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The silent threat and countermeasures:Navigating the mixture risk of endocrine-disrupting chemicals on pregnancy loss in China

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Eco-Environment & Health 2024年第3期3卷 266-270页

作者： Yaqian Xu thanh wang Jia Yin Ligang Hu Chunyang Liao School of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 310024China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of Physics Chemistry and Biology(IFM)Link€oping University58183 Link€opingSweden Department of Thematic Studies Environmental Change(TemaM) Link€oping University58183 Link€opingSweden College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Currently,many countries and regions worldwide face the challenge of declining population growth due to persistently low rates of female *** 2017,China's birth rate has hit historic lows and continued to decline,with the death rate now equaling the birth *** have emerged regarding the potential impact of environmental contaminants on reproductive health,including pregnancy ***-disrupting chemicals(EDCs)like phthalate esters(PAEs),bisphenol A(BPA),triclosan(TCS),and perfluoroalkyl substances(PFASs)have raised attention due to their adverse effects on biological *** China's 14th Five-Year Plan(2021–2025)for national economic and social development included the treatment of emerging pollutants,including EDCs,there are currently no national appraisal standards or regulatory frameworks for EDCs and their *** the risk of EDC mixtures is an urgent matter that needs consideration from China's perspective in the near *** this Perspective,we delve into the link between EDC mixture exposure and pregnancy loss in *** focus areas include establishing a comprehensive national plan targeting reproductive-aged women across diverse urban and rural areas,understanding common EDC combinations in women and their surrounding environment,exploring the relationship between EDCs and pregnancy loss via epidemiology,and reconsidering the safety of EDCs,particularly in mixtures and low-dose *** envision that this study could aid in creating preventive strategies and interventions to alleviate potential risks induced by EDC exposure during pregnancy in China.

关键词： Endocrine-disrupting chemicals Targeted and nontargeted analysis Mixture effect Birth rate Pregnancy loss

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Alterations of endogenous metabolites in urine of rats exposed to decabromodiphenyl ether using metabonomic approaches

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Journal of Environmental Sciences 2014年第4期26卷 900-908页

作者： Weijin Yang Jianjie Fu thanh wang Hanxia Liu Yawei wang Qunfang Zhou Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

There is large usage of polybrominated diphenyl ethers （PBDEs） especially for decabromodiphenyl ether （BDE-209, Deca-BDE） in controlling the risks of fire. The toxicological effects of PBDEs are worth being concerned about. Female SD rats were daily gavaged with BDE-209 ether at the dose of 100 mg/kg for 20 days. Histological observation was performed for the screening of the target organs for BDE-209 exposure. The distribution and metabolism of PBDEs in the exposed main organs were evidenced by HRGC-HRMS. Alterations of the endogenous metabolite concentrations in urine were investigated using metabonomic approaches based on IH NMR spectrum. Histopathological changes including serious edema in kidney, hepatocellular spotty necrosis and perivasculitis in liver indicated that BDE-209 caused potential influences on endogenous metabolism in the exposed liver and the kidney. BDE-209 was found to be highly accumulated in lipid, ovary, kidney and liver after 20 days＇ exposure. Occurrence of other lower brominated PBDEs in the rats demonstrated that reductive debromination process happened in vivo. Hydroxylated and methoxylated-BDEs, as metabolism products, were also detected in the rat tissues. A total of 12 different endogenous metabolites showed obvious alterations in urine from the exposed rats, indicating the disturbance of the corresponding internal biochemical processes induced by BDE-209 exposure. These findings in vivo suggested the potential health risk might be of concern due to the toxicological effects of BDE-209 as a ubiquitous compound in the environment.

关键词： decabromodiphenyl ether metabonomic approaches endogenous metabolites

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Detection of tris-(2, 3-dibromopropyl) isocyanurate as a neuronal toxicant in environmental samples using neuronal toxicity-directed analysis

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Science China Chemistry 2011年第10期54卷 1651-1658页

作者： QU GuangBo SHI JianBo LI ZhuoNa RUAN Ting FU JianJie wang Pu wang thanh JIANG GuiBin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Neuronal toxic pollutants in environment possess hazards to human health. It is essential to determine the causative neuronal toxicants in environmental samples. In the present study, viability of primary cultured cerebellar granule neurons (CGNs), combined with sample extraction, chemical fractionation and identification, was applied for screening acid-resistant neuronal toxic substances in environmental samples. River sediments and agricultural soils along the river near a brominated flame retardant (BFR) manufacturing plant in South China were collected to screen the key neuronal toxicants. The results indicated that the manufacturing plant was a source of neuronal toxicity risks. In the sediment and soil near the plant, one of the causative toxicants was identified as tris-(2,3-dibromopropyl) isocyanurate (TBC) using HPLC-MS/MS. In addition, an unknown chemical possibly causing significant neuronal toxicity was isolated from all the soil samples in the region.

关键词： neuronal toxicity brominated flame retardant bioassay directed analysis

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Understanding the Water Crisis in China:Towards a Harmonious Aquatic Environment

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Bulletin of the Chinese Academy of Sciences 2011年第1期25卷 50-51页

作者： wang thanh State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences

The water resources in China are much often regarded as insufficient and unevenly distributed. As a result of fast economic development and urbanization in recent years,serious water shortage,contamination and deterioration of aquatic ecosystem are arising. In order to establish a sustainable development,scientific utilization of water resources and protection of the aquatic environment are urgently needed in China.

关键词：中国水环境水危机和谐水生生态系统可持续发展水生环境水资源

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Intra-arterial tenecteplase during thrombectomy for acute stroke(BRETIS-TNK II):rationale and design

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Stroke & Vascular Neurology 2024年第1期9卷 59-65页

作者： Zi-Ai Zhao Jing Qiu Wei Li thanh Nguyen Shouchun wang Huaizhang Shi Ming Wei Feng wang Di Li Hui-Sheng Chen Department of Neurology General Hospital of Northern Theater CommandShenyangLiaoning ProvinceChina Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Department of Neurology First Affiliated Hospital of Jilin UniversityChangchunJilinChina Department of Neurosurgery First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Tianjin Huanhu HospitalTianjinTianjinChina Department of Interventional Therapy First Affiliated Hospital of Dalian Medical UniversityDalianChina Neurological Intervention Department Dalian Municipal Central HospitalDalianLiaoningChina

Background Our recent pilot study suggests intra-arterial tenecteplase(TNK)during the first pass of endovascular treatment(EVT)seems safe,may increase first-pass reperfusion and good outcome in acute ischaemic stroke(AIS)patients with large-vessel occlusion(LVO).Aims To determine the efficacy and safety of intra-arterial TNK administration during EVT in AIS-LVO patients presenting up to 24 hours from symptom *** size estimates A maximum of 380 patients are required to test the superiority hypothesis with 80%power according to a two-side 0.05 level of significance,stratified by age,gender,baseline systolic blood pressure,prestroke modified Rankin Scale(mRS),baseline National Institute of Health stroke scale,baseline ASPECTS,time from onset to groin puncture,intravenous thrombolysis before EVT,stroke territory and stroke *** Intra-arterial TNK during thrombectomy for acute stroke(BRETIS-TNK II)study is a prospective,randomised,adaptive enrichment,open-label,blinded end point,multicentre *** AIS-LVO patients are randomly assigned into the experimental group and control group with a ratio of 1:*** experimental group will be treated with intra-arterial infusion of TNK during *** control group will be treated with standard *** The primary end point is a favourable outcome,defined as an mRS score of 0–2 at 90 *** primary safety end point is symptomatic intracranial haemorrhage within 48 hours,which is defined as an increase in the National Institutes of Health Stroke Scale score of≥4 points as a result of the intracranial *** The results of BRETIS-TNK II will provide evidence for the efficacy and safety of intra-arterial TNK administration during EVT in AIS patients with LVO.

关键词： rational stratified TNK

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Inter-layer interference for multi-layered tight gas reservoir in the absence and presence of movable water

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Petroleum Science 2024年第3期21卷 1751-1764页

作者： Tao Zhang Bin-Rui wang Yu-Long Zhao Lie-Hui Zhang Xiang-Yang Qiao Lei Zhang Jing-Jing Guo Hung Vo thanh National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu60500SichuanChina Shaanxi Yanchang Petroleum(Group)Corp.Ltd. Xian710075ShaanxiChina Waseda Research Institute for Science and Engineering Waseda UniversityTokyoJapan

Due to the dissimilarity among different producing layers,the influences of inter-layer interference on the production performance of a multi-layer gas reservoir are ***,systematic studies of inter-layer interference for tight gas reservoirs are really limited,especially for those reservoirs in the presence of *** this work,five types of possible inter-layer interferences,including both absence and presence of water,are identified for commingled production of tight gas ***,a series of reservoir-scale and pore-scale numerical simulations are conducted to quantify the degree of influence of each type of *** field evidence from the Yan'an tight gas reservoir(Ordos Basin,China)is found to support the simulation ***,suggestions are proposed to mitigate the potential inter-layer *** results indicate that,in the absence of water,commingled production is favorable in two situations:when there is a difference in physical properties and when there is a difference in the pressure system of each *** reservoirs with a multi-pressure system,the backflow phenomenon,which significantly influences the production performance,only occurs under extreme conditions(such as very low production rates or well shut-in periods).When water is introduced into the multi-layer system,inter-layer interference becomes nearly *** both the gas-rich layer and water-rich layer for commingled production is not desirable,as it can trigger water invasion from the water-rich layer into the gas-rich *** gas-rich layer might also be interfered with by water from the neighboring unperforated water-rich layer,where the water might break the barrier(eg weak joint surface,cement in fractures)between the two layers and migrate into the gas-rich ***,the gas-rich layer could possibly be interfered with by water that accumulates at the bottom of the wellbore due to gravitational diff

关键词： Tight gas Comingled production Interference Two-phase flow Water blocking

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In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging

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Nano Research 2024年第5期17卷 4379-4390页

作者： Yuzhou Chen Mo Chen Chengxuan Yu Huizhu Li Liman Sai Nguyen T.K.thanh Yueming wang Yan Wo Jian Zhang Xing Yang Evgenii L.Guryev Andrei V.Zvyagin Hao De Min Tang Shiyi Chen Yunxia Li Yuefeng Hao Sijia Feng Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Department of Physics Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCL Healthcare Biomagnetic and Nanomaterials Laboratories London W1S 4BSUK Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mathematical Institute University of OxfordOxford OX26GGUK Institute of Natural Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage *** this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their *** delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)*** Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with *** results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.

关键词： macrophage cell therapy NIR-II in vivo imaging delayed therapy tendon healing

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SWIR FluorescenceImaging In Vivo Monitoring and Evaluating Implanted M2 Macrophages in Skeletal Muscle Regeneration

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Engineering 2024年第2期33卷 283-294页

作者： Mo Chen Yuzhou Chen Sijia Feng Shixian Dong Luyi Sun Huizhu Li Fuchun Chen Nguyen Thi Kim thanh Yunxia Li Shiyi Chen You wang Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Key Laboratory of Infrared System Detection&Imaging Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK Healthcare Biomagnetic and Nanomaterials Laboratories University College LondonLondon W1S 4BSUK

Skeletal muscle has a robust regeneration ability that is impaired by severe injury,disease,and *** in a decline in skeletal muscle ***,improving skeletal muscle regeneration is a key challenge in treating skeletal muscle-related *** to their significant role in tissue regeneration,implantation of M2 macrophages(M2MФ)has great potential for improving skeletal muscle ***,we present a short-wave infrared(SWIR)fluorescence imaging technique to obtain more in vivo information for an in-depth evaluation of the skeletal muscle regeneration effect after M2MФ*** fluorescence imaging was employed to track implanted M2MФin the injured skeletal muscle of mouse *** is found that the implanted M2MФaccumulated at the injury site for two ***,SWIR fluorescence imaging of blood vessels showed that M2MФimplantation could improve the relative perfusion ratio on day 5(1.09±0.09 vs 0.85±0.05;p=0.01)and day 9(1.38±0.16 vs 0.95±0.03;p=0.01)post-injury,as well as augment the degree of skeletal muscle regencration on day 13 ***,multiple linear regression analyses determined that post-injury time and relative perfusion ratio could be used as predictive indicators to evaluate skeletal muscle *** results provide more in vivo details about M2MФin skeletal muscle regeneration and confirm that M2MФcould promote angiogenesis and improve the degree of skeletal muscle repair,which will guide the research and development of M2MФimplantation to improve skeletal muscle regeneration.

关键词： In vivo Short-wave infrared Skeletal muscle Macrophage Regeneration

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大连市海产品中短链氯化石蜡的含量与分布研究

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环境科学 2014年第5期35卷 1955-1961页

作者：虞俊超王宝盛王亚韡孟梅陈茹江桂斌山东大学环境研究院济南250100 中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室北京100085

在大连市金石滩采集海产品,使用GC/ECNI-LRMS技术对样品中短链氯化石蜡(SCCPs)的累积和分布特征进行了研究.结果表明,ΣSCCPs在香螺样品中含量最低,毛蚶样品中含量最高,干重浓度分别为77 ng·g-1和8 250 ng·g-1.ΣSCCPs在鱼类、虾蟹和... 详细信息

在大连市金石滩采集海产品,使用GC/ECNI-LRMS技术对样品中短链氯化石蜡(SCCPs)的累积和分布特征进行了研究.结果表明,ΣSCCPs在香螺样品中含量最低,毛蚶样品中含量最高,干重浓度分别为77 ng·g-1和8 250 ng·g-1.ΣSCCPs在鱼类、虾蟹和贝类中的干重浓度分别为100~3 510、394~5 440和77~8 250 ng·g-1.总体上看,海产品中SCCPs碳原子同族体以C10和C11为主,约占总量的61.1%,ΣSCCPs含量越高的海产品倾向于累积更高比重的C12和***7、Cl8和Cl6为主要的氯原子同族体,约占总量的87.6%.除了Cl5与Cl10,样品中SCCPs各碳(氯)同族体之间均存在显著相关性,这表明它们可能有着相同的来源和相似的生物蓄积以及迁移转化过程.

关键词：短链氯化石蜡海产品累积分布相关性

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新型有机污染物研究进展

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化学通报 2013年第1期76卷 3-14页

作者：王亚韡王宝盛傅建捷阮挺曲广波汪畅曾力希刘倩袁博江桂斌环境化学与生态毒理学国家重点实验室中国科学院生态环境研究中心北京100085

新型有机污染物的研究是目前国际上环境化学研究的热点领域,其所引起的环境污染和人体健康问题也是我国环境健康研究的重要组成部分。随着国际斯德哥尔摩公约履约活动的不断深入,我国正面临着履行公约以及削减与控制持久性有机污染物的... 详细信息

新型有机污染物的研究是目前国际上环境化学研究的热点领域,其所引起的环境污染和人体健康问题也是我国环境健康研究的重要组成部分。随着国际斯德哥尔摩公约履约活动的不断深入,我国正面临着履行公约以及削减与控制持久性有机污染物的巨大挑战。本文总结了笔者课题组近几年在新型有机污染物研究方面的进展,讨论了本领域学科前沿和履约工作的科学需求。

关键词：新型有机污染物环境行为

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