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Fucosyltransferase 8 regulates adult neurogenesis and cognition of mice by modulating the Itga6-PI3K/Akt signaling pathway

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Science China(Life Sciences) 2024年第7期67卷 1427-1440页

作者： Hongfeng Guo Qihang Sun Xiaoli Huang xiaohao wang Feng Zhang Wenzheng Qu Jinling Liu Xuejun Cheng Qiang Zhu Wen Yi Qiang Shu Xuekun Li The Children’s Hospital National Clinical Research Center for Child HealthSchool of MedicineZhejiang UniversityHangzhou 310052China The Institute of Translational Medicine School of MedicineZhejiang UniversityHangzhou 310029China College of Life Sciences Zhejiang UniversityHangzhou 310058China Binjiang Institute of Zhejiang University Hangzhou 310053China Zhejiang University Cancer Center Zhejiang UniversityHangzhou 310029China

Fucosyltransferase 8(Fut8)and core fucosylation play critical roles in regulating various biological processes,including immune response,signal transduction,proteasomal degradation,and energy ***,the function and underlying mechanism of Fut8 and core fucosylation in regulating adult neurogenesis remains *** have shown that Fut8 and core fucosylation display dynamic features during the differentiation of adult neural stem/progenitor cells(aNSPCs)and postnatal brain ***8 depletion reduces the proliferation of a NSPCs and inhibits neuronal differentiation of aNSPCs in vitro and in vivo,***,Fut8 deficiency impairs learning and memory in ***,Fut8 directly interacts with integrinα6(Itga6),an upstream regulator of the PI3kAkt signaling pathway,and catalyzes core fucosylation of *** of Fut8 enhances the ubiquitination of Itga6 by promoting the binding of ubiquitin ligase Trim21 to *** levels of Itga6 inhibit the activity of the PI3K/Akt signaling ***,the Akt agonist SC79 can rescue neurogenic and behavioral deficits caused by Fut8 *** summary,our study uncovers an essential function of Fut8 and core fucosylation in regulating adult neurogenesis and sheds light on the underlying mechanisms.

关键词： Fut8 adult neural stem/progenitor cells neurogenesis Itga6 PI3K/Akt

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Mercury removals by existing pollutants control devices of four coal-fired power plants in China

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Journal of Environmental Sciences 2011年第11期23卷 1839-1844页

作者： Juan wang Wenhuawang Wei Xu xiaohao wang Song Zhao School of Environmental Science ＆ Engineering Shanghai Jiao Tong University Shanghai 200240 China Shanghai Environmental Monitoring Center Shanghai 200030 China

The mercury removals by existing pollution control devices and the mass balances of mercury in four coal-fired power plants of China were carried out based on a measurement method with the aluminum matrix *** the plants are equipped with a cold-side electrostatic precipitator （ESP） and a wet flue gas desulfurization （FGD） in *** the course of coal stream,the samples,such as coal,bottom ash,fly ash,gypsum and flue gas,were *** Hg concentrations in coals were measured by CVAAS after appropriate preparation and acid *** solid samples were measured by the RA-915 ＋ Zeeman Mercury *** vapor phase Hg was collected by a sorbent trap from flue gas and then measured using CVAAS followed by acid *** mercury mass balances were estimated in this study were 91.6%,77.1%,118% and 85.8% for the four power plants,*** total Hg concentrations in the stack gas were ranged from 1.56–5.95 μg/m *** relative distribution of Hg in bottom ash,ESP,WFGD and stack discharged were ranged between 0.110%–2.50%,2.17%–23.4%,2.21%–87.1%,and 21.8%–72.7%,*** distribution profiles were varied with the coal type and the operation *** Hg in flue gas could be removed by ESP and FGD systems with an average removal efficiency of 51.8%.The calculated average emission factor was 0.066 g/ton and much lower than the results obtained ten years ago.

关键词： mercury power plant mass balance distribution removal efficiency emission factor

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基于锚杆系统横向振动频率响应特征的轴力检测方法

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山东科技大学学报（自然科学版） 2024年第3期43卷 11-20页

作者：王晓皓邢明录于凤海陈建崇山东科技大学能源与矿业工程学院山东青岛266590 山东科技大学矿山灾害预防控制省部共建国家重点实验室培育基地山东青岛266590 鄂尔多斯市昊华红庆梁矿业有限公司内蒙古鄂尔多斯017000

基于锚杆系统自由段横向振动特性的检测方法可实现对锚杆的大范围快速有效检测。为提升锚杆轴力检测精度,建立锚杆系统横向振动力学模型,测试了全尺寸锚杆系统轴向加载过程中的频率响应。结果表明:锚杆系统横向振动固有频率对转动刚度... 详细信息

基于锚杆系统自由段横向振动特性的检测方法可实现对锚杆的大范围快速有效检测。为提升锚杆轴力检测精度,建立锚杆系统横向振动力学模型,测试了全尺寸锚杆系统轴向加载过程中的频率响应。结果表明:锚杆系统横向振动固有频率对转动刚度及锚杆自由段长度比较敏感;通过试验校准理论模型的转动刚度,所得理论预计轴力与试验结果的吻合度较好,频率阶次越低,轴力检测误差越小;轴力较低时,基频轴力检测的平均相对误差为5.8%,轴力较高时,平均相对误差仅为0.6%;当锚杆杆体进入塑性或界面脱粘滑移后,锚杆自由段长度变化较大,通过实时修正锚杆自由段长度,可实现锚杆系统损伤阶段的轴力检测,基频轴力检测的平均相对误差在4.1%以内。锚杆轴力的快速、无损检测方法对于支护系统及围岩稳定性评估具有重要意义。

关键词：锚杆系统无损检测锚杆轴力振动模型固有频率

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The Influencing Factors of Disposable Acetylcholinesterase Biosensor for in Situ Detection of Organophosphorus Pesticide

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稀有金属材料与工程 2006年第A3期35卷 389-391页

作者： Xiaowen Xu xiaohao wang Fei Tang Zhaoying Zhou State Key Laboratory of Precision Measurement Technology and Instruments Tsinghua University Beijing 100084 China

An amperometric biosensor based on acetylcholinesterase (ACHE) is assembled by simple adsorption of the AChE on 7,7,8,8-tetracyanoquinodimethane (TCNQ) modified screen-printed *** biosensor is used to detect the inhibitory effect of organophosphorus pesticides on AChE *** detection of organophosphorus pesticides is done with acetylthiocboline chloride (ATCh) as *** order to obtain the optimized response to substrate,the influencing factors of the biosensor are investigated,including temperature,pH,incubation time,substrate concentration and AChE concentration. The measurements were performed after inhibition by immersing the enzyme electrode into the parathion methyl solution. Under the optimized conditions,that is,500 U/ml AChE concentration,pH 7.2,10 min incubation time,2 mmol/L substrate concentration and temperature of 37℃,from 5×10^(-8) mol/L to 5×10^(-5) mol/L is close to linear (regression equation: y(%)=124.055+15.7991gx,R^2=0.99644),which corresponds to 8.7%～56.1% AChE *** the optimized conditions, the lowest detectable amount of parathion methyl is 13×10^(-9).

关键词： biosensor AChE screen-printed electrodes influencing factors organophosphorus pesticides

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Experimental and simulation research on the influence of voltage amplitude,frequency and carrier gas flow rate on the performance of FAIMS

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Science China(Technological Sciences) 2011年第6期54卷 1407-1414页

作者： TANG Fei LI Hua wang xiaohao YANG Ji ZHANG Liang wang Fan State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision Instruments and Mechanology Tsinghua University Beijing 100084 China School of Electronics and Computer Science and Technology North University of China Taiyuan 030051 China

A micro sensor chip of High-field Asymmetric Waveform Ion Mobility Spectrometry(FAIMS) was designed and fabricated by inductively coupled plasma(ICP) etching on the both sides of silicon and double silicon-glass bonding,with dimensions of 18.8 mm×12.4 mm×*** sample ions were created at ambient pressure by VUV lamp ion source,which was equipped with a 10.6 eV photo discharge lamp(λ=116.5 nm).The 2-pentanone was adopted to illustrate the influences of high-field rectangular asymmetric waveform voltage amplitude,frequency and carrier gas flow rate on the performance of FAIMS sensor *** experiment results showed that with the frequency or carrier gas flow rate increasing,or voltage amplitude decreasing,the FAIMS sensitivity increases,and that the resolution decreases with the increasing of the frequency or flow *** FAIMS simulation results based on the SIMION software was in agreement with the experimental *** FAIMS detection sensitivity experiment showed that the FAIMS sensor chip can detect positive and negative ions simultaneously,and has detection sensitivity as low as 0.1 ppm for acetic acid.

关键词： FAIMS vacuum ultraviolet lamp MEMS rectangular asymmetric waveform voltage SIMION

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Disposable Amperometric Acetylcholinesterase Biosensor for the Detection of Organophosphorus Pesticides

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稀有金属材料与工程 2006年第A3期35卷 333-336页

作者： xiaohao wang Xiaowen Xu Fei Tang Zhaoying Zhou State Key Laboratory of Precision Measurement Technology and Instruments Tsinghua University Beijing 100084 China

A rapid,simple,disposable and inexpensive acetylcholinesterase (ACHE) amperometric biosensor for the detection of organophosphorus pesticides was developed by simple adsorption of the enzyme on screen-printed *** biosensor consisted of an Ag/AgCl reference electrode and a graphite working *** mixture of graphite and the 7,7,8,8-tetracyanoquinodimethane (TCNQ) was printed on *** detection of organophosphorus pesticides was done with acetylthiocholine chloride (ATCh) as *** biosensor was used to detect the inhibitory effect of organophosphorus pesticides on AChE *** 1μl of enzyme solution containing 0.1 U AChE and 1% bovine serum albumin (BSA) were simply dropped on the working electrode *** biosensor operated at a potential of 300 mV vs. Ag/AgCl in a pH 7.2 0.1 mol/L phosphate buffer and 0.1 mol/L *** obtained a calibration plot of the percentage inhibition versus the logarithm of parathion methyl concentration following an incubation time of 10 mix in parathion methyl solution. The lowest detectable amount of parathion methyl was 0.026 *** amperometric biosensor based on acetylcholinesterase was disposable and low cost (about 1 yuan RMB).

关键词： amperometric biosensor AChE screen-printed electrodes organophosphorus pesticides

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Development of Disposable Amperometric Cholesterol Biosensor

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稀有金属材料与工程 2006年第A3期35卷 321-323页

作者： xiaohao wang Fei Tang Xiaowen Xu Zhencheng Chen State Key Laboratory of Precision Measurement Technology and Instruments Tsinghua University Beijing 100084 China

A novel disposable cholesterol biosensor based on electrochemical process is developed adopting screen printing *** system consists of a graphite reference electrode and a working *** mixture of cholesterol oxidase and K_4Fe (CN)_6 is printed on the *** biosensor determines total cholesterol content through indirect determination of free cholesterol in the whole human *** 0.3V voltage is applied to the electrodes,the range of detection is from 250 mg/L to 2000 mg/L,with the correlation coefficient of *** total detective duration is less than 200s,and the sample volume is only 4μL.

关键词： cholesterol biosensor carbon electrode screen printing

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Application of Dynamic Linear Detecting Method in Data Processing of the Portable Blood Sugar Analyzer

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稀有金属材料与工程 2006年第A3期35卷 80-82页

作者： xiaohao wang Ran Liu Fei Tang Yangchun Yu Zhaoying Zhou State Key Laboratory of Precision Measurement Technology and Instruments Dept. of Precision Instruments Tsinghua Univ. Beijing 100084 China Dept. of Biomedical Engineering Tsinghua Univ. Beijing 100084 China

In this paper,a dynamic linear detecting method,that the non-linear coefficient NL% was led and the non-linearity of data were estimated continuously and dynamically and determined when NL% exceeded reference value (5%),was used for data processing and could solve the problem caused by the phenomenon of substrate depleting occurred following the redox reaction in portable blood sugar *** contrast to the conventional end-point method,the dynamic linear detecting method is based on multipoint data *** of measuring the calibration glucose solution with 8 various concentrations from 50 mg/dl to 400 mg/dl were carried out with the analyzer developed by our *** linear regression curve,whose correlation for the data was 0.9995 and the residual was 2.8080,were *** obtained correlation,residual, and the computation workload are all fit for the portable blood sugar analyzer.

关键词： data processing portable blood sugar analyzer dynamic linear detecting method

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Three-Probe Error Separation with Chromatic Confocal Sensors for Roundness Measurement

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Nanomanufacturing and Metrology 2021年第4期4卷 247-255页

作者： Jiao Bai Yingzuo wang xiaohao wang Qian Zhou Kai Ni Xinghui Li Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Institute of Materials China Academy of Engineering PhysicsMianyang 621907China

In this study,three-probe error separation was developed with three chromatic confocal displacement sensors for roundness ***,the harmonic suppression is discussed first to set suitable orientation angles among three *** Carlo simulation is utilized to test the error separation and optimize the orientation angles and off-axial *** experimental setup is established using chromatic confocal sensors with a precise rotary *** experimental results show that the measured roundness with an orientation-angle combination of(0°,90.1°,and 178.6°)is much better than that of another nonoptimal selection(0°,90.4°,and 177.4°).The roundness error is only 0.7%between the proposed measurement system and an expensive ultraprecision roundness ***,it is proven that the eccentricity distance should be decreased as small as possible to improve the measurement *** sum,this paper proposes a feasible method for roundness measurement with reliable simulations,easily integrated sensors,and an ordinary precision rotary platform.

关键词： Roundness measurement Three-probe error separation Chromatic confocal sensor Monte Carlo simulation

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Facile construction of highly efficient MOF-based Pd@UiO-66-NH_(2)@ZnIn_(2)S_(4)flower-like nanocomposites for visible-light-driven photocatalytic hydrogen production

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Journal of Materials Science & Technology 2021年第17期76卷 189-199页

作者： Mengting Cao Fengli Yang Quan Zhang Juhua Zhang Lu Zhang Lingfeng Li xiaohao wang Wei-Lin Dai Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan UniversityShanghai 200438China

Construction of metal-organic-frame works-based composite photocatalysts has attracted much attention for the reasonable band gap and high surface areas to improve the photocatalytic *** this study,the ternary heterojunction Pd@UiO-66-NH_(2)@ZnIn_(2)S_(4)nanocomposites were facilely prepared for the first time by a two-step *** visible-light-promoted hydrogen production rate of 0.3%Pd@UiO-66-NH_(2)@ZnIn_(2)S_(4)reaches up to 5.26 mmol g^(-1)h^(-1),which is evidently much higher than pure UiO-66-NH_(2),ZnIn_(2)S_(4)and binary UiO-66-NH_(2)/ZnIn_(2)S_(4)*** a huge improvement in the photocatalytic performance is mainly attributed to the matched band gap of ZnIn_(2)S_(4)and UiO-66-NH_(2),and the introduction of Pd NPs into photocatalysts that broaden spectral response range and promote the photon induced charge carrier *** work may provide a feasible approach for the design and construction of metal-organic-frameworks-based photocatalytic materials.

关键词： Metal-organic frameworks(MOFs) UiO-66-NH_(2) ZnIn_(2)S_4 Pd nanoparticles Photocatalytic hydrogen production

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