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熊去氧胆酸胶囊口服联合腺苷蛋氨酸静脉滴注对妊娠期肝内胆汁淤积症患者的疗效分析

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中国实用医药 2024年第14期19卷 121-123页

作者：杨璠程慧英王晓珍上饶卫生学校(上饶卫校附属医院) 334600 上饶卫校附属医院广丰区妇幼保健院 334600

目的探究熊去氧胆酸胶囊口服联合腺苷蛋氨酸静脉滴注对妊娠期肝内胆汁淤积症患者的疗效。方法105例妊娠期肝内胆汁淤积症患者,按照随机数字表法分为对照组(52例)与观察组(53例)。对照组单用熊去氧胆酸胶囊口服治疗,观察组联用熊去氧胆... 详细信息

目的探究熊去氧胆酸胶囊口服联合腺苷蛋氨酸静脉滴注对妊娠期肝内胆汁淤积症患者的疗效。方法105例妊娠期肝内胆汁淤积症患者,按照随机数字表法分为对照组(52例)与观察组(53例)。对照组单用熊去氧胆酸胶囊口服治疗,观察组联用熊去氧胆酸胶囊口服、腺苷蛋氨酸静脉滴注治疗。比较两组患者的治疗效果、肝功能指标[谷氨酸氨基转移酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、直接胆红素(DBIL)、总胆红素(TBIL)、血清总胆汁酸(TBA)]、不良妊娠结局发生情况。结果观察组治疗总有效率98.11%高于对照组的76.92%(P<0.05)。治疗2周后,观察组ALT、AST、ALP、DBIL、TBIL、TBA分别为(82.34±10.56)U/L、(103.12±10.16)U/L、(51.23±8.54)U/L、(6.14±1.43)μmol/L、(18.23±3.24)μmol/L、(18.79±3.65)μmol/L,低于对照组的(128.56±13.27)U/L、(156.43±13.19)U/L、(89.96±9.67)U/L、(9.68±1.62)μmol/L、(24.05±3.78)μmol/L、(29.94±4.37)μmol/L(P<0.05);治疗2周后,两组ALT、AST、ALP、DBIL、TBIL、TBA低于治疗前(P<0.05)。观察组不良妊娠结局发生率5.66%低于对照组的23.08%(P<0.05)。结论妊娠期肝内胆汁淤积症联用熊去氧胆酸胶囊口服、腺苷蛋氨酸静脉滴注治疗,可提高治疗效果,改善肝功能指标与母婴妊娠结局,值得临床推广。

关键词：妊娠期肝内胆汁淤积症熊去氧胆酸胶囊腺苷蛋氨酸治疗效果肝功能指标不良妊娠结局

基于修订肠内营养耐受性评分表的干预方案对ICU患者早期肠内营养喂养不耐受的影响

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中国现代药物应用 2024年第8期18卷 162-165页

作者：林小琳王小珍黄燕玲泉州市第一医院重症医学科 362000

目的评价基于修订肠内营养耐受性评分表的干预方案对重症加强护理病房(ICU)患者早期肠内营养(EN)喂养不耐受(FI)的影响。方法82例ICU行早期EN的患者为研究对象,采用随机数字表法分为研究组与对照组,每组41例。对照组通过监测胃残留量(G... 详细信息

目的评价基于修订肠内营养耐受性评分表的干预方案对重症加强护理病房(ICU)患者早期肠内营养(EN)喂养不耐受(FI)的影响。方法82例ICU行早期EN的患者为研究对象,采用随机数字表法分为研究组与对照组,每组41例。对照组通过监测胃残留量(GRV)评估EN耐受性并进行分级干预,研究组采用修订肠内营养耐受性评分表评估EN耐受性并进行分级干预。比较两组患者FI发生率、目标喂养达标率与营养指标[血清总蛋白(TP)、血清白蛋白(ALB)与血红蛋白(Hb)]。结果研究组与对照组FI发生率分别为19.4%与35.4%,目标喂养达标率分别为77.4%与62.3%。研究组FI发生率低于对照组,目标喂养达标率高于对照组(P0.05)。结论基于修订肠内营养耐受性评分表的干预方案可提升ICU患者对EN的耐受性与目标喂养达标率,提升营养支持效果。

关键词：重症加强护理病房肠内营养喂养不耐受肠内营养耐受性评分表

Modified trabeculotomy for primary congenital glaucoma

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Chinese Medical Journal 2013年第19期126卷 3793-3794页

作者： WAN Xiu-hua wang xiao-zhen wang Ning-li Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Science Key Laboratory Beijing 100710 China Beijing Institute of Ophthalmology Beijing 100710 China Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Science Key Laboratory Beijing 100710 China

In traditional trabeculotomy,a radial incision is performed at the corneoscleral transition zone to locate the Schlemm＇s ***,in some conditions,finding the Schlemm＇s canal is difficult because of the enlargement of the comea,developmental anomalies of the angle,*** our study,we performed a modified trabeculotomy,to locate the Schlemm＇s canal easily and accurately and evaluated the outcomes.

关键词： congenital glaucoma trabeculotomy intraocular pressure

Polymer-to-Monomers Chemically Recyclable Poly(imide-imine)Plastics with Extreme-Condition Resistance and Flame Retardancy

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Chinese Journal of Polymer Science 2024年第10期42卷 1525-1535,I0012页

作者： zhen-Yu wang xiao-Kong Liu State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012China

Polyimides are a family of high-tech plastics that have irreplaceable applications in the fields of aerospace,defense,and opto-electronics,but polyimides are difficult to be reprocessed and recycled at the end of their service life,resulting in a significant waste of ***,it is of great significance to develop recyclable polyimides with comparable properties to the commercial ***,we report a novel polymer-to-monomers chemically recyclable poly(imide-imine)(PtM-CR-PII)plastic,synthesized by cross-linking the amine-terminated aromatic bisimide monomer and the hexa-vanillin terminated cyclophosphazene monomer via dynamic imine *** PtM-CR-PII plastic exhibits comparable mechanical and thermal properties as well as chemical stability to the commercial *** PtM-CR-PII plastic possesses a high Young’s modulus of≈3.2 GPa and a tensile strength as high as≈108 MPa,which also exhibits high thermal stability with a glass transition temperature of≈220℃.Moreover,the PtM-CR-PII plastic exhibits outstanding waterproofness,acid/alkali-resistance,and solvent-resistance,its appearance and mechanical properties can be well maintained after long-term soaking in water,highly concentrated acid and base,and various organic ***,the cyclophosphazene moieties endow the PtM-CR-PII plastic with excellent flame *** PtM-CR-PII plastic exhibits the highest UL-94 flame-retarding rating of V-0 and a limiting oxygen index(LOI)value of 45.5%.Importantly,the PtM-CR-PII plastic can be depolymerized in an organic solvents-acid mixture medium at room temperature,allowing easy separation and recovery of both monomers in high *** recovered pure monomers can be used to regenerate new PtM-CR-PII plastics,enabling sustainable polymer-monomers-polymer circulation.

关键词： Chemical recyclability Polyimides Polyimines Dynamic imine bonds Mechanical properties Chemical stability

Testing of Seedborne Fungi in Wheat Germplasm Conserved in the National Crop Genebank of China

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Agricultural Sciences in China 2007年第6期6卷 682-687页

作者： DUAN Can-xing wang xiao-ming ZHU zhen-dong WU xiao-fei Institute of Crop Sciences Chinese Academy of Agricultural Sciences~The National Key Facilities for Crop Gene Resources and GeneticImprovement （NFCRI） Beijing 100081 P.R.China

There is a primary understanding of the dominant fungi in wheat seeds conserved in the National Crop Genebank of China （NCGB） and an evaluation of the healthy status of wheat germplasm propagated in different regions. A total of 1 465 wheat accessions were detected for seedbone fungi by blotter, agar plate, and wash tests. By blotter test, 17 genera of fungi, including more than 30 species, were detected in 712 wheat accessions from Shaanxi, Hebei, and Qinghai provinces, China. Alternaria was the most frequently detected in wheat seeds from Shaanxi Province, followed by Rhizopus, Penicillium, Aspergillus, Bipolaris, Cladosporium, Gonatobotrys, Chaetomium, and others. Seedborne fungi in wheat seeds from Hebei Province, with relatively high incidence were Alternaria, Rhizopus, Penicillium, Aspergillus, Bipolaris, Cladosporium, and Fusarium. In the seeds from Qinghai Province, Alternaria, Rhizopus, Bipolaris, Cladosporium, and Trichothecium are important seed-borne fungi. The seed germination was reduced substantially when seeds were infected by Fusarium verticillioides （syn. F. moniliforme）, Bipolaris nodulosa, and Cladosporium herbarum. Eighteen genera and 25 species of fungi were identified in 353 accessions from Shaanxi Province using the agar plate test. The dominant fungi were Alternaria, Aspergillus, Bipolaris, Gonatobotrys, Penicillium, and Fusarium. The smut fungi, Ustilago tritici, was detected by the wash test in 400 accessions, but it was low in incidence in 300 seed samples from Shaanxi Province （1.3%）, and in 100 samples from Hebei Province （2.0%）. Totally 19 genera of fungi were detected in wheat seed samples, and some seedborne fungi were saprophytic and others were biotrophic which could cause seedborne diseases in the field.

关键词： wheat gerrnplasm seedborne fungi seed health detection

Progress and challenges of electrolyte modulation in aqueous zinc-ion batteries

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Rare Metals 2024年第7期43卷 2940-2967页

作者： Qi-Hang Yang Lu-Fei wang xiao-Yu wang Meng-Meng zhen Tianjin Key Laboratory of Clean Energy and Pollution Control School of Energy and Environmental EngineeringHebei University of TechnologyTianjin 300071China

As a new type of green battery system,aqueous zinc-ion batteries(AZIBs)have gradually become a research hotspot due to their low cost,high safety,excellent stability,high theoretical capacity(820 mAh·g^(-1))of zinc anode,and low redox potential(-0.76 V *** hydrogen electrode(SHE)).AZIBs have been expected to be an alternative to lithium-ion batteries for large-scale commercial energy storage ***,they are facing thorny issues such as degradation of cycling performance,zinc dendrites,and side *** the same time,these problems cause short cycling life of batteries,thus severely limiting their commercial *** recent years,many more researches have been conducted on the modification of anode and cathode materials of AZIBs,but there is a lack of in-depth discussion on the characteristics and mechanism of electrolyte *** this review,we will make a systematic summary of the current problems with two electrodes in AZIBs,as well as the types and functions of electrolyte ***,we further systematically describe the modulation mechanism of electrolyte additives in the performance of the cathode and *** prospects and development directions of additive modulation strategies for AZIBs electrolytes are prospected.

关键词： Electrolyte additives Aqueous zinc-ion batteries Zinc anode protection Cathode chemistry

Revisiting the island of hexadecapoledeformation nuclei in the A≈150 mass region:focusing on the model application to nuclear shapes and masses

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Communications in Theoretical Physics 2024年第2期76卷 74-88页

作者： xiao-Yang Wei Hua-Lei wang zhen-zhen Zhang Min-Liang Liu School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Key Laboratory of High Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Based on the potential-energy-surface calculation,the impact of different deformation degrees of freedom on a single-particle structure and binding energies in nuclei around^(152)Nd,located on one of the hexadecapole-deformation islands,is analyzed in a multi-dimensional deformation *** energy maps,curves and tables are presented to indicate nuclear *** calculated equilibrium deformations and binding energies with different potential parameters are compared with experimental data and other *** is found that the inclusion of the hexadecapole deformations,especially the axial one,can improve the theoretical description of both nuclear shapes and *** addition,our calculated potential-energy curve shows that a critical deformation-point,β_(2)≈0.4,exists—the triaxial(hexadecapole)deformation effect can be neglectable but the hexadecapole(triaxial)one plays an important role before(after)such a critical point.

关键词： hexadecapole deformation binding energy potential-energy-surface calculation nuclear property

Laser manufacturing of spatial resolution approaching quantum limit

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Light(Science & Applications) 2024年第3期13卷 421-428页

作者： xiao-Jie wang Hong-Hua Fang zhen-Ze Li Dan wang Hong-Bo Sun State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University2699 Qianjin StreetChangchun 130012China

Atomic and close-to-atom scale manufacturing is a promising avenue toward single-photon emitters,single-electron transistors,single-atom memory,and quantum-bit devices for future communication,computation,and sensing *** manufacturing is outstanding to this end for ease of beam manipulation,batch production,and no requirement for *** is,however,suffering from optical diffraction ***,we report a spatial resolution improved to the quantum limit by exploiting a threshold tracing and lock-in method,whereby the two-order gap between atomic point defect complexes and optical diffraction limit is surpassed,and a feature size of<5 nm is *** underlying physics is that the uncertainty of local atom thermal motion dominates electron excitation,rather than the power density slope of the incident *** show that the colour centre yield in hexagonal boron nitride is transformed from stochastic to deterministic,and the emission from individual sites becomes polychromatic to *** a result,single colour centres in the regular array are deterministically created with a unity yield and high positional accuracy,serving as a step forward for integrated quantum technological applications.

关键词： quantum limit resolution

A novel real-time RT-PCR with TaqM an-MGB probes and its application in detecting BVDV infections in dairy farms

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Journal of Integrative Agriculture 2015年第8期14卷 1637-1643页

作者： ZHANG Yong-qiang LIU Hai-sheng WU xiao-dong wang xiao-zhen LI Jin-ming ZHAO Yong-gang Lü Yan REN Wei-jie GE Sheng-qiang wang Zhi-liang China Animal Health and Epidemiology Center Beijing Dabeinong Technology Group Co. Ltd.

A real-time RT-PCR assay using Taq Man-MGB probes was developed to detect and type the bovine viral diarrhea virus（BVDV） in *** primers and Taq Man-MGB probes were designed from the 5′-untranslated region of known pestiviral *** to optimizing the assay, c RNAs were transcribed in vitro from the BVDV 1 and BVDV 2 RTPCR products to make standard *** detection limit of the assay was 1.72×102 copies for BVDV 1 and 2.14×102copies for BVDV *** specificity of the assay evaluated on several BVDV strains including bovine herpesvirus 1（BHV 1）, foot and mouth disease virus（FMDV） and several classical swine fever virus（CSFV） strains showed specific detection of the positive virus over 40 *** assay was highly reproducible with the coefficient of variance ranging from 1.04 to 1.33% for BVDV 1 and from 0.83 to 1.48% for BVDV 2, *** this method, we tested a total of 2 327 cattle from three dairy farms for the presence of BVDV persistently infected（PI） *** this assay, each RT-PCR template contained a mixture of ten samples from different *** occurrence rate of PI cattle in three farms ranging from 0.9 to 2.54% could represent partly the PI rates in cattle farm in *** conclusion, using our real-time PCR assay, we could effectively detect and type BVDV and identify PI cattle in a rapid and cost-effective manner.

关键词： bovine viral diarrhea virus(BVDV) real-time RT-PCR persistently infected(PI) animals Taq Man-MGB occurrence rate of PI cattle