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Biomedical and Environmental Sciences 2007年第3期20卷 208-211页

作者： JIA-qi MA LI-PING wang xiao-PENG qi xiao-MING SHI GONG-HUAN YANG National Center for Public Health Surveillance and Information Services Chinese Center for Disease Control and Prevention Beijing 100050 China

Objective To establish a conceptual model of automatic early warning of infectious diseases based on internet reporting surveillance system, with a view to realizing an automated warning system on a dally basis and timely identifying potential outbreaks of infectious diseases. Methods The statistic conceptual model was established using historic surveillance data with movable percentile method. Results Based on the infectious disease surveillance information platform, the conceptual model for early warning was established. The parameter, threshold, and revised sensitivity and specificity of early warning value were changed to realize dynamic alert of infectious diseases on a dally basis. Conclusion The instructive conceptual model of dynamic alert can be used as a validating tool in institutions of infectious disease surveillance in different districts.

关键词： Infectious disease Automated warning Information system

Interventional Radionuclide Therapy of Hepatocellular Carcinoma： Assessment of Intratumoral Retention of HPMA Copolymers

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Chemical Research in Chinese Universities 2013年第1期29卷 183-188页

作者： YUAN Jian-chao MIAO Cheng-ping ZENG Xian-wu GUO Hong-yun wang xiao-qi LIAO Shi-qi XIE xiao-li Key Laboratory of Eco-environment-related Polymer Materials Ministry of Education Key Laboratory of Polymer Materials of Gansu Province College of Chemistry and Chemical Engineering Department of Nuclear Medicine Gansu Academy of Medical Sciences & Gansu Provincial Tumor Hospital Lanzhou 730050 P. R. China

To develop new radiopharmaceuticals for the interventional radionuclide therapy of recurrent hepatocellular carcinoma, poly（HPMA）-APMA-DTPA[HPMA=N-（2-hydroxypropyl） methacrylamide; APMA=N-（3-aminopropyl）methacrylamide; DTPA=diethylenetriaminepentaacetic acidl was synthesized by free radical precipitation polymerization in acetone/dimethylsulfoxide with N,N＇-azobis（isobutyronitrile） as the initiator. The copolymers were characterized with nuclear magnetic resonance（NMR） spectroscopy and gel permeation chromatography（GPC, Mn=2.2xl04, Mw/Mn=l.38）. Subsequently, poly（HPMA）-APMA-DTPA was conjugated with 99mTC radionuclide. Prolonged retention of poly（HPMA）-APMA-DTPA conjugate within the tumor tissues was demonstrated by single-photon emission computed tomography computed tomography（SPECT-CT） at 1, 2, 4 and 24 h following intra-tumoral injection of the conjugate to hepatocellular carcinoma xenografts in mice. DTPA-99mTc was also synthesized and characterized for comparison. The data suggest that the poly（HPMA）-APMA-DTPA conjugates might be useful for the interventional radionuclide therapy of recurrent hepatocellular carcinoma in humans.

关键词： Hepatocellular carcinoma Interventional radionuclide therapy HPMA copolymer Radiotracer

Protective Effects and Potential Mechanism of Tongxinluo on Mice with Thromboangiitis Obliterans Induced by Sodium Laurate

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Chinese Journal of Integrative Medicine 2023年第7期29卷 608-616页

作者： GU Jiao-jiao WEI Ya-ru MA Ku wang xiao-qi GAO Huai-lin Graduate School Hebei University of Chinese MedicineShijiazhuang050090China Department of Endocrinology Hebei Yiling HospitalShijiazhuang050091China

Objective To investigate the effects of Tongxinluo(TXL)on thromboangiitis obliterans(TAO)and the underlying *** Ninety male C57/BL6J mice were randomly divided into 6 groups according to a random number table:the sham group,TAO model group,Compound Danshen Tablet(CDT)group,and the high-,medium-,and low-dose TXL *** mice except the sham group were injected with sodium laurate(0.1 mL,5 mg/mL)in the femoral artery to establish TAO mouse *** modeling,mice in the sham and TAO model groups were intragastrically administered 0.5%(w/v)sodium carboxymethylcellulose,mice in the CDT group were intragastrically administered 0.52 g/kg CDT,and mice in the TXL-H,TXL-M,and TXL-L groups were intragastrically administered 1.5,0.75,and 0.38 g/kg TXL,*** 4 weeks of gavage,the recovery of blood flow in the lower limbs of mice was detected by Laser Doppler *** pathological changes and thrombosis of the femoral artery were observed by morphological *** expressions of tumor necrosis factorα(TNF-α)and inducible nitric oxide synthase(iNOS)in the femoral artery wall were detected by HE *** of thromboxane B2(TXB2),6-keto-prostaglandin F1α(6-keto-PGF1α),endothelin-1(ET-1),interleukin(IL)-1βand IL-6 were measured using enzyme-linked immunosorbent assay(ELISA).Levels of activated partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT)and fibrinogen(FIB)were detected by a fully automated biochemical *** TXL promoted the restoration of blood flow in the lower limbs,reduced the area of thrombosis in the femoral artery,and alleviated the pathological changes in the femoral artery ***,the levels of TXB2,ET-1,IL-6,IL-1β,TNF-αand iNOS were significantly lower in the TXL groups compared with the model group(P<0.05 or P<0.01),while the level of 6-keto-PGF1αwas significantly higher(P<0.01).In addition,APTT,PT,and TT were significantly prolonged in TXL groups compared with the model group(P<0

关键词： Tongxinluo thromboangitis obliterans thrombosis inflammation

Genetic dissection of hexanol content in soybean seed through genome-wide association analysis

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Journal of Integrative Agriculture 2019年第6期18卷 1222-1229页

作者： XIA Ning YAN Wen-bing wang xiao-qi SHAO Yu-peng YANG Ming-ming wang Zhi-kun ZHAN Yu-hang TENG Wei-li HAN Ying-peng SHI Yan-guo Key Laboratory of Soybean Biology Ministry of Education/Key Laboratory of Soybean Biology and Breeding/GeneticsMinistry of Agriculture and Rural Affairs/Agricultural CollegeNortheast Agricultural UniversityHarbin 150030P.R.China School of Food Engineering Harbin University of CommerceHarbin 150030P.R.China

Hexanol is a major compound contributing to the off-flavors(the bean-like odor)of soybean derived *** most effective way to reduce the off-flavors of soymilk is the screening and utilization of soybean cultivars with improved hexanol ***,no genome-wide genetic analysis for this particular trait has been conducted to *** objective of the present study was to dissect the genetic basis of hexanol content in soybean seed through genome-wide association analysis(GWAS).A total of 105 soybean accessions were analyzed for hexanol content in a three-year experiments and genotyped by sequencing using the specific locus amplified fragment sequencing(SLAF-seq)approach.A total of 25 724 single nucleotide polymorphisms(SNPs)were obtained with minor allele frequencies(MAF)>5%.GWAS showed that 25 quantitative trait nucleotides(QTNs)were significantly associated with the hexanol concentration in soybean *** identified QTNs distributed on different genomic regions of the 15 chromosomes.A total of 91 genes were predicted as candidate genes underlying the seed hexanol level and six candidates were predicted possibly underlying the seed hexanol by gene based *** this study,GWAS has been proven to be an effective way to dissect the genetic basis of the hexanol concentration in multiple genetic *** identified beneficial alleles and candidate genes might be valuable for the improvement of marker-assisted breeding efficiency for low hexanol level and help to explore possible molecular mechanisms underlying hexanol content in soybean seed.

关键词： genome-wide association mapping soybean hexanol concentration candidate genes

Cross-sectional study of congenital heart disease among Tibetan children aged from 4 to 18 years at different altitudes in qinghai Province

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Chinese Medical Journal 2008年第24期121卷 2469-2472页

作者： CHEN qiu-hong wang xiao-qin qi Sheng-gui Central Laboratory Qinghai Cardiovascular Diseases Vocational Hospital Xining Qinghai 810012 China

Background Congenital heart disease （CHD） is a common heart condition which does considerable harm to the health of children and adolescents. CHD epidemiological characteristics of Tibetan children whose ages ranged from 4 to 18 years were investigated in qinghai Province. Methods A total of 32 578 Tibetan children, living at altitudes of 2535 m, 3600 m and 4200 m, were examined using a three-stage protocol： prescreening, rechecking and diagnosis using a color Doppler. The distribution of CHD at different altitudes was analyzed together with differences in occurrence according to age and gender. Results A total of 235 CHD cases were discovered. The total prevalence of CHD was 7.21‰. Prevalence of CHD has been shown to increase along with increase in altitude with 5.45‰ at an altitude of 2535 m, 6.80‰ at 3600 m and 9.79‰ at 4200 m. There were no statistically significant differences between the prevalence at 2535 m and 3600 m （Х^2=1.594, P 〉0.05）. However, there was a significant difference between the prevalence at 2535 m and 4200 m （Х^2=7.002, P 〈0.01）. Also, apparent differences existed between the prevalence at 3600 m and at 4200 m （Х^2=5.540, P 〈0.05）. There was no statistically significant difference in prevalence according to age at an altitude of 2535 m, but the rate of CHD increased significantly along with increasing age at 3600 m and 4200 m. The total prevalence ratio of children aged from 16 to 18 years was significantly higher than that of children from 4 to 7, and from 8 to 12 with Х^2 values of 10.79 （P 〈0.005）, and 5.60 （P 〈0.05） respectively. Within the constituent ratio of CHD, the prevalence of atrial septal defect （ASD） was the highest at 39.10%, followed by the prevalence of ventricular septal defect （VSD） at 32.8% and patent ductus arteriosus （PDA） at 24.7%. Furthermore the proportion of the four categories of CHD varied at different altitude levels： at 2535 m, of those diagnosed with CHD, the prevalence rate of VSD was the highest at 43.5%, at

关键词： congenital heart disease epidemiological monitoring prevalence Tibetan

Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 608-615页

作者： WEI Ya-ru HOU Yun-long YIN Yu-jie LI Zhen LIU Yi HAN Ning-xin wang Zi-xuan LIU Lu wang xiao-qi HAO Yuan-jie MA Kun GU Jiao-jiao JIA Zhen-hua Graduate School Hebei University of Chinese MedicineShijiazhuang050090China Shijiazhuang Yiling Pharmaceutical New Drug Evaluation Center Shijiazhuang050035China Hebei Institute of Integrated Traditional and Western Medicine Shijiazhuang050035China National Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang050035China Department of Cardiology Hebei Yiling HospitalShijiazhuang050091China Graduate School Hebei Medical UniversityShijiazhuang050017China

Objective To investigate the potential role of Tongxinluo(TXL)in attenuating myocardial fibrosis after myocardial ischemia-reperfusion injury(MIRI)in *** A MIRI mouse model was established by left anterior descending coronary artery ligation for 45 *** to a random number table,66 mice were randomly divided into 6 groups(n=11 per group):the sham group,the model group,the LY-294002 group,the TXL group,the TXL+LY-294002 group and the benazepril(BNPL)*** day after modeling,TXL and BNPL were administered by *** injection of LY-294002 was performed twice a week for 4 consecutive *** was used to measure cardiac function in *** staining was used to evaluate the degree of myocardial fibrosis in *** and quantitative analysis of endothelial mesenchymal transition(EndMT)after MIRI was performed by immunohistochemistry,immunofluorescence staining and flow cytometry,*** protein expressions of platelet endothelial cell adhesion molecule-1(CD31),α-smoth muscle actin(α-SMA),phosphatidylinositol-3-kinase(PI3K)and phospho protein kinase B(p-AKT)were assessed using Western *** TXL improved cardiac function in MIRI mice,reduced the degree of myocardial fibrosis,increased the expression of CD31 and inhibited the expression ofα-SMA,thus inhibited the occurrence of EndMT(P0.05).In addition,the use of the PI3K/AKT pathway-specific inhibitor LY-294002 to block this pathway and combination with TXL intervention,eliminated the protective effect of TXL,further supporting the protective effect of *** TXL activated the PI3K/AKT signaling pathway to inhibit EndMT and attenuated myocardial fibrosis after MIRI in mice.

关键词： myocardial fibrosis endothelial mesenchymal transition myocardial ischemia-reperfusion injury phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)pathway

中国交通运输碳排放强度时空交互特征及跃迁机制

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环境科学 2024年第6期45卷 3433-3445页

作者：李健刘舒琪王晓祺天津理工大学管理学院天津300384 天津大学管理与经济学部天津300372

采取多种空间分析的方法,对2002~2020年交通运输业碳排放强度的时空交互特征进行剖析,通过得到的时空跃迁类型与面板分位数模型进行嵌套来探究其跃迁机制,最后根据不同的跃迁机制引入地理探测器模型来考察影响交通运输业碳排放强度的不... 详细信息

采取多种空间分析的方法,对2002~2020年交通运输业碳排放强度的时空交互特征进行剖析,通过得到的时空跃迁类型与面板分位数模型进行嵌套来探究其跃迁机制,最后根据不同的跃迁机制引入地理探测器模型来考察影响交通运输业碳排放强度的不同因素之间的交互作用效应.结果表明:①中国30个省区的交通运输业碳排放强度整体呈波动下降态势,在空间上的聚集水平也相对稳定.②ESTDA的时空交互特征表明,西北地区和周边邻接空间单位的关系不稳定,变化和波动较大.而东部沿海城市等经济发达地区已经形成了成熟的交通运输网络,因此局部空间格局也相对稳定,但仍有部分地区存在时空竞争性.③交通运输业碳排放强度时空跃迁可分为4类驱动或制约模式(人口-经济-城镇化制约模式;人口-经济-城镇化-设施制约模式;技术-消费-产业驱动模式和技术-产业-规制驱动模式).大部分省份受低分位制约和高分位驱动两种模式的影响,仅有少部分省份受高分位制约和低分位驱动的作用影响,且绝大多数属于西北或西南地区.④根据得出的交通运输业碳排放强度跃迁机制进一步引入地理探测器模型,注重多因子的协调发展,加强区域间协同治理.

关键词：交通运输业碳排放强度时空交互跃迁机制分位数回归地理探测器

人为排放及气象因素对空气质量影响的定量分析——以疫情期间邢台市为例

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中国环境科学 2022年第8期42卷 3512-3521页

作者：亓浩雲王晓琦程水源北京工业大学环境与生命学部区域大气复合污染防治北京市重点实验室北京100020

选择河北省邢台市作为研究对象,将2020疫情作为一个极限管控措施下的极限减排实验情景,把2021疫情作为未来常态化疫情防控实验分析情景.与疫情前期对比,两次疫情期间臭氧浓度均有提升且2021疫情时期颗粒物浓度同样有提高,2020疫情时期... 详细信息

选择河北省邢台市作为研究对象,将2020疫情作为一个极限管控措施下的极限减排实验情景,把2021疫情作为未来常态化疫情防控实验分析情景.与疫情前期对比,两次疫情期间臭氧浓度均有提升且2021疫情时期颗粒物浓度同样有提高,2020疫情时期其他污染物浓度均有不同程度的改善,而与2019历史同期相比,两次疫情期间臭氧浓度同样有升高现象,除此以外,2021疫情时期污染物改善较好.利用长短期记忆网络(LSTM)算法和空气质量预报模式系统(WRF-CMAQ)量化了两次疫情时期气象因素对于污染物浓度变化的影响,根据空气质量模拟法反推了不同污染物受人为影响的浓度变化.实验结果表明,LSTM算法在两次疫情期间的模拟均显示人为影响对污染物产生了负影响(降低了污染物浓度)且在总变化影响中占比较高,而CMAQ模式模拟结果中的气象因素影响占比远高于LSTM算法.CMAQ模式在两次疫情模拟中表现出了不同的结果,在2020疫情中人为影响占据了主导,而在2021疫情中,相比较2020疫情时期,除NO_(2)外,人类活动对其他污染物的影响均为正值(促进了污染物浓度升高).

关键词：机器学习算法空气质量模型新冠肺炎邢台市 PM_(2.5)

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基于投影的嵌入式系统需求分析方法

软件学报 2024年第12期35卷 5397-5418页

作者：王小齐陈小红金芝顾斌綦艳霞上海高可信计算重点实验室(华东师范大学) 上海200062 高可信软件技术教育部重点实验室(北京大学) 北京100871 北京大学计算机学院北京100871 北京控制工程研究所北京100190

嵌入式系统正变得越来越复杂,其软件系统的需求分析成为嵌入式系统开发的瓶颈问题.设备依赖性和执行逻辑的交织性是嵌入式软件系统的典型特征,要求需求分析方法能根据所依赖的设备进行有效的需求解耦.从基于环境建模的需求工程思想出发... 详细信息

嵌入式系统正变得越来越复杂,其软件系统的需求分析成为嵌入式系统开发的瓶颈问题.设备依赖性和执行逻辑的交织性是嵌入式软件系统的典型特征,要求需求分析方法能根据所依赖的设备进行有效的需求解耦.从基于环境建模的需求工程思想出发,针对嵌入式软件系统的特征,提出一种基于投影的从系统需求到软件需求的分析方法,帮助需求工程师对需求进行有效解耦.首先总结嵌入式软件系统的系统需求与软件需求描述,基于交互环境特性定义嵌入式软件系统的需求解耦策略,并设计从系统需求到软件需求的规约过程.在航天器太阳搜索系统进行实际案例研究,并通过耦合度与内聚性两个指标对5个代表性案例场景进行量化评估,展示所提方法的有效性.

关键词：嵌入式系统需求分析需求解耦问题投影软件需求

典型输送通道城市冬季PM_(2.5)污染与传输变化特征

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环境科学 2024年第1期45卷 23-35页

作者：代武俊周颖王晓琦齐鹏北京工业大学环境与生命学部区域大气复合污染防治北京市重点实验室北京100124

以京津冀典型输送通道上的河北西南4个城市邯郸、邢台、衡水和沧州为例,分析了2019~2021年冬季3 a气象条件与PM_(2.5)浓度变化特征,运用潜在源贡献分析(PSCF)和浓度权重分析(CWT)识别了研究期内4个城市PM_(2.5)输送特征,基于气象-空气... 详细信息

以京津冀典型输送通道上的河北西南4个城市邯郸、邢台、衡水和沧州为例,分析了2019~2021年冬季3 a气象条件与PM_(2.5)浓度变化特征,运用潜在源贡献分析(PSCF)和浓度权重分析(CWT)识别了研究期内4个城市PM_(2.5)输送特征,基于气象-空气质量模型(WRF-CMAQ)传输矩阵法和传输通量法量化评估了邯郸、邢台、衡水和沧州与周边地区之间的PM_(2.5)传输贡献,揭示了PM_(2.5)传输净通量的垂直分布变化特征,并进一步识别4个城市两条PM_(2.5)污染主要传输路径.结果表明,在研究期间,4个城市PM_(2.5)浓度呈下降趋势,下降比例分别为45.85%、49.45%、42.40%和31.65%;邯郸和邢台潜在源贡献较大的区域主要分布在山西中南部(临汾、长治和晋中)和河南北部(新乡、开封和郑州)以及少部分内蒙古部分地区(PSCF>0.9),衡水和沧州潜在贡献较大的区域主要集中在河北南部(邯郸、石家庄)、山西中部(太原、阳泉)和部分山东地区(PSCF>0.7),CWT结果显示与PSCF类似;研究时段内4个城市冬季PM_(2.5)均呈现本地贡献率(51.11%~62.99%)略高于区域贡献率(37.01%~48.89%)的特征,受水平湍流和垂直扩散等影响,4个城市2020年区域传输影响较其他年份稍高(0.50%~9.52%),而2021年由于PM_(2.5)浓度较低、气象因素影响等原因,区域传输影响较其他年份稍低(-2.15%~-9.52%);邯郸、邢台、衡水和沧州这4个城市3 a冬季与周边区域总流入(流出)通量强度大小均为:2020年>2021年>2019年,对于总净通量而言,4个城市3 a冬季分别为邯郸:0.094、-0.070和0.087 kt·d^(-1);邢台:0.212、0.395和0.544 kt·d^(-1);衡水:-0.040、-0.228和0.185 kt·d^(-1);沧州:0.062、0.126和0.128 kt·d^(-1).在研究期间邯郸、邢台和沧州多作为污染传输受体,而衡水多为传输源体.在0~1260 m之间,PM_(2.5)净传输通量强度基本随着高度的升高而增大,不同时期不同城市最大净通量不同,邯郸最大净通量位于252~1261 m,邢台最大净通量位于817 m,衡水最大净通量位于252~817 m,沧州最大净通量位于252~359 m;分析4个城市传输特征发现存在两条主要PM_(2.5)传输方向,即西北-东南方向(山西→邯郸→河南、山东;石家庄→邢台→邯郸、山东;保定→沧州→山东)以及西南-东北方向(山西→邢台→衡水→沧州→渤海湾).

关键词： PM_(2.5) 潜在源贡献分析法(PSCF) 浓度权重分析法(CWT) 气象-空气质量模型(WRF-CMAQ) 传输贡献传输通量