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阻尼器支架刚度对悬索桥吊索减振效果影响的数值研究

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湖南大学学报（自然科学版） 2017年第1期44卷 9-15页

作者：李寿英王世峰陈政清湖南大学风工程与桥梁工程湖南省重点实验室湖南长沙410082

采用数值方法,研究了阻尼器支架刚度对悬索桥吊索减振效果的影响.首先,将阻尼器支架简化为弹簧振子模型,建立了吊索-阻尼器-支架系统的自由振动偏微分方程组.其次,对不连续的狄拉克函数进行近似处理,采用有限差分方法对该方程进行数值... 详细信息

采用数值方法,研究了阻尼器支架刚度对悬索桥吊索减振效果的影响.首先,将阻尼器支架简化为弹簧振子模型,建立了吊索-阻尼器-支架系统的自由振动偏微分方程组.其次,对不连续的狄拉克函数进行近似处理,采用有限差分方法对该方程进行数值离散求解,研究了阻尼器支架刚度对无量纲阻尼比曲线、可实现的最优阻尼比及其对应的最优阻尼系数等的影响,研究了阻尼器支架模态质量的影响,并与相关文献结果进行比较.研究结果表明,随着阻尼器支架刚度的减小,能实现的最优阻尼比减小,对应的最优阻尼系数也减小,会影响阻尼器效率;另外,各阶模态的无量纲阻尼比曲线不一致,不能采用统一的无量纲阻尼比曲线来设计阻尼器参数;阻尼器支架的模态质量对阻尼器效率影响很小.

关键词：悬索桥吊索阻尼器支架刚度阻尼

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滇西无量山逆冲推覆带山前飞来峰的构造成因

地质学报 2005年第3期79卷 317-322页

作者：王世锋王二七中国科学院地质与地球物理研究所北京100029

印度板块相对于我国华南地块的向北运动在滇西三江地区造成许多地块发生大规模的顺时针旋转,其中,由于刚性度上的差异,临沧花岗岩基的旋转对邻近地块的影响最为明显,导致兰坪—思茅盆地的大规模缩短和无量山的隆升。无量山的隆升是一系... 详细信息

印度板块相对于我国华南地块的向北运动在滇西三江地区造成许多地块发生大规模的顺时针旋转,其中,由于刚性度上的差异,临沧花岗岩基的旋转对邻近地块的影响最为明显,导致兰坪—思茅盆地的大规模缩短和无量山的隆升。无量山的隆升是一系列逆冲断片的叠置造成的,其中,古生界无量山群浅变质岩位于最上部,三叠系麦初箐组含煤砂板岩位于中部,侏罗-白垩系红层位于最下部。在无量山的北东山前散布有许多飞来峰,盖在侏罗-白垩系红层之上,由于这些飞来峰的岩性和无量山群及麦初箐组很相似,前人将其视为推覆体。近年来,笔者针对这些飞来峰的变形和地貌特征以及与无量山的构造关系开展系统研究,认为它们是在重力作用下从无量山滑覆下来的岩块,并在滑覆的过程中岩石发生了掀斜。无量山的顶部山峰大多位于同一高度,十分平坦,代表一次侵蚀夷平事件,这说明在推覆造山之后发生过大规模的侵蚀作用,在此之前无量山要高的多,因此造山带边缘的推覆岩片具有很大的势能,这是重力滑覆作用得以发生的条件。可以推测飞来峰的滑覆发生在造山期后,很可能发生在无量山大规模的侵蚀作用期间,因为在此时大气降水多,山体边坡稳定性差。

关键词：无量山飞来峰构造成因逆冲滇西推覆带侏罗-白垩系临沧花岗岩基侵蚀作用顺时针旋转边坡稳定性三江地区华南地块印度板块思茅盆地浅变质岩系统研究构造关系地貌特征重力作用造山期后大气降水规模滑覆

Influence of periodontitis and nonsurgical periodontal intervention on atherosclerosis diseases

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Advances in Bioscience and Biotechnology 2012年第4期3卷 531-537页

作者： Tielou Chen shifeng wang Guoqin Liu Xinhai Zhang Dahai Tang Zhifen Wu Department of Clinical Medical Laboratory hospital 411 of CPLA Shanghai PR China Department of Periodontol college of Stomatology Fourth Military Medical University Xi an Shanxi province PR China Department of Periodontol Diagnosis & Treatment Center of Stomatological Diseases of CPLA Hospital 411 of CPLA. 15 Dong Jiang Wan Road 200081 Shanghai PR China Naval Medical Research Institute Shanghai PR China

Objective: Periodontitis and atherosclerosis diseases are chronic inflammatory disorders which are highly prevalent in populations. Nonsurgical periodontal intervention belongs to the initial therapy strategy to periodontal diseases. Periodontal pathogen can enter into blood stream through the ulceration epithelial resulting in bacteraemia when periodontitis is severe. The objective is to investigate the relationship between periodontitis and atherosclerosis diseases, and the influence of nonsurgical periodontal intervention on atheroma and atherosclerosis diseases. Methods: This study reviewed and analyzed the papers which published in the world associated with periodontitis or periodontal intervention on atherosclerosis diseases. Results: Periodontitis and periodontal infectious are important risk factors for atherosclerotic diseases. Much evidence has proved the durative severe periodontitis can result in bacteraemia and systemic inflammation, elevated C-response protein in serum, gingival microcirculation changed, periodontal microorganism reproduced, and endothelial dys-function and endocarditis. Nonsurgical periodontal intervention can remove the pathogenesis bacteria and calculus to recover periodontal health. Effective periodontal therapy can reduce bacteraemia and stop the hurt to vessels. Nonsurgical periodontal therapy may interfere periodontal bacteria, inhibit inflammation response and C-response protein, improving gingival microcirculation and vessel epithelial function to prevent atherosclerosis. Conclusion: Nonsurgical periodontal intervention can improve or decrease the rate of atherosclerotic disease by interfere the severe periodontitis. The detailed mechanism of periodontal intervention on atheroma and atherosclerotic disease is still need to be explored.

关键词： Atherosclerosis Diseases Nonsurgical Periodontal Intervention Periodontitis Epithelial Function C-Response Protein

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滇西一些新生代飞来峰的构造演化

地质科学 2006年第1期41卷 170-180,I0005-I0006页

作者：王二七王世锋樊春王刚中国科学院地质与地球物理研究所岩石圈演化国家重点实验室北京100029

在印度和欧亚大陆相互作用下,滇西三江造山带在新生代中期发生了强烈的东西向缩短,地壳物质的大规模推覆作用形成众多的飞来峰。野外调查发现:这些飞来峰中有的在就位后没有再发生过变形,如分布在兰坪—思茅盆地中段的无量山东北山麓一... 详细信息

在印度和欧亚大陆相互作用下,滇西三江造山带在新生代中期发生了强烈的东西向缩短,地壳物质的大规模推覆作用形成众多的飞来峰。野外调查发现:这些飞来峰中有的在就位后没有再发生过变形,如分布在兰坪—思茅盆地中段的无量山东北山麓一带的一系列上三叠统灰岩飞来峰;有的飞来峰在就位后再次遭受到强烈的变形,如分布在兰坪盆地金顶一带的上三叠统灰岩飞来峰,在渐新世时与下伏岩层一同卷入了强烈的褶皱变形;分布在大理地区鹤庆盆地西侧的中三叠统灰岩飞来峰因受到后期东西向伸展构造的破坏,已被改造成分选极差的重力滑塌沉积。这些古近纪飞来峰由于在就位后再次发生了变形,所以不应称之为飞来峰,应称为异地岩或者是外来岩块。

关键词：三江造山带飞来峰褶皱重力滑塌异地岩原地岩

In silico investigation of the association of the TRPM8 ion channel with the pungent flavor of Chinese herbs

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Journal of Traditional Chinese Medical Sciences 2016年第4期3卷 248-255页

作者： Yuxin Zhang Xing wang shifeng wang Qiao Zhang Sha Peng Xi Li Yanling Zhang Yanjiang Qiao Key Laboratory of TCM-Information Engineer of State Administration of TCM School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 100102China Beijing Key Lab of Traditional Chinese Medicine(TCM)Collateral Disease Theory Research School of Traditional Chinese MedicineCapital Medical UniversityBeijing 100069China

Objective:Explicating the property and action of traditional Chinese medicine(TCM)in the perspectives of modern science deepens the insight into the property of TCM,and provides the basis for new drug discovery and clinical *** this study,we investigated the relationship between transient receptor potential melastatin 8(TRPM8)and pungent flavor using three-dimensional pharmacophores based on virtual screening ***:Firstly,an inhouse database was established to identify the related pharmacological action according to the traditional Chinese herbs expressing an action of promoting blood ***,several therapeutic targets,3-hydroxy-3-methylglutaryl-coenzyme A reductase(HMG-CoAR),cholesteryl ester transfer protein(CETP),Niemann-Pick C1-Like 1(NPC1L1)and platelet-activating factor receptor(PAFR),were selected to screen traditional Chinese herbs,and the common virtual screening hits with various hit scores providing data to reveal the correlation among TRPM8 and therapeutic ***:According to the screening results,TRPM8 agonists were able to identify the effective components of pungent herbs and TRPM8,which shares the common virtual screening hits with the therapeutic targets,was considered to be related to the action of pungent ***:The novel ideas and methods in this study are beneficial to unveil the scientific relationship between a TCM property and its action.

关键词： Five flavors Pungent flavor TRPM8 Pharmacophore Pharmacological action

Identification of berbamine dihydrochloride from barberry as an anti-adipogenic agent by high-content imaging assay

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Journal of Traditional Chinese Medical Sciences 2016年第2期3卷 91-99页

作者： shifeng wang Qiao Zhang Yuxin Zhang Yanling Zhang Qinghua Wu Shiyou Li Yanjiang Qiao School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100102China HD Biosciences Co. Ltd.Shanghai 201201China Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences1 Beichen West RoadChaoyang DistrictBeijing 100101China

Objective:Lipid droplet(LD)deposition in adipose tissue is a critical factor leading to metabolic *** herbal medicines in traditional Chinese medicine(TCM)are used to treat hyperlipidemia,type 2 diabetes,obesity,and other *** objective of this study was to identify potential anti-adipogenic agents from TCM herbal ***:One hundred and twenty compounds were evaluated in terms of their effect on adipocyte differentiation through image-based high content ***-adipogenic effects of identified hits were further confirmed at various *** addition,drug-induced liver injury assay was performed with HepG2 cells to test the hepatotoxicity of hit ***:Berbamine(BBM),a chemical isolated from barberry,and a derivative of BBM,berbamine dihydrochloride(BBMD),reduced LDs formation by more than 50%.Dose-dependent effects were observed and the IC50 values of the two hits,BBM and BBMD,were determined as 1.88 mM and 0.95 mM,***,BBM induced mild HepG2 cell injury,while its dihydrochloridedBBMD did not exhibit hepatotoxicity within 40 ***:This study demonstrates that BBMD may be a potential therapeutic candidate for disorders associated with elevated LDs accumulation.

关键词： 3T3-L1 adipocyte Berbamine dihydrochloride Hepatotoxicity High content screening Lipid droplet

Dietary administration of Bacillus subtilis HAINUP40 enhances growth,digestive enzyme activities,innate immune responses and disease resistance of tilapia,Oreochromis niloticus

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Dietary administration of Bacillus subtilis HAINUP40 enhance...

SBS/胶粉复合改性中海沥青的热储存稳定性

中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会

作者： shifeng wang Haitian Liu Yan Cai Wei Yuan Yongcan Zhou Key Laboratory of Tropical Biological Resources of Ministry of Education College of Marine SciencesHainan University

The probiotic properties of Bacillus subtilis HAINUP40 isolated from the aquatic environment,and the effects of dietary administration of *** HAINUP40 on the growth performance,intestinal probiotic recovery,digestive enzyme activities,innate immunity and disease resistance of tilapia(Oreochromis niloticus) were *** probiotic properties investigated include tolerance to simulated gastrointestinal stress,auto-aggregation,cell surface hydrophobicity and extracellular enzyme *** cell number of *** changed little after 4 h in simulated gastric fluid at pH = 2.0,3.0,4.0 and small intestinal fluid at pH = *** HAINUP40 revealed a strong auto-aggregation property(34.6-87.0%) after a 24 h incubation *** exhibited significant cell surface hydrophobicity in xylene(28.8%) and chloroform(41.3%) and produced extracellular proteases and *** tilapia(mean weight = 95.02 ± 7.65 g) were fed with a diet containing 10cfu/g *** HAINUP40,their final body weight,percent weight gain(PWG),specific growth rate(SGR),total antioxidant capacity(T-AOC) and serum superoxide dismutase(SOD) increased significantly(p<0.05) after 8weeks;feed conversion rate(FCR) is significantly lower(p < 0.05) after 8 weeks;the protease and amylase activity in the digestive tract increased significantly(p<0.05) after 4 and 8 weeks;and respiratory bursts and serum lysozyme activity increased significantly(p< 0.05) after 2 ***,being challenged with pathogenic Streptococcus agalactiae for 2 weeks,the relative percent survival(RPS%) is 52.94%.The results of this study strongly suggest that dietary supplement of *** HAINUP40 can effectively enhances the growth performance,immune response,and disease resistance of Nile tilapia.

关键词： Bacillus subtilis HAINUP40 Tilapia(Oreochromis niloticus) Growth Digestive enzyme activity Innate immunity Protection

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高分子材料科学与工程 2015年第6期31卷 102-106,111页

作者：姚鸿儒王仕峰张勇上海交通大学高分子材料研究所上海200240

苯乙烯-丁二烯-苯乙烯三嵌段共聚物(SBS)改性中海沥青难以热储存稳定,将SBS、脱硫胶粉和相容剂经密炼机共混后改性中海沥青,制备了热储存稳定的复合改性沥青。采用改性沥青离析试验与显微结构分析研究了SBS与脱硫胶粉比例、相容剂种类... 详细信息

苯乙烯-丁二烯-苯乙烯三嵌段共聚物(SBS)改性中海沥青难以热储存稳定,将SBS、脱硫胶粉和相容剂经密炼机共混后改性中海沥青,制备了热储存稳定的复合改性沥青。采用改性沥青离析试验与显微结构分析研究了SBS与脱硫胶粉比例、相容剂种类和用量、胶粉粒径等对复合改性沥青热储存稳定性的影响。结果表明,当相容剂在复合物中质量分数不小于1%、SBS/脱硫胶粉质量比为2/3~1/1时,复合改性沥青热储存稳定。根据稳定形成条件及显微结构分析,脱硫胶粉与SBS可产生力化学结合,能减小与沥青的密度差;相容剂能提高SBS、脱硫胶粉与沥青的结合。从而能改善复合改性沥青的热储存稳定性。

关键词：复合改性苯乙烯-丁二烯-苯乙烯三嵌段共聚物胶粉热储存稳定相容剂

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北澜沧江花岗岩地球化学特征及其构造意义

地质科学 2024年第5期59卷 1361-1373页

作者：张圣听王世锋王淇宋立才中国地质科学院地质力学研究所北京100081 北京大学地球与空间科学学院北京100871 防灾科技学院河北三河065201

藏东地区广泛发育古特提斯花岗岩,如与金沙江缝合带相关的江达—维西花岗岩带和与甘孜—理塘缝合带相关的义敦花岗岩带。但是与龙木错—双湖(碧土)古特提斯主缝合带相关的北澜沧江花岗岩带并没有得到普遍认可。本文选取北澜沧江花岗岩... 详细信息

藏东地区广泛发育古特提斯花岗岩,如与金沙江缝合带相关的江达—维西花岗岩带和与甘孜—理塘缝合带相关的义敦花岗岩带。但是与龙木错—双湖(碧土)古特提斯主缝合带相关的北澜沧江花岗岩带并没有得到普遍认可。本文选取北澜沧江花岗岩带南端的碧罗雪山花岗岩展开研究,揭示其岩石学、年代学和地球化学特征,并进一步揭示其构造意义。岩石样品中锆石具有明显的岩浆岩振荡环带,年龄数据聚集在在217±1 Ma左右,ε_(Hf)(t)均值为-13.5,ε_(Nd)(t)值为-12.0,Sr-Nd-Hf同位素二阶段模式年龄均在2.0 Ga左右;岩石显微观察及地化特征表明岩石为花岗岩类,样品的岩浆来自具有古老地壳重熔成因的中上地壳酸性岩,构造判别图显示岩石为陆陆碰撞阶段花岗岩特征,这与主特提斯洋向东俯冲于兰坪—思茅地块之下以及随后发生陆陆碰撞的构造演化模型相契合。岩石地化特征和其构造位置支持碧罗雪山花岗岩带是北澜沧江花岗岩带的南端。由此,藏东地区存在一条长达700 km的花岗岩带,该花岗岩带从类乌齐、昌都吉塘、左贡东大山、芒康盐井、德钦梅里雪山延伸到维西碧罗雪山。碧罗雪山花岗岩的岩石年代学、地球化学数据为龙木措—双湖缝合带与昌宁—孟连缝合带的对接提供了详细的证据。

关键词：北澜沧江花岗岩带碧罗雪山花岗岩古特提斯缝合带地球化学特征 S型花岗岩