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Nitro-oleic acid ameliorates erectile dysfunction in a streptozotocin-induced rat model of diabetes by inhibiting oxidative stress and apoptosis and activating the NO/cGMP pathway

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Asian Journal of Andrology 2024年第1期26卷 57-66页

作者： Chang-Bo Zhao Wei-Bo Chen wen-Zhen wang Fang-Xin Gong Cui-Qin Fan Ye li Tian Lan wen-Jing wang Ming-Zhen Yuan Department of Urology Shandong Provincial HospitalShandong UniversityJinan 250012China Department of Andrology Liaocheng People's HospitalShandong UniversityLiaocheng 252000China Department of Urology The Second Hospital of Shandong UniversityJinan 250012China Department of Physiology School of Basic Medical SciencesShandong UniversityJinan 250012China

The major vascular complications associated with diabetes make the management of diabetic mellitus erectile dysfunction(DMED)a challenging *** factors contributing to DMED include oxidative stress,nitric oxide(NO)/cyclic guanosine monophosphate(cGMP)pathway activation,and apoptosis,while nitro-oleic acid(NO,-OA)has been shown to be beneficial in treating these aspects of this ***,herein,investigated the effects and possible mechanisms of NO,-OA on erectile function as assessed in a streptozotocin-induced rat model of *** results revealed that the erectile function of DMED rats was significantly impaired compared with that of the control ***,in response to 4 weeks of NO,-OA treatment,there was an improvement in erectile *** expression of oxidative stress-related indicators was significantly increased and the NO/cGMP pathway was impaired in the DMED *** expression of proapoptotic factors was increased,while that of antiapoptotic factors was decreased in the DMED ***,the cell morphology in the cavernous tissue of the DMED group also changed ***,-OA treatment significantly reversed all these changes observed in the DMED *** conclusion,NO,-OA treatment partially improved erectile function in DMED rats through mechanisms that included inhibition of oxidative stress,activation of the NO/cGMP pathway,and a reduction in apoptosis.

关键词： apoptosis diabetic mellitus erectile dysfunction nitro-oleic acid NO/cGMP pathway oxidative stress

《园林绿化工程安全隐患识别与分类》团体标准解读

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中国标准化 2024年第8期 149-152页

作者：黄开战吴海霞张圣东陈亮王丽文杭州市园林绿化发展中心

随着我国社会经济的不断发展,园林绿化在城市化进程中的重要性日益凸显,然而,在园林绿化工程中往往隐藏着各种安全隐患,导致了安全事故的发生。《园林绿化工程安全隐患识别与分类》从园林绿化工程实际的作业类型出发,对其中存在的安全... 详细信息

随着我国社会经济的不断发展,园林绿化在城市化进程中的重要性日益凸显,然而,在园林绿化工程中往往隐藏着各种安全隐患,导致了安全事故的发生。《园林绿化工程安全隐患识别与分类》从园林绿化工程实际的作业类型出发,对其中存在的安全隐患进行识别与分类。本文介绍了标准制定的背景和意义,对标准的内容进行了详细解读,总结提出标准的创新点,以更好地用于指导园林绿化工程安全隐患的识别与分类,推动标准的贯彻落实。

关键词：园林绿化工程安全隐患标准解读

Calmodulin-like 5 promotes PEDV replication by regulating late-endosome synthesis and innate immune response

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Virologica Sinica 2024年第3期39卷 501-512页

作者： wen-Jun Tian Xiu-Zhong Zhang Jing wang Jian-Feng liu Fu-Huang li Xiao-Jia wang National Key Laboratory of Veterinary Public Health and Safety College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China College of Animal Science and Technology China Agricultural UniversityBeijing 100193China Beijing General Station of Animal Husbandry Service(South Section) Beijing102218China

The infection caused by porcine epidemic diarrhea virus(PEDV)is associated with high mortality in piglets *** factors involved in the efficient replication of PEDV,however,remain largely *** recent proteomic study in the virus-host interaction network revealed a significant increase in the accumulation of CALML5(EF-hand protein calmodulin-like 5)following PEDV infection.A further study unveiled a biphasic increase of CALML5 in 2 and 12 h after viral *** trends were observed in the intestines of piglets in the early and late stages of the PEDV ***,CALML5 depletion reduced PEDV mRNA and protein levels,leading to a one-order-of-magnitude decrease in virus *** the early stage of PEDV infection,CALML5 affected the endosomal trafficking pathway by regulating the expression of endosomal sorting complex related cellular ***5 depletion also suppressed IFN-βand IL-6 production in the PEDV-infected cells,thereby indicating its involvement in negatively regulating the innate immune *** study reveals the biological function of CALML5 in the virology field and offers new insights into the PEDV-host cell interaction.

关键词： Porcine epidemic diarrhea virus(PEDV) EF-hand protein calmodulin-like 5(CALML5) Late endosomes Innate immune response

A Simple yet Effective Framework for Active Learning to Rank

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Machine Intelligence Research 2024年第1期21卷 169-183页

作者： Qingzhong wang Haifang li Haoyi Xiong wen wang Jiang Bian Yu Lu Shuaiqiang wang Zhicong Cheng Dejing Dou Dawei Yin Baidu Incorporated Beijing 100085China

While China has become the largest online market in the world with approximately 1 billion internet users,Baidu runs the world's largest Chinese search engine serving more than hundreds of millions of daily active users and responding to billions of queries per *** handle the diverse query requests from users at the web-scale,Baidu has made tremendous efforts in understanding users'queries,retrieving relevant content from a pool of trillions of webpages,and ranking the most relevant webpages on the top of the *** the components used in Baidu search,learning to rank(LTR)plays a critical role and we need to timely label an extremely large number of queries together with relevant webpages to train and update the online LTR *** reduce the costs and time con-sumption of query/webpage labelling,we study the problem of active learning to rank(active LTR)that selects unlabeled queries for an-notation and training in this ***,we first investigate the criterion-Ranking entropy(RE)characterizing the entropy of relevant webpages under a query produced by a sequence of online LTR models updated by different checkpoints,using a query-by-com-mittee(QBC)***,we explore a new criterion namely prediction variances(PV)that measures the variance of prediction res-ults for all relevant webpages under a *** empirical studies find that RE may favor low-frequency queries from the pool for la-belling while PV prioritizes high-frequency queries ***,we combine these two complementary criteria as the sample selection strategies for active *** experiments with comparisons to baseline algorithms show that the proposed approach could train LTR models to achieve higher discounted cumulative gain(i.e.,the relative improvement DCG4=1.38%)with the same budgeted labellingefforts.

关键词： Search information retrieval learning to rank active learning query by committee

7-Oxa-2,3-Diazanorbornene:A One-Step Accessible Monomer for living Ring-Opening Metathesis Polymerization to Produce Backbone-Biodegradable Polymers

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CCS Chemistry 2024年第9期6卷 2305-2317页

作者： Xiaoyang wang Yixing wen Yu wang Wei li Xueguang Lu Wei You Beijing National Laboratory for Molecular Sciences(BNLMS) CAS Key Laboratory of Engineering PlasticsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 Beijing National Laboratory for Molecular Sciences(BNLMS) CAS Key Laboratory of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049

Traditional ring-opening metathesis polymerization(ROMP)reactions exhibit broad functional group compatibility and precise control over polymer architectures,albeit with non-biodegradable *** progress has resulted in a series of biodegradable ROMP products with diverse cleavable functional groups,yet the majority of the monomers display moderate to low ring strain,which restricts their living polymerization *** this study,a novel category of readily available 7-oxa-2,3-diazanorbornenes(ODAN)is presented,which exhibits the highest ring strain(22.8 kcal/mol)compared to existing degradable ROMP *** trait endows ODAN with the ability to perform living polymerization reactions,generating narrowly dispersed homopolymers,block copolymers,and statistical copolymers with various cyclic olefin comonomers,thereby enabling precise control over distribution of the biodegradable functional ***,the resultant polymers comprise directly connected allyl hemiaminal ether and urethane units,which are hydrolyzable at controllable ***,these well-defined,structure-tunable,and backbone-biodegradable ROMP polymers are applied as nanoetching materials and biodegradable delivery carriers.

关键词： biodegradable polymers ring-opening metathesis polymerization living polymerization nanoetching materials high ring strain

Variations in Column Concentration of Greenhouse Gases in China and Their Response to the 2015-2016 El Niño Event

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Journal of Meteorological Research 2024年第3期38卷 608-619页

作者： Ningwei liU lingjun XIA Youjun DOU Shaorou DONG Jing wen Ying wang Rui FENG Ruonan wang Yuhe li Institute of Atmospheric Environment China Meteorological AdministrationShenyang110166China Jiangxi Ecological Meteorology Centre Nanchang330096China Beijing Xiangyuan Academy of Meteorological Observing Technology Beijing100081China Climate Centre of Guangdong Province Guangzhou510641China Guangdong Meteorological Service Guangzhou510062China liaoning Provincial Meteorological Equipment Support Centre Shenyang110166China Meteorological Centre of Northeast Air Traffic Administration of Civil Aviation of China Shenyang110161China

Since the industrial revolution,enhancement of atmospheric greenhouse gas concentrations as a result of human activities has been the primary cause of global *** monitoring and evaluation of greenhouse gases are significant prerequisites for carbon emission *** monthly data of global atmospheric carbon dioxide(CO_(2))and methane(CH4)column concentrations(hereinafter XCO_(2) and XCH_(4),respectively)retrieved by the Greenhouse Gas Observation Satellite(GOSAT),we analyzed the variations in XCO_(2)and XCH_(4)in China during 2010-2022 after confirming the reliability of the ***,the influence of a strong El Niño event in 2015-2016 on XCO_(2) and XCH_(4) variations in China was further *** results show that the retrieved XCO_(2) and XCH_(4) from GOSAT have similar temporal variation trends and significant correlations with the ground observation and emission inventory data of an atmospheric background station,which could be used to assess the variations in XCO_(2) and XCH_(4) in ***_(2) is high in spring and winter while XCH_(4) is high in *** XCO_(2) and XCH_(4) gradually declined from Southeast China to Northwest and Northeast China,with variation ranges of 401-406 and 1.81-1.88 ppmv,respectively;and the high value areas are located in the middle-lower Yangtze River ***_(2) and XCH_(4) in China increased as a whole during 2010-2022,with rapid enhancement and high levels of XCO_(2) and XCH_(4) in several *** significant increases in XCO_(2) and XCH_(4) over China in 2016 might be closely related to the strong El Niño-Southern Oscillation(ENSO)event during *** a global warming background in 2015,XCO_(2) and XCH_(4) increased by 0.768%and 0.657%in 2016 in *** analysis reveals that both the XCO_(2) and XCH_(4) variations might reflect the significant impact of the ENSO event on glacier melting in the Tibetan Plateau.

关键词： greenhouse gases column concentration CO_(2) CH4 El Niño-Southern Oscillation(ENSO) El Niño

Biomimetic microchannel network with functional endothelium formed by sacrificial electrospun fibers inside 3D gelatin methacryloyl(GelMA)hydrogel models

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第1期25卷 79-96页

作者： Haoyu SUN Haiyang MA li wang Yang liU Tian HOU wenjie TANG Qing YU Meiwen AN Meiling wen Institute of Biomedical Engineering College of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan030024China

Three-dimensional(3D)hydrogel models play a crucial role in tissue engineering for promoting tissue regeneration.A biomimetic microchannel network system in the 3D hydrogel model is necessary for optimal cellular *** report describes the preparation of a biomimetic hydrogel scaffold with an internal microchannel network,using electrospinning techniques and the sacrificial template method for 3D cell *** and cavities were created within the gelatin methacryloyl(GelMA)hydrogel by sacrificing polyvinyl alcohol(PVA)electrospun fibers(>10µm),resulting in the creation of microvessel-like *** characterizations,swelling properties,and biodegradation analysis were conducted to investigate the feasibility of a biomimetic microchannel network hydrogel scaffold for 3D cell culture *** to pure GelMA hydrogel,the hydrogel with microchannels promoted cell proliferation,adhesion,and endothelial tube ***,the results confirmed that the biomimetic microchannel network scaffold had a major impact on the distribution and arrangement of human umbilical vein endothelial cells(HUVECs)and can enable the formation of artificial microvasculature by the culture of HUVECs and cell media perfusion.

关键词： Biomimetic scaffold Photocrosslinking Microchannel network Tissue engineering Artificial microvascular

NIR-switchable local hydrogen generation by tandem bimetallic MOFs nanocomposites for enhanced chemodynamic therapy

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Regenerative Biomaterials 2024年第1期3卷 58-68页

作者： Jun Zhong Xiang Zheng Yuan wen Yuewei li Jianting Zhang Ranjith Kumar Kankala Shibin wang Aizheng Chen Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamen 361021China Fujian Provincial Key Laboratory of Biochemical Technology Huaqiao UniversityXiamen 361021China Fujian Provincial Key Laboratory of Biomass Low-Carbon Conversion Huaqiao UniversityXiamen 361021China

The inadequate quantity of hydrogen peroxide(H_(2)O_(2))in cancer cells promptly results in the constrained success of chemodynamic therapy(CDT).Significant efforts made throughout the years;nevertheless,researchers are still facing the great challenge of designing a CDT agent and securing H_(2)O_(2) supply within the tumor *** this study,taking advantage of H_(2)O_(2) level maintenance mechanism in cancer cells,a nanozyme-based bimetallic metal-organic frameworks(MOFs)tandem reactor is fabricated to elevate intracellular H_(2)O_(2) levels,thereby enhancing *** addition,under nearinfrared excitation,the upconversion nanoparticles(UCNPs)loaded into the MOFs can perform photocatalysis and generate hydrogen,which increases cellular susceptibility to radicals induced from H_(2)O_(2),inhibits cancer cell energy,causes DNA damages and induces tumor cell apoptosis,thus improving CDT therapeutic efficacy *** proposed nanozyme-based bimetallic MOFs-mediated CDT and UCNPs-mediated hydrogen therapy act as combined therapy with high efficacy and low toxicity.

关键词： chemodynamic therapy nanozyme bimetallic MOFs gas therapy

Single-source-precursor synthesis and air-plasma ablation behavior of(Ti,Zr,Hf)C/SiC ceramic nanocomposites at 2200℃

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Journal of Advanced Ceramics 2024年第7期13卷 1043-1059页

作者： li Lu Qingbo wen Jinrun Hu Tianxing Jiang Xiangchao Ren Yalei wang Yi Zeng Xiang Xiong State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

Dense monolithic(Ti,Zr,Hf)C/SiC ceramic nanocomposites with four different molar ratios of metallic elements in the(Ti,Zr,Hf)C phase(i.e.,Ti:Zr:Hf=1:1:1,2:3:5,2:3:3,and 1:2:1)were prepared upon pyrolysis of novel(Ti,Zr,Hf)-containing single-source precursors(SSPs),followed by spark plasma sintering(SPS).A thorough characterization was conducted to elucidate the synthesis of the SSPs,polymer-to-ceramic transformation,chemical/phase compositions,and microstructure of the SiTiZrHfC-based *** results revealed the feasibility of synthesizing nanocomposites with high(Ti,Zr,Hf)C contents using the SSP *** nanocomposites were characterized by a unique microstructure with in situ generated(Ti,Zr,Hf)C@C core-shell nanoparticles homogeneously mixed withβ-*** ablation behavior of the nanocomposites was evaluated on an air-plasma device for 60 ***,the nanocomposites exhibited excellent ablation resistance,and the lowest linear ablation rate reached−0.58μm/s at 2200°***,the ablation resistance can be dramatically improved by precisely tailoring the atomic ratios of metal elements within the(Ti,Zr,Hf)C phase via the molecular design of the *** formation of a multiple-oxide layer with both a high-meltingpoint phase((Ti,Zr,Hf)O_(2))and low-melting-point phases((Zr,Hf)TiO_(4))and glassy SiO_(2),as well as their structure,played a critical role in the enhanced ablation *** uniform distribution of the high-melting-point(Ti,Zr,Hf)O_(2)nano/microparticles throughout the glassy SiO_(2)matrix significantly enhanced the viscosity and stability of the oxide layer by the pinning effect,offering superior protection against the ingress of oxygen atoms and excellent resistance to mechanical erosion.

关键词： ultrahigh-temperature ceramics(UHTCs) multicomponent carbide nanocomposites ablation behavior multiple oxides