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Commissioning of laser electron gamma beamline SLEGS at SSRF

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Nuclear Science and Techniques 2022年第7期33卷 103-114页

作者： Hong-Wei wang Gong-Tao Fan Long-Xiang Liu Hang-Hua Xu wen-Qing Shen Yu-Gang Ma Hiroaki Utsunomiya Long-Long Song Xi-Guang Cao Zi-Rui Hao Kai-Jie Chen Sheng Jin Yu-Xuan Yang xin-Rong Hu xin-Xiang Li Pan Kuang Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai201800China University of Chinese Academy of Science Beijing100049China Fudan University Shanghai200433China Department of Physics Konan UniversityKobe658-8501Japan ShanghaiTech University Shanghai201210China Zhengzhou University Zhengzhou450001China

The Shanghai Laser Electron Gamma Source(SLEGS)is a powerful gamma source that provides MeV gamma-ray beams for nuclear science and *** was developed as one of the 16 beamline stations in the Phase Ⅱ Project of the Shanghai Synchrotron Radiation *** slant-scattering mode is for the first time systematically employed in laser Compton scattering at SLEGS to produce energy-tunable quasi-monoenergetic gamma-ray *** SLEGS officially completed its commissioning from July to December *** rays in the energy range of 0.25-21.7 MeV with a flux of 2.1×10^(4)-1.2×10^(7) photons/s and an energy spread of 2-15% were produced during the *** paper reports the results from commissioning the SLEGS beamline.

关键词： SLEGS Laser Compton scattering Slant-scattering mode Backscattering mode

Flexible ultrathin all-solid-state supercapacitors

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Rare Metals 2018年第6期37卷 536-542页

作者： Rui wang Qing-Rong wang Min-Jie Yao Ke-Na Chen xin-Yu wang Li-Li Liu Zhi-Qiang Niu Jun Chen Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) College of Chemistry Nankai University Tianjin Key Laboratory for Photoelectric Materials and Devices School of Materials Science and Engineering Tianjin University of Technology

The flexible ultrathin all-solid-state supercapacitors with good electrochemical and mechanical performance were fabricated by the facile methods. The singlewall carbon nanotubes （SWCNTs）-polyaniline （PANI） film electrodes and poly（vinyl alcohol）（PVA）/H3PO4 electrolyte film were prepared by spray-printing and spincoating strategies, respectively. Thus, the thickness of a supercapacitor is only 8.4 μm. When the mass ratio of SWCNT to PANI is 1：1, the tensile strength and Young＇s modulus of the electrode are 10.9 and 655 MPa, respectively. The interior contact resistance of the supercapacitors based on this electrode is only 15-30 Ω. Furthermore, the specific capacitance of this electrode can reach about 355.5 F·g^-1, and the supercapacitor based on this electrode maintains 87.2% of its initial specific capacitance over 5000 charging/discharging cycles. Moreover, the supercapacitor shows an excellent electrochemical stability at different bending states. Therefore, the all-solid-state supercapacitors prepared by our strategies would meet the demands of wearable, lightweight, and compact energy storage devices.

关键词： Supercapacitor Ultrathin Spray printing Carbon nanotube

Targeting m6A modification inhibits herpes virus 1 infection

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Genes & Diseases 2022年第4期9卷 1114-1128页

作者： Zhuoying Feng Fanghang Zhou Miaomiao Tan Tingting wang Ying Chen wenwen Xu Bin Li xin wang xin Deng Ming-Liang He Department of Biomedical Sciences City University of Hong KongKowloonHong KongPR China MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic MedicineInstitute of BiomedicineCollege of Life Science and TechnologyJinan UniversityGuangzhouGuangdong 510632PR China CityU Shenzhen Research Institute ShenzhenGuangdong 518057PR China

The latent infection by herpes virus type 1(HSV-1)may be lifelong in trigeminal ganglia and a suspected cause of Alzheimer's Disease(AD)and Amyotrophic lateral sclerosis(ALS).Whether and how N6-methyladenosine(m6A)modification of viral RNAs affects virus infection are poorly ***,we report that HSV-1 infection enhanced the expression of m6A writers(METTL3,METTL14)and readers(YTHDF1/2/3)at the early infection stage and decreased their expression later on,while suppressed the erasers'(FTO,ALBKH5)expression immediately upon infection to facilitate viral *** m6A modification by 3-deazaadenosine(DAA)significantly decreased viral replication and reduced viral reproduction over 1000 *** interestingly,depleting the writers and readers by siRNAs inhibited virus replication and reproduction;whereas depleting the erasers promoted viral replication and *** YTHDF3 strikingly decreased viral replication by up to 90%,leading to reduction of up to 10-fold viral replication and over 100-fold virus reproduction,*** of m6A initiator METTL3(by 60%–70%)by siRNA correlatedly decreased viral replication 60%–70%,and reduced virus yield over ***,ectopic expression of METTL3 largely increased virus ***3 knockdown suppressed the HSV-1 intermediate early and early genes(ICP0,ICP8 and UL23)and late genes(VP16,UL44,UL49 and ICP47);while ectopic expression of METTL3 upregulated these gene *** from our study shed the lights on the importance for m6A modification to initiate HSV-1 early *** components of m6A modification machinery,particularly m6A initiator METTL3 and reader YTHDF3,would be potential important targets for combating HSV-1 infections.

关键词： Gene silencing HSV-1 infection m6A modification Virus replication Virus reproduction

Remove of Heavy Metals（Cu2＋, Pb2＋, Zn2＋ and Cd2＋） in Water Through Modified Diatomite

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Chemical Research in Chinese Universities 2013年第3期29卷 445-448页

作者： LIU Jia wang Hong-liang LU Chun-xin LIU Han-fei GUO Zhi-xin KANG Chun-li Key Laboratory of Groundwater Resources and Environment Ministry of Education Jilin University Changchun 130012 P. R. China

At present, heavy metal pollution has become a major environmental problem, influencing the survival of human and other creatures. Developing heavy metal ion adsorbents, which are environment friendly, of low cost and good performance is one of the effective means to solve heavy metal pollution. Rich low-grade diatomite mineral, as raw material, was modified with calcium carbonate to improve the adsorption properties of diatomite for heavy metal ions. The effects of dosage（m）, pH, adsorbing time（t）, temperature（T） and concentration of adsorbent（c） on the removal rate of heavy metal ions（Cu2＋, Pb2＋, Zn2＋ and Cd2＋） were studied. The results show that under the suitable conditions, T=15 ℃, c=1.5 mmol/L, m=10 g/L, t=60 min, in a weak acid environment, the removal effect of the four kinds of metal ions by modified diatomite is the best.

关键词： Diatomite Heavy metal Modification Adsorption

Stellettin B renders glioblastoma vulnerable to poly (ADPribose) polymerase inhibitors via suppressing homologydirected repair

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1388-1391页

作者： xin Peng Yingying wang Shaolu Zhang Zhennan Tao Yuxiang Dai Francois X.Claret Moshe Elkabets Hou-wen Lin Zhe-Sheng Chen Dexin Kong Tianjin Key Laboratory of Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of PharmacyTianjin Medical UniversityTianjin 300070China Key Laboratory of Immune Microenvironment and Diseases(Ministry of Education) Tianjin Medical UniversityTianjin 300070China Department of Systems Biology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Neurosurgery the Affiliated Drum Tower HospitalSchool of MedicineNanjing UniversityNanjing 210008China The Shraga Segal Department of Microbiology Immunology and GeneticsFaculty of Health SciencesBen-Gurion University of the NegevBeer-Sheva 84105Israel Research Center for Marine Drugs State Key Laboratory of Oncogenes and Related GenesDepartment of PharmacyRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

Dear Editor,Glioblastoma(GBM)is one of the most fatal brain *** first-line post-surgery regimens for GBM including radiotherapy and temozolomide(TMZ)chemotherapy show very limited efficacy.1,2 Novel therapeutic approaches for GBM patients are urgently *** products are important sources for drug discovery,especially in the field of cancer treatment.3 We previously isolated stellettin B(STELB)(Fig.1a)from marine sponge(Jaspis stellifera)and reported the remarkable and specific anticancer ***,a series of stellettins has been totally synthesized and the core chemical structure has been indicated.4 However,the specific mechanism and its role in regulating tumor biology remain largely unknown.

关键词： chemotherapy surgery render

不同类型学业压力对不同年级高中生执行功能子成分的影响

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心理学报 2025年第1期57卷 18-35页

作者：马超汪彦云付军军赵鑫甘肃省行为与心理健康重点实验室西北师范大学心理学院兰州730070

选取985名高一~高三年级的学生,采用相关分析和结构方程模型等方法考察了学业压力4个子维度在不同年级高中生各执行功能成分中的作用。结果发现,随着高中生年级的升高,父母压力和教师压力对各执行功能成分的负向预测作用逐渐增强,社交... 详细信息

选取985名高一~高三年级的学生,采用相关分析和结构方程模型等方法考察了学业压力4个子维度在不同年级高中生各执行功能成分中的作用。结果发现,随着高中生年级的升高,父母压力和教师压力对各执行功能成分的负向预测作用逐渐增强,社交压力对各执行功能成分的负向预测作用逐渐减弱。相比之下,自我压力对高中生的干扰抑制、反应抑制和注意转换能力均显示出了正向预测作用,并随年级的升高而增强。这表明,不同类型学业压力对各执行功能成分的预测作用存在差异,并将随高中生年级的升高而发生变化。本研究所产生的结论对于教育工作者有效制定高中生学业压力应对策略具有重要的启示意义。

关键词：执行功能学业压力高中生结构方程模型

Convergence of Generalized Alternating Direction Method of Multipliers for Nonseparable Nonconvex Objective with Linear Constraints

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Journal of Mathematical Research with Applications 2018年第5期38卷 523-540页

作者： Ke GUO xin wang School of Mathematics and Information China West Normal University

In this paper, we consider the convergence of the generalized alternating direction method of multipliers(GADMM) for solving linearly constrained nonconvex minimization model whose objective contains coupled functions. Under the assumption that the augmented Lagrangian function satisfies the Kurdyka-Lojasiewicz inequality, we prove that the sequence generated by the GADMM converges to a critical point of the augmented Lagrangian function when the penalty parameter in the augmented Lagrangian function is sufficiently large. Moreover, we also present some sufficient conditions guaranteeing the sublinear and linear rate of convergence of the algorithm.

关键词： generalized alternating direction method of multipliers Kurdyka-Lojasiewicz inequality nonconvex optimization

NiO nanoparticles-decorated ZnO hierarchical structures for isopropanol gas sensing

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Rare Metals 2022年第3期41卷 960-971页

作者： Shi-Chao wang Xiao-Hu wang Gao-Qun Qiao Xiao-Yan Chen xin-Zhen wang Nan-Nan Wu Jian Tian Hong-Zhi Cui School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China

In this paper,a three-dimensional(3D)hierar-chical ZnO structure consisting of nanosheets modified with ultrafine NiO particles was synthesized via a facile two-step chemical precipitate *** techniques characterized the as-synthesized ZnO/NiO composites and pure *** p-NiO/n-ZnO junctions formed between adjacent ZnO and NiO nanoparticles,improving the gas sensing *** ZnO/NiO composite with the Ni:Zn atomic ratio of 7.42:100 exhibited the best iso-propanol sensing *** to pure ZnO,it showed high selectivity and sensitivity(R_(a)/R_(g)=221.3 toward 400×10^(-6)isopropanol),fast response rate(less than 10 s),short recovery time,and simultaneously low operating ***,the ZnO/NiO composite exhibited a wide sensing range(1×10^(-6)-1000×10^(-6))to isopropanol and processed good long-term *** experimental results suggested the potential application in fabricating efficient isopropanol sensors using this ZnO/NiO *** enhanced isopropanol sensing mech-anism is also discussed in charge transfer between heterojunctions,surface area,and surface defects.

关键词： ZnO NiO Hierarchical structure Gas sensor Isopropanol

Inactivation of Poliovirus by Ozone and the Impact of Ozone on the Viral Genome

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Biomedical and Environmental Sciences 2019年第5期32卷 324-333页

作者： JIANG Han Ji CHEN Na SHEN Zhi Qiang YIN Jing QIU Zhi Gang MIAO Jing YANG Zhong Wei SHI Dan Yang wang Hua Ran wang xin Wei LI Jun wen YANG Dong JIN Min Department of Environment and Health Tianjin Institute of Environmental & Operational Medicine Key Laboratory of Risk Assessment and Control for Environment & Food Safety

Objective To investigate the mechanisms underlying ozone-induced inactivation of poliovirus type 1(PV1). Methods We used cell culture, long‐overlapping RT‐PCR, and spot hybridization assays to verify and accurately locate the sites of action of ozone that cause PV1 inactivation. We also employed recombinant viral genome RNA infection models to confirm our observations. Results Our results indicated that ozone inactivated PV1 primarily by disrupting the 5′-non‐coding region(5′‐NCR) of the PV1 genome. Further study revealed that ozone specifically damaged the 80‐124 nucleotide(nt) region in the 5′-NCR. Recombinant viral genome RNA infection models confirmed that PV1 lacking this region was non‐infectious. Conclusion In this study, we not only elucidated the mechanisms by which ozone induces PV1 inactivation but also determined that the 80‐124 nt region in the 5′‐NCR is targeted by ozone to achieve this inactivation.

关键词： Poliovirus Poliomyelitis Ozone Disinfection