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工程建设与设计 2024年第13期 209-211页

作者：田洪亮汪绍福陈梓陌汤亮严美中国建筑第二工程局有限公司北京101100

针对案例工程中全现浇混凝土外墙、铝合金模板、爬架等快穿插施工体系非标准层施工难的问题,采用全现浇外墙结构非标准层悬挑外架逆作法施工方法。论文详细介绍了该施工施工方法的施工流程和操作要点,并提出质量和安全控制措施。

关键词：全现浇外墙结构铝模爬架非标准层悬挑脚手架逆作法

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In-situ synthesis of quantum dots in the nucleus of live cells

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National Science Review 2024年第3期11卷 172-182页

作者： Yusi Hu Zhi-Gang wang Haohao fu Chuanzheng Zhou Wensheng Cai Xueguang shao Shu-Lin Liu Dai-Wen Pang State Key Laboratory of Medicinal Chemical Biology Frontiers Science Centre for New Organic MatterTianjin Key Laboratory of Biosensing and Molecular Recognition Research Centre for Analytical Sciences College of Chemistry School of Medicine and Frontiers Science Centre for Cell Responses Nankai University Haihe Laboratory of Sustainable Chemical Transformations

The cell nucleus is the main site for the storage and replication of genetic material, and the synthesis of substances in the nucleus is rhythmic, regular and strictly regulated by physiological processes. However,whether exogenous substances, such as nanoparticles, can be synthesized in situ in the nucleus of live cells has not been reported. Here, we have achieved in-situ synthesis of CdSxSe1-xquantum dots（QDs） in the nucleus by regulation of the glutathione（GSH） metabolic pathway. High enrichment of GSH in the nucleus can be accomplished by the addition of GSH with the help of the Bcl-2 protein. Then, high-valence Se is reduced to low-valence Se by glutathione-reductase-catalyzed GSH, and interacts with the Cd precursor formed through Cd and thiol-rich proteins, eventually generating QDs in the nucleus. Our work contributes to a new understanding of the syntheses of substances in the cell nucleus and will pave the way for the development of advanced ‘supercells’.

关键词： glutathione live cell nucleus quantum dot intracellular synthesis

A GMM approach in coupling internal data and external summary information with heterogeneous data populations

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Science China Mathematics 2024年第5期67卷 1115-1132页

作者： Jun shao Jinyi wang Lei wang Key Laboratory of Advanced Theory and Application in Statistics and Data Science(East China Normal University) Ministry of EducationShanghai 200062China School of Statistics East China Normal UniversityShanghai 200062China Department of Statistics University of Wisconsin-MadisonWI 53706USA School of Statistics and Data Science KLMDASRLEBPS and LPMCNankai UniversityTianjin 300071China

Because of advances in data collection and storage,statistical analysis in modern scientific research and practice now has opportunities to utilize external information such as summary statistics from similar studies.A likelihood approach based on a parametric model assumption has been developed in the literature to utilize external summary information when the populations for external and main internal data are assumed to be the *** this article,we instead consider the generalized estimation equation(GEE)approach for statistical inference,which is semiparametric or nonparametric,and show how to utilize external summary information even when internal and external data populations are not the *** approach is coupling the internal data and external summary information to form additional estimation equations and then applying the generalized method of moments(GMM).We show that the proposed GMM estimator is asymptotically normal and,under some conditions,is more efficient than the GEE estimator without using external summary *** of the asymptotic covariance matrix of the GMM estimators are also *** results are obtained to confirm our theory and quantify the improvements by utilizing external *** example is also included for illustration.

关键词： adjustment for heterogeneity constraint data integration generalized method of moments summarystatistic

Benefit-Risk Assessment of Chinese Medicine Injections for Primary Liver Cancer Based on Multi-criteria Decision Analysis

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Chinese Journal of Integrative Medicine 2024年第6期30卷 559-564页

作者： ZHANG Rong-rong shao Ming-yi fu Yu ZHAO Rui-xia wang Jing-wen FANG Yu-xuan The First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450046China Personal Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Scientific Research Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Digestive Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

ObjectiveTo evaluate the benefit-risk of 3 commonly used Chinese medicine injections, Aidi Injection (ADI), Cinobufagin Injection (CINI) and Compound Kushen Injection (CKI), in the treatment of primary liver cancer (PLC), so as to provide a reference for clinical *** controlled trials (RCTs) of ADI, CINI and CKI in the treatment of PLC published in the databases of China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, SinoMed, PubMed, Cochrane Library, and Web of Science were retrieved from January 2020 to October 2022. The data of benefit and risk indicators were combined to obtain the effect value. The multi-criteria decision analysis (MCDA) model was applied to build the decision tree. The benefit value, risk value and benefit risk value of the 3 injections in PLC treatment were calculated. Monte Carlo simulation was carried out to calculate the 95% confidence interval and probability of differences among the 3 injections, so as to optimize the evaluation *** total of 71 RCTs were included. The benefit values of ADI, CINI and CKI combined with transcatheter arterial chemoembolization (TACE) were 42, 38 and 36, respectively. The risk values were 42, 25 and 37, respectively. The benefit risk values were 42, 31 and 37, respectively. The benefit risk differences of ADI vs. CINI, ADI vs. CKI, and CKI vs. CINI were 11 (−0.86, 17.75), 5 (−5.01, 11.09), and 6 (−1.87, 12.63), respectively. The probability that ADI superior to CINI, ADI superior to CKI, and CKI superior to CINI was 96.26%, 77.27%, and 92.62%, *** on the results of MCDA model, CINI combined with TACE has the greatest risk in the treatment of the PLC. Considering the efficacy and safety, the possible priority of the 3 Chinese medicine injections combined with TACE in the treatment of PLC is ADI, CKI and CINI.

关键词： multi-criteria decision analysis benefit-risk assessment Chinese medicine injections primary livercancer

Neurokinin-2 receptor antagonist SR48968 induced necroptosis of myeloid leukemia cells by calcium overload-driven reactive oxygen species accumulation

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Genes & Diseases 2024年第5期11卷 33-35页

作者： Zhibin Yan Xiangyu Hong Qihao Lin Leijie wang Gang shao Chentao Ge Ruilong Xia Caiyun fu Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhouZhejiang 310018China College of Life Sciences China Jiliang UniversityHangzhouZhejiang 310018China

Increasing evidence highlight tachykinin receptors as a prominent player in hematological *** previously revealed the proto-oncogenic role of neurokinin-1 receptor(NK-1R)in acute myeloid leukemia(AML),1 whereas the role of neurokinin-2 receptor(NK-2R)has not been ***,we found NK-2R was significantly up-regulated in AML patients in The Cancer Genome Atlas *** result was further confirmed in blood from AML patients and a range of human leukemia ***,we verified that blocking NK-2R by SR48968 markedly promoted cell death in human myeloid leukemia without cytotoxicity to normal ***,we uncovered that SR48968 induced cytotoxicity through necroptosis mediated by calcium overload-driven reactive oxygen species(ROS)*** summary,our results propose that NK-2R antagonist SR48968 may be used as a new therapeutic approach for myeloid leukemia.

关键词： myeloid antagonist markedly

Single-cell RNA sequencing reveals abnormal transcriptome signature of erythroid progenitors in pure red cell aplasia

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Genes & Diseases 2024年第1期11卷 49-52页

作者： Yumei Liu Haiyue Niu Jie Ren Zhiqin wang Li Yan Limin Xing Zonghong shao Rong fu Zhigang Cai Huaquan wang Department of Hematology Tianjin Medical University General HospitalTianjin 300052China School of Basic Medical Sciences Tianjin Medical UniversityTianjin 300070China

Pure red cell aplasia(PRCA)is a bone marrow failure syndrome characterized by severe anemia,reticulocytopenia,selective reduction,and even the absence of bone marrow erythroid precursors,while leukocyte and platelet counts are normal.1 Acquired PRCA can be divided into primary and *** are mediated by immune *** in the quantity and dysfunction of committed erythroid progenitors(EPs),including burst forming uniterythroid(Bfu-E)and colony forming unit-erythroid(Cfu-E),may be the source of reduced erythropoiesis and needs to be elucidated.

关键词： progenitor anemia leukocyte

Observing strain glass transition in Ti_(33)Nb_(15)Zr_(25)Hf_(25)O_(2)high entropy alloy with Elinvar effect

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Journal of Materials Science & Technology 2024年第1期168卷 16-23页

作者： Kaichao Zhang Kai wang Bin wang Chao Lv Jiaxing Zheng Guanqi Li Yu fu Wenlong Xiao Qingqing Cai Xutao Nie Yingfeng shao Huilong Hou Xinqing Zhao School of Materials Science and Engineering Beihang UniversityBeijing 100191China China Aerodynamics Research and Development Center Mianyang 621000China State Key Laboratory of Nonlinear Mechanics Chinese Academy of SciencesInstitute of MechanicsBeijing 100190China Tianmushan Laboratory(Zhejiang Provincial Laboratory for Aviation) Hangzhou 310000China

Exploring the phase transition of high entropy alloys(HEAs)with multiple major elements is of great importance for understanding the underlying physical *** martensitic phase tran-sition has been frequently reported in HEAs,however,nanoscale microstructural phase evolution has not been investigated to the same ***,we have prepared the Ti_(33)Nb_(15)Zr_(25)Hf_(25)O_(2)HEA and investi-gated the strain glass transition and its associated properties using dynamic mechanical analysis and mi-crostructure *** have found that the elastic modulus in Ti_(33)Nb_(15)Zr_(25)Hf_(25)O_(2)HEA deviates from Wachtman’s equation and observed the Elinvar effect in the form of temperature-independent mod-ulus in the temperature range from 150 K to 450 K and frequency-dependence modulus around 220 *** strain glass transition has been evidenced in Ti_(33)Nb_(15)Zr_(25)Hf_(25)O_(2)HEA by the formation and growth of nano-sized domains during in-situ transmission electron microscopy(TEM)cooling,and substantiated by the broken ergodicity during zero-field-cooling/*** strain glass transition is believed to account for the Elinvar effect,where the modulus hardening of nano-sized domains compensates dynam-ically with the modulus softening of the transformable matrix.

关键词： High entropy alloys Strain glass transition Elinvar effect Microstructural evolution Nanodomains

Distributional and behavioral responses of the wintering Oriental Storks to drought in China’s largest freshwater lake

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Avian Research 2024年第2期15卷 187-195页

作者： fucheng Yang Mingqin shao Jianying wang College of Life Science Jiangxi Normal UniversityNanchang330022China

Extreme droughts are increasing in frequency and severity globally as a result of climate *** understanding of species’responses to drought is crucial for their conservation,especially in regions experi-encing increased *** numerous studies have investigated birds’responses to drought,the emphasis has primarily been on *** can significantly alter the wetland environments that waterbirds inhabit,but the response of waterbirds to drought remains *** this study,we surveyed the distri-bution and behavior of Oriental Storks(Ciconia boyciana)in Poyang Lake,which is the largest freshwater lake in *** indicate that drought-induced catchment areas at the lowest water level limited the total popu-lation size of Oriental Storks in the ***-lakes with large catchment areas at the lowest water level demonstrated a capacity to support a larger population of wintering Oriental *** time,Oriental Storks exhibited a gradual concentration in Changhu Lake,characterized by larger catchments,after resource depletion in sub-lakes with smaller ***,the duration of Oriental Storks’vigilance and moving be-haviors decreased significantly compared with that observed before the *** the drought,Oriental Storks increased their foraging efforts,as evidenced by increased presence in deeper water and reaching their heads and necks into deeper water to forage,higher search rates,but lower foraging *** accordance with area-restricted search theory,reductions in habitat quality resulting from drought,including extensive fish die-offs,forced Oriental Storks to increase their foraging *** a specific water area in sub-lakes during droughts can preserve resource availability,which is crucial for the conservation of Oriental ***-menting measures such as water level control and micro-modification of lake bottoms in sub-lakes might mitigate the impact of drought on the pisc

关键词： Climate change Extreme drought Foraging behavior Oriental stork Poyang lake

Dynamic Constraint-Driven Event-Triggered Control of Strict-Feedback Systems Without Max/Min Values on Irregular Constraints

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 569-580页

作者： Zhuwu shao Yujuan wang Zeqiang Li Yongduan Song the State Key Laboratory of Power Transmission Equipment&System Security and New Technology and the School of AutomationChongqing UniversityChongqing 400044China IEEE

This work proposes an event-triggered adaptive control approach for a class of uncertain nonlinear systems under irregular *** the constraints considered in most existing papers,here the external irregular constraints are considered and a constraints switching mechanism(CSM)is introduced to circumvent the difficulties arising from irregular output *** on the CSM,a new class of generalized barrier functions are constructed,which allows the control results to be independent of the maximum and minimum values(MMVs)of constraints and thus extends the existing ***,we proposed a novel dynamic constraint-driven event-triggered strategy(DCDETS),under which the stress on signal transmission is reduced greatly and no constraints are violated by making a dynamic trade-off among system state,external constraints,and inter-execution *** is proved that the system output is driven to close to the reference trajectory and the semi-global stability is guaranteed under the proposed control scheme,regardless of the external irregular output *** also verifies the effectiveness and benefits of the proposed method.

关键词： Adaptive control dynamic constraint-driven event-triggered control irregular output constraints nonlinear strict-feed-back systems

Influences of Co-Flow and Counter-Flow Modes of Reactant Flow Arrangement on a PEMFC at Start-Up

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1337-1356页

作者： Qianqian shao Min wang Nuo Xu School of Petroleum Engineering Guangdong University of Petrochemical TechnologyMaoming525000China Mechanics Division Beijing Computational Science Research CenterBeijing100193China

To investigate the influences of co-flowand counter-flowmodes of reactant flowarrangement on a proton exchange membrane fuel cell(PEMFC)during start-up,unsteady physical and mathematical models fully coupling the flow,heat,and electrochemical reactions in a PEMFC are *** continuity equation and momentum equation are solved by handling pressure-velocity coupling using the SIMPLE *** electrochemical reaction rates in the catalyst layers(CLs)of the cathode and anode are calculated using the Butler-Volmer *** multiphase mixture model describes the multiphase transport process of gas mixtures and liquid water in the fuel *** validation,the influences of co-flow and counter-flow modes on the PEMFC performance are investigated,including the evolution of the current density,flow field,temperature field,and reactant concentration field during start-up,as well as the steady distribution of the current density,reactant concentration,andmembrane water content when the start-up ***-flow and counter-flow modes influence the current density distribution and temperature *** the one hand,the co-flow mode accelerates the start-up process of the PEMFC and leads to a more evenly distributed current density than the counter-flow *** the other hand,the temperature difference between the inlet and outlet sections of the cell is up to 10.1℃ under the co-flow mode,much larger than the 5.0℃ observed in the counter-flow ***,the counter-flowmode results in a more evenly distributed temperature and a lower maximum temperature than the co-flow ***,in the flow field design of a PEMFC,the reactant flow arrangements can be considered to weigh between better heat management and higher current density distribution of the cell.

关键词： PEMFC full coupling model Butler-Volmer equation multiphase mixture model co-flow mode counter-flow mode