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Relationship of PARG with PARP,VEGF and b-FGF in Colorectal Carcinoma

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Chinese Journal of Cancer Research 2009年第2期21卷 135-141页

作者： ling lin Jia Li Ya-lan wang xiao lin Department of Pathology Molecular Medicine and Cancer Research Center Chongqing Medical UniversityChongqing 400016 China

Objective： To investigate the relationship of poly（ADP-ribose）glycohydrolase（PARG） with poly （ADP-ribose） polymerase（PARP）, vascular endothelial growth factor （VEGF） and basic fibroblast growth factor（b-FGF） in colorectal carcinoma（CRC）. Methods： Immunohistochemical analysis was used to detect PARG, PARP, VEGF and b-FGF in human colorectal carcinoma. Flow cytometry was used to detect PARG and PARP in murine CT26 cell line. Gallotannin （GLTN） was served as PARG inhibitor. Results： The individual positive rates of PARG, PARE VEGF and b-FGF were 55.81%（24/43）, 97.67%（42/43）, 79.07%（34/43） and 81.40%（35/43）, respectively, which were significantly higher than those of control group. The positive PARG was correlated to PARP（r=0.3703, P〈0.05） and b-FGF （r=0.4838, P〈0.05）. The positive PARP was correlated to VEGF （r=0.3968, P〈0.05） and b-FGF （r=0.5610, P〈0.05）. Both PARG and PARP were expressed in CT26 cells. The positive staining rates of PARG and PARP in GLTN-treated group were 7.3% and 52.38%, respectively. They were markedly reduced than those of control group （55.41% and 95.28%, P〈0.01, n=10000）. Conclusion： The data suggest that PARG expression probably plays a role for VEGF and b-FGF expression in colorectal carcinoma.

关键词： PARG PARP VEGF b-FGF Colorectal carcinoma

A convenient microwave-assisted synthesis of cinchona alkaloid-derived ligands

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Chinese Chemical Letters 2008年第12期19卷 1440-1444页

作者： Hai Bo wang Ping An wang Quan Jun wang xiao Li Sun lin lin Jing Department of Chemistry School of Pharmacy Fourth Military Medical University Xi＇an 710032 China

An efficient synthesis of cinchona alkaloid-derived ligands based on solvent-free microwave-assisted reaction was described. The coupling of 1,4-dichlorophthalazine or 3,6-dichloropyridazine with quinine, cinchonine or cinchonidine provide bis-or monocinchona alkaloid-derived ligands in moderate to good yields （52-89%） within 15 min under optimum microwave conditions.

关键词： Cinchona alkaloids Solvent-free microwave synthesis AD reaction

Phase Evolution and Magnetic Properties of Sn_(1-2x)Fe_xNb_xO_2(0.45≤x≤0.50)

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Chemical Research in Chinese Universities 2010年第6期26卷 876-879页

作者： wang Yu JIA xiao-lin DONG lin GUAN Shao-kang School of Materials Science and Engineering Zhengzhou University Zhengzhou 450001 P. R. China

Sn1-2xFexNbxO2（0.45≤x≤0.50） samples were prepared at 1000 ℃ via a simple chemical co-precipitation *** effects of the concentrations of Sn doped on the structures and magnetic properties of the samples have been investigated.A systematic variation from monoclinic to orthorhombic FeNbO4 structure was observed with increasing Sn *** phase evolutions were observed from monoclinic structure with x=0.50 to the coexistence of monoclinic and orthorhombic structures with x=0.48,0.47,0.46,and then to orthorhombic structure with x=*** behavior was observed for all the samples,and the magnetic ordering temperatures decrease with increasing Sn concentration,which further indicated the sequence of phase *** results suggest that the incorporation of Sn can stabilize the orthorhombic FeNbO4.

关键词： FeNbO4 Sn doping Structure Magnetic behavior

Poverty reduction within the framework of SDGs and Post-2015 Development Agenda

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Advances in Climate Change Research 2015年第1期6卷 67-73页

作者： LIU Qian-Qian YU Man wang xiao-lin The International Cooperation Department Development Research Center of the State Council School of Economics Peking University Information Center of the State Council Leading Group Office of Poverty Alleviation and Development

The eradication of poverty is one of the largest global challenges facing the world. This article examines poverty reduction goals within the framework of Post-2015 Development Agenda and the Sustainable Development Goals(SDGs). It also discusses the relationship between poverty reduction and sustainable development. Poverty reduction and sustainable development are inseparable and poverty reduction is the premise for sustainable development. Furthermore, several key bones of contention on the role of poverty reduction and sustainable development and implications of Post-2015 Development Agenda are also discussed. It concludes that to end poverty and inequality should continuously be given top priority for the Chinese government, because poverty reduction is China's soft power. Meanwhile, new ways of poverty alleviation should be explored and government should make great efforts to create a new partnership for poverty reduction and development.

关键词： Poverty reduction Sustainable development Post-2015 Development Agenda

Adaptive Polarization Control of Fiber Amplifier Based on SPGD Algorithm

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Chinese Physics Letters 2012年第12期29卷 116-118页

作者： XIONG Yu-Peng SU Rong-Tao LI xiao HOU Pu wang xiao-lin XU xiao-Jun College of Optoelectric Science and Engineering National University of Defense TechnologyChangsha 410073

We demonstrate an adaptive polarization control system of a 10.2 W non-polarization-maintaining fiber amplifier based on stochastic parallel gradient decent(SPGD)*** experimental investigation shows that the system can used to compensate for the polarization fluctuation of the fiber amplifier effectively and perform well over a long-time *** the adaptive polarization control system is in closed loop,the extinction ratio increases from 2.28 dB to 11.54 dB,and more than 93.4%of the total power in desired polarization direction is achieved.

关键词： polarization amplifier fiber

Mechanism and behaviors of Cr3+-doped TiO2

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Journal of Central South University of Technology 2005年第Z1期12卷 59-64页

作者： CHEN Jian-hua wang xiao-lin GONG Zhu-qing School of Metallurgical Science and Engineering Central South University Changsha 410083 China College of Resources and Environment Guangxi University Nanning 530004 China College of Resources and Environment Guangxi University Nanning 530004 China School of Metallurgical Science and Engineering Central South University Changsha 410083 China

TiO2 powder and TiO2 thin film on the surface of glazed ceramic tile were prepared by sol-gel *** influences of different doping Cr3+ concentration on the photocatalytic activity of TiO2 were discussed, UV-visible and X-ray diffraction analysis were used to test the performance of TiO2 powder and film. The results indicate that photocatalytic activity of doping Cr3+-TiO2 thin film is higher than that of powder, and the interaction between Cr3+-doped and substrate can greatly enhance the photocatalytic activity. The results of X-ray diffraction and photoabsorption show that the Cr3+ -doped energy level in TiO2 is 0. 62 eV high from the top of valence band, which belongs to the type of deep energy level doping. On the basis of the semiconductor energy level theory and Cr3+ dopant energy level, the semiconductor energy level model of Cr3+ in TiO2 powder and thin film were established, and the doping mechanisms of Cr3+-doped in TiO2 powder and thin film were analyzed.

关键词： sol-gel method TiO2 powders and thin films Cr3+ -doped photocatalytic activity

Increasing nitrogen absorption and assimilation ability under mixed NO_(3)^(–)and NH_(4)^(+) supply is a driver to promote growth of maize seedlings

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Journal of Integrative Agriculture 2023年第6期22卷 1896-1908页

作者： wang Peng wang Cheng-dong wang xiao-lin WU Yuan-hua ZHANG Yan SUN Yan-guo SHI Yi MI Guo-hua Key Laboratory of Tobacco Biology and Processing Ministry of Agriculture and Rural AffairsTobacco Research InstituteChinese Academy of Agricultural SciencesQingdao 266101P.R.China Department of Plant Nutrition College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193P.R.China

Compared with sole nitrate (NO_(3)^(-)) or sole ammonium (NH_(4)^(+)) supply,mixed nitrogen (N) supply may promote growth of maize *** study suggested that mixed N supply not only increased photosynthesis rate,but also enhanced leaf growth by increasing auxin synthesis to build a large sink for C and N ***,whether this process depends on N absorption is ***,maize seedlings were grown hydroponically with three N forms (NO_(3)^(-)only,75/25 NO_(3)^(-)/NH_(4)^(+) and NH_(4)^(+) only).The study results suggested that maize growth rate and N content of shoots under mixed N supply was little different to that under sole NO_(3)^(-)supply at 0–3 d,but was higher than under sole NO_(3)^(-)supply at 6–9 d.^(15)N influx rate under mixed N supply was greater than under sole NO_(3)^(-) or NH_(4)^(+) supply at 6–9 d,although NO_(3)^(-) and NH_(4)^(+) influx under mixed N supply were reduced compared to sole NO_(3)^(-) and NH_(4)^(+) supply,***-PCR determination suggested that the increased N absorption under mixed N supply may be related to the higher expression of NO_(3)^(-) transporters in roots,such as ZmNRT1.1A,ZmNRT1.1B,ZmNRT1.1C,ZmNRT1.2 and ZmNRT1.3,or NH_(4)^(+) absorption transporters,such as Zm AMT1.1A,especially the ***,plants had higher nitrate reductase (NR)glutamine synthase (GS) activity and amino acid content under mixed N supply than when under sole NO_(3)^(-) *** experiments with inhibitors of NR reductase and GS synthase further confirmed that N assimilation ability under mixed N supply was necessary to promote maize growth,especially for the reduction of NO_(3)^(-) by NR *** research suggested that the increased processes of NO_(3)^(-)and NH_(4)^(+) assimilation by improving N-absorption ability of roots under mixed N supply may be the main driving force to increase maize growth.

关键词： maize NO_(3)^(-)/NH_(4)^(+)ratio N absorption N assimilation plant growth

Molecular dynamics simulations of point defects in plutonium grain boundaries

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Chinese Physics B 2012年第2期21卷 398-406页

作者： Ao Bing-Yun Xia Ji-Xing Chen Pi-Heng Hu wang-Yu wang xiao-lin National Key Laboratory for Surface Physics and Chemistry P.O.Box 718-35Mianyang 621907China Department of Applied Physics Hunan UniversityChangsha 410082China

A modified analytic embedded atom method （MAEAM） potential is constructed for fcc 5-Pu. Molecular dynamics （MD） simulations with the potential are performed to investigate the interactions between two symmetrical tilt grain boundaries （GBs） and point defects such as He atom, vacancy and self-interstitial atom （SIA） in Pu. The calculated results show that point defect formation energies are on average lower than those in the lattice but variations from site to site along the GBs are very remarkable. Both substitutional and interstitial He atoms are trapped at GBs. Interstitial He atom is more strongly bound at the GB core than the substitutional He atom. The binding energy of SIA at GB core is higher than those of He atom and vacancy. GB core can bind many He atoms and SIAs due mainly to the fact that it contains many vacancies. Compared with He atom and SIA, the vacancy far from GB core is difficult to diffuse into the core. The GBs can act as sinks and sources of He atoms and SIAs, which may be a reason for the swelling of Pu after a period of self-irradiation because of the higher concentration of vacancy in the bulk.

关键词： plutonium molecular dynamics crystal defect radiation damage

Functional dyspepsia of ulcer-dysmotility type:clinical incidence and therapeutic strategy

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World Journal of Gastroenterology 1998年第4期4卷 95-96页

作者： wang xiaoZhong and lin GuZhen

Ｆｕｎｃｔｉｏｎａｌｄｙｓｐｅｐｓｉａｏｆｕｌｃｅｒｄｙｓｍｏｔｉｌｉｔｙｔｙｐｅ：ｃｌｉｎｉｃａｌｉｎｃｉｄｅｎｃｅａｎｄｔｈｅｒａｐｅｕｔｉｃｓｔｒａｔｅｇｙＷＡＮＧＸｉａｏＺｈｏｎｇａｎｄＬＩＮＧｕＺｈｅ... 详细信息

Ｆｕｎｃｔｉｏｎａｌｄｙｓｐｅｐｓｉａｏｆｕｌｃｅｒｄｙｓｍｏｔｉｌｉｔｙｔｙｐｅ：ｃｌｉｎｉｃａｌｉｎｃｉｄｅｎｃｅａｎｄｔｈｅｒａｐｅｕｔｉｃｓｔｒａｔｅｇｙＷＡＮＧＸｉａｏＺｈｏｎｇａｎｄＬＩＮＧｕＺｈｅｎＳｕｂｊｅｃｔｈｅａａｄｉｎｇｓ...

关键词： dyspepsia/drug therapy famotidine/therapeutic use cisapride/therapeutic use peptic ulcer gastrointestinal motility