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Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep

Genomics, Proteomics & Bioinformatics 2024年第2期22卷 43-56页

作者： Chao Li Bingchun Chen Suo Langda Peng Pu Xiaojia Zhu Shiwei Zhou Peter Kalds Ke Zhang Meenu Bhati Alexander Leonard Shuhong Huang Ran Li Awang Cuoji Xiran wang Haolin Zhu Yujiang Wu Renqin Cuomu Ba Gui Ming Li Yutao wang Yan Li Wenwen Fang Ting Jia Tianchun Pu Xiangyu Pan Yudong Cai Chong He Liming wang Yu Jiang Jian-Lin Han {4. Chen Ping Zhou Hubert Pausch Xiaolong wang International Joint Agriculture Research Center for Animal Bio-Breeding Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal GeneticsBreeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Animal Genomics ETH ZürichZürich 8092Switzerland institute of Animal Science Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China School of Biological and Pharmaceutical Engineering Lanzhou Jiaotong UniversityLanzhou 730070China College of Life sciences Shaanxi Normal UniversityXi’an 710119China Zoology and Evolutionary Biology Department of BiologyUniversity of Konstanz78457 KonstanzGermany College of Life and Geographic sciences Kashi UniversityKashi 844000China beijing Key Laboratory of Captive Wildlife Technologies Beijing ZooBeijing 100044China Department of Medical Research Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Key Laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural Affairs/Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent ServiceCollege of Information EngineeringNorthwest A&F UniversityYangling 712100China institute of Animal Husbandry and Veterinary Medicine Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China State Key Laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China Livestock Genetics Program International Livestock Research InstituteNairobi 00100Kenya

Sheep were domesticated in the Fertile Crescent and then spread globally,where they have been encountering various environmental *** Tibetan sheep has adapted to high altitudes on the Qinghai-Tibet Plateau over the past 3000 *** explore genomic variants associated with high-altitude adaptation in Tibetan sheep,we analyzed Illumina short-reads of 994.whole genomes representing∼60 sheep breeds/populations at varied altitudes,PacBio High fidelity(HiFi)reads of 13 breeds,and 96 transcriptomes from 12 sheep *** testing between the inhabited altitudes and 34.298,967 variants was conducted to investigate the genetic architecture of altitude *** accurate HiFi reads were used to complement the current ovine reference assembly at the most significantly associatedβ-globin locus and to validate the presence of two haplotypes A and B among 13 sheep *** haplotype A carried two homologous gene clusters:(1)HBE1,HBE2,HBB-like,and HBBC,and(2)HBE1-like,HBE2-like,HBB-like,and HBB;while the haplotype B lacked the first *** high-altitude sheep showed highly frequent or nearly fixed haplotype A,while the low-altitude sheep dominated by haplotype *** further demonstrated that sheep with haplotype A had an increased hemoglobin–O2 affinity compared with those carrying haplotype *** highly associated genomic region contained the EGLN1 gene which showed varied expression between high-altitude and low-altitude *** results provide evidence that the rapid adaptive evolution of advantageous alleles play an important role in facilitating the environmental adaptation of Tibetan sheep.

关键词： Environmental adaptation High altitude Hypoxia Selection signature Sheep

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Paleosandstorm characteristics and lake evolution history deduced from investigation on lacustrine sediments——The case of Hongjiannao Lake, Shaanxi Province

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Science Bulletin 2005年第20期 101-107页

作者： SHEN Ji1, wang Yong1,2, YANG Xiangdong1, ZHANG Enlou1, YANG Bao3 & JI Junfeng4. 1. Nanjing institute of Geography and Limnology, chinese academy of {4., Nanjing 210008, China 2. Graduate School, chinese academy of sciences, beijing 100039, China 3. Key Laboratory of Ice and Cold Region Environment, Cold and Arid Regions Environmental and Engineering Research institute, chinese academy of {4., Lanzhou 730000, China 4. institute of Surfacial Geochemistry, State Laboratory of Mineral De- posits Research, Department of Earth {4., Nanjing University, Nanjing 210009, China

Sediment cores from desert lakes serve as good records of the frequency and intensity of sandstorms in his- tory. By multi-proxy analysis of grain-size, magnetic suscep- tibility, TOC and Rb/Sr ratio, the paleosandstorm character- istics and lake evolution history in yulin Area for the past 80 years. are discussed in this article. It is revealed that Hong- jiannao Lake formed in about 1928 A.D. and in its initial stage sandstorms were prevalent with three extremes taking place in 1936 A.D., 1939 A.D. and 194. A.D.. During the ex- pansion period of 1952―1960 A.D., inflow waters to the lake increased sharply and a lot more weathered materials were carried into the lake. The frequency and intensity of sand- storms have reduced a lot since 1960s and the “double peaks” feature of the grain-size frequency curve has changed into the “single peak” feature. Study on the catchment ecol- ogy of the lake shows that the occurrence of sandstorms has been effectively restrained by the forest plantation and water and soil conservation.

关键词： lacustrine sediment paleosandstorm characteristics lake evolution history Hongjiannao Lake.

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DISCOVERY OF THE LATEST MARINE NON-CARBONATE SEDIMENT WESTERN TINGRI, SOUTHERN TIBET

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地学前缘 2000年第S1期7卷 54-55页

作者： Li Xianghui 1, wang Chengshan 1, Hu Xiumian 1, Wan Xiaoqiao 2, and Xu yulin 2(1 institute of Sedimentary Geology, Chengdu University of Technology, Chengdu 610059, China 2 Geology Department, China University of Geosciences, {4. 100083, China

The marine non\|carbonate sediment is exposed at the southwestern flank of the Zhepure Syncline where it lies about 4.km east to the typical cross\|section, Gongzha cross\|section (Hao and Wan, 1985; Willems et al., 1993, 1996) and ca.75km north to the Qomolangma. There are few people who can approach the place of the cross\|section, even so are endemic Tibetan. The cross\|section is named of the Qumiba cross\|section in this abstract. The new discovery, conformed on the massive Zhepure Formation limestone, here is named of Qumiba Formation. It is composed of two series of terrigenous sediments: Enba Member—lower gray shales intercalating with sandstones, and Zhaguo Member—upper reddish shales interbedding with sandstones. Abundant nannofossils with chronological meanings are first found *** Member Common calcareous nannofossils in the Lutetian such as Chiastozygus barbatus, Chiasmolithus sp., Discoaster barbadiensis, Helicosphaera compacta, Reticulofenstra bisecta, Sphenolithus radians are processed in sample S12W1\|S17W1, in which the Helicosphaera compacta and Sphenolithus radians are part of the indicators of the nannofossil zone NP15. So it is proposed that Units S12\|17, 110 m in thickness, could have been deposited during Middle\|Late Lutetian.

关键词： marine non\|carbonate sediment Tingri Southern Tibet

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不同尺度的土壤含水量主被动微波联合反演方法研究

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地学前缘 2024年第2期31卷 42-53页

作者：刘奇鑫顾行发王春梅杨健占玉林中国科学院空天信息创新研究院北京100094 中国科学院大学北京100049 北华航天工业学院遥感信息工程学院河北廊坊065000

土壤含水量是水文、农业和气象等领域的关键参数,而微波遥感是目前监测土壤含水量最有效的手段之一。本文利用主动微波与被动微波数据,结合其他多源遥感数据,运用随机森林算法分别在主动微波数据分辨率尺度和被动微波数据分辨率尺度下... 详细信息

土壤含水量是水文、农业和气象等领域的关键参数,而微波遥感是目前监测土壤含水量最有效的手段之一。本文利用主动微波与被动微波数据,结合其他多源遥感数据,运用随机森林算法分别在主动微波数据分辨率尺度和被动微波数据分辨率尺度下完成主被动微波数据的土壤含水量联合反演。首先对被动微波尺度的地表覆盖类型与归一化植被指数(NDVI)参数进行空间分辨率优化,再利用回归ReliefF方法对两种尺度所用的输入变量的重要性进行评估,并对输入变量进行优选,最后对比主被动微波数据土壤含水量联合反演和单独利用主动/被动微波数据进行反演的精度,分析主被动微波联合反演方法的有效性。结果表明:在主动微波尺度,主被动微波联合反演的精度相比单独利用主动微波数据反演的精度有所提升,相关系数r由0.691升至0.74.,RMSE由0.084. cm^(3)/cm^(3)降至0.0796 cm^(3)/cm^(3);在被动微波尺度,主被动微波联合反演的精度反而比单独利用被动微波数据反演的精度更低,相关系数r由0.94.变为0.939,RMSE由0.04.5 cm^(3)/cm^(3)变为0.04.1 cm^(3)/cm^(3)。因此在主动微波尺度更适合进行主被动微波的联合反演。

关键词：土壤含水量微波遥感联合反演随机森林空间优化重要性评估

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中国北方农牧交错区土地利用类型转换驱动因子分析

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水土保持学报 2004年第4期18卷 113-116页

作者：甘红刘彦随王静吴佩林中国科学院地理科学与资源研究所国土资源部土地利用重点实验室北京100029

依据TM影像解译的土地利用类型转换数据和社会经济数据,以地处中国北方农牧交错区的陕西省榆林市为例,分析了1990～2000年土地利用类型转换的主要驱动因子。自然因子为海拔与坡度,人类驱动因子为治沙种草与造林、农业结构调整、土地退... 详细信息

依据TM影像解译的土地利用类型转换数据和社会经济数据,以地处中国北方农牧交错区的陕西省榆林市为例,分析了1990～2000年土地利用类型转换的主要驱动因子。自然因子为海拔与坡度,人类驱动因子为治沙种草与造林、农业结构调整、土地退化、开垦耕地、建设用地和退耕还林(草);同时运用定性与定量相结合的方法,揭示了土地利用类型转换随海拔和坡度的规律性变化,以及生态建设驱动因子在榆林市土地利用类型转换中起着决定性作用。

关键词：中国北方地区农牧交错区土地利用转换驱动因子

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The differential effects of integrase strand transfer inhibitors and efavirenz on neuropsychiatric conditions and brain imaging in HIV-positive men who have sex with men

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Biosafety and Health 2024年第4期6卷 216-224页

作者： Yihui He Yang Zhang Jiaxin Zhen Guangqiang Sun Zhen Li Bo Yang Bin Yang Keyi Chang Xue Chen yulin Zhang Caiping Guo Wen wang Ping Wu Tong Zhang Lei wang Postgraduate Union Training Base of Jinzhou Medical University PLA Rocket Force Characteristic Medical CenterBeijing 100088China Department of Neurology PLA Rocket Force Characteristic Medical CenterBeijing 100088China Center for Infectious Disease Beijing Youan HospitalCapital Medical UniversityBeijing 100069China beijing Key Laboratory for HIV/AIDS Research Beijing 100069China beijing institute for Sexually Transmitted Disease Control Beijing 100069China beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders and National Center for Mental DisordersBeijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China The Second Hospital of beijing Beijing 100031China Department of Respiratory and Critical Care Medicine Beijing Youan HospitalCapital Medical UniversityBeijing 100069China National institute on Drug Dependence and beijing Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China Key Discipline for Neuroscience of the Ministry of Education Department of NeurobiologySchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Integrase strand transfer inhibitors(INSTIs)have emerged as the first‐line choice for treating human immunodeficiency virus(HIV)infection due to their superior efficacy and ***,the impact of INSTIs on the development of neuropsychiatric conditions in people living with HIV(PLWH)is not fully understood due to limited *** this study,we conducted a cross‐sectional examination of PLWH receiving antiretroviral therapy,with a specific focus on HIV‐positive men who have sex with men(MSM)on INSTI‐based regimens(n=61)and efavirenz(EFV)‐based regimens(n=28).Participants underwent comprehensive neuropsychiatric evaluations and multimodal magnetic resonance imaging(MRI)scans,including T1‐weighted images and resting‐state functional *** to the EFV group,the INSTI group exhibited primarily reduced gray matter volume(GMV)in the right superior parietal gyrus,higher regional homogeneity(ReHo)in the left postcentral gyrus,lower ReHo in the right orbital part of the inferior frontal gyrus,and increased voxel‐wise functional connectivity for the seed region in the left inferior temporal gyrus with clusters in the right ***,the analysis revealed a main effect of antiretroviral drugs on GMV changes,but no main effect of neuropsychiatric disorders or their *** repeated analysis of participants who did not switch regimens confirmed the GMV changes in the INSTI group,validating the initial *** study demonstrated gray matter atrophy and functional brain changes in PLWH on INSTI‐based regimens compared to those on EFV‐based *** neuroimaging results provide valuable insights into the characteristics of brain network modifications in PLWH receiving INSTI‐based regimens。

关键词： Human immunodeficiency virus(HIV) Multimodal magnetic resonance imaging(MRI) Integrase strand transfer inhibitors(INSTIs) Efavirenz(EFV)

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More active glycolytic pathway in esophageal squamous cell carcinoma

More active glycolytic pathway in esophageal squamous cell c...

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全国肿瘤流行病学和肿瘤病因学学术会议

作者： Zhao Xiaohang~1,Liu Fei~1,wang Lishun~2,Liu Siqi~2,wang Rong~3, Xu Ningzhi~1,Xu Yang~1,Sun yulin~1 1 State Key Laboratory of Molecular Oncology,Cancer institute & Hospital,{4. academy of Medical sciences & Peking Union Medical College,beijing 100021,China 2 beijing institute of Genomics,{4. academy of sciences,beijing,101300,China. 3 Department of Genetic and Genomic Science,Department of Structural and Chemical Biology, Mount Sinai,School of Medicine,New York City,NY,USA

Cancer cells are resistant to apoptosis and show a shift in energy production from mitochondrial oxidative phosphorylation to cytosolic *** observe the metabolic reprogramming of esophageal cancer,8 pairs of tissue specimens of esophageal squamous cell carcinoma(ESCC) were separated and identified via 2-DE-MALDI-TOF-MS strategy.A total of 37 differentially expressed proteins were recognized as an exclusive profile that could distinguish ESCC from normal esophagus tissues,including 23 up-regulated and 14.down-regulated proteins. In which,five key proteins of glycolytic pathway were identified overexpressed in ESCC with lymph node *** glucose metabolism and lactate production of ESCC cells were found more active than that of the normal epithelia *** migration of esophageal cancer cells KYSE4.0 was found more effective than that of KYSE30 ***,it was also found KYSE4.0 with higher aerobic glycolysis and invasion capability than that of KYSE30 ***,the oligomycin,a respiration suppressor through suppressing the ATPase-F1 subunit, was enhanced glycolysis of KYSE30 cells,whereas it was no effect on KYSE4.0 *** may be energy supportment of KYSE30 partially depended on oxygen respiration and KYSE4.0 was more depending on *** data suggested that the Warburg effect may also exist in esophageal cancer and cancer cell movement was correlated with aerobic glycolysis.

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基坑开挖过程中埋地管线沉降位移解析计算

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水文地质工程地质 2024年第2期51卷 144-154页

作者：卢玉林何金泽陈晓冉王丽防灾科技学院土木工程学院北京101601 中国地震局建筑物破坏机理与防御重点实验室北京101601 防灾科技学院地质工程学院北京101601

基坑开挖会诱发邻近埋地管线产生沉降变形,获取管线变形量对评估管线的正常使用和安全具有重要意义。基于弹性地基梁理论,建立地下管线沉降位移的计算公式,并分析地表中心沉降量和计算长度对管线沉降位移的影响;根据埋地管线与基坑边缘... 详细信息

基坑开挖会诱发邻近埋地管线产生沉降变形,获取管线变形量对评估管线的正常使用和安全具有重要意义。基于弹性地基梁理论,建立地下管线沉降位移的计算公式,并分析地表中心沉降量和计算长度对管线沉降位移的影响;根据埋地管线与基坑边缘的几何关系,将计算长度取值依据界定为5种工况;通过与两个标定算例对比,验证解析方法的合理性;以北京某基坑工程为例,分析管线沉降位移的时空变化规律。研究结果表明:不同时期的沉降位移计算值和实测值变化趋势一致,但计算值略高于实测值;地表中心沉降量对管线沉降位移影响显著,输入值越大,沉降曲线形状越“凹”,输入值越小,沉降曲线越平缓;管线沉降位移自中心点向两端降低速率依次增加,在边界点附近降低速率减小,范围约为计算长度的1/10。所提方法在管线沉降预估方面偏于保守,是现有埋地管线沉降理论的一个补充,可为施工前期预判管线沉降分布提供重要参考依据。

关键词：基坑开挖地下管线沉降位移解析分析

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基于STFrFT的间歇采样转发干扰抑制

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系统工程与电子技术 2024年第10期46卷 3312-3324页

作者：李晋杰曹运合张钰林王蒙西安电子科技大学雷达信号处理全国重点实验室陕西西安710071 北京机电工程研究所北京100074

干扰机对雷达脉冲快速切片、转发形成间歇采样转发干扰,若从雷达主瓣进入,将对雷达目标检测形成严重威胁。从波形设计和时频分析的角度出发,提出一种基于短时分数阶傅里叶变换(short-time fractional Fourier transform,STFrFT)的主瓣... 详细信息

干扰机对雷达脉冲快速切片、转发形成间歇采样转发干扰,若从雷达主瓣进入,将对雷达目标检测形成严重威胁。从波形设计和时频分析的角度出发,提出一种基于短时分数阶傅里叶变换(short-time fractional Fourier transform,STFrFT)的主瓣间歇采样转发干扰抑制方法。首先设计脉内捷变频信号,提升干扰与目标信号的差异;接着采用STFrFT进行时频分析,相比传统短时傅里叶变换大大提升了时频分辨率,相比分数阶傅里叶变换类方法没有对信号参数的限制;最后结合图像学方法对干扰进行剔除,对从主瓣进入的高干信比干扰也可形成有效抑制。仿真结果表明,所提方法可在多种环境下有效对抗间歇采样转发干扰。

关键词：间歇采样转发干扰短时分数阶傅里叶变换图像处理频率捷变

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RESISTIVITY PRECURSORS AND SPREADING OF FAULT PRIOR TO ITS INSTABILITY

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Science in China,Ser.B 1985年第4期28卷 420-436页

作者：王新华祁贵仲赵玉林 institute of geophysics State Seismological Bureau beijing

Based on fracture mechanics it has been found that earthquake precursors related to volumetric strain e are characterized by quadrants, blind zone and uneven propagation, and the approximate formulae for spreading range of precursor have been obtained. These results are coincident with the information of resistivity ρx observed before the Tangshan earthquake, and then mechanical explanations have been made for some precursors of ρx, such as precursors appearing concentratedly within the period of 1—2 years before the instability of the fault （i.e. subcritical period in which the fault spreads acceleratingly）. Before instability of the spreading of fault, the range of e=10-6 reaches about 150 km, its propagating velocity is about 100 km/yr, the amplification coefficient of ρx is about 104. etc. The half length of fault before instability is about 35km. It seems that in propagating process the spreading of the fault is delayed by barrier.

关键词： spreading blind propagating approximate volumetric instability formulae contour resistivity appearing

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