patients with corpus luteum rupture.

关键词： Corpus Luteum Rupture Surgical Treatment Prediction Model

经皮穴位电刺激联合阶梯式运动想象疗法对脑卒中上肢和手功能的闭环康复疗效分析

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同济大学学报（医学版） 2024年第2期45卷 228-235页

作者：高佳佳王鹤玮刘兰兰夏小迪纪兆颖王晓文刘强曹叶凡陈瑶上海市第三康复医院康复医学科上海200436 复旦大学附属华山医院康复医学科上海200040

目的探究经皮穴位电刺激联合阶梯式运动想象疗法对脑卒中患者上肢和手功能康复的疗效。方法选取2021年1月—2023年4月上海市静安区北部地区医疗服务共同体成员单位脑卒中患者80例随机分为试验组(n=40)和对照组(n=40)。两组患者均接受常... 详细信息

目的探究经皮穴位电刺激联合阶梯式运动想象疗法对脑卒中患者上肢和手功能康复的疗效。方法选取2021年1月—2023年4月上海市静安区北部地区医疗服务共同体成员单位脑卒中患者80例随机分为试验组(n=40)和对照组(n=40)。两组患者均接受常规康复,试验组在此基础上接受基于“闭环康复”的经皮穴位电刺激联合阶梯式运动想象疗法,而对照组则接受经皮穴位电刺激治疗和注意力无效对照干预,总共干预4周。分别于治疗前后对两组患者进行Fugl-Meyer上肢运动功能评定量表(Fugl-Meyer assessment-upper extremities,FMA-UE)、积木盒障碍测试(boxing and blocking test,BBT)、改良Ashworth评分(modified Ashworth scale,MAS)和改良Barthel指数(modified Barthel index,MBI)的评定,并采用手心理旋转测试评价患者干预前的运动想象能力。结果试验组和对照组分别有35名和36名患者完成研究的所有干预和评定。治疗后两组FMA-UE、BBT、MBI评分均显著改善(t>3.545,P2.187,P<0.05)。相关性分析显示试验组患者FMA-UE的远端子项目评分变化值与治疗前心理旋转反应时间呈负相关(r=-0.676,P<0.001)。结论经皮穴位电刺激治疗联合阶梯式运动想象疗法可有效改善脑卒中的上肢和手运动功能,其疗效与患者的基线运动想象能力有关。

关键词：脑卒中经皮穴位电刺激阶梯式运动想象上肢手功能

Theoretical Study on the Kinetics for the Reactions of Heptyl Radicals with Methanol

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Chemical Research in Chinese Universities 2018年第5期34卷 786-791页

作者： ZHAO Zhongrui SONG Jinou SU Boyang wang xiaowen State Key Laboratory of Engines Tianjin University Tianjin 300072 R R. China

Ab initio study of the reactions ofn-heptyl radicals（1-C7H15, 2-C7H15, 3-C7H15, and 4-C7H15） with metha- nol was conducted over the temperature range of 300--1500 K. Transition states for the reaction channels producing CTH15OH, CH3, C7H15OCH3, H, C7H16, CH2OH and CH30 were identified and the geometries of all stationary points were calculated at BB1K/MG3S level of theory. The potential barrier heights of the corresponding transition states were predicted by the CBS-QB3//BB1K and G4//BB1K methods, indicating that the eight H-abstraction channels are more kinetically favorable than the channels where OH transfers from CH3OH to C7H15 and where the CTHIsOCH3＋H products are given. Tile rate constants of H-abstraction channels were calculated with TST and TST/Eck. Both the forward and reverse rate constants have positive temperature dependence and the ttmneling effect is only important at the temperature lower than 700 K. For the reactions of H-atom abstraction from methyl in CH3OH by n-heptyl, a reverse and the corresponding forward rate constant are roughly equal. For the reactions of H-atom abstraction from OH in CH3OH by n-heptyl, a reverse rate constant is larger by several orders of magnitude thin1 the corresponding forward one.

关键词： n-Heptane Methanol Ab initio calculation Conventional transition state theory Tunneling effect

LncRNA-CCAT5-mediated crosstalk between Wnt/β-Catenin and STAT3 signaling suggests novel therapeutic approaches for metastatic gastric cancer with high Wnt activity

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Cancer Communications 2024年第1期44卷 76-100页

作者： Chenchen Liu Aiwen Shen Junquan Song Lei Cheng Meng Zhang Yanong wang xiaowen Liu Department of Gastric Surgery Fudan University Shanghai Cancer CenterShanghaiP.R.China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiP.R.China Department of Nephrology Shanghai Ninth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiP.R.China Department of Pulmonary Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiP.R.China Department of Pathology Fudan University Shanghai Cancer CenterShanghaiP.R.China

Background:Although the constitutively activated Wnt/β-catenin signaling pathway plays vital roles in gastric cancer(GC)progression,few Wnt inhibitors are approved for clinical ***,the clinical significance of long non-coding RNAs(lncRNAs)in GC intraperitoneal dissemination(IPD)remains ***,we investigated the function and therapeutic potential of Wnt-transactivated lncRNA,colon cancer-associated transcript 5(CCAT5),in GC ***:LncRNA-sequencing assay was performed to document abun-dance changes of lncRNAs induced by Wnt family member 3A(Wnt3a)and degradation-resistantβ-catenin(S33Y mutated)in ascites-derived GC cells with low Wnt *** reporter,Chromatin immunoprecipitation(ChIP)-re-ChIP assays were performed to determine how CCAT5 was *** clinical significance of CCAT5 was examined in 2 cohorts of GC *** biological function of CCAT5 was investigated through gain-and loss-of-function *** molecular mechanism was explored through RNA-sequencing,mass spectrometry,and CRISPR/Cas9-knocknout *** therapeutic potential of CCAT5 was examined through RNAi-based cell xenograft model and patient-derived xenograft(PDX)model of ***:WeidentifiedanovelWnt-regulatedlncRNA,CCAT5,whichwastrans-activated by theβ-catenin/transcription factor 3(TCF3)***5 was significantly upregulated in GC and predicted poor *** studies confirmed the promotive role of CCAT5 in GC growth and ***-tically,CCAT5 bound to the C-end domain of signal transducer and activator of transcription 3(STAT3)and blocks Src homology 2 domain-containing protein tyrosine phosphatase 1(SHP-1)-mediated STAT3 Y705 dephosphorylation,leading to STAT3 nuclear entry and transactivation,thus accelerating GC ***,we demonstrated that both Wnt3a andβ-catenin acted as activa-tor of STAT3 signaling pathway,and the interplay between CCAT5 and STAT3 was functionally essential for Wnt-

关键词： CCAT5 gastric cancer intraperitoneal dissemination STAT3 Wnt/β-catenin

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1例经肛回肠脱垂病例报告

结直肠肛门外科 2024年第3期30卷 379-383,388页

作者：李勇骑牛明了张龙江赵玉洲程艺伟唐诚馨王晓雯河南中医药大学第二临床医学院河南郑州450002 河南省中医院肛肠科河南郑州450002 河南省肿瘤医院普外科河南郑州450003

直肠脱垂术后复发是临床关注的问题,术后复发性直肠脱垂患者的再次手术治疗需要综合患者因素、手术特点和手术风险、医师团队的临床实践经验等方面的情况来选择手术方案,以减轻患者对于手术治疗的心理负担和提升患者对于手术治疗的满意... 详细信息

直肠脱垂术后复发是临床关注的问题,术后复发性直肠脱垂患者的再次手术治疗需要综合患者因素、手术特点和手术风险、医师团队的临床实践经验等方面的情况来选择手术方案,以减轻患者对于手术治疗的心理负担和提升患者对于手术治疗的满意度。笔者团队收治了1例经肛回肠脱垂患者,其曾因复发性直肠脱垂反复接受手术治疗。该患者在回肠脱出于肛门外之后接受了回肠系膜折叠+末端回肠系膜悬吊固定+肛门环缩术治疗,术后1年内未再诉肛内肿物脱出。本文报告该患者的临床诊治过程,与同道交流。

关键词：回肠脱垂复发性直肠脱垂 Altemeier术回肠系膜折叠术

pH-Responsive polymer boosts cytosolic siRNA release for retinal neovascularization therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 781-794页

作者： Shuai Guo Chunhui Li Changrong wang xiaowen Cao Xinyue Liu Xing-Jie Liang Yuanyu Huang Yuhua Weng School of Medical Technology Advanced Research Institute of Multidisciplinary ScienceSchool of Life ScienceKey Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China School of Pharmacy Shandong New Drug Loading&Release Technology and Preparation Engineering LaboratoryBinzhou Medical UniversityYantai 264003China School of Ophthalmology and Optometry School of Biomedical EngineeringThe Eye HospitalWenzhou Medical UniversityWenzhou 325027China Chinese Academy of Sciences(CAS) Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China

Small interfering RNA(siRNA)has a promising future in the treatment of ocular diseases due to its high efficiency,specificity,and low toxicity in inhibiting the expression of target genes and ***,due to the unique anatomical structure of the eye and various barriers,delivering nucleic acids to the retina remains a significant *** this study,we rationally design PACD,an A-B-C type non-viral vector copolymer composed of a hydrophilic PEG block(A),a siRNA binding block(B)and a pH-responsive block(C).PACDs can self-assemble into nanosized polymeric micelles that compact siRNAs into polyplexes through simple *** evaluating its pH-responsive activity,gene silencing efficiency in retinal cells,intraocular distribution,and anti-angiogenesis therapy in a mouse model of hypoxia-induced angiogenesis,we demonstrate the efficiency and safety of PACD in delivering siRNA in the *** are surprised to discover that,the PACD/siRNA polyplexes exhibit remarkable intracellular endosomal escape efficiency,excellent gene silencing,and inhibit retinal *** study provides design guidance for developing efficient nonviral ocular nucleic acid delivery systems.

关键词： SiRNA Oculardeliverysystem Block polymer Endosomalescape Retinal neovascularization Blood-retinal barrier VEGFA Safety

A VGGNet-based correction for satellite altimetry-derived gravity anomalies to improve the accuracy of bathymetry to depths of 6500 m

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Acta Oceanologica Sinica 2024年第1期43卷 112-122页

作者： Xiaolun Chen xiaowen Luo Ziyin Wu Xiaoming Qin Jihong Shang Huajun Xu Bin Li Mingwei wang Hongyang Wan Key Laboratory of Submarine Geosciences Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Ocean College Zhejiang UniversityZhoushan 316021China Key Laboratory of Ocean Space Resources Management Technology Marine Academy of ZhejiangHangzhou 310012China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200240China School of Civil Engineering and Architectures Zhejiang University of Science and TechnologyHangzhou 310023China National Center for Archaeology Beijing 100013China

Understanding the topographic patterns of the seafloor is a very important part of understanding our *** the science involved in bathymetric surveying has advanced much over the decades,less than 20%of the seafloor has been precisely modeled to date,and there is an urgent need to improve the accuracy and reduce the uncertainty of underwater survey *** this study,we introduce a pretrained visual geometry group network(VGGNet)method based on deep *** apply this method,we input gravity anomaly data derived from ship measurements and satellite altimetry into the model and correct the latter,which has a larger spatial coverage,based on the former,which is considered the true value and is more *** obtaining the corrected high-precision gravity model,it is inverted to the corresponding bathymetric model by applying the gravity-depth *** choose four data pairs collected from different environments,i.e.,the Southern Ocean,Pacific Ocean,Atlantic Ocean and Caribbean Sea,to evaluate the topographic correction results of the *** experiments show that the coefficient of determination(R~2)reaches 0.834 among the results of the four experimental groups,signifying a high *** standard deviation and normalized root mean square error are also evaluated,and the accuracy of their performance improved by up to 24.2%compared with similar research done in recent *** evaluation of the R^(2) values at different water depths shows that our model can achieve performance results above 0.90 at certain water depths and can also significantly improve results from mid-water depths when compared to previous ***,the bathymetry corrected by our model is able to show an accuracy improvement level of more than 21%within 1%of the total water depths,which is sufficient to prove that the VGGNet-based method has the ability to perform a gravity-bathymetry correction and achieve outstanding results.

关键词： gravity anomaly bathymetry inversion VGGNet multibeam sonar satellite altimetry