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Emplacement age and tectonic implications of the brecciated limestone at the edge of the Longmenshan klippe

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Science China Earth Sciences 2016年第3期59卷 590-600页

作者： XUE Zhen Hua SHANG qing Hua JIANG Wen Ying wang qing chen LI Shuang Jian State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences Betljing 100029 Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences Beijing 100044 China University of Chinese Academy of Sciences Beijing 100049 China Institute of Petroleum Exploration and Development China Petroleum and Chemical Corporation Beijing 100083 China

The Longmenshan thrust belt(LMTB) is one of the best natural laboratories for thin-skinned tectonics and has developed a series of NE-SW trending fold-and-thrust structures represented by a series of nappes and klippes, exemplified by the Tangbazi and Bailuding klippe. However, the timing and emplacement mechanism of these klippes are still in dispute. Three possible mechanisms have been proposed:(1) a Mesozoic-Cenozoic southeastward thrusting,(2) a Cenozoic gravity gliding, and(3) glacial deposition. Almost all of these klippes are tectonic and overlaid on folded Late Triassic sandstone except the Tangbazi klippe, which is located in the center of the LMTB and has a narrow tail extending southeastward and covering Jurassic-Quaternary rocks. This geometric relationship is considered the most important stratigraphic evidence to support the post-Cenozoic emplacement of the Longmenshan klippe. Our structural and petrological observations show that the rocks at the front of the Tangbazi and Bailuding structures are brecciated limestone, which is assumed to have been generated by a gravitational collapse and is not characteristic of the massive Permian strata. Artemisia pollen, which has been exclusively recognized in post-Late Eocene strata in Central Asia, was found in the matrix of this brecciated limestone. Therefore, our discovery indicates that the brecciated limestone was deposited after the Late Eocene rather than during the Permian as annotated on the geological map. In contrast, unbrecciated, massive Permian limestone overlaid on the folded Late Triassic rocks. Hence, the anomalous relationship of Permian strata overlaying Late Triassic rocks cannot be evidence of Cenozoic emplacement. According to currently recognized bulk strata relationships, we can only be sure that the klippe was emplaced in the post Late Triassic. The petrological characteristics of the brecciated limestone show that it was crumbled before the re-sedimentation of the breccia, implying tha

关键词： Longmenshan thrust belt Klippe Artemisia Brecciated limestone Thin-skinned structure

Improved quality of life in patients with gastric cancer after esophagogastrostomy reconstruction

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World Journal of Gastroenterology 2009年第25期15卷 3183-3190页

作者： Hao Zhang Zhe Sun Hui-Mian Xu Ji-Xian Shan Shu-Bao wang Jun-qing chen State Key Department of General Surgery Department of Surgical Oncology First Affiliated Hospital of China Medical University Shenyang 110001 Liaoning Province China

AIM:To compare postoperative quality of life (QOL) in patients with gastric cancer treated by esophagogastrostomy reconstruction after proximal ***: QOL assessments that included functional outcomes (a 24-item survey about treatment-specific symptoms) and health perception (Spitzer QOL Index) were performed in 149 patients with gastric cancer in the upper third of the stomach, who had received proximal gastrectomy with additional ***: Fifty-four patients underwent reconstruction by esophagogastric anterior wall end-to-side anastomosis combined with pyloroplasty (EA group); 45 patients had reconstruction by esophagogastric posterior wall end-to-side anastomosis (EP group); and 50 patients had reconstruction by esophagogastric end-to-end anastomosis (EE group). The EA group showed the best postoperative QOL, such as recovery of body weight, less discomfort after meals, and less heart burn or belching at 6 and 24 mo postoperatively. However, the survival rates, surgical results and Spitzer QOL index were similar among the three ***: Postoperative QOL was better in the EA than EP or EE group. To improve QOL after proximal gastrectomy for upper third gastric cancer, the EA procedure using a stapler is safe and feasible for esophagogastrostomy.

关键词： Gastric cancer Proximal gastrectomy Esophagogastrostomy Quality of life

Treatment of urinary lithiasis following kidney transplantation with extracorporeal shock-wave lithotripsy

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Chinese Medical Journal 2011年第9期124卷 1431-1434页

作者： LI Sha-dan wang qing-tang chen Wei-guo Department of Urology General Hospital of Chengdu Military Command Chengdu Sichuan 610083 China

Background The incidence of urinary lithiasis following kidney transplantation is very low, and decision-supporting data are not available. The aim of this study was to review the diagnosis and treatment of urinary lithiasis following kidney transplantation, which is of realistic significance to reduce urinary lithiasis following kidney transplantation, prolong the survival of renal *** The incidence, diagnosis and treatment of urinary lithiasis in ten patients following kidney transplantation were analyzed retrospectively. Seven out of these patients had stones sized approximately 0.4-1.1 cm, and they were treated with low-voltage, low-frequency extracorporeal shock-wave lithotripsy （ESWL）. Two patients had stones sized ＜0.3 cm and they underwent cystoscopy and ureteroscopy. The ureteral catheter endoscopes were inserted in a retrograde manner to mobilize stones repeatedly. After elimination of obstruction, a ureteral double J stent was *** patient had a pelvic stone （1.2 cm）, which was removed *** The major clinical manifestations were hematuria, oliguria or anuria. Some patients were asymptomatic and they were diagnosed through laboratory tests and imaging examinations, e.g., ultrasonography. After elimination of obstruction, subjective symptoms disappeared in all patients, and the function of renal allografts recovered. A six-month follow-up indicated no remnant stones or lithiasis *** The diagnosis and treatment of renal allograft lithiasis are challenging. After prompt and appropriate treatment, the prognosis was satisfactory, and permanent renal functional impairment did not occur in most patients.

关键词： kidney transplantation lithiasis extracorporeal shock-wave lithotripsy

Cross-talk between MEK1/2-ERK1/2 signaling and G protein-couple signaling in synoviocytes of collagen-induced arthritis rats

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Chinese Medical Journal 2008年第22期121卷 2278-2283页

作者： ZHANG Ling-ling WEI Wei wang qing-tong chen Jing-yu chen Yin Institute of Clinical Pharmacology Anhui Medical University Key Laboratory of Anti-inflammatory and Immuno-pharmacology in Anhui Province Key Laboratory of Research & Development of Chinese Medicine in Anhui Province Hefei Anhui 230032 China

Background Signaling pathways that regulate the production of cytokines and destructive enzymes have been implicated in rheumatoid arthritis （RA） pathogenesis. There are co-relations between signaling pathways. The aim of this study was to investigate interactions and cross-talks between MEK1/2-extracellular signal-related kinase （ERK1/2） signaling and G protein-couple signaling in synoviocytes of collagen-induced arthritis （CIA） rats by the stimulation of interleukin-1 （IL-1）, U0126, isoprenaline hydrochloride and aminophyline respectively. Methods Twenty Sprague-Dawley （SD） rats were induced by chicken type II collagen. Synoviocytes of CIA rats were isolated and cultured. The expressions of Gi, phosphorylated MEK1/2 （p-MEK1/2） and phosphorylated ERK1/2 （p-ERK1/2） were detected by Western blotting, cAMP level and protein kinase A （PKA） activity were measured by radioimmunoassay and kinase-glo luminescent kinase assay respectively. Results There was remarkable inflammation in CIA rats accompanied by swelling paws, hyperplastic synovium, pannus and cartilage erosion, cAMP level and PKA activity of synoviocytes decreased. Gi, p-ERK1/2 and p-MEK1/2 increased, rlL-la improved the expression of Gi, p-ERK1/2 and p-MEK1/2, cAMP and PKA increased with stimulation of rlL-1α. U0126 inhibited Gi, cAMP and PKA of synoviocytes stimulated by rlL-la. Isoprenaline hydrochloride enhanced Gi, cAMP and PKA, but had no effects on p-MEK1/2 and p-ERK1/2. Aminophyline increased cAMP and PKA, but inhibited p-MEK1/2 and p-ERK1/2. Conclusions Mitogen-activated protein kinases （MAPKs） and G protein-couple signaling are associated with synovitis. There are cross talks between MAPKs and G protein-couple signaling. The two signaling pathways represent potential therapeutic targets for RA.

关键词： arthritis signaling cross-talk G protein MAP kinases

Cluster-based composition rule for Laves phase-related BCC solid solution hydrogen storage alloys

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Rare Metals 2006年第z1期25卷 252-255页

作者： wang qing chen Feng WU Jiang QIANG Jianbing DONG Chuang ZHANG Yao XU Fen SUN Lixian State Key Laboratory of Materials Modification Dalian University of Technology Dalian 116024 China State Key Laboratory of Materials Modification Dalian University of Technology Dalian 116024 China State Key Laboratory of Materials Modification Dalian University of Technology Dalian 116024 China State Key Laboratory of Materials Modification Dalian University of Technology Dalian 116024 China State Key Laboratory of Materials Modification Dalian University of Technology Dalian 116024 China International Center of Materials Physics Metals Research Institute Chinese Academy of Sciences Shenyang 110015 China Materials & Thermochemistry Laboratory Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Materials & Thermochemistry Laboratory Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Materials & Thermochemistry Laboratory Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

A new cluster line approach for the composition rule of Laves phase-related BCC solid solution hydrogen-storage alloys was presented. The cluster line in a ternary phase diagram refers to a straight composition line linking a specific binary cluster to the third element. In the Laves phase-related BCC solid solution alloy system such as Ti-Cr-V, Ti-Cr tends to form binary Cr2Ti Laves phase while Ti-V and Cr-V to form solid solutions. This Laves phase is characterized by a close-packing icosahedral cluster Cr7Ti6. A cluster line Cr7Ti6-V is then constructed in this system. Alloy rods with a diameter of 3 mm of compositions along this line were prepared by copper-mould suction method. The alloy structure is found to vary with the V contents. Furthermore, the P-C-T measurements indicate that the cluster-line (Cr7Ti6)1-xVx alloys have large hydrogen storage capacities.

关键词： Ti-Cr-V alloys composition rule cluster hydrogen storage

Distribution of solitary Iymph nodes in primary gastric cancer:A retrospective study and clinical implications

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World Journal of Gastroenterology 2007年第35期13卷 4776-4780页

作者： Cai-Gang Liu Ping Lu Yang Lu Feng Jin Hui-Mian Xu Shu-Bao wang Jun-qing chen Department of Surgical Oncology First Affiliated Hospital of China Medial University Heping Shenyang110001 Liaoning Province China

AIM： To investigate the distribution pathway of metastatic lymph nodes in gastric carcinoma as a foundation for rational lymphadenectomy. METHODS： We investigated 173 cases with solitary or single station metastatic lymph nodes （LN） from among 2476 gastric carcinoma patients. The location of metastatic LN, histological type and growth patterns were analyzed retrospectively. RESULTS： Of 88 solitary node metastases cases, 65 were limited to perigastric nodes （N1）, while 23 showed skipping metastasis. Among 8 tumors in the upper third stomach, 3 involved right paracardial LN （station number： No.1）, and one in the greater curvature was found in No.1. In the 28 middle third stomach tumors, 10 were found in LN of the lesser curvature （No.3） and 6 in LN of the left gastric artery （No.7）; 5 of the 20 cases on the lesser curvature spread to No.7, while 2 of the 8 on the greater curvature metastasized to LN of the spleen hilum （No.10）. Of 52 lower third stomach tumors, 13 involved in No.3 and 19 were detected in inferior pyloric LN （No.6）; 9 of the 29 cases along the lesser curvature were involved in No.6. CONCLUSION： Transversal and skipping metastases of sentinel lymph nodes （SLN） are notable, and rational lymphadenectomy should, therefore, be performed.

关键词： Gastric cancer Metastatic lymph node,Lymph node dissection Rational lymphadenectomy Sentinel lymph node

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浅议华南陆块群的沉积大地构造学问题

沉积学报 2009年第5期27卷 811-817页

作者：王清晨中国科学院地质与地球物理研究所岩石圈演化国家重点实验室北京100029

华南陆块群指我国南方一系列大大小小的古陆块,包括扬子陆块、武夷陆块、云开陆块等在内,它们连同所在海域构成多岛海。这些古陆块在古生代早期曾位于冈瓦纳大陆边缘,在晚古生代至中生代早期不断拼合,成为亚洲大陆的一部分。华南陆块群... 详细信息

华南陆块群指我国南方一系列大大小小的古陆块,包括扬子陆块、武夷陆块、云开陆块等在内,它们连同所在海域构成多岛海。这些古陆块在古生代早期曾位于冈瓦纳大陆边缘,在晚古生代至中生代早期不断拼合,成为亚洲大陆的一部分。华南陆块群的大地构造演化特征可概括为12个字:"小陆块、晚拼合、弱张裂、强挤压",而其陆内变形则以"多动力、广分布"为特征。华南陆块群演化中有几个悬而未决的沉积大地构造学问题:(1)华夏陆块与扬子陆块是否存在过华南洋?早古生代时华南陆块群的沉积作用有何特征?(2)伴随晚古生代张裂活动和岩浆活动,华南陆块群晚古生代沉积环境和古地理发生了哪些重要变化?(3)华南陆块群中生代陆内变形有哪些沉积响应?相信对这些问题的逐步解决将会有助于深入认识华南地质,并丰富大陆动力学的知识宝库。

关键词：华南陆块群多岛海沉积大地构造大陆动力学

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探索叶连俊先生理论创新之路

沉积学报 2013年第5期31卷 751-756页

作者：王清晨中国科学院地质与地球物理研究所岩石圈演化国家重点实验室北京100029

叶连俊先生是《沉积学报》创办人和第一任主编,是我国沉积学的开拓者和奠基人。本文把叶连俊先生沉积成矿理论研究的主线概括为三个环节:成矿来源—成矿作用过程—成矿预测。其中,"外生矿床陆源汲取成矿论"侧重强调成矿来源问题,"工业... 详细信息

叶连俊先生是《沉积学报》创办人和第一任主编,是我国沉积学的开拓者和奠基人。本文把叶连俊先生沉积成矿理论研究的主线概括为三个环节:成矿来源—成矿作用过程—成矿预测。其中,"外生矿床陆源汲取成矿论"侧重强调成矿来源问题,"工业磷块岩物理富集成矿说"、"沉积矿床多因素多阶段成矿论"和"生物有机质成矿说"侧重强调成矿作用过程与因素,而"沉积矿床成矿时代的地史意义"则侧重强调成矿预测问题。文中指出,叶先生理论创新的工作基础主要有两条,一是他的新思想来自对研究对象的认真观察,二是他的新理论来自对表观现象的深入思考。叶先生的理论创新之路告诉我们,取得理论创新需精于野外观察,善于总结提高,敢于挑战传统和勤于超前思考。

关键词：叶连俊理论创新认真观察深入思考

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： qing He Zhen wang Yuchen wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge Xu Gong chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming