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Phytochemistry and pharmacology of genus Ephedra

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Chinese Journal of Natural Medicines 2018年第11期16卷 811-828页

作者： ZHANG Ben-Mei wang Zhi-Bin XIN Ping wang qiu-hong BU He KUANG Hai-Xue Key Laboratory of Chinese Materia Medica (Ministry of Education) Heilongjiang University of Chinese Medicine Department of Natural Medicinal Chemistry College of Pharmacy Guangdong Pharmaceutical University

The genus Ephedra of the Ephedraceae family contains more than 60 species of nonflowering seed plants distributed throughout Asia, America, Europe, and North Africa. These Ephedra species have medicinal, ecological, and economic value. This review aims to summarize the chemical constituents and pharmacological activities of the Ephedra species to unveil opportunities for future research. Comprehensive information on the Ephedra species was collected by electronic search(e.g., GoogleScholar, Pubmed, Sci Finder, and Web of Science) and phytochemical books. The chemical compounds isolated from the Ephedra species include alkaloids, flavonoids, tannins, polysaccharides, and others. The in vitro and in vivo pharmacological studies on the crude extracts, fractions and few isolated compounds of Ephedra species showed anti-inflammatory, anticancer, antibacterial, antioxidant, hepatoprotective, anti-obesity, antiviral, and diuretic activities. After chemical and pharmacological profiling, current research is focused on the antibacterial and antifungal effects of the phenolic acid compounds, the immunosuppressive activity of the polysaccharides, and the antitumor activity of flavonoids.

关键词： Ephedra Phytochemistry Pharmacology

Cycloartenol triterpenoid saponins from Cimicifuga simplex(Ranunculaceae) and their biological effects

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Chinese Journal of Natural Medicines 2015年第2期13卷 81-89页

作者： WU Lun CHEN Zhi-Li SU Yang wang qiu-hong KUANG Hai-Xue Key Laboratory of Chinese Materia Medica Heilongjiang University of Chinese Medicine Ministry of Education

The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9,19-cyclolanostane triterpenoid glycosides, which are distributed widely in Cimicifuga plants, but not in other members of the Ranunculaceae family, and are considered to be characteristics of the Cimicifuga genus. This type of triterpenoid glycoside possesses several important biological activities. More than 120 cycloartane triterpene glycosides have been isolated from Cimicifuga simplex Wormsk. The aim of this review article is to summarize all the major findings based on the available scientific literatures on C. simplex, with a focus on the identified 9,19-cyclolanostane triterpenoid glycosides. Biological studies of cycloartane triterpene glycosides from Cimicifuga spp. are also discussed.

关键词： Cimicifuga simplex Ranunculaceae Cycloartenol triterpenoid saponins Biological effects

Photochemistry and pharmacology of 9,19-cyclolanostane glycosides isolated from genus Cimicifuga

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Chinese Journal of Natural Medicines 2016年第10期14卷 721-731页

作者： SU Yang CHI Wen-Cheng WU Lun wang qiu-hong KUANG Hai-Xue Department of Microbiology Immunology&Molecular GeneticsUniversity of California Los AngelesLos AngelesCA 90025USA Key Laboratory of Chinese Materia Medica Department of PharmacologyHeilongjiang University of Chinese MedicineHarbin 150040China The University of Sydney NSW 2006Australia

The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9, 19-cyclolanostane triterpenoid glycosides, which often exhibit extensive pharmacological activities. 9, 19-Cyclolanostane triterpenoid glycosides are distributed widely in genus Cimicifuga rather than in other members of the Ranunculaceae family. So far, more than 140 cycloartane triterpene glycosides have been isolated from Cimicifuga spp.. The aim of this review was to summarize all 9, 19-cyclolanostane triterpenoid glycosides based on the available relevant scientific literatures from 2000 to 2014. Biological studies of cycloartane triterpene glycosides from Cimicifuga spp. are also discussed.

关键词： Cimicifuga spp 9,19-Cyclolanostane glycosides Chemical structure Biological effects

Probiotics with anti-type 2 diabetes mellitus properties:targets of polysaccharides from traditional Chinese medicine

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Chinese Journal of Natural Medicines 2022年第9期20卷 641-655页

作者： Lun WU Yue GAO Yang SU Jing LI Wen-Chen REN qiu-hong wang Hai-Xue KUANG Institute of Traditional Chinese Medicine Heilongjiang University of Chinese MedicineHarbin 150040China School of Pharmacy Heilongjiang University of Chinese MedicineKey Laboratory of Medicinal MaterialsChinese Academy of SciencesHarbin150040China Faculty of Microbiology and Immunogenetics University of CaliforniaLos AngelesCA 90095USA School of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510000China

Traditional Chinese medicine polysaccharides is a biologically active ingredient that is not easy to be *** is fermented by intestinal microflora to promote qualitative and selective changes in the composition of the intestinal microbiome,which often result in beneficial effects on the health of the *** call it“prebiotics”.In this review,we systematically summarized the anti-diabetic effect of traditional Chinese medicine *** polysaccharides regulate the metabolism of sugar and lipids by inter-influence with the intestinal microflora,and maintain human health,while improving type 2 diabetes-like symptoms such as high blood glucose,and abnormal glucose and lipid metabolism.

关键词： Traditional Chinese medicine polysaccharide Prebiotics Intestinal microflora Type 2 diabetes mellitus

Multi-well wavelet-synchronized inversion based on particle swarm optimization

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Applied Geophysics 2024年第4期21卷 728-739,879,880页

作者： Yuan Huan Yuan San-Yi Su Qin wang hong-qiu Zeng Hua-Hui Yue Shi-Jun College of Geophysics China University of Petroleum(Beijing)Beijing 102249China Research Institute of Petroleum Exploration and Development-Northwest PetrochinaLanzhou730020China.

Wavelet estimation is an important part of high-resolution seismic data ***,itis diffi cult to preserve the lateral continuity of geological structures and eff ectively recover weak geologicalbodies using conventional deterministic wavelet inversion methods,which are based on the joint inversionof wells with seismic *** this study,starting from a single well,on the basis of the theory of single-welland multi-trace convolution,we propose a steady-state seismic wavelet extraction method for synchronizedinversion using spatial multi-well and multi-well-side seismic *** proposed method uses a spatiallyvariable weighting function and wavelet invariant constraint conditions with particle swarm optimization toextract the optimal spatial seismic wavelet from multi-well and multi-well-side seismic data to improve thespatial adaptability of the extracted wavelet and inversion *** simulated data demonstrate that thewavelet extracted using the proposed method is very stable and *** at a low signal-to-noise ratio,the proposed method can extract satisfactory seismic wavelets that refl ect lateral changes in structures andweak eff ective geological *** processing results for the fi eld data show that the deconvolution resultsimprove the vertical resolution and distinguish between weak oil and water thin layers and that the horizontaldistribution characteristics are consistent with the log response characteristics.

关键词： particle swarm optimization synchronized inversion wavelet estimation spatial adaptability weak eff ective signal

Analysis on air-leakage law of goal in condition of ascending mining for top-coal caving

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Journal of Coal Science & Engineering(China) 2009年第1期15卷 81-84页

作者： MA Li WEN Hu XIAO Yang wang qiu-hong wang Zhen-ping ZHANG Guang-wen College of Energy Science ＆ Engineering Xi＇an University of Science and Technology Xi＇an 710054 China Yanzhou Coal Mining Company Limited Zoucheng 273500 China

Using the Jisan Coalmine's top-coal caving for the 3down coal seam with ascending mining as the project background, the air-leakage characteristics of the goaf wasanalyzed. Through data fitting of the in situ observation, the models of gas seepage, diffusion and air-leakage in the goaf were established in ascending mining. The ComputationFluid Dynamics software Fluent was used to simulate the air-leakage law of the goaf. Theresults of the numerical simulation provide a basis for the use of the technology of ventilation and fire prevention in the working face of an ascending mining, which ensures thesafety in production in the working face of the top-coal caving for 3_down coal seam in theJisan Coalmine.

关键词： top-coal caving ascending mining goaf air-leakage law

Heterotic loci identified for plant height and ear height using two CSSLs test populations in maize

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Journal of Integrative Agriculture 2016年第12期15卷 2726-2735页

作者： wang hong-qiu ZHANG Xiang-ge YANG Hui-li CHEN Yong-qiang YUAN Liang LI Wei-hua LIU Zong-hua TANG Ji-hua KANG Ding-ming College of Agriculture and Biotechnology China Agricultural University National Key Laboratory of Wheat and Maize Crop Science Ministry of Education/Collaborative Innovation Center of Henan Grain CropsCollege of AgronomyHenan Agricultural University College of Agronomy Sichuan Agricultural University

Heterosis is an important biological phenomenon, and it has been used to increase grain yield, quality and resistance to abiotic and biotic stresses in many crops. However, the genetic mechanism of heterosis remains unclear up to now. In this study, a set of 184 chromosome segment substitution lines （CSSLs） population, which derived from two inbred lines Ix9801 （the recurrent parent） and Chang 72 （the donor parent）, were used as basal material to construct two test populations with the inbred lines Zheng 58 and Xun 9058. The two test populations were evaluated in two locations over two years, and the heterotic loci for plant height and ear height were identified by comparing the performance of each test hybrid with the corresponding CK at P〈0.05 significant level using one-way ANOVA analysis and Duncan＇s multiple comparisons. There were 24 and 29 different heterotic loci （HL） identified for plant height and ear height in the two populations at two locations over two years. Three HL （hlPH4a, hlPH7c, hlPHlb） for plant height and three （hlEHld, hlEH6b, hlEHlb） for ear height were identified in the CSSLs×Zheng 58 and CSSLs×Xun 9058 populations as contributing highly to heterosis performance of plant height and ear height across four environments. Among the 29 HL identified for ear height, 12 HL （41.4%） shared the same chromosomal region associated with the HL （50.0%） identified for plant height in the same test population and environment.

关键词： maize CSSLs test population plant height ear height heterotic loci

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优选阻燃材料惰化锆粉云燃烧的效果和机理

吉林大学学报（工学版） 2020年第3期50卷 929-938页

作者：王秋红王力文西安科技大学安全科学与工程学院西安710054 西安科技大学陕西省煤火灾害防治重点实验室西安710054

为探索惰化锆粉云燃烧的机理,采用粉尘云最低着火温度测试系统及热重-差热同步热分析系统,对纯锆粉、单一阻燃材料与锆粉混合体系悬浮粉尘云状态下的最低着火温度进行研究,进而筛选出效果较好的阻燃材料,并分析其惰化机理。结果表明:0.... 详细信息

为探索惰化锆粉云燃烧的机理,采用粉尘云最低着火温度测试系统及热重-差热同步热分析系统,对纯锆粉、单一阻燃材料与锆粉混合体系悬浮粉尘云状态下的最低着火温度进行研究,进而筛选出效果较好的阻燃材料,并分析其惰化机理。结果表明:0.2 g锆粉在喷尘压力为100 kPa、恒温时间为10 s条件下的最低着火温度为344℃。锆粉与单一阻燃材料混合体系悬浮粉尘云状态下的最低着火温度随阻燃材料添加量的增加而呈上升趋势,其中,ABC粉对混合体系悬浮粉尘云状态下的最低着火温度提升最为明显,在添加比为1∶1、1.5∶1、2∶1、3∶1时,最低着火温度分别提升了48.35%、81.31%、92.31%、97.8%。分析机理可知:锆粉样品中水分蒸发和ABC粉热分解吸热都会降低混合体系的反应温度、提高锆粉云燃烧的初始温度。ABC粉中NH4H2PO4分解生成NH3,吸收火焰区内大量的热量,在一定程度上会降低火焰区的温度。

关键词：安全技术及工程锆粉尘云最低着火温度阻燃材料热重-差热分析

关于培养汉藏双语法律人才的探讨——以四川民族学院为例

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民族教育研究 2014年第1期25卷 115-118页

作者：王秋红四川民族学院政法系四川康定626001

伴随着西部地区经济发展和法治建设的进程,四川藏区迫切需要一批精通汉藏双语、适应基层工作的法律人才。四川民族学院开拓的汉藏双语法学教育,对于缓解甘孜地区双语法律人才的紧缺状况起到了重要作用。如何在不发达民族地区高校培养高... 详细信息

伴随着西部地区经济发展和法治建设的进程,四川藏区迫切需要一批精通汉藏双语、适应基层工作的法律人才。四川民族学院开拓的汉藏双语法学教育,对于缓解甘孜地区双语法律人才的紧缺状况起到了重要作用。如何在不发达民族地区高校培养高质量的双语法律人才,是笔者在本文中试图探讨的重要问题。

关键词：甘孜藏区民族高校汉藏双语法律人才