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Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期 249-262页

作者： Jinliang wang Wenyong Zhou Yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang wang Leo Li Chunwei Xu wenxian wang Shangli Cai Zhijie wang Jie wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteraction<0.001).Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs（P=0.040） and sqNSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

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Interfacial Morphology and Bonding Mechanism of Explosive Weld Joints

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Chinese Journal of Mechanical Engineering 2021年第2期34卷 201-212页

作者： Tingting Zhang wenxian wang Zhifeng Yan Jie Zhang Advanced Forming and Intelligent Equipment Research Institute Taiyuan University of TechnologyTaiyuan 030024China College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China

Interfacial structure greatly affects the mechanical properties of laminated ***,the critical material properties that impact the interfacial morphology,appearance,and associated bonding mechanism of explosive welded plates are still *** this paper,the same base plate(AZ31B alloy)and different flyer metals(aluminum alloy,copper,and stainless steel)were used to investigate interfacial morphology and *** and TEM results showed that typical sine wave,wave-like,and half-wave-like interfaces were found at the bonding interfaces of Al/Mg,Cu/Mg and SS/Mg clad plates,*** different interfacial morphologies were mainly due to the differences in hardness and yield strength between the flyer and base *** results of the microstructural distribution at the bonding interface indicated metallurgical bonding,instead of the commonly believed solid-state bonding,in the explosive welded clad *** addition,the shear strength of the bonding interface of the explosive welded Al/Mg,Cu/Mg and SS/Mg clad plates can reach up to 201.2 MPa,147.8 MPa,and 128.4 MPa,*** proposed research provides the design basis for laminated composite metal plates fabrication by explosive welding technology.

关键词： Interfacial structure Bonding mechanism Explosive welding Metallurgical bonding Magnesium alloy

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Unique Duplex Microstructure and Porosity Effect on Mechanical Properties of AlCoCrFeNi_(2.1) Eutectic High-Entropy Alloys Processed by Selective Laser Melting

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Acta Metallurgica Sinica(English Letters) 2023年第9期36卷 1465-1481页

作者： Liwei Lan wenxian wang Zeqin Cui Xiaohu Hao College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of TechnologyMinistry of EducationTaiyuan030024China Shanxi–Zhejiang University New Materials and Chemical Research Institute Taiyuan030032China

Selective laser melting(SLM)was performed on AlCoCrFeNi_(2.1) eutectic high-entropy alloys(EHEAs),and the unique duplex microstructure and porosity were investigated as well as the negative effect on mechanical *** printed AlCoCrFeNi_(2.1) EHEAs is composed of face-centered cubic and BCC/B2 phases,and the surface texture of samples perpendicular to and parallel to the building direction is *** the bottom of the molten pool to the inside,the structure changes from dendrites to columnar crystals and then to cellular crystals,the distribution of elements in and around the molten pool is uniform,and there is no element *** surface hardness of as-printed AlCoCrFeNi_(2.1) EHEAs is higher than that of as-cast ones due to the grain refinement strengthening,and there is anisotropy in different surface hardness,the highest hardness is 580 HV(X–Y plane)and 560 HV(X–Z plane).The reduction of bearing area and tip stress concentration caused by pores have adverse effects on the tensile strength and elongation of the alloy,the ultimate tensile strength increased from 1060 to 1289 MPa.

关键词： Selective laser melting Eutectic high-entropy alloys Metallurgical porosity Microstructure evolution Grains and interfaces

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Interfacial bonding characteristics and mechanical properties of H68/AZ31B clad plate

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International Journal of Minerals,Metallurgy and Materials 2022年第6期29卷 1237-1248页

作者： Tingting Zhang wenxian wang Jie Zhang Zhifeng Yan Advanced Forming and Intelligent Equipment Research Institute Taiyuan University of TechnologyTaiyuan 030024China College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan 030024China Shanxi Key Laboratory of Advanced Magnesium-based Materials Taiyuan 030024China

Interfacial bonding,microstructures,and mechanical properties of an explosively-welded H68/AZ31B clad plate were systematically *** to the results,the bonding interface demonstrated a“wavy-like”structure containing three typical zones/layers:(1)diffusion layer adjacent to the H68 brass plate;(2)solidification layer of melted metals at the interface;(3)a layer at the side of AZ31B alloy that experienced severe *** copper,CuZn_(2),andα-Mg phases were observed in the melted-solidification *** polygonal grains with twins were found at the H68 alloy side,while fine equiaxed grains were found at the AZ31B alloy side near the interface due to *** results revealed the formation of brittle intermetallic CuZn_(2) phases at the bonding *** interface was bonded well through metallurgical reactions due to diffusion of Cu,Zn,and Mg atoms across the interface and metallurgic reaction of partially melted H68 and AZ31B alloys.

关键词： explosive welding interfacial bonding numerical simulation nanoindentation dissimilar metal composite

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FeS2@C nanorods embedded in three-dimensional graphene as high-performance anode for sodium-ion batteries

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Frontiers of Materials Science 2020年第3期14卷 255-265页

作者： Zhenxiao Lu wenxian wang Jun Zhou Zhongchao Bai College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024China Department of Mechanical Engineering Pennsylvania State University ErieThe Behrend CollegeEriePA16563USA

FeS2 has drawn tremendous attention as electrode material for sodium-ion batteries(SIBs)due to its high theoretical capacity and abundant ***,it suffers from severe volume expansion and dull reaction kinetics during the cycling process,leading to poor rate capacity and short ***,a well-designed FeS2@C/G composite constructed by FeS2 nanoparticles embedded in porous carbon nanorods(FeS2@C)and covered by three-dimensional(3D)graphene is ***2 nanoparticles can shorten the Na+diffusion distance during the sodiation-desodiation *** carbon nanorods and 3D graphene not only improve conductivity but also provide double protection to alleviate the volume variation of FeS2 during ***,FeS2@C/G exhibits excellent cyclability(83.3%capacity retention after 300 cycles at 0.5A·g−1 with a capacity of 615.1 mA·h·g−1)and high rate capacity(475.1 mA·h·g−1 at 5A·g−1 after 2000 cycles).The pseudocapacitive process is evaluated and confirmed to significantly contribute to the high rate capacity of FeS2@C/G.

关键词： FeS2 electrode material sodium-ion battery nanoparticles graphene

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Microstructure evolution and corrosion resistance of AZ31 magnesium alloy tube by stagger spinning

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International Journal of Minerals,Metallurgy and Materials 2022年第7期29卷 1361-1372页

作者： Fanlin Zheng Hongsheng Chen Yuanqi Zhang wenxian wang Huihui Nie College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Advanced Magnesium-Based Materials Taiyuan 030024China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China

This study fabricates an AZ31 magnesium alloy tube by spinning technology-power stagger forward *** microstructure evolution of the tube is investigated by combining electron backscatter diffraction and transmission electron microscopy analysis,and the corrosion resistance is measured by an electrochemical corrosion *** show that the grains are obviously more uniform and finer along the wall thickness’s direction of the AZ31 alloy tube after the third spinning *** number of twins ascends first and then descends,while the varying trend of low-angle grain boundaries(LAGBs)is opposite to that of the twins as the spinning pass *** the increase of the total spinning deformation,the deformation texture initially increases and the c-axis of the{0001}crystal plane gradually rotates to the axial direction of the tube;the deformation texture then decreases and the orientation of grains becomes more *** main mechanism of grain refinement is dynamic recrystallization by the twin-induced way and bowing out of the nucleation at grain boundaries during the first and second ***,the dominant mechanism of the refined grain is the high-temperature dynamic recovery in the third pass,and the microstructure mainly consists of substructured *** the spinning deformation,the corrosion resistance of the AZ31 alloy tube decreases due to the combined effect of twins and high density-dislocations.

关键词： AZ31 magnesium alloy power stagger forward spinning microstructure evolution corrosion resistance

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Anisotropy study of the microstructure and properties of AlCoCrFeNi2.1 eutectic high entropy alloy additively manufactured by selective laser melting

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Journal of Materials Science & Technology 2022年第34期129卷 228-239页

作者： Liwei Lan wenxian wang Zeqin Cui Xiaohu Hao Dong Qiu College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of TechnologyMinistry of EducationTaiyuan 030024China Shanxi-Zhejiang University New Materials and Chemical Research Institute Taiyuan 030024China Centre for Additive Manufacturing School of EngineeringRMIT UniversityMelbourneVictoria 3001Australia

The AlCoCrFeNi2.1 eutectic high-entropy alloy(EHEA) was prepared by selective laser melting(SLM), focusing on the anisotropy of microstructure and mechanical performance. The AlCoCrFeNi2.1 EHEA printed by SLM has face-centered cubic(FCC) and body-centered cubic(BCC)/B2 phases, and the FCC phase accumulates at the boundary of the molten pool. With the increase in volumetric energy density(VED), the content of the FCC phase parallel to the surface in the direction of the building increases from 30.9% to 41%. The X–Z plane mainly produces columnar crystals along the temperature gradient, while a large number of equiaxed crystals are produced in the X–Y direction. When the volume energy density is 157 k J/mol(VED 157), the average grain size is 1.33 μm for BCC and 1.14 μm for FCC, which is significantly smaller than other preparation methods. Due to defect distribution and size, the microhardness of the X–Y plane is generally higher than that of the X–Z plane, with maximum hardnesses of 660 HV and 655 HV, respectively, which is much higher than those of traditionally manufactured *** compression performance of SLM process AlCoCrFeNi2.1 EHEAs shows maximum yield strength of 1567 MPa, and the ultimate compressive strength can reach 3276 MPa.

关键词： Selective laser melting High-entropy alloys Anisotropy Metallurgical defects Microstructure evolution

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Effect of Sintering Time on the Mechanical and Corrosion Behavior of Zn-Mg Composites with a Core-Shell Structure Prepared by SPS

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Acta Metallurgica Sinica(English Letters) 2023年第8期36卷 1305-1316页

作者： Zeqin Cui Lei Zhou Xiaohu Hao Mengda Luo wenxian wang Jianzhong wang Weiguo Li College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan University of TechnologyTaiyuan030000China State Key Laboratory of Porous Metal Materials Northwest Institute for Non-Ferrous Metal ResearchXi’an710016China Engineering Training Center Taiyuan University of TechnologyTaiyuan030024China

Zn-10 Mg composite with a core-shell structure was prepared by spark plasma sintering(SPS)technology,and a systematic study of the microstructure and properties has been conducted for different sintering *** shell layer dominated by the hard MgZn2 phase thickens with the increase in sintering time,which has a positive effect on the mechanical and degradation properties of the *** sample sintered for 20 min(T-20)has the best mechanical properties,with a compressive strength of 226 MPa and a compression rate of 6.5%.The corrosion resistance of samples increases as the sintering time prolongs,while the hydrogen evolution volume and pH value decrease in the immersion ***,the increase in the shell thickness significantly reduces the corrosion rate,which is attributed to the weakening of the galvanic corrosion reaction between the Mg core and the MgZn2 ***,composite with unique core-shell structure provides an advanced design idea for degradable biomaterials,and a reasonable control of sintering time can provide the optimal design strategy.

关键词： Zn-Mg composite Spark plasma sintering(SPS) Core-shell structure Mechanical property Degradation mechanism

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Anisotropy of Fatigue Behavior and Tensile Behavior of 5A06 Aluminum Alloy Based on Infrared Thermography

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Journal of Wuhan University of Technology(Materials Science) 2017年第1期32卷 155-161页

作者：闫志峰张红霞 CHEN Pengda wang wenxian Shanxi Key Laboratory of Advanced Magnesium-Based Materials Taiyuan University of Technology030024 TaiyuanChina School of Materials Science and Engineering Taiyuan University of TeehnologyTaiyuan 030024China

The fatigue behavior during high cycle fatigue testing and the tensile behavior of 5A06 aluminum alloy considering the anisotropy were *** types of specimens including longitudinal specimen（parallel to the rolling direction） and transverse specimen（perpendicular to the rolling direction） were *** thermography was employed to monitor the temperature evolution during the fatigue and tensile *** temperature evolution curves in the two directions were contrastively *** is found that the temperature evolution during fatigue process possesses four stages：initial temperature rise stage,slow temperature decline stage,rapid temperature rise stage,and finial temperature decline *** heat generating mechanisms of the four stages are *** differences can be found between the longitudinal specimen and transverse specimen in fatigue strength and fatigue *** fatigue strength and fatigue life of longitudinal specimen are higher than those of transverse *** the tensile and fatigue testing process,the fracture temperature in the transverse direction are higher than that in the longitudinal *** fatigue strength prediction by means of infrared thermography has a good consistency with that by the traditional method.

关键词： aluminum alloy anisotropy fatigue strength infrared thermography

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Ultrasound-Assisted Transient Liquid Phase Bonding of Magnesium Alloy Using Brass Interlayer in Air

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Journal of Materials Science & Technology 2017年第6期33卷 567-572页

作者： Zhiwei Lai Ruishan Xie Chuan Pan Xiaoguang Chen Lei Liu wenxian wang Guisheng Zou School of Materials Science and Engineering Tsinghua University Department of Mechanical Engineering Key Laboratory for Advanced Manufacturing by Materials Processing Technology Tsinghua University China Iron & Steel Research Institute Group R&D Department Yongtai Electric (Dong Guan) Co. Ltd College of Materials Science and Engineering Shanxi Key Laboratory of Advanced Magnesium-based Materials Taiyuan University of Technology

The microstructure evolution and oxide film behavior in ultrasound-assisted transient liquid phase（U-TLP） bonding of Mg alloy were investigated by applying different ultrasonic time at 460？C with brass interlayer in air. The results indicated that with increasing ultrasonic time, brass interlayer disappeared gradually and the Mg-Cu-Zn eutectic compounds were formed. The eutectic compounds in the joint decreased as the ultrasonic time increased further. The oxide removal process was divided into four steps. Continuous oxide film at the interface was partially fractured by ultrasonic vibration,and then suspended into liquid by undermining eutectic reaction. After that, the suspended oxide film was broken into small oxide fragments by ultrasonic cavitation effect, which was finally squeezed out of the joint by ultrasonic squeeze action. In addition, the mechanical properties of the joints were investigated. The maximum shear strength of the joint reached 105 MPa, which was 100% of base metal.

关键词： Magnesium alloy Bonding Ultrasound Oxide film Microstructure

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