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Tungsten 2024年第1期6卷 114-123页

作者： Jin-Hui wang Shao-Wei Yang Fu-Bin Ma Yi-Ke zhao Shi-Nuo zhao Zheng-Yu Xiong Dong Cai Hai-Dong Shen Kai Zhu Qiu-Yu Zhang Yue-ling Cao Tian-Shuai wang He-Peng Zhang Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Xi’an Key Laboratory of Functional Organic Porous Materials School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710129China School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China Chongqing Science and Technology Innovation Center of Northwestern Polytechnical University Chongqing 401135China

Developing cost-effective electrocatalysts with high activity and stability especially at high current density is of great significance for the large-scale commercial application of electrochemical water splitting to hydrogen production but still remains ***,we report an effective confinement pyrolysis strategy to fabricate embedded ruthenium-cobalt nanoclusters supported on N-doped porous two-dimensional carbon nanosheets(RuCo@CN).Markedly,the embedded structure can effectively prevent the migration,agglomeration,and leaching of nanoparticles,thus endowing the RuCo@CN catalyst with high *** be exact,high stability with up to 650 h can be achieved at high current density(-500 and-1000 mA·cm^(-2)).Besides,the RuCo@CN catalysts also exhibit highly reactive with low overpotentials of only 11mV at-10 mA·cm^(-2).Density functional theory calculations reveal that the introduction of cobalt reduces the decomposition barrier of H_(2)O for RuCo@CN alloy,thus promoting hydrogen evolution reaction.

关键词： Hydrogen evolution reaction Confinement pyrolysis strategy Mosaic structure Stability

Separator functionalization enables high-performance zinc anode via ion-migration regulation and interfacial engineering

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Chinese Chemical Letters 2024年第9期35卷 496-500页

作者： Ningning zhao Yuyan Liang Wenjie Huo Xinyan Zhu Zhangxing He Zekun Zhang Youtuo Zhang xianwen Wu Lei Dai Jing Zhu ling wang Qiaobao Zhang School of Chemical Engineering North China University of Science and TechnologyTangshan 063009China School of Chemistry and Chemical Engineering Jishou UniversityJishou 416000China Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamen 361005China

Aqueous zinc ion batteries(AZIBs)are promising energy storage ***,the formation of dendrites,hydrogen evolution,and corrosion reaction seriously affect their electrochemical ***,the synergistic effect of ion-migration regulation and interfacial engineering has been confirmed as the potential strategy by kaolin functionalized glass fiber separator(KL-GF)to alleviate these *** rapid and orderly Zn^(2+)migration was achieved to improve the transfer kinetics and induced uniform zinc deposition by more zinc-philic sites of *** on the interfacial engineering,the side reactions were effectively mitigated and crystal planes were regulated through *** hydrophilicity of KL alleviated the corrosion and hydrogen ***,a preferential orientation of Zn(002)crystal plane by KL-GF was induced to further realize dendrite-free deposition by density functional theory(DFT)and X-ray diffraction(XRD)***,the Zn|KL-GF|MnO_(2)cell maintained a high discharge capacity of 96.8 mAh/g at 2 A/g after 1000 *** work can provide guidance enabling high-performance zinc anode for AZIBs.

关键词： Energy storage Aqueous zinc ion batteries Separators Ion-migration regulation Interfacial engineering

Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

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Zoological Research 2024年第3期45卷 551-566页

作者： Chen ling Su-Su Liu Yu-Ya wang Gui-Tao Huo Yan-Wei Yang Nan Xu Hong wang Yong Wu Yu-Fa Miao Rui Fu Yu-Wei zhao Chang-Fa Fan College of Life Sciences Northwest UniversityProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceXi’anShaanxi 710069China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China National Center for Safety Evaluation of Drugs National Institutes for Food and Drug Control(NIFDC)Beijing 100176China Division of HIV/AIDS and Sexually Transmitted Virus Vaccines Institute for Biological Products ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China Division of Laboratory Animal Monitoring Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China

Hepatocellular carcinoma(HCC),a prevalent solid carcinoma of significant concern,is an aggressive and often fatal disease with increasing global incidence rates and poor therapeutic *** etiology and pathological progression of non-alcoholic steatohepatitis(NASH)-related HCC is multifactorial and ***,no single animal model can accurately mimic the full NASH-related HCC pathological progression,posing considerable challenges to transition and mechanistic ***,a novel conditional inducible wild-type human HRAS overexpressed mouse model(HRAS-HCC)was established,demonstrating 100%morbidity and mortality within approximately one month under normal dietary and lifestyle *** symptoms of HCC such as ascites,thrombus,internal hemorrhage,jaundice,and lung metastasis were successfully replicated in ***-depth pathological features of NASH-related HCC were demonstrated by pathological staining,biochemical analyses,and typical marker gene *** murine anti-PD-1 and sorafenib treatment effectively prolonged mouse survival,further confirming the accuracy and reliability of the *** on protein-protein interaction(PPI)network and RNA sequencing analyses,we speculated that overexpression of HRAS may initiate the THBS1-COL4A3 axis to induce NASH with severe fibrosis,with subsequent progression to ***,our study successfully duplicated natural sequential progression in a single murine model over a very short period,providing an accurate and reliable preclinical tool for therapeutic evaluations targeting the NASH to HCC continuum.

关键词： HRAS THBS1 HCC driver factor NASH Fibrosis Cirrhosis HCC Treatment evaluation

Evolution of inner wall wrinkle defects in the sinking zone of a thick-walled steel tube during radial forging

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Advances in Manufacturing 2024年第2期12卷 396-408页

作者： Yu-zhao Yang Cheng Xu Li-xia Fan School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094People’s Republic of China

An axial wrinkle defect was observed in the inner wall of the sinking zone of a thick-wall steel tube processed by cold radial *** can evolve into *** present study focuses on the evolution of wrinkles and the effects of process parameters on them using a three-dimensional radial forging process finite element model,radial forging experiments,and surface morphology *** results indicated that the vertical section angle of the hammer die and the size of the tube blank significantly affect the evolution of *** height-to-width ratioλwas introduced to describe the morphology of *** had an approximately linear relationship with the radius reduction in the sinking *** was a linear correlation between the growth slope ofλand the axial to circumferential strain ratio|εr/εθ|,which can predict theλunder few process *** the 30SiMn2MoVA steel,at the junction of the forging and sinking zones,the threshold ofλof the wrinkle that can evolve into a fissure is approximately 1.123.

关键词： Radial forging Inner wall Wrinkle defects Evolution Sinking zone

Analysis of Phenotypes Associated with Deficiency of PAX6 Haplotypes in Chinese Aniridia Families

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Current Medical Science 2024年第4期44卷 820-826页

作者： xiao-lu HAO Ran CHEN Wei LIU Bao-ke HOU ling-hui QU zhao-hui LI Da-jiang wang Xin JIN Hou-bin HUANG Senior Department of Opthalmology the Third Medical Center of Chinese PLA General HospitalBeijing100039China Bolin Eye Care Group Beijing100098China Department of Ophthalmology Hainan Hospital of Chinese PLA General HospitalSanya572000China Department of Ophthalmology the 74th Army Group HospitalGuangzhou510318China

Objective To examine the clinical phenotype and genetic deficiencies present in Chinese aniridia families with PAX6 haplotype *** A comprehensive questionnaire and ophthalmological assessments were administered to both affected patients and unaffected *** clinical feature analysis included the evaluation of visual acuity,intraocular pressure,slit-lamp anterior segment examination,fundus photography,and spectral domain optical coherence *** identify the mutation responsible for aniridia,targeted next-generation sequencing was used as a beneficial *** A total of 4 mutations were identified,consisting of two novel frameshift mutations(c.314delA,p.K105Sfs*33 and c.838_845dup AACACACC,p.S283Tfs*85),along with two recurring nonsense mutations(c.307C>T,p.R103X and c.619A>T,p.K207*).Complete iris absence,macular foveal hypoplasia,and nystagmus were consistent in these PAX6 haplotype-deficient Chinese aniridia families,while corneal lesions,cataracts,and glaucoma exhibited heterogeneity both among the families and within the same *** In our study,two novel PAX6 mutations associated with aniridia were identified in Chinese families,which expanded the phenotypic and genotypic spectrum of PAX6 *** also analyzed the clinical characteristics of PAX6 haplotype deficiency in Chinese aniridia families.

关键词： aniridia PAX6 mutation haplotype deficiency phenotype genotype

Simplified p-i-n Perovskite Solar Cells with a Multifunctional Polyfullerene Electron Transporter

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Chinese Journal of Polymer Science 2024年第8期42卷 1060-1066页

作者： Fei-Fei wang Tian-xiao Liu Ze-Wei Cui ling-Yuan wang Yun-Jie Dou xiao-Yu Shi Si-Wei Luo xiao-Dong Hu Zhi-Jun Ren Yang-Yang Liu Yu zhao Shang-Shang Chen State Key Laboratory of Coordination Chemistry MOE Key Laboratory of High Performance Polymer Materials&TechnologySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 21003China

In prevailing p-i-n perovskite solar cells(PSCs),solution-processible fullerene molecules are widely used as electron-transporting layers(ETLs)but they typically suffer from poor uniformity and undesirable stability ***,a separate bathocuproine(BCP)layer is needed to block hole tran sfer,increasing fabrication complexity and ***,we address these limitations by develo ping a novel polymeric ETL(named PF BCP)synthesized by polymerizing C_(60)with *** innovative material achieves both efficient electron transport and hole blocking,while its excellent uniformity minimizes interface recombination and enhances ***,our blade-coated PSCs utilizing PFBCP achieve a high power conversion efficiency exceeding 22%and retain 91%of initial efficiency after 1200 h of light *** development not only paves the way for commercially viable PSCs but also opens avenues for future ETL design to realize even more efficient and stable PSCs.

关键词： Polyfullerene Perovskite solar cells Electron transporter Stability

Characterization of a 4.1 Mb inversion harboring the stripe rust resistance gene YR86 on wheat chromosome 2AL

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The Crop Journal 2024年第4期12卷 1168-1175页

作者： Qiang Cao Zhanwang Zhu Dengan Xu Jianhui Wu xiaowan Xu Yan Dong Yingjie Bian Fugong Ding Dehui zhao Yang Tu ling Wu Dejun Han Caixia Lan xianchun xia Zhonghu He Yuanfeng Hao College of Agronomy Northwest A&F UniversityYangling 712100ShaanxiChina State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural Sciences(CAAS)Beijing 100081China Food Crops Institute Hubei Academy of Agricultural Sciences/Wheat Disease Biology Research Station for Central ChinaWuhan 430064HubeiChina Crop Research Institute Sichuan Academy of Agricultural SciencesChengdu 610066SichuanChina Hubei Hongshan Laboratory College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina CIMMYT-China Office C/O CAASBeijing 100081China

Wheat cultivar Zhongmai 895 was earlier found to carry YR86 in an 11.6 Mb recombination-suppressed region on chromosome 2AL when crossed with Yangmai *** fine-map the YR86 locus,we developed two large F2 populations from crosses Emai 580/Zhongmai 895 and Avocet S/Zhongmai ***,both populations exhibited suppressed recombination in the same 2AL *** analysis across Chinese Spring,Aikang 58,and 10+wheat genomes revealed a 4.1 Mb chromosomal inversion spanning 708.5-712.6 Mb in the Chinese Spring reference *** markers were developed in the breakpoint and were used to assess a wheat cultivar panel,revealing that Chinese Spring,Zhongmai 895,and Jimai 22 shared a common sequence named InvCS,whereas Aikang 58,Yangmai 16,Emai 580,and Avocet S shared the sequence named *** inverted configuration explained the suppressed recombination observed in all three bi-parental *** recombination was observed in a Jimai 22/Zhongmai 895 F2 population,facilitating mapping of YR86 to a genetic interval of 0.15 cM corresponding to 710.27-712.56 Mb falling within the inverted ***-three high-confidence genes were annotated in the interval using the Chinese Spring reference genome,with six identified as potential candidates for YR86 based on genome and transcriptome *** results will accelerate map-based cloning of YR86 and its deployment in wheat breeding.

关键词： Adult-plant resistance Chromosomal inversion Puccinia striiformis Triticum aestivum

The First Reported Case of Co-Infection with Neisseria Meningitidis and Bordetella Pertussis in the Cerebrospinal Fluid Specimen of a Normal Four-Year-Old Child

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Biomedical and Environmental Sciences 2024年第4期37卷 432-435页

作者： xia xian LI Guo Ming TANG Yi wang Si Quan HE Fei JIANG Yong Zhong YANG Hong Mei JIANG Hong Lin LYU Jing MAO ling Feng Hubei Key Laboratory of Edible Wild Plants Conservation&Utilization Hubei Normal UniversityHuangshi 430070HubeiChina Hubei Provincial Center for Disease Control and Prevention Wuhan 430079HubeiChina Joint Research Center for Molecular Diagnosis of Severe Infection in Children Binjiang Institute of Zhejiang UniversityHangzhou 310058ZhejiangChina

Pertussis is an acute and highly contagious respiratory disease caused by Bordetella pertussis(***),which occurs in people of all ages and is most dangerous for young children,especially *** introduction of whole-cell pertussis vaccines(wPVs)in the 1950s dramatically reduced the incidence of pertussis worldwide[1].However,over the past two decades,many studies have reported the resurgence of pertussis in different countries[2].Epidemiological surveillance in Hubei Province over the last 3 years revealed a clear increasing trend in the incidence of pertussis during the coronavirus disease 2019(COVID-19)epidemic.

关键词： Pertussis dangerous Hubei

Conversion therapy in advanced perihilar cholangiocarcinoma based on patient-derived organoids:A case report

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4274-4280页

作者： Yong-Gang He ling-Yu Zhang Jing Li Zheng wang Chong-Yu zhao Lu Zheng xiao-Bing Huang Department of Hepatobiliary The Second Affiliated Hospital of Army Medical UniversityChongqing 400037China School of Clinical Oncology Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina Fujian Key Laboratory of Translational Cancer Medicine Fuzhou 350014Fujian ProvinceChina

BACKGROUND Patient-derived organoids(PDOs)have been demonstrated to predict the response to drugs in multiple cancer ***,it remains unclear about its application in *** SUMMARY A 59-year-old woman was admitted to the hospital due to upper abdominal pain for over 8 *** to relevant examinations,she was diagnosed as perihilar cholangiocarcinoma(pCCA)with intrahepatic metastasis and perihilar lymphatic *** multidisciplinary team discussion,percutaneous transhepatic cholangiodrainage was performed to relieve biliary obstruction,and puncture biopsy was conducted to confirm the pathological *** chemoembolization with nab-paclitaxel was used in combination with toripalimab and lenvatinib,but the levels of tumor markers including alpha fetal protein,carcinoembryonic antigen,carbohydrate antigen 15-3 and cancer antigen 125 were still *** PDO for drug screening showed sensitive to gemcitabine and ***,the chemotherapy regimen was adjusted to gemcitabine and cisplatin in combination with toripalimab and *** 4 cycles of treatment,the tumor was assessed resectable,and radical surgical resection was performed *** year after surgery,the patient was still alive,and no recurrence or *** PDOs for drug sensitivity contribute to screening effective chemotherapy drugs for advanced pCCA,promoting conversion therapy and improving the prognosis.

关键词： Patient-derived organoids Perihilar cholangiocarcinoma Conversion therapy Drug screening Intrahepatic metastasis Case report

High-quality genome assemblies for two Australimusa bananas(Musa spp.)and insights into regulatory mechanisms of superior fiber properties

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Plant Communications 2024年第1期5卷 245-261页

作者： Run Zhou Shuo wang Ni Zhan Weidi He Guiming Deng Tongxin Dou Xi-Tong Zhu Wen-zhao Xie Yu-Yu Zheng Chunhua Hu Fangcheng Bi Huijun Gao Tao Dong Siwen Liu Chunyu Li Qiaosong Yang lingqiang wang Jia-Ming Song Jiangbo Dang Qigao Guo Ganjun Yi ling-ling Chen Ou Sheng Institute of Fruit Tree Research Guangdong Academy of Agricultural SciencesKey Laboratory of South Subtropical Fruit Biology and Genetic Resource UtilizationMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Tropical and Subtropical Fruit Tree ResearchGuangzhou 510640China College of Informatics Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China

Bananas(Musa spp.)are monocotyledonous plants with high genetic diversity in the Musaceae family that are cultivated mainly in tropical and subtropical *** fruits are a popular food,and the plants themselves have diverse *** genetic groups(genomes)are thought to have contributed to current banana cultivars:Musa acuminata(A genome),Musa balbisiana(B genome),Musa schizocarpa(S genome),and species of the Australimusa section(T genome).However,the T genome has not been effectively ***,we present the high-quality TT genomes of two representative accessions,Abaca(Musa textilis),with high-quality naturalfiber,and Utafun(Musa troglodytarum,Fe’i group),with abundant *** the Abaca and Utafun assemblies comprise 10 pseudochromosomes,and their total genome sizes are 613 Mb and 619 Mb,*** genome analysis revealed that the larger size of the T genome is likely attributable to rapid expansion and slow removal of *** with those of Musa AA or BB accessions or sisal(Agava sisalana),Abacafibers exhibit superior mechanical properties,mainly because of their thicker cell walls with a higher content of cellulose,lignin,and *** of MusaCesA cellulose synthesis genes peaks earlier in Abaca than in AA or BB accessions during plant development,potentially leading to earlier cellulose accumulation during secondary cell wall *** Abaca-specific expressed gene MusaMYB26,which is directly regulated by MusaMYB61,may be an important regulator that promotes precocious expression of secondary cell wall ***,MusaWRKY2 and MusaNAC68,which appear to be involved in regulating expression of MusaLAC and MusaCAD,may at least partially explain the high accumulation of lignin in *** work contributes to a better understanding of banana domestica-tion and the diverse genetic resources in the Musaceae family,thus providing resources for Musa genetic improvement.

关键词： Australimusa bananas T genome Musaceae evolution structural variations fiber