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Characterization and Comparison Analysis of WHO Monographs on Selected Medicinal Plants and Iso Standards of Chinese Materia Medica

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Chinese Journal of Integrative Medicine 2023年第6期29卷 540-548页

作者： YANG Jing-yi SANG Zhen wang rui SHI Yan-hong HUANG Yi-ran School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai(201203)China Institute of Traditional Chinese Medicine International Standardization Shuguang Hospital Affliated to Shanghai University of Traditional Chinese MedicineShanghai(201203)China Institute of Traditional Chinese Medicine International Standardization Shanghai University of Traditional Chinese MedicineShanghai(201203)China

Medicinal plants or Chinese materia medica(CMM)are now attracting worldwide attention as they have increasingly prominent advantages over chemical drugs in disease treatment and healthcare.Since the 1990s,World Health Organization(WHO)and International Organization for Standardization established the Technical Committee of Traditional Chinese Medicine(ISO/TC 249)have carried out the development of quality standards on medicinal plants or CMMs respectively,and a considerable number of monographs and international standards have been published.Since the two international organizations adhere to different principles,the standards they develop naturally have different emphasis.Driven by market demand and international trade,ISO mainly takes quality,efficacy and safety into consideration when developing standards,while WHO pays more attention to clinical practice,quality control and medication guidance.Up to now,there is a lack of comparative analysis on the records,background,principles,basic content,and main requirements of quality standards on medicinal plants or CMMs respectively published by WHO and ISO.Therefore,based on international standards of CMM developed by ISO/TC 249 platform and WHO Monographs on Selected Medicinal Plants,this paper systematically compares the purposes,selected principles,standard-developing process,basic content,and main quality requirements to summarize their similarities and differences,and find their merits,aiming to serve as a reference to the development of international standards for CMMs that helps them go global.

关键词： Chinese materia medica medicinal plants international standards International Organization for Standardization Technical Committee of Traditional Chinese Medicine World Health Organization

Current status and impact of the Young Scientist Foundation of the National Natural Science Foundation on Chinese young scholars in cardiovascular research

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Science China Life Sciences 2024年

作者： Fei Gao Zhenzhen Chen Wendong Li Hujun Jiang rui wang Department of Cardiology Beijing Anzhen HospitalCapital Medical University Hypertension Center Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular DiseaseNational Center for Cardiovascular Diseases Department of Vascular Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School Department of Health Sciences National Natural Science Foundation of China

Cardiovascular disease (CVD) remains the leading cause of disease burden globally,and continued efforts are required in identifying new targets for CVD prevention and treatment (Vaduganathan et al.,2022).Breakthroughs in basic research are urgently needed to fully understand the CVD mechanism and improve clinical treatment modality.

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Bioinformatics Analysis and Identification of Key Candidate Genes Associated with Nephrotoxicity Induced by Cobalt

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Biomedical and Environmental Sciences 2023年第2期36卷 201-205页

作者： wang rui ZHANG Ding ZHUGE rui Jian XUE Qian HE Chang Hao MA Wen Xuan SHEN Zhu Bin GUO Li Department of Toxicology School of Public HealthJilin UniversityChangchun 130021JilinChina Department of Spine Surgery China-Japan Union HospitalJilin UniversityChangchun 130033JilinChina Department of Security Xiamen Rehabilitation HospitalXiamen 36100FujianChina

Cobalt(Co)is a silver-gray,high-intensity,widely distributed metal element that exists in cobalt compounds,and its common valences are bivalence(Co2+)and trivalence(Co3+)[1].The main routes of Co-exposure are occupational and environmental exposures.The human body can be exposed to high concentrations of Co2+through inhalation of contaminated air,consumption of contaminated food and water,or ingestion of Co-containing supplements[2].

关键词： valence silver cobalt

Washed microbiota transplantation for Crohn’s disease:A metagenomic,metatranscriptomic,and metabolomic-based study

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World Journal of Gastroenterology 2024年第11期30卷 1572-1587页

作者： Shi-Ju Chen Da-Ya Zhang Xia Wu Fa-Ming Zhang Bo-Ta Cui Yi-Hao Huang Zu-Lun Zhang rui wang Fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Microbiota Medicine&Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216Hainan ProvinceChina

BACKGROUND Fecal microbiota transplantation(FMT)is a promising therapeutic approach for treating Crohn’s disease(CD).The new method of FMT,based on the automatic washing process,was named as washed microbiota transplantation(WMT).Most existing studies have focused on observing the clinical phenomena.However,the mechanism of action of FMT for the effective management of CD-particularly in-depth multi-omics analysis involving the metagenome,metatranscriptome,and metabolome-has not yet been reported.AIM To assess the efficacy of WMT for CD and explore alterations in the microbiome and metabolome in response to WMT.METHODS We conducted a prospective,open-label,single-center clinical study.Eleven CD patients underwent WMT.Their clinical responses(defined as a decrease in their CD Activity Index score of>100 points)and their microbiome(metagenome,metatranscriptome)and metabolome profiles were evaluated three months after the procedure.RESULTS Seven of the 11 patients(63.6%)showed an optimal clinical response three months post-WMT.Gut microbiome diversity significantly increased after WMT,consistent with improved clinical symptoms.Comparison of the metagenome and metatranscriptome analyses revealed consistent alterations in certain strains,such as Faecalibac-terium prausnitzii,Roseburia intestinalis,and Escherichia coli.In addition,metabolomics analyses demonstrated that CD patients had elevated levels of various amino acids before treatment compared to the donors.However,levels of vital amino acids that may be associated with disease progression(e.g.,L-glutamic acid,gamma-glutamyl-leucine,and prolyl-glutamine)were reduced after WMT.CONCLUSION WMT demonstrated therapeutic efficacy in CD treatment,likely due to the effective reconstruction of the patient’s microbiome.Multi-omics techniques can effectively help decipher the potential mechanisms of WMT in treating CD.

关键词： Crohn’s disease Clinical trials Fecal microbiota transplant Metagenome Metatranscriptome Metabolome

Dynamic immune recovery process after liver transplantation revealed by single-cell multi-omics analysis

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The Innovation 2024年第3期5卷 55-68页

作者： rui wang Xiao Peng Yixin Yuan Baojie Shi Yuan Liu Hengxiao Ni Wenzhi Guo Qiwei Yang Pingguo Liu Jie wang Zhaojie Su Shengnan Yu Dehua Liu Jinyan Zhang Junjie Xia Xueni Liu Hao Li Zhengfeng Yang Zhihai Peng Organ Transplantation Clinical Medical Center of Xiamen University Department of General SurgeryXiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361102China Organ Transplantation Institute of Xiamen University Xiamen Human Organ Transplantation Quality Control CenterXiamen Key Laboratory of Regeneration MedicineFujian Provincial Key Laboratory of Organ and Tissue RegenerationSchool of MedicineXiamen UniversityXiamen 361102China Department of General Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Department of Hepatobiliary&Pancreatic Surgery The National Key Clinical SpecialtyZhongshan Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361102China Precision Research Center for Refractory Diseases Institute for Clinical ResearchShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China

Elucidating the temporal process of immune remodeling under immunosuppressive treatment after liver transplantation(LT)is critical for precise clinical management strategies.Here,we performed a single-cell multi-omics analysis of peripheral blood mononuclear cells(PBMCs)collected from LT patients(with and without acute cellular rejection[ACR])at 13 time points.Validation was performed in two independent cohorts with additional LT patients and healthy controls.Our study revealed a four-phase recovery process after LT and delineated changes in immune cell composition,expression programs,and interactions along this process.The intensity of the immune response differs between the ACR and non-ACR patients.Notably,the newly identified inflamed NK cells,CD14+RNASE2+monocytes,and FOS-expressing monocytes emerged as predictive indicators of ACR.This study illuminates the longitudinal evolution of the immune cell landscape under tacrolimus-based immunosuppressive treatment during LT recovery,providing a four-phase framework that aids the clinical management of LT patients.

关键词： process analysis precise

Study on Thermal Characteristics of a Novel Glass Curtain Wall System

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Journal of Thermal Science 2022年第6期31卷 1959-1969页

作者： FENG Chaoqing CHEN Xin’ge wang rui XU Zhao ZHANG Lizhuang YAN Suying College of Energy and Power Engineering Inner Mongolia University of TechnologyHohhot 010051China China National Institute of Standardization Beijing 100191China

In order to solve the conflict between indoor lighting and PV cells in building-integrated photovoltaic/thermal(BIPV/T) systems, a glass curtain wall system based on a tiny transmissive concentrator is proposed. This glass curtain wall has a direct influence on the heat transfer between indoor and outdoor, and the operating parameters of air and water inlet temperature, indoor and outdoor temperature, and radiation intensity have a significant influence on the heat transfer characteristics of the glass curtain wall. The 3D model is established by SoildWorks software, and the thermal characteristics of the new glass curtain wall system are simulated through computational fluid dynamics(CFD) method. Thermal performance was tested under actual weather for the winter working conditions. The CFD simulation results are verified by the test results under actual weather. The results show that thermal efficiency simulation results are in good agreement with the experimental results of the new glass curtain wall system. The simulation conditions were designed by using the orthogonal method, and the significance analysis of the influencing factors of the indoor wall surface heat gain was carried out. With the increase of the bottom heat flux and the air velocity, the heat absorption of the inner wall surface increases. When the wind speed is 0.1 m/s, the heat flow on the bottom surface rises from 500 W/m^(2) to 2500 W/m^(2), and the heat flow intensity on the interior wall changes from 10.31 W/m^(2) to -29.12 W/m^(2). Under typical working conditions, the new glass curtain wall system can reduce the indoor heat load by 47.5% than ordinary glass curtain wall.

关键词： glass curtain wall thermal characteristics orthogonal experimental design significant influencing factors

Embedded Majorana islands

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Jin-Xing Hou Alex Weststr?m rui wang Wen-Li Yang Jian Li Institute of Modern Physics Northwest University Department of Physics School of Science Westlake University Shaanxi Key Laboratory for Theoretical Physics Frontiers Institute of Natural Sciences Westlake Institute for Advanced Study National Laboratory of Solid State Microstructures and Department of Physics Nanjing University Collaborative Innovation Center for Advanced Microstructures Peng Huanwu Center for Fundamental Theory

Mesoscopic superconducting islands hosting Majorana zero modes(MZMs), or Majorana islands in short, offer a prototype of topological qubits. In this work we investigate theoretically the model of a generic Majorana island tunneling-coupled to a singlepiece metallic substrate, hence an embedded Majorana island. We show the crucial consequences of an interplay between the topological ground states nonlocally addressed by the MZMs and the metallic bath with coherent electron propagation: on the one hand, the topological degeneracy on the Majorana island can be preserved, by virtue of the particle-hole symmetry, despite the apparent bath-induced coupling between MZMs; on the other hand, the electronic interference in the metallic bath may lead to profound alterations to the renormalization group behavior of the hybrid system towards low energy/temperature compared with conventional Kondo physics. This work serves to establish the model of embedded Majorana islands as an experimentally relevant and theoretically intriguing problem particularly in the direction of topological quantum computation.

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Efficacy of luteolin on the human gastric cancer cell line MKN45 and underlying mechanism

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Journal of Traditional Chinese Medicine 2023年第1期43卷 34-41页

作者： DING Yajie LIU Feng LI Zhaoyan Xu Yan CAO Nida ZHANG Guangao wang rui ZHAO Aiguang Department of Oncology Medicine Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China

OBJECTIVE:To investigate the antitumour efficacy of luteolin on gastric cancer(GC)and study the mechanism underpinning the action.METHODS:Effects of luteolin on cell growth inhibition,apoptosis,and cell cycle arrest in MKN45 cells were investigated using the cell counting kit-8 assay.Changes in the mitochondrial membrane potential after luteolin treatment were assessed using 5,5′,6,6’-tetra-chloro-1,1’,3,3’-tetraethy lbenzimidazolcar bocyanineiodi-de(JC-1)staining.To investigate whether apoptotic effect by luteolin is related to the phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene(PI3K/Akt)pathway,cells were additionally treated with LY294002,a PI3K/Akt pathway inhibitor.Moreover,the expressions of apoptosis-related proteins,namely B-cell lymphoma 2(Bcl-2),Bcl-2 associated X protein(Bax),Akt,p-Akt,caspase-3,and cytochrome C,were detected after luteolin treatment.RESULTS:The study revealed that in MKN45 cells,luteolin could inhibit the cell proliferation in a time-and dose-dependent manner;block the cell cycle in the Sphase;induce apoptosis;reduce the mitochondrial membrane potential;increase the expression of Bax,caspase-3,and cytochrome C;and decrease the expression of Bcl-2 and p-Akt.Luteolin might be involved in the PI3K/Akt signalling pathway,indicating that this pathway could be a therapeutic target for GC treatment.CONCLUSION:Luteolin could inhibit the proliferation of GC cells and block the cell cycle in the S-phase.The mechanism of inducing apoptosis in these cells was related to the PI3K/Akt signalling pathway.

关键词： stomach neoplasms luteolin apoptosis phosphoinositide 3-kinase Akt signal transduction

Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1283-1301页

作者： Qian Zhao Jiale Dong Han Liu Hui Chen Huan Yu Shuyin Ye Shuangjin Yu Yu Li Longhui Qiu Nazi Song Hongjiao Xu Qi Liu Zhiteng Luo Yuyi Li rui wang Guodong Chen Xianxing Jiang School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of Chiral Molecule and Drug DiscoverySun Yat-sen UniversityGuangzhou 510006China Organ Transplant Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510006China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510006China Shenzhen Turier Biotech.Co. Ltd.Shenzhen 518118China School of Life Sciences Key Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical SciencesLanzhou UniversityLanzhou 730000China

The role of co-agonists of glucagon-like peptide-1 receptor(GLP-1R)and glucagon receptor(GCGR)in chronic kidney disease(CKD)remains unclear.Herein we found that GLP-1R and GCGR expression levels were lower in the kidneys of mice with CKD compared to healthy mice and were correlated with disease severity.Interestingly,GLP-1R or GCGR knockdown aggravated the progression of kidney injury in both diabetic db/db mice and non-diabetic mice undergoing unilateral ureteral obstruction(UUO).Based on the importance of GLP-1R and GCGR in CKD,we reported a novel monomeric peptide,1907-B,with dual-agonism on both GLP-1R and GCGR.The data confirmed that 1907-B had a longer half-life than long-acting semaglutide in rats or cynomolgus monkeys(~2-3 fold)and exhibited better therapeutic contribution to CKD than best-in-class monoagonists,semaglutide,or glucagon,in db/db mice and UUO mice.Various lock-of-function models,including selective pharmacological activation and genetic knockdown,confirmed that 1907-B’s effects on ameliorating diabetic nephropathy in db/db mice,as well as inhibiting kidney fibrosis in UUO mice,were mediated through GLP-1 and glucagon signaling.These findings highlight that 1907-B,a novel GLP-1R and GCGR co-agonist,exerts multifactorial improvement in kidney injuries and is an effective and promising therapeutic option for CKD treatment.

关键词： GLP-1 receptor Glucagon receptor Chronic kidney disease Diabetic nephropathy Kidney fibrosis Dual-agonism