检索结果-南通市图书馆

Comprehensive circRNA-microRNA-mRNA network analysis revealed the novel regulatory mechanism of Trichosporon asahii infection

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2021年第4期8卷 523-534页

作者： Ming-wang Zhang Zhi-hong Zhu Zhi-Kuan Xia Xin yang Wan-Ting Luo jun-hong ao rong-ya yang Department of Dermatology Southwest HospitalArmy Medical UniversityChongqing 400038China. Department of Dermatology the Seventh Medical Center of PLA General Hospital5 NanmencangDongcheng DistrictBeijing 100700China. Department of Ophthalmology Hainan Hospital of Chinese PLA General HospitalSanya 572000HainanChina. The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510280GuangdongChina.

Background:Invasive Trichosporon asahii(***)infection frequently occurs with a high mortality in immunodeficient hosts,but the pathogenesis of *** infection remains *** RNAs(circRNAs)are a type of endogenous noncoding RNA that participate in various disease ***,the mechanism of circRNAs in *** infection remains completely ***:RNA sequencing(RNA-seq)was performed to analyze the expression profiles of circRNAs,microRNAs(miRNAs),and mRNAs in THP-1 cells infected with *** or uninfected *** of the RNA-seq results were verified by *** Ontology(GO)enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses were used to analyze the differentially expressed mRNAs.A circRNA-miRNA-mRNA network was constructed and verified by dual-luciferase reporter assay and overexpression ***:A total of 46 circRNAs,412 mRNAs and 47 miRNAs were differentially expressed at 12 h after *** *** and KEGG analyses showed that the differentially expressed mRNAs were primarily linked to the leukocyte migration involved in the inflammatory response,the Toll-like receptor signaling pathway,and the TNF signaling pathway.A competing endogenous RNA(ceRNA)network was constructed with 5 differentially expressed circRNAs,5 differentially expressed miRNAs and 42 differentially expressed *** them,hsa_circ_0065336 was found to indirectly regulate PTPN11 expression by sponging ***:These data revealed a comprehensive circRNA-associated ceRNA network during *** infection,thus providing new insights into the pathogenesis of the ***-host interactions.

关键词： Trichosporon asahii Circular RNA Competing endogenous RNA RNA sequencing

Breakthrough trichosporonosis in patients receiving echinocandins： case report and literature review

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2012年第14期125卷 2632-2635页

作者： LIao Yong Thomas Hartmann ZHENG Tao yang rong-ya ao jun-hong wang wen-ling Department of Dermatology GeneralHospital of Beijing Military Command Beijing 100_700~ China Department of Intensive Care Unit GeneralHospital of Beijing Military Command Beijing 100700 China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of Sciences Beijing 100101 China

Trichosporon species now ranks as the second most common cause of disseminated yeast infections with a high mortality rate. Breakthrough trichosporonosis in patients receiving echinocandins therapy is being recognized recently. We present a case of breakthrough trichosporonosis with acute viral myocarditis while receiving caspofungin therapy. Trichosporon infection should be considered in patients, who have risk factors for invasive fungal infection and develop unexplained clinical manifestations of infection despite treatment with echinocandins.

关键词： trichosporonosis caspofungin echinocandins

Pathogenicity of Trichosporon asahii in a murine model of disseminated trichosporonosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2008年第24期121卷 2557-2560页

作者： yang rong-ya wang wen-ling ao jun-hong Hao Zhen-feng ZHANG Jie wang Cong-min Department of Dermatology General Hospital of Beijing Military Region of PLA Beijing 100700 China

Background In recent years, superficial and deep mycoses caused by trichosporon were occasionally reported. In 2001, we reported the first case of disseminated trichosporonosis caused by Trichosporon asahfi （T. asahii） in China. In this study, the pathogenicity of T. asahii was investigated in a murine model of disseminated trichosporonosis. Methods Seventy-five mice were randomly divided into 7 groups. Each group was inoculated with T. asahii, through intradermal, gastrointestinal tract or intravenous injection. The mice in the experimental groups were given an intraperitoneal injection of cyclophosphamide （CY） to induce granulocytopenia. Mice in the therapeutic group were given both liposomal amphotericin B and fluconazole. The main viscera of the mice were examined by means of tissue culture and pathologic sections. Results In the two intravenous inoculation groups, T. asahfi was isolated from at least one organ in 10 of the 12 granulocytopenic mice and 2 of the 14 immunocompetent mice. Two of the 7 mice in the granulocytopenia group presented with lesions in the inoculation position, but none of the 30 mice in the granulocytopenia and the control group which were inoculated intradermally or through the gastrointestinal tract had viscera infection. In the therapeutic group, the ratio of consequently dead mice, the number of involved viscera, and the incidence of systemic infection were significantly less than the untreated group. Acute purulent inflammation and granulomatous inflammation were the main pathological changes in the course of the infection. Arthrospores and filaments were found in the focus. Conclusions T. asahii is an opportunistic pathogen that causes cutaneous and visceral infections in immunologically impaired hosts. An immunocompetent host was to be infected by the invading T. asahii. Several organs, namely the liver, lungs, kidneys, spleen and heart, were predisposed. The therapy of combining liposomal amphotericin B with fluconazole can preven

关键词： trichosporonosis Trichosporon asahii pathogenicity

Prenatal prednisone exposure disturbs fetal kidney development and its characteristics

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第11期145卷 75-87页

作者： Zhiping Xia Songdi wang wen wang Yutang Liu Tianshu yang Hui wang Ying ao Department of Pharmacology Wuhan University School of Basic Medical SciencesWuhan 430071China Hubei Provincial Key Laboratory of Developmentally Originated Disease Wuhan 430071China

Prednisone is a synthetic glucocorticoid that is commonly used in both human and veterinary ***,it is also recognized as an emerging environmental *** be exposed to prednisone actively or passively throughmultiple pathways and cause developmental toxicity to the ***,the impact of prenatal prednisone exposure(PPE)on fetal kidney development remains *** this study,pregnant mice were administered prednisone intragastrically during full-term pregnancy with different doses(0.25,0.5,or 1 mg/(kg·day)),or at the dose of 1 mg/(kg·day)in different gestational days(GD)(GD0-9,GD10-18,or GD0-18).The pregnant mice were euthanized on *** staining revealed fetal kidney dysplasia,with an enlarged glomerular Bowman’s capsule space and a reduced capillary network in the PPE *** expression of the podocyte and the mesangial cell marker genes was significantly reduced in the PPE ***,overall gene expression in renal tubules and collecting ducts were markedly *** of the above effects were more pronounced in high-dose,full-term pregnancy,and female *** on the mechanism of the female fetal kidney have revealed that PPE reduced the expression of Six2,increased the expression of Hnf1β,Hnf4α,and Wnt9b,and inhibited the expression of glial cell line-derived neurotrophic factor(GDNF)and Notch signaling *** conclusion,this study demonstrated that there is a sex difference in the developmental toxicity of PPE to the fetal kidney,and the time effect is manifested as full-term pregnancy>early pregnancy>mid-late pregnancy.

关键词： Prenatal prednisone exposure Kidney developmental toxicity Glomerulus Toxicity characteristics

Development of an Eight-gene Prognostic Model for Overall Survival Prediction in Patients with Hepatocellular Carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2021年第6期9卷 898-908页

作者： De-Zhen Guo ao Huang Yu-Peng wang ya Cao Jia Fan Xin-rong yang Jian Zhou Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityKey Labo-ratory of Carcinogenesis and Cancer Invasion(Fudan University)Ministry of EducationShanghai Key Laboratory of Organ TransplantationZhongshan HospitalFudan UniversityShanghaiChina Cancer Research Institute Xiangya School of MedicineCentral South UniversityKey Laboratory of Carcinogenesis and Cancer InvasionMinistry of EducationXiangya HospitalCentral South UniversityChangshaHunanChina Institute of Biomedical Sciences Fudan UniversityShanghaiChina State Key Laboratory of Genetic Engineering Fudan UniversityShanghaiChina

Background and Aims:The overall survival(OS)of hepatocellular carcinoma(HCC)remains *** analysis of transcriptome data could identify patients with poor OS and may facilitate clinical *** study aimed to develop a prognostic gene model for ***:GSE14520 was retrieved as a training set to identify differential expressed genes(DEGs)between tumor and adjacent liver tissues in HCC patients with different OS.A DEG-based prognostic model was then constructed and the TCGA-LIHC and ICGC-LIRI datasets were used to validate the *** area under the receiver operating characteristic curve(AUC)and hazard ratio(HR)of the model for OS were calculated.A model-based nomogram was estab-lished and ***:In the training set,differential expression analysis identified 80 genes dysregulated in oxidation-reduction and metabolism *** univariate Cox and LASSO regression,eight genes(LPCAT1,DHRS1,SORBS2,ALDH5A1,SULT1C2,SPP1,HEY1 and GOLM1)were selected to build the prognostic *** AUC for 1-,3-and 5-year OS were 0.779,0.736,0.754 in training set and 0.693,0.689,0.693 in the TCGA-LIHC validation set,*** AUC for 1-and 3-year OS were 0.767 and 0.705 in the ICGC-LIRI validation *** analysis confirmed the model was an independent prognostic factor(training set:HR=4.422,p<0.001;TCGA-LIHC validation set:HR=2.561,p<0.001;ICGC-LIRI validation set:HR=3.931,p<0.001).Furthermore,a nomogram combining the model and AJCC stage was established and validated,showing increased OS predictive efficacy compared with the prognostic model(p=0.035)or AJCC stage(p<0.001).Conclusions:Our eight-gene prognostic model and the related nomogram represent as reliable prognostic tools for OS prediction in HCC patients.

关键词： Prognostic model Hepatocellular carcinoma Bioinformatic analysis

In situ polymerization of 1,3-dioxolane infiltrating 3D garnet framework with high ionic conductivity and excellent interfacial stability for integrated solid-state Li metal battery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2022年第11期41卷 3694-3705页

作者： Lin-Hui Chen Ze-ya Huang Shi-Le Chen rong-ao Tong Hai-Long wang Gang Shao Chang-An wang State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing210016China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450001China

The polymer-ceramic composite electrolyte is considered as one of promising electrolytes for solid-state ***,in previous research,ceramic particles are usually dispersed in polymer matrix and could not form continuous Li+conductive *** agglomeration of ceramic particles could also lead to low ionic conductivity and poor interfacial electrode/electrolyte *** this paper,self-supported porous Li_(6.4)La_(3) Zr_(1.4)Ta_(0.6)O_(12)(LLZTO) electrolyte is synthesized by gelcasting process,which possesses three-dimensional(3D) interconnected pore channels and relatively high *** 1,3-dioxolane(DOL) could penetrate into the porous LLZTO framework for its excellent *** subsequent in situ polymerization process by thermal treatment could completely fill the internal pores and improve the interfacial contact with *** resulting 3D composite electrolyte with dual continuous Li+transport channels in ceramic and polymer components exhibits high ionic conductivity of 2.8 × 10^(-4) S·cm^(-1) at room temperature and low Li/electrolyte interfacial resistance of 94 Ω·cm^(2) at 40 ℃.The corresponding Li/Li symmetric cell delivers stable voltage profiles for over 600 h under 0.1 and 0.2 mA·cm^(-2).The solid-state Li/LiFePO_(4) battery shows superior rate and cycling performance under 0.1 C and 0.2 *** work guides the preparation of composite electrolyte with dual continuous Li+conductive paths as well as high ceramic ratio and interface modification strategy for solid-state Li metal battery.

关键词： Garnet electrolyte 1,3-dioxolane(DOL) In situ polymerization Three-dimensional(3D)composite electrolyte Continuous Li^(+)conductive channel

In-situ scalable fast fabrication of Cu-Cu_(2+1)O nanorods for highly efficient electrocatalytic reduction into ammonia under neutral medium

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2023年第24期155卷 111-118页

作者： Sai Huang ao wang Xin-Yue Dong Jin-Kun Li yan Meng jun-ling Song International Joint Research Center for Photoresponsive Molecules and Materials School of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China

The development of a highly efficient and durable electrocatalyst for nitrate reduction reaction(NO_(3)RR)wastewater valorization to ammonia(NH_(3))is a promising ***,it is challenging to design scalable low-cost electrocatalysts with high activity,high selectivity,and long-term stability by a facile and simple ***,we construct this scalable Cu-based nanoarray with muti-oxidation states grown directly on nickel foam(NF)substrate(Cu_(2+1)O@Cu/NF)using a facile molten salt method combined in-situ electrochemical *** as-prepared Cu_(2+1)O@Cu/NF nanoarrays reveal a high NH_(3) yield of 20.14 mg h^(−1) cm^(−2) at−0.95 V vs.a reversible hydrogen electrode(***),Faradaic efficiency of 99.38%at−0.55 V *** in the neutral potassium phosphate(PBS)buffer solution with 50 mM NaNO_(3),which is ascribed to its electron redistribution with abundant oxygen vacancies and favorable charge/mass transfer.

关键词： Cu-Cu2+1O nanorods with multi-oxidation states High NH3 yield Molten salt method Neutral medium Nitrate electrochemical reduction Scalable fabrication

SnS_(2) nanosheets decorated SnO_(2) hollow multishelled nanostructures for enhanced sensing of triethylamine gas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第5期43卷 2339-2348页

作者： wen-Di Liu ya Xiong ao Shen Xin-Zhen wang Xiao Chang wen-Bo Lu Jian Tian School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China College of Physics Qingdao UniversityQingdao 266071China Zernike Institute for Advanced Materials University of Groningen9747 AG GroningenThe Netherlands

Highly sensitive,fast and low-temperature detection of triethylamine(TEA)gas based on SnO_(2) is attractive yet remains ***,SnS_(2) nanosheets(NSs)/SnO_(2) hollow multishelled structures(HoMSs)-based sensors are designed by the synthesis of SnO_(2) HoMSs,followed by in situ sulfuration with *** varying the thioacetamide levels,Sn S_(2)/SnO_(2) heterostructures with different SnS_(2) contents were obtained and their TEA gas sensing performances were investigated.

关键词： SnS attractive sheets

Analyses and identifications of quantitative trait loci and candidate genes controlling mesocotyl elongation in rice

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2023年第2期22卷 325-340页

作者： ZHANG Xi-juan LAI Yong-cai MENG Ying TANG ao DONG wen-jun LIU You-hong LIU Kai wang Li-zhi yang Xian-li wang wen-long DING Guo-hua JIANG Hui REN yang JIANG Shu-kun Institute of Crop Cultivation and Tillage Heilongjiang Academy of Agricultural SciencesHeilongjiang Provincial Key Laboratory of Crop Physiology and Ecology in Cold RegionHeilongjiang Provincial Engineering Technology Research Center of Crop Cold DamageHarbin 150086P.R.China Northeast Branch of National Salt–Alkali Tolerant Rice Technology Innovation Center Harbin 150086P.R.China Qiqihar Branch Heilongjiang Academy of Agricultural SciencesQiqihar 161006P.R.China

Rice direct seeding has the significant potential to save labor and water,conserve environmental resources,and reduce greenhouse gas emissions ***,rice direct seeding is becoming the major cultivation technology applied to rice production in many *** and utilizing genes controlling mesocotyl elongation is an effective approach to accelerate breeding procedures and meet the requirements for direct-seeded rice(DSR) *** study used a permanent mapping population with 144 recombinant inbred lines(RILs) and 2 828 bin-markers to detect quantitative trait loci(QTLs) associated with mesocotyl length in 2019 and *** mesocotyl lengths of the rice RILs and their parents,Lijiangxintuanheigu(LTH) and Shennong 265(SN265),were measured in a growth chamber at 30°C in a dark environment.A total of 16 QTLs for mesocotyl length were identified on chromosomes 1(2),2(4),3(2),4,5,6,7,9,11(2),and *** of these QTLs,including qML1a,qML1b,qML2d,qML3a,qML3b,qML5,and qML11b,were reproducibly detected in both years via the interval mapping *** major QTL,qML3a,was reidentified in two years via the composite interval mapping method.A total of 10 to 413 annotated genes for each QTL were identified in their smallest genetic intervals of 37.69 kb to 2.78 Mb,*** predicted genes within a relatively small genetic interval(88.18 kb) of the major mesocotyl elongation QTL,qML3a,were more thoroughly ***,the coding DNA sequence variations among SN265,LTH,and Nipponbare indicated that the LOC_Os03g50550 gene was the strongest candidate gene for the qML3a QTL controlling the mesocotyl *** LOC_Os03g50550 gene encodes a mitogen-activated protein *** gene expression analysis using qRT-RCR further revealed that the expression levels of the LOC_Os03g50550 gene in the mesocotyl of LTH were significantly lower than in the mesocotyl of *** conclusion,these results further strengthen our knowled

关键词： japonica rice direct-seeded rice(DSR) mesocotyl elongation quantitative trait loci candidate gene