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Organic heterojunction synaptic device with ultra high recognition rate for neuromorphic computing

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Nano Research 2024年第6期17卷 5614-5620页

作者： Xuemeng Hu Jialin Meng Tianyang Feng tianyu wang Hao Zhu Qingqing Sun David Wei Zhang Lin Chen School of Microelectronics State Key Laboratory of Integrated Chips and SystemsFudan UniversityShanghai 200433China National Integrated Circuit Innovation Center Shanghai 201203China

Traditional computing structures are blocked by the von Neumann bottleneck,and neuromorphic computing devices inspired by the human brain which integrate storage and computation have received more and more ***,a flexible organic device with 2,7-dioctyl[1]benzothieno[3,2-b][1]benzothiophene(C8-BTBT)and 2,9-didecyldinaphtho[2,3-b:2′,3′-f]thieno[3,2-b]thiophene(C10-DNTT)heterostructural channel having excellent synaptic behaviors was fabricated on muscovite(MICA)substrate,which has a memory window greater than 20 *** device shows better electrical characteristics than organic field effect transistors with single organic semiconductor ***,the device simulates organism synaptic behaviors successfully,such as paired-pulse facilitation(PPF),long-term potentiation/depression(LTP/LTD)process,and transition from short-term memory(STM)to long-term memory(LTM)by optical and electrical ***,the neuromorphic computing function was verified using the Modified National Institute of Standards and Technology(MNIST)pattern recognition,with a recognition rate nearly 100%without *** research proposes a flexible organic heterojunction with the ultra-high recognition rate in MNIST pattern recognition and provides the possibility for future flexible wearable neuromorphic computing devices.

关键词： organic heterojunction neuromorphic computing synapse behaviors optical modulation Modified National Institute of Standards and Technology(MNIST)pattern recognition

Enhancing milk quality and modulating rectal microbiota of dairy goats in starch‑rich diet:the role of bile acid supplementation

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Journal of Animal Science and Biotechnology 2024年第2期15卷 862-877页

作者： Qingyan Yin Junjian Yu Jiaxiao Li Tianci Zhang tianyu wang Yufei Zhu Jun Zhang Junhu Yao College of Animal Science and Technology Northwest A&F UniversityYangling 712100ShaanxiP.R.China Key Laboratory of Livestock Biology Northwest A&F UniversityYangling 712100ShaanxiP.R.China DAYU Bioengineering(Xi’an)Industrial Development Research Institute Xi’an 710000ShaanxiP.R.China

Background Diets rich in starch have been shown to increase a risk of reducing milk fat content in dairy *** bile acids(BAs)have been used as a lipid emulsifier in monogastric and aquatic animals,their effect on ruminants is not well *** study aimed to investigate the impact of BAs supplementation on various aspects of dairy goat physiology,including milk composition,rumen fermentation,gut microbiota,and BA *** We randomly divided eighteen healthy primiparity lactating dairy goats(days in milk=100±6 d)into two groups and supplemented them with 0 or 4 g/d of BAs undergoing 5 weeks of feeding on a starch-rich *** results showed that BAs supplementation positively influenced milk yield and improved the quality of fatty acids in goat *** supplementation led to a reduction in saturated fatty acids(C16:0)and an increase in monounsaturated fatty acids(cis-9 C18:1),resulting in a healthier milk fatty acid *** observed a significant increase in plasma total bile acid concentration while the proportion of rumen short-chain fatty acids was not ***,BAs supplementation induced significant changes in the composition of the gut microbiota,favoring the enrichment of specific bacterial groups and altering the balance of microbial *** analysis revealed associations between specific bacterial groups(Bacillus and Christensenellaceae R-7 group)and BA types,suggesting a role for the gut microbiota in BA *** prediction analysis revealed notable changes in pathways associated with lipid metabolism,suggesting that BAs supplementation has the potential to modulate lipid-related *** These findings highlight the potential benefits of BAs supplementation in enhancing milk production,improving milk quality,and influencing metabolic pathways in dairy *** research is warranted to elucidate the underlying mechanisms and explore the broader implications of these findi

关键词： Bile acids Dairy goats Lipid metabolism Gut microbiota

A high-speed 2D optoelectronic in-memory computing device with 6-bit storage and pattern recognition capabilities

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Nano Research 2022年第3期15卷 2472-2478页

作者： Jialin Meng tianyu wang Zhenyu He Qingxuan Li Hao Zhu Li Ji Lin Chen Qingqing Sun David Wei Zhang State Key Laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghai 200433China National Integrated Circuit Innovation Center No.825 Zhangheng RoadShanghai 201203China

The explosively developed era of big-data compels the increasing demand of nonvolatile memory with high efficiency and excellent storage ***,we fabricated a high-speed photoelectric multilevel memory device for neuromorphic *** novel two-dimensional(2D)MoSSe with a unique Janus structure was employed as the channel,and the stack of Al_(2)O_(3)/black phosphorus quantum dots(BPQDs)/Al_(2)O_(3)was adopted as the *** storage performance of the resulting memory could be verified by the endurance and retention tests,in which the device could remain stable states of programming and erasing even after 1,000 cycles and 1,000 *** multibit storage could be realized through both different voltage amplitudes and pulse numbers,which could achieve 6 bits(64 distinguishable levels)under pulse width of 50 ***,our memory device also could realize the simulations of synapses in human brain with optical and electric modulations synergistically,such as excitatory post-synaptic current(EPSC),long-term potentiation/depression(LTP/LTD),and spike-timing-dependent plasticity(STDP).Neuromorphic computing was successfully achieved through a high recognition of handwritten digits up to 92.5%after 103 *** research is a promising avenue for the future development of efficient memory and artificial neural network systems.

关键词： memory multibit two-dimensional(2D) MoSSe Co-modulation

Hepatocellular SETDB1 Regulates Hepatic Ischemia-Reperfusion Injury through Targeting Lysine Methylation of ASK1 Signal

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Research 2024年第3期6卷 305-317页

作者： Kang Xia tianyu wang Zhongbao Chen Jiayu Guo Bo Yu Qi Chen Tao Qiu Jiangqiao Zhou Shusen Zheng Department of Organ Transplantation Renmin Hospital of Wuhan UniversityWuhanChina Department of Urology Renmin Hospital of Wuhan UniversityWuhanChina. Department of general surgery Renmin Hospital of Wuhan UniversityWuhanChina Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Key Laboratory of Combined Multi-Organ Transplantation Ministry of Public HealthHangzhouChina Key Laboratory of Organ Transplantation HangzhouZhejiang ProvinceChina Key Laboratory of the Diagnosis and Treatment of Organ Transplantation CAMSHangzhouChina.

Background: Hepatic ischemia-reperfusion injury (HIRI) stands as an unavoidable complication arising from liver surgery, profoundly intertwined with its prognosis. The role of lysine methyltransferase SET domain bifurcated 1 (SETDB1) in HIRI remains elusive, despite its confirmation as a potential therapeutic target for diverse diseases. Here, we investigated the mechanism by which SETDB1 regulated HIRI. Methods: RNA sequencing data were used to identify the expression and potential targets of SETDB1 through bioinformatics analysis. To elucidate the impact of SETDB1 on HIRI, both an in vivo model of HIRI in mice and an in vitro model of hepatocyte hypoxia/reoxygenation were established. Biochemical and histological analyses were used to investigate the influence of SETDB1 on liver damage mediated by HIRI. Chromatin immunoprecipitation and coimmunoprecipitation were implemented to explore the in-depth mechanism of SETDB1 regulating HIRI. Results: We confirmed that hepatocellular SETDB1 was up-regulated during HIRI and had a close correlation with HIRI-related inflammation and apoptosis. Moreover, inhibition of SETDB1 could mitigate HIRI-induced liver damage, inflammation, and apoptosis. Through our comprehensive mechanistic investigation, we revealed that SETDB1 interacts with apoptosis-signal-regulating kinase 1 (ASK1) and facilitates the methylation of its lysine residues. Inhibition of SETDB1 resulted in reduced phosphorylation of ASK1, leading to a marked suppression of downstream c-Jun N-terminal kinase (JNK)/p38 signaling pathway activation. The therapeutic effect on inflammation and apoptosis achieved through SETDB1 inhibition was nullified by the restoration of JNK/p38 signaling activation through ASK1 overexpression. Conclusions: The findings from our study indicate that SETDB1 mediates lysine methylation of ASK1 and modulates the activation of the ASK1–JNK/p38 pathway, thus involved in HIRI-induced inflammation and apoptosis. These results suggest that SETD

关键词： SETDB1 inflammation ASK1

InGaZnO-based photoelectric synaptic devices for neuromorphic computing

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Journal of Semiconductors 2024年第9期45卷 42-47页

作者： Jieru Song Jialin Meng tianyu wang Changjin Wan Hao Zhu Qingqing Sun David Wei Zhang Lin Chen School of Microelectronics State Key Laboratory of Integrated Chips and SystemsFudan UniversityShanghai 200433China School of Integrated Circuits Shandong UniversityJinan 250100China National Integrated Circuit Innovation Center Shanghai 201203China School of Electronic Science and Engineering Nanjing UniversityNanjing 210023China Jiashan Fudan Institute Jiashan 314102China

Photoelectric synaptic devices could emulate synaptic behaviors utilizing photoelectric effects and offer promising prospects with their high-speed operation and low crosstalk. In this study, we introduced a novel InGaZnO-based photoelectric memristor. Under both electrical and optical stimulation, the device successfully emulated synaptic characteristics including excitatory postsynaptic current (EPSC), paired-pulse facilitation (PPF), long-term potentiation (LTP), and long-term depression (LTD). Furthermore, we demonstrated the practical application of our synaptic devices through the recognition of handwritten digits. The devices have successfully shown their ability to modulate synaptic weights effectively through light pulse stimulation, resulting in a recognition accuracy of up to 93.4%. The results illustrated the potential of IGZO-based memristors in neuromorphic computing, particularly their ability to simulate synaptic functionalities and contribute to image recognition tasks.

关键词： InGaZnO artificial synapse neuromorphic computing photoelectric memristor

Resilience mediates the association between alexithymia and stress in Chinese medical students during the COVID-19 pandemic

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General Psychiatry 2023年第1期36卷 43-49页

作者： Yuqun Zhang tianyu wang Shengji Jin Heng Zhang Lixia Chen Shizheng Du School of Nursing Nanjing University of Chinese MedicineNanjingJiangsuChina Department of Psychosomatics and Psychiatry Southeast UniversityNanjingJiangsuChina

Background Evidence indicates that medical students have had high rates of mental health problems,especially during the COVID-19 pandemic,which could be affected by alexithymia—a marked dysfunction in emotional awareness,social attachment and interpersonal relationships—and ***,psychological resilience might relieve alexithymia and stress *** This study aimed to investigate the role of resilience in alexithymia and stress in medical *** A total of 470 medical students completed online and offline surveys,including the Toronto Alexithymia Scale-20(TAS-20),the Connor-Davidson Resilience Scale(CD-RISC)and the College Student Stress Questionnaire(CSSQ).The data of five participants were excluded because of a lack of ***-Whitney U test or Kruskal-Wallis test was used to compare group differences in the CD-RISC scores among categorical *** correlation analysis was employed to evaluate the associations between resilience and alexithymia and between resilience and *** analysis was used to test the mediating effect of resilience between alexithymia and *** Of the medical students considered in the analysis,382(81.28%)were female and 88(18.72%)were *** was a significant negative correlation between the TAS-20 scores and the total and subtotal CD-RISC scores(p<0.001).The CSSQ scores also significantly negatively correlated with the total and subtotal CD-RISC scores(p<0.001).Resilience mediated the relationship between alexithymia and stress(total effect=1.0447,p<0.001).The indirect effect of alexithymia significantly impacted stress through resilience(effect=0.1670,95%CI:0.069 to 0.281).Conclusions Our findings suggest that resilience might effectively reduce alexithymia and *** also contributed to a better understanding of the mediating effects of resilience on alexithymia and stress during the COVID-19 *** evidence from these results encourages universities to focus on i

关键词： emotional stress finding

Multispectral smart window:Dynamic light modulation and electromagnetic microwave shielding

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Light(Science & Applications) 2024年第10期13卷 2331-2341页

作者： Ruicong Zhang Zicheng Song Wenxin Cao Gang Gao Lei Yang Yurong He Jiecai Han Zhibo Zhang tianyu wang Jiaqi Zhu Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin 150080China Zhengzhou Research Institute Harbin Institute of TechnologyZhengzhou 450018China Research Center of Analysis and Measurement Harbin Institute of TechnologyHarbin 150080China School of Energy Science&Engineering Harbin Institute of TechnologyHarbin 150080China

A novel multispectral smart window has been proposed,which features dynamic modulation of light transmittance and effective shielding against electromagnetic microwave *** design integrates liquid crystal dynamic scattering and dye doping techniques,enabling the dual regulation of transmittance and scattering within a singlelayer smart ***,the precise control of conductive film thickness ensures the attainment of robust microwave signal *** present a theoretical model for ion movement in the presence of an alternating electric field,along with a novel approach to manipulate negative dielectric *** proposed model successfully enables a rapid transition between light transparent,absorbing and haze states,with an optimum drive frequency adjustable to approximately 300 ***,the resistive design of the conductive layer effectively mitigates microwave radiation within the 2−18 GHz *** findings offer an innovative perspective for future advancements in environmental construction.

关键词： microwave smart spectral

3D dahlia-like NiAl-LDH/CdS heterosystem coordinating with 2D/2D interface for efficient and selective conversion of CO_(2)

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Chinese Chemical Letters 2022年第4期33卷 2111-2116页

作者： Xiaoyue Zhang Yong Yang Lijun Xiong tianyu wang Zheng Tang Panjie Li Nan Yin Aiwu Sun Jinyou Shen Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse School of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Soft Chemistry and Functional Materials Ministry of EducationSchool of Chemistry and Chemical EngineeringNanjing University of Science and TechnologyNanjing 210094China Faculty of Chemical Engineering Huaiyin Institute of TechnologyHuaiyin 223001China

Developing photocatalyst with high activity,superior stability and prominent selectivity for CO_(2)conversion is of great importance for the target of carbon ***,3 D dahlia-like NiAl-LDH/CdS heterosystem is developed through in-situ decoration of exfoliated CdS nanosheets on the scaffold of NiAl-LDH and the on-spot *** formation of a hierarchical architecture collaborating with well-defined 2 D/2 D interfacial interaction is constructed by optimizing the ratio of CdS integrated in the formation of the *** light-harvesting capacity of NiAl-LDH/CdS is improved by this unique scaffold,and the charge transfer between NiAl-LDH and CdS is effectively facilitated by virtue of the unique 2 D/2 D *** a result,the 3 D hierarchical NiAl-LDH/CdS heterosystem presents 12.45μmol g^(-1)h^(-1)of CO production(3.3 and 1.6 folds of pristine NiAl-LDH and CdS) with 96% selectivity and superior *** 3 D hierarchical design collaborating with 2 D/2 D interfacial interaction provides a new avenue to develop ideal catalysts for artificial photosynthesis.

关键词： Photocatalysis CdS Photocorrosion NiAl-LDH CO_(2)Conversion

SoftSSD:enabling rapid flash firmware prototyping for solid-state drives

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Frontiers of Information Technology & Electronic Engineering 2023年第5期24卷 659-674页

作者： Jin XUE Renhai CHEN tianyu wang Zili SHAO Department of Computer Science and Engineering The Chinese University of Hong KongHong Kong 999077China College of Intelligence and Computing Tianjin UniversityTianjin 300354China

Recently,solid-state drives(SSDs)have been used in a wide range of emerging data processing ***,an SSD is a complex embedded system that involves both hardware and software *** the latter,firmware modules such as the flash translation layer(FTL)orchestrate internal operations and flash management,and are crucial to the overall input/output performance of an *** the rapid development of new SSD features in the market,the research of flash firmware has been mostly based on simulations due to the lack of a realistic and extensible SSD development *** this paper,we propose SoftSSD,a software-oriented SSD development platform for rapid flash firmware *** core of SoftSSD is a novel framework with an event-driven programming *** the programming model,new FTL algorithms can be implemented and integrated into a full-featured flash firmware in a straightforward *** resulting flash firmware can be deployed and evaluated on a hardware development board,which can be connected to a host system via peripheral component interconnect express and serve as a normal non-volatile memory express *** from existing hardware-oriented development platforms,SoftSSD implements the majority of SSD components(e.g.,host interface controller)in software,so that data flows and internal states that were once confined in the hardware can now be examined with a software debugger,providing the observability and extensibility that are critical to the rapid prototyping and research of flash *** describe the programming model and hardware design of *** also perform experiments with real application workloads on a prototype board to demonstrate the performance and usefulness of SoftSSD,and release the open-source code of SoftSSD for public access.

关键词： Solid-state drives Storage system Software hardware co-design