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农药施用对兴凯湖水中农药残留的影响及其风险评价

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环境科学 2024年第5期45卷 2678-2685页

作者：王蔚青徐雄刘权震林利华吕婧王东红中国科学院生态环境研究中心工业废水无害化与资源化国家工程研究中心北京100085 中国科学院大学北京100049

主要研究了中国东北兴凯湖周围水稻种植区域农药残留以及对湖水水质的影响.分别于水稻抽穗期和水稻成熟期在兴凯湖地区对稻田、排干和大小兴凯湖地表水进行采集并对27种农药及其降解产物进行分析.结果表明,在水稻抽穗期所分析的27种农... 详细信息

主要研究了中国东北兴凯湖周围水稻种植区域农药残留以及对湖水水质的影响.分别于水稻抽穗期和水稻成熟期在兴凯湖地区对稻田、排干和大小兴凯湖地表水进行采集并对27种农药及其降解产物进行分析.结果表明,在水稻抽穗期所分析的27种农药及其降解产物全部检出,总浓度范围为247.97~6094.49 ng·L^(−1);水稻成熟期检出25种,总浓度范围为485.36~796.23 ng·L^(−1),两时期对比,抽穗期的农药及其降解产物检出数量更多且总浓度更高;在水稻抽穗期阿特拉津、西草净和多效唑为主要检出农药,在水稻成熟期阿特拉津和稻瘟灵为主要检出农药;大小兴凯湖水中农药的分布特征与排干水相似,表明大小兴凯湖水中农药及其降解产物很可能来源于稻田排干的输入;在排干和大小兴凯湖水中,阿特拉津、西草净、扑草净、丁草胺、稻瘟灵和草酮RQ均值大于0.1,对水生生物存在潜在生态风险.

关键词：农药残留分布特征风险评价兴凯湖水稻

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唐前姜尚形象接受传播考论

宝鸡文理学院学报（社会科学版） 2024年第1期44卷 129-136页

作者：王渭清赵磊宝鸡文理学院文学与新闻传播学院陕西宝鸡721013

姜尚作为中国历史文化名人,在历代接受中不断被解读重构,形成了多维立体的形象内涵。历史的姜尚在不同时代的多个面向,折射了文人心态的时代特征;文学的姜尚在士不遇、隐逸和神异化三种文本中折射出文学传播对人格价值的形塑作用;文化... 详细信息

姜尚作为中国历史文化名人,在历代接受中不断被解读重构,形成了多维立体的形象内涵。历史的姜尚在不同时代的多个面向,折射了文人心态的时代特征;文学的姜尚在士不遇、隐逸和神异化三种文本中折射出文学传播对人格价值的形塑作用;文化传播符号层面的姜尚在军事才能和隐士情结上双向延伸,使得姜尚形象内涵趋于稳定。分析姜尚的历史、文学、文化形象,有助于清晰地认识历史人物的丰富内涵,理解历史人物在后世传播变迁的原由,推动传统文化精神的弘扬。

关键词：姜尚历史人物文学形象文化传播符号

超高压烧结对WC-8Co硬质合金微观组织及力学性能的影响

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稀有金属与硬质合金 2024年第3期52卷 91-97页

作者：金广辉李彦涛王庆伟河南工业大学材料科学与工程学院河南郑州450001

使用六面顶压机在相同温度(1 400℃)和保温时间(6 min)条件下,研究了不同烧结压力(4.0~6.0 GPa)对WC-8Co硬质合金试样微观组织及力学性能的影响。结果表明:在1 400℃、4.0~6.0 GPa超高压条件下,WC-8Co硬质合金试样可在6 min内完成烧结;... 详细信息

使用六面顶压机在相同温度(1 400℃)和保温时间(6 min)条件下,研究了不同烧结压力(4.0~6.0 GPa)对WC-8Co硬质合金试样微观组织及力学性能的影响。结果表明:在1 400℃、4.0~6.0 GPa超高压条件下,WC-8Co硬质合金试样可在6 min内完成烧结;随着烧结压力的增加,WC-8Co硬质合金试样中WC晶粒的平均尺寸逐渐增大,甚至出现局部WC晶粒异常长大的情况,进而导致硬质合金试样的矫顽磁力、维氏硬度和断裂韧性随之逐渐减小。在考察压力范围内,烧结压力为4.0 GPa时,WC-8Co硬质合金试样的力学性能最好,在载荷为30 kgf(294 N)、保持时间为10 s的检测条件下,试样的维氏硬度为15.2 GPa,断裂韧性为14.9 MPa·m^(1/2),与相同检测条件下的商用YG8硬质合金的力学性能(维氏硬度15.6 GPa,断裂韧性15.9 MPa·m^(1/2))接近。随着烧结压力的增加,硬质合金试样的断裂形式从沿晶断裂占主导逐渐过渡到沿晶断裂与穿晶断裂共存,且穿晶断裂所占的比例逐渐增大。

关键词：超高压烧结 WC-8Co 硬质合金微观结构力学性能断裂形式

引入智能虚拟讲解员的云展厅构建与交互反馈研究

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软件学报 2024年第3期35卷 1534-1551页

作者：刘舫吕天刘心阁叶盛郭锐张烈马翠霞王庆伟刘永进清华大学计算机科学与技术系北京100084 普适计算教育部重点实验室(清华大学) 北京100084 清华大学美术学院交互媒体研究所北京100084 人机交互北京市重点实验室(中国科学院软件研究所) 北京100190 中国科学院大学北京100049 首都体育学院管理与传播学院北京100091

奥林匹克遗产是全人类的宝贵财富,利用科技与文化艺术相融合,对实现北京冬奥会及奥林匹克遗产和精神文化的多元呈现和高效传播至关重要.线上云展厅作为信息时代数字博物馆发展的重要趋势,虽然在单项数字博物馆与交互系统技术研究方面已... 详细信息

奥林匹克遗产是全人类的宝贵财富,利用科技与文化艺术相融合,对实现北京冬奥会及奥林匹克遗产和精神文化的多元呈现和高效传播至关重要.线上云展厅作为信息时代数字博物馆发展的重要趋势,虽然在单项数字博物馆与交互系统技术研究方面已具备较好的基础,但尚未形成体系化、智能化、交互友好的冬奥会奥林匹克数字博物馆系统.面向北京2022年冬季奥林匹克运动会,提出一种具有交互反馈的云展厅系统构建方式,通过构建具有虚拟讲解员的智能交互云展厅,进一步探索交互反馈在知识传播型的数字博物馆中对于非物质文化遗产的传播作用.为了探索视听交互反馈对云展厅的奥林匹克精神文化传播的影响,同时提升知识传播型云展厅中的用户体验,对32名参与者进行用户实验.研究结果表明,所构建的云展厅能够极大地促进奥林匹克文化与精神的传播;同时,在云展厅中引入视听交互反馈能够提高用户的感知控制,从而有效地提升用户体验.

关键词：奥林匹克云展厅交互反馈智能虚拟讲解员感知控制

钠-葡萄糖共转运蛋白2抑制剂与2型糖尿病患者泌尿生殖系统感染风险的Meta分析

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中国新药与临床杂志 2024年第2期43卷 148-154页

作者：谷优优张丽索艳王维清姜云生王肃刘晓智天津市第五中心医院内分泌科天津300450 天津市第五中心医院医院中心实验室天津300450 天津市早产儿器官发育表观遗传重点实验室天津300450

目的评价钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂与2型糖尿病(T2DM)患者泌尿生殖系统感染风险的关系。方法计算机检索中国生物医学文献、万方、中国知网、Cochrane Library、PubMed数据库,检索时限为建库至2020年12月31日,收集关于SGLT-2... 详细信息

目的评价钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂与2型糖尿病(T2DM)患者泌尿生殖系统感染风险的关系。方法计算机检索中国生物医学文献、万方、中国知网、Cochrane Library、PubMed数据库,检索时限为建库至2020年12月31日,收集关于SGLT-2抑制剂与T2DM患者泌尿生殖系统感染风险关系的随机对照研究,采用RevMan 5.4软件进行Meta分析。结果最终纳入27项研究,共22572例患者。Meta分析结果显示,SGLT-2抑制剂不增加T2DM患者泌尿系统感染的风险(OR=1.07,95%CI:0.94~1.21,P=0.29)。亚组分析显示,在不同SGLT-2抑制剂、干预周期、性别分层下,SGLT-2抑制剂均不增加T2DM患者泌尿系统感染风险(P>0.05)。与对照组相比,SGLT-2抑制剂显著增加了T2DM患者生殖系统感染的风险(OR=4.14,95%CI:3.45~4.97,P<0.05)。亚组分析显示,在不同类型SGLT-2抑制剂、干预周期、性别分层下,均发现SGLT-2抑制剂显著增加T2DM患者生殖系统感染风险(P<0.01)。结论SGLT-2抑制剂可增加T2DM患者生殖系统感染的风险,并未增加T2DM患者泌尿系统感染的风险。

关键词：钠-葡萄糖共转运蛋白2抑制剂糖尿病,2型泌尿生殖系统感染 Meta分析

Role of ferroptosis in fibrosis:From mechanism to potential therapy

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Chinese Medical Journal 2024年第7期137卷 806-817页

作者： Xuemeng Qiu qing Bi Jiyue Wu Zejia Sun wei wang Department of Urology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Surgery Third Clinical Medical CollegeCapital Medical UniversityBeijing 100020China Urinary and Nephropathy Center Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Institute of Urology Capital Medical UniversityBeijing 100020China

Fibrosis,which is a manifestation of the physiological response to injury characterized by excessive accumulation of extracellular matrix components,is a ubiquitous outcome of the repair ***,in cases of repetitive or severe injury,fibrosis may become dysregulated,leading to a pathological state and organ *** recent years,a novel form of regulated cell death,referred to as ferroptosis,has been identified as a possible contributor to fibrosis;it is characterized by iron-mediated lipid *** has garnered attention due to the growing body of evidence linking ferroptosis and fibrogenesis,which is believed to be driven by underlying inflammation and immune *** the increasing interest in the relationship between ferroptosis and fibrosis,a comprehensive understanding of the precise role that ferroptosis plays in the formation of fibrotic tissue remains *** review seeks to synthesize previous research related to the *** categorized the different direct and indirect mechanisms by which ferroptosis may contribute to fibrosis into three categories:(1)iron overload toxicity;(2)ferroptosis-evoked necroinflammation,with a focus on ferroptosis and macrophage interplay;and(3)ferroptosis-associated pro-fibrotic factors and ***,the review considers the potential implications of these findings and highlights the utilization of ferroptosis-targeted therapies as a promising strategy for mitigating the progression of *** conclusion,novel anti-fibrotic treatments targeting ferroptosis could be an effective treatment for fibrosis.

关键词： Ferroptosis Fibrosis Anti-fibrotic Iron metabolism Necroinflammation Epithelial-mesenchymal transition

Identification of an immune-related gene signature for predicting prognosis and immunotherapy efficacy in liver cancer via cell-cell communication

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World Journal of Gastroenterology 2024年第11期30卷 1609-1620页

作者： Jun-Tao Li Hong-Mei Zhang wei wang Dong-qing wei College of Mathematics and Information Science Henan Normal UniversityXinxiang 453007Henan ProvinceChina College of Computer and Information Engineering Henan Normal UniversityXinxiang 453007Henan ProvinceChina State Key Laboratory of Microbial Metabolism and School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China

BACKGROUND Liver cancer is one of the deadliest malignant tumors *** has provided hope to patients with advanced liver cancer,but only a small fraction of patients benefit from this treatment due to individual *** immune-related gene signatures in liver cancer patients not only aids physicians in cancer diagnosis but also offers personalized treatment strategies,thereby improving patient survival *** several methods have been developed to predict the prognosis and immunotherapeutic efficacy in patients with liver cancer,the impact of cell-cell interactions in the tumor microenvir-onment has not been adequately *** To identify immune-related gene signals for predicting liver cancer prognosis and immunotherapy *** Cell grouping and cell-cell communication analysis were performed on single-cell RNA-sequencing data to identify highly active cell groups in immune-related *** active immune cells were identified by intersecting the highly active cell groups with B cells and T *** significantly differentially expressed genes between highly active immune cells and other cells were subsequently selected as features,and a least absolute shrinkage and selection operator(LASSO)regression model was constructed to screen for diagnostic-related *** genes that were selected more than 5 times in 10 LASSO regression experiments were included in a multivariable Cox regression ***,3 genes(stathmin 1,cofilin 1,and C-C chemokine ligand 5)significantly associated with survival were identified and used to construct an immune-related gene *** The immune-related gene signature composed of stathmin 1,cofilin 1,and C-C chemokine ligand 5 was identified through cell-cell *** effectiveness of the identified gene signature was validated based on experi-mental results of predictive immunotherapy response,tumor mutation burden analysis,immune cell infiltrat

关键词： Liver cancer Cell-cell communication Gene signature Prognosis Immunotherapy Single-cell RNA sequencing

Significantly Enhanced Melt Memory Effect of Metallocene-made Isotactic Polypropylene Containing Talc

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Chinese Journal of Polymer Science 2024年第2期42卷 213-222,I0008页

作者： Hong-Wen Sun Fu-Shan wang Yan Gao Fu-qing wei Jia-Chun Feng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China Lanzhou Petrochemical Corporation of PetroChina Lanzhou730060China Lanzhou Petrochemical Research Center Petrochemical Research Institute of PetroChinaLanzhou730060China

The melt memory effect is a widely observed phenomenon in semi-crystalline polymers. In practical applications, various additives are usually introduced into polymers, which may affect their melt memory behavior. In this work, the effect of talc on the melt memory effect of metallocene-made isotactic polypropylene(M-PP) was investigated in detail by using the differential scanning calorimetry. The results indicated that the introduction of talc significantly strengthened the melt memory effect of M-PP. Specifically, the upper limit temperature of Domain II increased from 161 ℃ to 174 ℃, resulting in a substantial widening of the temperature range of Domain IIa from 1 ℃ to 14 ℃. Analysis of the crystal orientation of the M-PP containing talc cooled from various Ts suggested that the remarkably enhanced melt memory effect could be ascribed to the stabilization of oriented nuclei facilitated by talc. This stabilizing effect was likely attributable to the prefreezing effect or the sorption interaction between talc and the M-PP chains.

关键词： Metallocene-made isotactic polypropylene Talc Melt memory effect Crystal orientation

RNA modifications in cellular metabolism:implications for metabolism-targeted therapy and immunotherapy

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1565-1594页

作者： wei-wei Liu Si-qing Zheng Tian Li Yun-Fei Fei Chen wang Shuang Zhang Fei wang Guan-Min Jiang Hao wang Department of Laboratory Medicine The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina School of Clinical Medicine Shandong UniversityJinanChina Core Unit of National Clinical Research Center for Laboratory Medicine HefeiChina Neurosurgical Department The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Department of Clinical Laboratory The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiChina

Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of *** studies have been constantly making inroads in our understanding of pathophysiology,and inspiring development of *** a crucial component of epigenetics at post-transcription level,RNA modification significantly determines RNA fates,further affecting various biological processes and cellular *** be noted,immunometabolism defines the metabolic alterations occur on immune cells in different stages and immunological *** this review,we characterize the distribution features,modifying mechanisms and biological functions of 8 RNA modifications,including N6-methyladenosine(m6A),N6,2'-O-dimethyladenosine(m6Am),N1-methyladenosine(m1A),5-methylcytosine(m5C),N4-acetylcytosine(ac4C),N7-methylguanosine(m7G),Pseudouridine(V),adenosine-to-inosine(A-to-l)editing,which are relatively the most studied *** regulatory roles of these RNA modification on metabolism in diverse health and disease contexts are comprehensively described,categorized as glucose,lipid,amino acid,and mitochondrial *** we highlight the regulation of RNA modifications on immunometabolism,further influencing immune *** all,we provide a thorough discussion about clinical implications of RNA modification in metabolism-targeted therapy and immunotherapy,progression of RNA modification-targeted agents,and its potential in RNAtargeted ***,we give legitimate perspectives for future researches in this field from methodological requirements,mechanistic insights,to therapeutic applications.

关键词： metabolism targeted alterations