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Analysis of Phospholipids in Crucian Carp(Carassius auratus) Muscle by Offline HPLC-MALDI-TOF MS

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Chemical Research in Chinese Universities 2011年第3期27卷 371-374页

作者： LI Guo-chen wang Yan-hong WU Ren-an wang shi-cheng Inspection and Testing Center of Agro-product Safety and Environment Quality Institute of Applied EcologyChinese Academy of SciencesShenyang 110016P.R.China National Chromatographic Research&Analysis Center Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023P.R.China

The interest in the analysis of phospholipids(PLs), especially phosphatidylcholine(PC), has been increasing due to the importance of them in biochemistry as well as in industry. A method was reported based on the offline combination of MALDI-TOF MS and normal-phase HPLC for analyzing PLs extracted from crucian carp. Total PLs of crucian carp were extracted and then separated by HPLC before the collected subfractions were analyzed by MALDI-TOF MS. The mass spectra obtained show peaks of H+, Na+ and K+ adducts of PC molecules. It is shown that the prior separation of PLs by HPLC is highly necessary to remove the signal suppressing and to avoid the possible overlapping. With this method, 9 possible PC molecules in crucian carp and the corresponding fatty acid compositions were given from the well-resolved mass spectra.

关键词： Phospholipid Phosphatidylcholine Phosphatidylethanolamine Sphingomyelin HPLC MALDI Crucian Carp

GATE simulation based feasibility studies of in-beam PET monitoring in ^(12)C beam cancer therapy

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Nuclear Science and Techniques 2010年第5期21卷 275-280页

作者： WU Jing LIU Yaqiang MA Tianyu WEI Qingyang wang shi cheng Jianping Key Laboratory of Particle & Radiation Imaging Ministry of Education Department of Engineering Physics Tsinghua University Beijing 100084 China

In comparison with conventional radiotherapy techniques,12C beam therapy has its significant advantage in cancer treatment because the radiation dose are mostly concentrated near the Bragg peak region and damage to normal tissues along the beam path is thus greatly ***-beam PET provides a way to monitor dose distribution inside human body since several kinds of positron-emitting nuclei are produced through the interaction between 12C beam and body *** this work,we study the quantitative relationship between the spatial location of the Bragg peak and the spatial distribution of positrons produced by positron-emitting *** Carlo package GATE is used to simulate the interactions between the incident 12C beam of different energies(337.5,270.0 and 195.0 MeV/u) and various target matters(water,muscle and spine bone).Several data post-processing operations are performed on the simulated positron-emitting nuclei distribution data to mimic the impacts of positron generation and finite spatial resolution of a typical PET imaging *** results are compared to published experimental data for *** all the simulation cases,we find that 10C and 11C are two dominant positron-emitting nuclei,and there exists a significant correlation between the spatial distributions of deposited energy and ***,we conclude that it is possible to determine the location of Bragg peak with 1 mm accuracy using current PET imaging systems by detecting the falling edge of the positron distribution map in depth direction.

关键词：放射治疗癌症治疗模拟聚酯正电子发射 Bragg峰监测辐射剂量

Effect of lead on ERK activity and the protective function of bFGF in rat primary culture astroglia

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第6期8卷 422-427页

作者： ZHANG Ying YE Li-ping wang Biao CAO shi-cheng SUN Li-guang Department of Biochemistry and Molecule Biology College of Basic Medical Sciences China Medical University. Shenyang 110001 China

Objective： To observe the effects of lead on levels ofphosphorylated extracellular signal regulated kinase （p-ERK） in the cytoplasm of primary cultures of rat astroglial cells and the possible protective effect of basic fibroblast growth factor （bFGF） on lead-induced effects. Methods： The primary astroglia cells from 1-6 d old Wistar rats were cultured. The cells pretreated with the MEK1 （mitogen-activated protein kinase kinase 1） inhibitor PD98059 and bFGF, respectively, were exposed to Pb acetate of different concentrations for different times. Western blotting and reverse transcription polymerase chain reaction （RT-PCR） methods were used to detect the protein and mRNA expressions of ERK. Results： mRNA expression for ERK peaked 15 min after initiation of lead exposure （P〈0.05） and protein expression of p-ERK peaked at 30 min （P〈0.05）. ERK mRNA levels and p-ERK protein levels returned to baseline after 60 and 120 min of lead exposure, respectively （P〉0.05）. The increase in p-ERK levels in lead-treated cells could be inhibited by PD098059. Activation of ERK in the cells by lead was prevented by pretreatment with bFGF. Total ERK protein levels did not change under the same experimental conditions （P〉0.05）. Conclusion： Low-level lead exposure resulted in transient activation of ERK through the MEK pathway, which then returned to basal levels in the continued presence of lead. Exogenous bFGF protected ERK signaling components in astroglia from lead poisoning.

关键词： Lead Astroglia Extracellular signal regulated kinase (ERK) Basic fibroblast growth factor (bFGF)

Fabrication and Optical Property of Copper Nanowires in Nuclear Track Membranes

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Chinese Physics Letters 1999年第2期16卷 126-128页

作者： PENG Liang-qiang JU Xin wang shi-cheng XIAN Ding-chang CHEN Hong HE Yuan-Jin Laboratory of Nuclear Analysis Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100080 Department of Physics Tsinghua UniversityBeijing 100084

The electrochemical growth of nanowires in nuclear track membranes has been studied and a strong plasma absorption of copper nanowires in the visible region of the electromagnetic spectrum is *** result of the plasma absorption is qualitatively in agreement with the prediction of the appropriate formulation of effective medium theory.

关键词： nanowires absorption formulation

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综合信息矿产预测理论与方法体系新进展

地质通报 2010年第10期29卷 1399-1403页

作者：王世称吉林大学吉林长春130061

综合信息矿产预测理论与方法以研究地质、地球物理、地球化学和遥感信息为基础,并研究信息之间的转换规律,建立综合信息找矿模型,开展成矿预测,应用间接信息找寻隐伏矿产资源体,达到找矿的目的。通过上述研究为国家做出矿产资源总体规... 详细信息

综合信息矿产预测理论与方法以研究地质、地球物理、地球化学和遥感信息为基础,并研究信息之间的转换规律,建立综合信息找矿模型,开展成矿预测,应用间接信息找寻隐伏矿产资源体,达到找矿的目的。通过上述研究为国家做出矿产资源总体规划和找矿勘探工程部署,指导实际找矿勘探工作。

关键词：综合信息矿产预测靶区找矿模型

切换网络拓扑下Euler-Lagrange系统的分布式协调控制(英文)

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自动化学报 2013年第7期39卷 1003-1010页

作者： MIN Hai-Bo LIU Zhi-Guo LIU Yuan wang shi-cheng YANG Yan-Li Hi-Tech Institute of Xi'an

This paper studies adaptive coordination control of Euler-Lagrange (EL) systems with unknown parameters in systemdynamics and possible switching *** introducing a novel adaptive control architecture,decentralized controllers are developed,which allow for parametric *** upon graph theory,Lyapunov theory and switching control theory,the stability of the proposed algorithms are demonstrated.A distinctive feature of this work is to address the coordination control of EL systems with unknown parameters and switching topology in a unified theoretical *** is shown that both static and dynamic coordinations can be reached even when the communication is *** results are provided to demonstrate the effectiveness of the obtained results.

关键词：拉格朗日系统拓扑网络协调控制开关欧拉自适应控制动力学参数分散控制器

考虑探测构形的多飞行器协同探测与制导一体化设计

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宇航学报 2018年第4期29卷 401-410页

作者：张帅郭杨王仕成火箭军工程大学精确制导与仿真实验室西安710025

针对多飞行器协同拦截机动目标时几何构形会影响协同探测和制导效果的问题,基于最优控制理论提出一种考虑探测构形的协同探测与制导一体化设计方法。基于飞行器相对运动学、动力学方程和双视线协同探测原理,建立了协同拦截模型。在制导... 详细信息

针对多飞行器协同拦截机动目标时几何构形会影响协同探测和制导效果的问题,基于最优控制理论提出一种考虑探测构形的协同探测与制导一体化设计方法。基于飞行器相对运动学、动力学方程和双视线协同探测原理,建立了协同拦截模型。在制导设计中引入视线分离角参量以调制协同探测几何构形、减小相对距离探测误差,从而在制导全程增强协同探测效果。将相对距离协同探测结果应用到剩余时间和制导律解算中,基于最优控制理论实现协同探测与制导环节一体化设计。仿真结果表明:在目标进行不同程度机动的情况下,与修正比例导引律相比,所提方法在协同探测和制导方面均具有明显优势。

关键词：协同探测协同制导视线角最优控制

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带有引诱角色的有限时间协同制导方法

宇航学报 2018年第3期29卷 308-317页

作者：张帅郭杨王仕成火箭军工程大学精确制导与仿真实验室西安710025

为实现高价值飞行器的有效突防,采用突防飞行器携带一枚防御器的协同突防方案,在突防器作为引诱角色的情况下,基于有限时间控制理论提出了一种带有拦截角约束的协同制导方法。基于飞行器相对运动学方程和一阶动力学特性,建立了带有拦截... 详细信息

为实现高价值飞行器的有效突防,采用突防飞行器携带一枚防御器的协同突防方案,在突防器作为引诱角色的情况下,基于有限时间控制理论提出了一种带有拦截角约束的协同制导方法。基于飞行器相对运动学方程和一阶动力学特性,建立了带有拦截角约束的协同反拦截模型;用度量矩阵刻画系统有限时间输入输出动态品质,基于微分线性矩阵不等式给出了有限时间状态反馈控制器设计方法。数学仿真表明,该方法能够确保防御器在有限时间内以预置的拦截角有效拦截对方拦截器;在突防器进行引诱配合的情况下,协同突防方案能够大幅节省防御器需用加速度,验证了协同制导方法的有效性;同时,所提制导方法在不同拦截角度和初始发射条件下都能达到较好的控制效果,表现出较强的鲁棒性。

关键词：协同制导引诱角色有限时间输入输出稳定拦截角

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运用综合信息开展地震区划

吉林大学学报（地球科学版） 2011年第3期41卷 892-899页

作者：王微王世称刘光胜马生忠吉林大学测试中心长春130026 吉林大学地球探测科学与技术学院长春130026

运用综合信息推断基底构造格架。研究表明:地震带和地震点位于莫霍面陡度带、低速层陡度带、重力线型构造、重力环型构造以及重力线型构造交汇处;地震带和地震点与地下水、温泉、放射性铀矿的分布规律一致,同受基底构造格架控制;我国水... 详细信息

运用综合信息推断基底构造格架。研究表明:地震带和地震点位于莫霍面陡度带、低速层陡度带、重力线型构造、重力环型构造以及重力线型构造交汇处;地震带和地震点与地下水、温泉、放射性铀矿的分布规律一致,同受基底构造格架控制;我国水系与线型构造关系密切,湖泊位于线型构造交汇处。利用上述研究成果开展地震区划,圈定安全区和安全岛,为我国的城市建设和重大工程建设的合理布局提供科学依据。

关键词：勘查地球物理综合信息基底构造格架地震区划安全区和安全岛