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Research on Ecological Corridor Planning of Lanzhou Yuzhong Ecological Innovation City from the Perspective of Ecological Civilization

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Frontiers Research of Architecture and Engineering 2021年第2期4卷 21-29页

作者： Jiaojiao wang Fenli Chen weihong wang Libao Dou College of Geography and Environmental Sciences Northwest Normal Universityand Key Laboratory of Resource Environment and Sustainable Development of OasisLanzhouGansu730070China Gansu Ecological Environment Science Design and Research Institute LanzhouGansu730030China

The practice and research of ecological civilization is a focus of current planning and design,as well as a scientific strategy under the current situation of resource constraint,environmental degradation and ecosystem *** elements such as buildings,green land,farmland,water systems and mountains can be connected by ecological corridors into a green ecological system *** present,many ecological and environmental problems,such as urban heat island effect,fog and haze,automobile exhaust have a negative effect on the construction of social ecological *** order to build a new modern city with prosperous economy,beautiful environment and social civilization,scientific and efficient ecological corridors should be designed to improve the environmental quality of the eco-city,and promote the construction and development of ecological civilization and green *** on the relevant research and specific practices of ecological corridors at home and abroad,combine the needs of the planning and construction of the Yuzhong Ecological Innovation City,and discuss on the connotation and characteristics of ecological corridors,and discuss the key elements of ecological corridor *** article will take the ecological corridor planning of Yuzhong Eco-Innovation City as an *** design ecological corridor based on field investigation,literature and geographic information system..The planning and design of the ecological corridor in the planning area proposed in this paper can provide positive suggestion on the planning and design of the ecological corridor in other ecological innovation cities.

关键词： Ecological civilization Ecological corridor Ecological planning Yuzhong Ecological Innovation City

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3,4-methylenedioxyamphetamine upregulates p75 neurotrophin receptor protein expression in the rat brain

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Neural Regeneration Research 2012年第12期7卷 955-959页

作者： Chaomin wang Zugui Peng weihong Kuang Hanyu Zheng Jiang Long Xue wang Mental Health Center West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

The p75 neurotrophin receptor, which is a member of the tumor necrosis factor receptor superfamil facilitates apoptosis during development and following central nervous system injury. Previous studies have shown that programmed cell death is likely involved in the neurotoxic effects of 3, 4-methylenedioxy-N-methylamphetamine （MDMA）, because MDMA induces apoptosis of immortalized neurons through regulation of proteins belonging to the Bcl-2 family. In the present study, intrapedtoneal injection of different doses of MDMA （20, 50, and 100 mg/kg） induced significant behavioral changes, such as increased excitability, increased activity, and irritability in rats. Moreover, changes exhibited dose-dependent adaptation. Following MDMA injection in rat brain tissue, the number of apoptotic cells dose-dependently increased and p75 neurotrophin receptor expression significantly increased in the prefrontal cortex, cerebellum, and hippocampus. These findings confirmed that MDMA induced neuronal apoptosis, and results suggested that this effect was related by upregulated protein expression of the p75 neurotrophin receptor.

关键词： 3, 4-methylenedioxyamphetamine apoptosis cytotoxicity neural regeneration p75 neurotrophin receptor

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Response of Ruppia maritima to the reclaimed wastewater in coastal artificial landscape river

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Chinese Journal Of Geochemistry 2006年第B8期25卷 167-168页

作者： weihong wang Min JI Yuwei XUE School of Environmental Science and Engineering Tianjin University Tianjin 300071 China

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Effect of Product Differemiation on Business Model Performance in B2B Market

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International English Education Research 2018年第1期 54-57页

作者： XU Yafu ZHAO Xiaokang wang weihong Glorious Sun School of Business and management Donghua University Shanghai 200051 China

Focusing on B2B market, this paper studies the effect of product differentiation on business model perlbrmance. After interviewing several experts and analyzing numbers of distributing questionnaires. the author discovered that product differentiation has a positive effect on business model performance. Through SEM. it is revealed that product differentiation at each level have positive effect on business model, with different effect weight. The main contributions of this research are summarized as follows： Firstly, the proposed model of the product differentiation on business model performance lays the basis for scientific measurement of product differentiation and its effect on business model performance; Secondly, this research ranks the importance of product differentiation at different level in B2B market; Finally, this research provides a good reference for enterprises to update their product strategy for better business model performance.

关键词： Product differentiation Business Model Performance B2B

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A Genomic Variation Map Provides Insights into the Genetic Basis of Spring Chinese Cabbage (Brassica rapa ***)Selection

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Molecular Plant 2018年第11期11卷 1360-1376页

作者： Tongbing Su weihong wang Peirong Li Bin Zhang Pan Li Xiaoyun Xin Honghe Sun Yangjun Yu Deshuang Zhang Xiuyun Zhao Changlong Wen Gang Zhou Yuntong wang Hongkun Zheng Shuancang Yu Fenglan Zhang Beijing Vegetable Research Center (BVRC) Beijing Academy of Agriculture and Forestry Science (BAAFS)Beijing100097China Department of Crop Genetics John Innes CentreNorwich NR47UHUK Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (North China) Ministry of AgncultureBeijing 100097China Beijing Key Laboratory of Vegetable Germplasm Improvement Beijing 100097China Biomarker Technologies Corporation BeijingChina

Chinese cabbage is the most consumed leafy crop in East Asian ***,premature bolting induced by continuous low temperatures severely decreases the yield and quality of the Chinese cabbage, and therefore restricts its planting season and geographic *** the past 40years,spring Chinese cabbage with strong winterness has been selected to meet the market ***,we report a genome variation map of Chinese cabbage generated from the resequencing data of 194 geographically diverse accessions of three ***-depth analyses of the selection sweeps and genome-wide patterns revealed that spring Chinese cabbage was selected from a specific population of autumn Chinese cabbage around the area of Shandong peninsula in northern *** identified 23 genomic loci that underwent intensive selection,and further demonstrated by gene expression and haplotype analyses that the incorporation of elite alleles of VERNALISATION INSENTIVE 3.1(BrVIN3.1)and FLOWER LOCUS C 1(BrFLC1)is a determinant genetic source of variation during ***,we showed that the quantitative response of BrVIN3.1 to cold due to the sequence variations in the cis elements of the BrVlN3.1 promoter significantly contributes to bolting-time variation in Chinese ***, our study provides valuable insights into the genetic basis of spring Chinese cabbage selection and will facilitate the breeding of bolting-resistant Varieties by molecular-marker-assisted selection,transgenic or gene editingapproaches.

关键词： Chinese-cabbage selection vernalization flowering time VERNALISA TION INSENTIVE 3 FLOWER LOCUS C 1

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Identification of long noncoding RNAs involved in resistance to downy mildew in Chinese cabbage

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Horticulture Research 2021年第1期8卷 537-551页

作者： Bin Zhang Tongbing Su Peirong Li Xiaoyun Xin Yunyun Cao weihong wang Xiuyun Zhao Deshuang Zhang Yangjun Yu Dayong Li Shuancang Yu Fenglan Zhang Beijing Vegetable Research Center(BVRC) Beijing Academy of Agriculture and Forestry Sciences(BAAFS)100097 BeijingChina Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(North China) Ministry of Agriculture100097 BeijingChina Beijing Key Laboratory of Vegetable Germplasm Improvement 100097 BeijingChina

Brassica downy mildew,a severe disease caused by Hyaloperonospora brassicae,can cause enormous economic losses in Chinese cabbage(Brassica rapa ***)*** some research has been reported recently concerning the underlying resistance to this disease,no studies have identified or characterized long noncoding RNAs involved in this defense *** this study,using high-throughput RNA sequencing,we analyzed the disease-responding mRNAs and long noncoding RNAs in two resistant lines(T12–19 and 12–85)and one susceptible line(91–112).Clustering and Gene Ontology analysis of differentially expressed genes(DEGs)showed that more DEGs were involved in the defense response in the two resistant lines than in the susceptible *** expression patterns and proposed functions of differentially expressed long noncoding RNAs among T12–19,12–85,and 91–112 indicated that each has a distinct disease response *** were significantly more cis-and trans-functional long noncoding RNAs in the resistant lines than in the susceptible line,and the genes regulated by these RNAs mostly participated in the disease defense ***,we identified a candidate resistance-related long noncoding RNA,MSTRG.19915,which is a long noncoding natural antisense transcript of a MAPK gene,*** an agroinfiltration-mediated transient overexpression system and virus-induced gene silencing technology,BrMAPK15 was indicated to have a greater ability to defend against ***.19915-silenced seedlings showed enhanced resistance to downy mildew,probably because of the upregulated expression of *** research identified and characterized long noncoding RNAs involved in resistance to downy mildew,laying a foundation for future in-depth studies of disease resistance mechanisms in Chinese cabbage.

关键词： resistance mostly concerning

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Degenerative alterations in noradrenergic neurons of the locus coeruleus in Alzheimer's disease

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Neural Regeneration Research 2013年第24期8卷 2249-2255页

作者： Lihua Liu Saiping Luo Leping Zeng weihong wang Liming Yuan Xiaohong Jian Department of Histology & Embryology School of Basic Medical Sciences Central South University Department of Nursing Medical College of Hunan Normal University Third Department of Surgery Agricultural Division Four Hospital Xinjiang Production and Construction Corps Department of Anatomy & Neurobiology School of Basic Medical Sciences Central South University Department of Anatomy Medical College of Hunan Normal University

Mice carrying mutant amyloid precursor protein and presenilin-1 genes （APP/PS1 double trans- genic mice） have frequently been used in studies of Alzheimer＇s disease; however, such studies have focused mainly on hippocampal and cortical changes. The severity of Alzheimer＇s disease is known to correlate with the amount of amyloid-13 protein deposition and the number of dead neurons in the locus coeruleus. In the present study, we assigned APP/PS1 double transgenic mice to two groups according to age： young mice （5-6 months old） and aged mice （16-17 months old）. Age-matched wild-type mice were used as controls. Immunohistochemistry for tyrosine hydroxylase （a marker of catecholaminergic neurons in the locus coeruleus） revealed that APP/PS1 mice had 23% fewer cells in the locus coeruleus compared with aged wild-type mice. APP/PS1 mice also had increased numbers of cell bodies of neurons positive for tyrosine hydroxylase, but fewer tyrosine hydroxylase-positive fibers, which were also short, thick and broken. Quantitative analysis using unbiased stereology showed a significant age-related increase in the mean volume of tyrosine hy- droxylase-positive neurons in aged APP/PS1 mice compared with young APP/PS1 mice. Moreover, the mean volume of tyrosine hydroxylase-positive neurons was positively correlated with the total volume of the locus coeruleus. These findings indicate that noradrenergic neurons and fibers in the locus coeruleus are predisposed to degenerative alterations in APP/PS1 double transgenic mice.

关键词： neural regeneration presenilin-1 Alzheimer's disease tyrosine hydroxylase locus coeruleus noradrenergic neuron ^-amyloid senile plaques grants-supported paper neuroregeneration

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Model Reference Adaptive Control for a Class of Aircraft with Actuator Saturation

Model Reference Adaptive Control for a Class of Aircraft wit...

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第37届中国控制会议

作者： Jiao Chen Jiangyun wang weihong wang School of Automation Science and Electrical Engineering Beihang University

Model reference adaptive control（MRAC） is known as a proper method to handle uncertainties of systems and achieve precision command tracking. However, actuator saturation of aircraft limits the ability of the adaptive controller in practice. In this paper, a modified automatic control architecture is presented for a class of aircraft in the presence of input saturation. The proposed controller is based on model reference adaptive control augmented with a modern anti-windup（AW） compensator. First, a standard MRAC with integral state feedback is described. Second, a Riccati-based AW compensator is employed to solve the input saturation problem. Finally, the control technique is applied to control the vertical acceleration of the aircraft with significant uncertainty in control effectiveness and matched uncertainties. Simulation results verify the performance of proposed method.

关键词： Model reference adaptive control Actuator saturation Anti-windup Compensator Aircraft

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基于隐函数转化的点取样模型布尔运算

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中国机械工程 2006年第14期17卷 1499-1503页

作者：王卫红秦绪佳浙江工业大学杭州310032 北京航空航天大学软件开发环境国家重点实验室

提出一种基于点取样模型的布尔运算算法。该算法首先将点模型隐式化,得到点模型的隐函数表示;然后采用隐式曲面的布尔运算方法对点模型进行布尔操作。提出了隐式曲面布尔运算的简单形式。点模型的隐式化采用散乱点径向基函数(RBF)变分插... 详细信息

提出一种基于点取样模型的布尔运算算法。该算法首先将点模型隐式化,得到点模型的隐函数表示;然后采用隐式曲面的布尔运算方法对点模型进行布尔操作。提出了隐式曲面布尔运算的简单形式。点模型的隐式化采用散乱点径向基函数(RBF)变分插值,采用该算法可由多个点模型构造复杂的点模型。所提出的点模型布尔操作算法可用于一般网格模型,实现网格模型的剪切/粘贴编辑处理。

关键词：点取样模型布尔运算隐函数 RBF插值

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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao Yuan Li Xi Liu Wenping Liang Yu Li Liyong Wu Zhe wang weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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