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Combination of fruquintinib with venetoclax for the treatment of colorectal cancer

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Oncology Research 2025年第1期33卷 225-234页

作者： wei ZHANG weiCHENG wang RUI wang xiaO HAN LIJUN ZHU WENJIE GUO YANHONG GU Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210029China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing210023China Department of Oncology The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou225300China

Background:As a novel blocker of vascular endothelial growth factor receptor(VEGFR),fruquintinib has been approved for treating colorectal cancer(CRC).However,its dosage and therapeutic efficacy are limited by its widespread adverse ***,recognized as the initial inhibitor of B-cell lymphoma protein 2(BCL2),has shown potential in boosting the effectiveness of immunotherapy against *** study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating *** and Materials:We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax’s efficacy against *** we employed various techniques to evaluate different aspects of the experimental *** was used to detect cell proliferation and angiogenesis in tumor *** blot analysis was utilized to examine the occurrence of cell apoptosis,and flow cytometry to quantitate immune cells within the tumor ***,immunofluorescence was employed to measure cytokine ***:The strongest inhibition on tumor growth was achieved by the combination of fruquintinib with venetoclax,as opposed to individual drug *** was found to amplify the impact of fruquintinib,leading to decreased cancer cell proliferation,increased cancer cell apoptosis,lowered angiogenesis,better vascular structure normalization,and improved immune cell ***:Our findings indicate that the addition of venetoclax enhances the impact of fruquintinib on vascular normalization and modulation of the tumor immune *** study presents the justification for utilizing the fruquintinib and venetoclax combination in treating *** holds promise in being assimilated into anticancer medications for CRC.

关键词： Colorectal cancer(CRC) B-cell lymphoma protein 2(BCL2) Venetoclax Vascular endothelial growth factor receptor(VEGFR) Fruquintinib Anti-angiogenesis Immunotherapy

Software-defined process-near-memory architecture using 3D hybrid bonding integration

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Science China(Information Sciences) 2025年第1期68卷 366-378页

作者： Anlin XU Chenchen DENG Jianfeng ZHU Yao wang Shaojun wei Leibo LIU School of Integrated Circuits Tsinghua University Beijing Institution of Tracking and Communication Technology Beijing National Research Center for Information Science and Technology Tsinghua University

With the unprecedented explosive growing amount of global data, the development of computing chips, which encounter bottlenecks such as power wall and memory wall, cannot satisfy the demanding requirement. This work proposes a software-defined process-near-memory(SDPNM) computing architecture implemented using 3D hybrid bonding *** software-defined chip architecture, featuring spatial computations and dynamic reconfiguration, innovates in a top-down manner to achieve high energy efficiency while maintaining flexibility after fabrication. The process-near-memory integration further advances the SDNPM chip in a bottom-up way to reduce the energy consumption of data movement while improving the bandwidth. Utilizing a relatively mature fabrication and bonding process can result in feasible solutions for both data-intensive and compute-intensive applications including digital signal processing and artificial intelligence. The logic die is fabricated in the SMIC 40 nm process and the DRAM die is fabricated in the PSMC 25 nm process. The hybrid bonding is implemented by XMC. The experimental results show that the energy efficiency of the proposed SDPNM chip is 33.1× better than the state-of-the-art FPGA ranging from 8.2× to 104.1×.

关键词： software-defined chips process near memory energy efficiency dynamic reconfiguration domain specific

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B细胞非霍奇金淋巴瘤患者肥大细胞及IL-9表达水平及其意义

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中华血液学杂志 2013年第10期34卷 851-856页

作者：封丽丽刘新王夏炜隋潇徽王欣山东大学附属省立医院血液科济南250021 山东大学附属省立医院烧伤整形外科济南250021

目的研究肥大细胞（MC）及IL-9在B细胞非霍奇金淋巴瘤（B-NHL）中的临床意义。方法采用Western blot法检测CDll7在B-NHL患者肿瘤组织中的表达水平，应用免疫组织化学染色观察MC在B-NHL患者肿瘤局部的浸润情况。通过计算MC与B-NHL患者肿... 详细信息

目的研究肥大细胞（MC）及IL-9在B细胞非霍奇金淋巴瘤（B-NHL）中的临床意义。方法采用Western blot法检测CDll7在B-NHL患者肿瘤组织中的表达水平，应用免疫组织化学染色观察MC在B-NHL患者肿瘤局部的浸润情况。通过计算MC与B-NHL患者肿瘤标志物间的相关系数来判断MC在预后中的意义。通过ELISA方法检测B-NHL患者外周血中IL-9水平。应用流式细胞仪检测小鼠骨髓衍化的MC（BMMC）的纯度，并应用RT-PCR检测IL-9对小鼠MC相关基因表达的影响。结果B-NHL患者肿瘤组织CDll7表达明显高于对照组（0．0551士O．0064对0．0192士0．0072，P〈0．01），局部浸润的MC明显增多，且与患者预后不良相关；B-NHL患者血清中IL-9水平明显高于健康对照组；体外实验证实IL-9可以诱导小鼠BMMC的分化及相关基因的表达，包括CDll7、Fcerla、Mcptl和Mcpt5。结论IL-9可增强MC介导的免疫反应，在促进肿瘤的生长中可能起重要作用。IL-9有可能成为B-NHL的免疫治疗的作用靶点。

关键词：肥大细胞白细胞介素9 淋巴瘤 B细胞

High-performance poly(aromatic pyridine) copolymers with crown ether moieties for high temperature polymer electrolyte membrane fuel cells

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Science China Chemistry 2025年

作者： Qian wang Songhao Zhao Yunpeng Guo wei wei Lele wang Jingshuai Yang Department of Chemistry College of Sciences Northeastern University Institute of Metal Research Chinese Academy of Sciences

This study concentrates on the development of high temperature polymer electrolyte membranes（HT-PEMs）, which are essential components for HT-PEM fuel cells（HT-PEMFCs）. Although the phosphoric acid（PA）-doped polybenzimidazole（PBI） has been regarded as the successful HT-PEM, this system still suffers from several challenges, including the use of carcinogenic monomers, complex synthesis procedures, and poor solubility in organic solvents. To develop more cost-effective, readily synthesized and high-performance alternatives, this study employs a simply superacid-catalyzed Friedel-Crafts reaction to synthesize a series of poly（triphenyl-co-dibenzo-18-crown-6 pyridine） copolymers, denoted as P(TPx%-co-CEy%), using ptriphenyl, dibenzo-18-crown-6 and 4-acetylpyridine as monomers. The copolymerized hydrophilic and bulky crown ether unites introduce large free volumes and multiple interaction sites with PA molecules, as elucidated by theoretical *** microphase separation structures are formed as confirmed by atomic force microscope（AFM）, transmission electron microscopy（TEM） and small-angle X-ray scattering（SAXS）. Thus P(TPx%-co-CEy%) membranes exhibit excellent PA absorption and proton conduction abilities. For example, after immersing in 85 wt% PA at 30 °C, the P(TP91%-co-CE9%) membrane achieves a PA doping content of 205% and a high conductivity of 0.138 S cm-1at 180 °C, while maintaining a tensile strength of 7.5 MPa at room temperature. Without humidification and backpressure, the peak power density of an H2-O2cell equipped with P(TP91%-co-CE9%)/205%PA reaches nearly 1200 mW cm-2, representing one of the highest performances reported for PA-doped HT-PEMs to date. This work demonstrates the enormous potential of poly（triphenyl-co-crown ether pyridine） membranes in the HT-PEMFC applications.

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氯化钙结合水杨酸雾化熏蒸延缓冬枣采后品质及抗氧化性的下降

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现代食品科技 2021年第6期37卷 136-143,243页

作者：王霞伟邓豪张平王曼李哲魏佳吴斌新疆农业大学食品科学与药学学院新疆乌鲁木齐830052 新疆农业科学院农产品贮藏加工研究所新疆乌鲁木齐830091 新疆人民广播电视台新疆乌鲁木齐830002

采用氯化钙(Calcium chloride,CaCl_(2))结合水杨酸(salicylic acid,SA)雾化熏蒸技术对新疆冬枣进行处理,研究该雾化熏蒸技术对冬枣采后品质及抗氧化性的影响。探索氯化钙结合水杨酸对冬枣采后品质的协同保鲜作用。结果表明:2%CaCl_(2)+... 详细信息

采用氯化钙(Calcium chloride,CaCl_(2))结合水杨酸(salicylic acid,SA)雾化熏蒸技术对新疆冬枣进行处理,研究该雾化熏蒸技术对冬枣采后品质及抗氧化性的影响。探索氯化钙结合水杨酸对冬枣采后品质的协同保鲜作用。结果表明:2%CaCl_(2)+100 mmol/L SA处理可以减缓冬枣转色进程,抑制冬枣贮藏期硬度、失重率、可滴定酸(TA)、抗坏血酸(VC)、总酚、类黄酮含量、DPPH自由基清除能力、ABTS阳离子清除能力和FRAP铁离子还原能力的下降。综合来看,2%CaCl_(2)+100 mmol/L SA处理较2%CaCl_(2)和2%CaCl_(2)+200 mmol/L SA处理保鲜效果更好,在第6 d时,a值为0.70、硬度为9.24 N、失重率为1.76%、TA含量为0.37%,表明CaCl_(2)结合SA雾化熏蒸可以很好的保持冬枣的采后品质和色泽转变,同时,2%CaCl_(2)+100 mmol/L SA处理后的冬枣Vc含量为2.65 mg/g·FW,总酚的含量为4.83 mg/g·FW,类黄酮的含量为1.38 mg/g·FW,分别是CK的1.35倍、1.21倍、1.31倍,DPPH、ABTS和FRAP的清除能力比CK高了51%、23%和40%,表明CaCl_(2)结合SA雾化熏蒸技术可以提高果实抗氧化能力,延长货架销售期。因此,CaCl_(2)结合SA雾化熏蒸技术可作为冬枣采后贮运保鲜新工艺的探索方向。

关键词：氯化钙水杨酸雾化熏蒸冬枣采后品质抗氧化性

塔里木河下游几种荒漠植物根际土壤微生物及其活性

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中国沙漠 2010年第3期30卷 571-576页

作者：王卫霞罗明潘存德新疆农业大学林学与园艺学院新疆乌鲁木齐830052 新疆农业大学农学院新疆乌鲁木齐830052

研究了塔里木河下游7种典型的优势荒漠植物的根际微生物数量、群落组成及其活性。结果表明：荒漠植物根际微生物数量、组成与根外有较大差异，具有不同的根际效应。黑果枸杞、刚毛柽柳、花花柴、盐穗木具有显著的根际正效应，其根际细菌... 详细信息

研究了塔里木河下游7种典型的优势荒漠植物的根际微生物数量、群落组成及其活性。结果表明：荒漠植物根际微生物数量、组成与根外有较大差异，具有不同的根际效应。黑果枸杞、刚毛柽柳、花花柴、盐穗木具有显著的根际正效应，其根际细菌的R／S为1．26～150．42，以黑果枸杞根际效应最为突出。骆驼刺、罗布麻和河西苣则产生负根际效应。生理群微生物氨化细菌和纤维素分解菌均表现出强烈的正根际效应，而硝化细菌未检出。荒漠植物的生长对根际土壤脲酶、碱性磷酸酶具有较强的促进作用，活性大于非根际土壤，但不同荒漠植物根际对土壤呼吸作用强度，过氧化氢酶活性的影响表现出较大差异。总体而言，荒漠植物增加了根际微生物的数量及活性，促进了土壤养分的积累和转化，对于维持荒漠生态系统的功能具有重要的作用。灌木的根际效能优于草本植物，可作为新疆受损荒漠生态系统植被恢复与重建优先考虑的物种。

关键词：荒漠植物根际微生物生物活性塔里木河下游

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu xiangbing Wu wei Wu Ying wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi xia George Smith Rui Li Nai-Kui Liu xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

去泛素化酶MYSM1调控人B细胞向浆细胞的分化

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中国实验血液学杂志 2019年第5期27卷 1627-1632页

作者：仲凯励黄小会王玉涵王斌王伟霞董晓惠张伟京江小霞首都医科大学附属北京世纪坛医院淋巴肿瘤科北京100038 安徽医科大学安徽合肥230032 军事科学院军事医学研究院军事认知与脑科学研究所北京100850 西藏职业技术学院西藏拉萨850032

目的:探讨去泛素化酶MYSM1对人B细胞向浆细胞分化的调控作用。方法:构建去泛素化酶MYSM1的干扰载体和过表达载体,包装相应慢病毒及对照慢病毒;经人外周血磁珠分选出的CD19^+B细胞;经慢病毒感染48 h后,LPS刺激诱导感染后的CD19^+B细胞向... 详细信息

目的:探讨去泛素化酶MYSM1对人B细胞向浆细胞分化的调控作用。方法:构建去泛素化酶MYSM1的干扰载体和过表达载体,包装相应慢病毒及对照慢病毒;经人外周血磁珠分选出的CD19^+B细胞;经慢病毒感染48 h后,LPS刺激诱导感染后的CD19^+B细胞向浆细胞分化。流式细胞术检测CD138表达,荧光定量PCR检测B细胞及分化过程中重要转录因子的表达变化。结果:干扰MYSM1表达后,B细胞向浆细胞分化比例显著升高(P<0.01),抑制浆细胞分化的转录因子Pax5和Bach2的表达水平显著下降(P<0.01),而促进浆细胞分化的转录因子Prdm1和Xbp1的表达水平显著升高(P<0.01)。相反,过表达MYSM1后,B细胞向浆细胞分化比例显著下降(P<0.01),抑制浆细胞分化的转录因子Pax5和Bach2的表达水平显著升高(P<0.01),而促进浆细胞分化的转录因子Prdm1和Xbp1的表达水平显著下降(P<0.01)。结论:去泛素化酶MYSM1负调控人B细胞向浆细胞的分化。

关键词：去泛素化酶 MYSM1 B细胞浆细胞

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触发式最小电流扰动的孤岛检测方法研究

郑州大学学报（理学版） 2016年第4期48卷 116-122页

作者：邢玥王瑞峰夏伟兰州交通大学自动化与电气工程学院甘肃兰州730070 国网宣城供电公司安徽宣城242000

针对目前采取主动电流扰动法,使并网逆变器输出功率带来一定时间变化的问题,提出一种触发式最小电流扰动方式.以电网侧低压断路器分闸时产生的电弧信号作为触发条件,启动最小电流扰动量的加入,从而快速检测孤岛现象.根据IEEE Std.929-2... 详细信息

针对目前采取主动电流扰动法,使并网逆变器输出功率带来一定时间变化的问题,提出一种触发式最小电流扰动方式.以电网侧低压断路器分闸时产生的电弧信号作为触发条件,启动最小电流扰动量的加入,从而快速检测孤岛现象.根据IEEE Std.929-2000技术标准对该方法进行仿真和实验研究,验证方法的有效性.研究结果表明,该方法不仅没有盲区,且大大减少了加入扰动的时间,改变逆变器一直处于过载或欠载的运行状态,提高了逆变器使用寿命.

关键词：并网逆变器孤岛检测触发信号最小电流扰动