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Characterization of two SARS-CoV-2 subgenomic RNA dynamics in severe COVID-19 patients

Virologica Sinica 2022年第1期37卷 30-37页

作者： Xiaohui Zou Shengrui Mu Yeming wang Li Guo Lili Ren Xiaoyan Deng Haibo Li Jiankang Zhao yulin Zhang Hui Li Binghuai Lu Chaolin Huang Bin Cao Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineNational Clinical Research Center for Respiratory DiseasesChina-Japan FriendshipHospitalBeijing100029China National Center for Respiratory Medicine Beijing100029China institute of Respiratory Medicine Chinese Academy of Medical SciencesBeijing100029China Department of Pulmonary and Critical Care Medicine Capital Medical UniversityBeijing100069China Tsinghua University-Peking University Joint Center for Life sciences Beijing100029China NHC Key Laboratory of Systems Biology of Pathogens and Christophe M erieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences&PekingUnion Medical CollegeBeijing100176China Jin Yin-tan Hospital Wuhan430013Hubei ProvinceChina

Little is known about Subgenomic RNA(sgRNA)dynamics in patients with Coronavirus diseases 2019(COVID-19).We collected 14. throat swabs,74.gut swabs and 4. plasma samples from 117 COVID-19 patients recruited in the LOTUS China trial(ChiCTR2000029308)and compared E and orf7a sgRNA load in patients with different illness duration,outcome,and *** sgRNAs were detected in all the three types of samples,with longest duration of 25,13,and 17 days for E sgRNA,and 32,28,and 17 days for orf7a sgRNA in throat,gut,and plasma,respectively.A total of 95%(57/60)of patients had no E sgRNA detected after 10 days post treatment,though 86%of them were still E RNA *** correlation on titer was observed between sgRNA encoding E and orf7a *** showed similar variation in the standard care and Lopinavir-Ritonavir *** with diabetes and heart diseases showed higher pharyngeal E sgRNA at the first day(P=0.016 and 0.013,respectively)but no difference at five days after treatment,compared with patients without such *** with hypertension and cerebrovascular diseases showed no difference in the pharyngeal sgRNA levels at both one and five days after treatment,compared with patients without these two commodities.E sgRNA levels in the initial infection showed no correlation with the serum antibody against spike,nucleoprotein,and receptor binding domains at ten days *** lasted a long period in COVID-19 patients and might have little effect on humoral response.

关键词： SARS-CoV-2 Subgenomic RNA(sgRNA) Viral load Antibody

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New Discovery of the 34. Ma Gabbro at Xiongcun District in the Southern Margin of Lhasa Terrane, Tibet

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Acta Geologica Sinica(English Edition) 2018年第1期92卷 420-421页

作者： LANG Xinghai LIU Dong DENG yulin TANG Juxing XIE Fuwei YANG Zongyao CUI Zhiwei wang Xuhui LI Zhijun ZHANG Zhong ZHANG Jinshu HUANG Yong College of Earth sciences and MLR Key Laboratory of Tectonic Controls on Mineralization and Hydrocarbon Accumulation Chengdu University of Technology Chengdu 610059 Sichuan China College of Management Science Chengdu University of Technology Chengdu 610059 Sichuan China institute of Mineral Resources Chinese Academy of Geological Sciences Beijing 100037 China Faculty of Geosciences and Environmental Engineering Southwest Jiaotong University Chengdu 611756 Sichuan China Tibet Tianyuan Minerals Exploration Co. Ltd Rikaze 857000 Tibet China College of Engineering Tibet University Lhasa 850012 Tibet China Chengdu Center of China Geological Survey Chengdu 610081 Sichuan China

Objective Lhasa terrane has recorded the geologic history conceming the formation and evolution of Paleo-Tethys and the intra-continental convergence in Qinghai-Tibet Plateau （Yin and Harrison, 2000）. Previous investigations have focused on the initial timing of the India-Asia collision and the Cretaceous-Cenozoic magmatism and sedimentation （wang Tianyang et al., 2017）, however, there are only few studies concerning the Paleozoic evolution in Lhasa terrane. This paper mainly reports a new discovery of 34. Ma gabbro, which is located in the Xiongcun copper-gold district at the southern margin of Lhasa terrane, Tibet. As an important magmatic record during the Paleozoic evolution process of Lhasa terrane, the Early Carboniferous Xiongcun gabbro will provide new constraints for the tectonic evolution of Paleo-Tethys Ocean in the Late Devonian to Early Carboniferous.

关键词： Ma Gabbro Tibet Xiongcun District

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Observation of Mott instability at the valence transition of f-electron system

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National Science Review 2023年第6期10卷 183-190页

作者： Haifeng Yang Jingjing Gao Yingying Cao Yuanji Xu Aiji Liang Xiang Xu Yujie Chen Shuai Liu Kui Huang Lixuan Xu Chengwei wang Shengtao Cui Meixiao wang Lexian Yang Xuan Luo Yuping Sun Yi-feng Yang Zhongkai Liu yulin Chen School of Physical Science and Technology Shanghai Tech University Key Laboratory of Materials Physics Institute of Solid State Physics Chinese Academy of Sciences Science Island Branch of Graduate School University of Science and Technology of China beijing National Laboratory for Condensed Matter Physics and institute of Physics Chinese Academy of Sciences University of chinese academy of sciences Shanghai Tech Laboratory for Topological Physics State Key Laboratory of Low Dimensional Quantum Physics and Department of Physics Tsinghua University State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology (SIMIT) Chinese Academy of Sciences High Magnetic Field Laboratory Chinese Academy of Sciences Collaborative Innovation Center of Microstructures Nanjing University Songshan Lake Materials Laboratory Department of Physics University of Oxford

Mott physics plays a critical role in materials with strong ele ctronic *** insulator-to-metal transition can be driven by chemical doping,external pressure,temperature and gate voltage,which is often seen in transition metal oxides with 3d electrons near the Fermi energy(*** superconductor).In4.-electron systems,however,the insulator-to-metal transition is mostly driven by Kondo hybridization and the Mott physics has rarely been explored in ***,by combining the angle-resolved photo emission spectroscopy and strongly correlated band structure calculations,we show that an unusual Mott instability exists in YbInCu4.ccompanying its mysterious first-order valence *** contrasts with the prevalent Kondo picture and demonstrates that YbInCu4.s a unique platform to explore the Mott physics in Kondo lattice *** work provides important insight for the understanding and manipulation of correlated quantum phenomena in the f-electron system.

关键词： valence transition orbital-selectiveMott transition Kondo coupling heavy fermions strong correlations ARPES DMFT

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1967~2033 nm波段硅基可调谐外腔半导体激光器设计与仿真

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中国激光 2024年第6期51卷 74-83页

作者：万浩然杨禹霖乔忠良李翔 Jia Xu Brian Sia 余文军翁登群李再金李林陈浩赵志斌薄报学高欣曲轶刘重阳汪宏张宇牛智川海南师范大学物理与电子工程学院海南省激光技术与光电子功能材料重点实验室半导体激光海南省国际联合研究中心海南海口571158 新加坡南洋理工大学电气与电子工程学院新加坡639798 新加坡南洋理工大学淡马锡实验室新加坡637553 中国科学院半导体研究所半导体超晶格国家重点实验室北京100083 长春理工大学高功率半导体激光器国家重点实验室吉林长春130022

2μm波长附近可调谐半导体激光器在分子光谱学和光通信领域中有广阔的应用前景。基于绝缘体上硅(SOI)平台,对2μm波长附近可调谐半导体激光器的外腔部分进行了设计优化。分析了不同尺寸光波导的模式损耗特性、单个微环谐振腔受总线波导... 详细信息

2μm波长附近可调谐半导体激光器在分子光谱学和光通信领域中有广阔的应用前景。基于绝缘体上硅(SOI)平台,对2μm波长附近可调谐半导体激光器的外腔部分进行了设计优化。分析了不同尺寸光波导的模式损耗特性、单个微环谐振腔受总线波导耦合间距的作用以及总线波导光反馈终端对外腔半导体激光器性能的影响。并提出了一种具有高工艺兼容度的多模环形光波导光反馈结构。所设计的可调谐半导体激光器硅基外腔可通过环形波导上的镍铬合金微加热器进行0.1 nm/K的高精度调谐,对单个微加热器施加3.2 V电压时,调谐范围可达66 nm(1967~2033 nm)。

关键词：硅光集成可调谐外腔半导体激光器环形谐振腔光波导终端

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荒漠化重建地区土壤有机碳动态研究

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水土保持学报 2004年第3期18卷 74-77,89页

作者：程淑兰欧阳华牛海山王琳田玉强张锋中国科学院地理科学与资源研究所北京100101 中国科学院研究生院北京100039

土壤有机碳(Soilorganiccarbon,SOC)是反映土地荒漠化的重要指标。本研究以陕西省榆林市为例,开展小区域沙漠化重建地区SOC动态的实证研究。SOC数据来源于1982年土壤普查和2003年重复采样,土样的采集、分析和统计方法分别为土钻取土法... 详细信息

土壤有机碳(Soilorganiccarbon,SOC)是反映土地荒漠化的重要指标。本研究以陕西省榆林市为例,开展小区域沙漠化重建地区SOC动态的实证研究。SOC数据来源于1982年土壤普查和2003年重复采样,土样的采集、分析和统计方法分别为土钻取土法、重铬酸钾氧化法、吸管法和面积加权法。研究结果表明:SOC含量与粗砂粒显著负相关(R=-0.50,a=0.01),与粘粒显著正相关(R=-0.4.,a=0.05),20年间土壤颗粒细化趋势比较明显;20年间原始剖面、1m深和耕层SOC含量、密度和储量都有不同程度的增加,其中对人类活动最敏感的耕层土壤变化最显著,SOC含量、密度和储量分别增加了0.55g/kg,0.15kg/m2,10.07GgC。该研究结果表明防风固沙、可持续性农耕等措施会卓有成效地促进土地沙漠化的恢复和重建。

关键词：荒漠化重建地区土壤有机碳动态分析

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Soil bacterial communities interact with silicon fraction transformation and promote rice yield after long-term straw return

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Soil Ecology Letters 2021年第4期3卷 395-408页

作者： Alin Song Zimin Li yulin Liao Yongchao Liang Enzhao wang Sai wang Xu Li Jingjing Bi Zhiyuan Si Yanhong Lu Jun Nie Fenliang Fan Key Laboratory of Plant Nutrition and Fertilizer Ministry of Agriculture and Rural Affairs/Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China Earth and Life institute Soil SciencesUniversitécatholique de Louvain(UCLouvain)Croix du Sud 2/L7.05.101348 Louvain‐la‐NeuveBelgium Soil and Fertilizer institute of Hunan province Hunan Academy of Agricultural SciencesChangsha 410125China Ministry of Education Key Laboratory of Environment Remediation and Ecological Health College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China

Returning crop straw into the soil is an important practice to balance biogenic and bioavailable silicon(Si)pool in paddy,which is crucial for the healthy growth of ***,owing to little knowledge about soil microbial communities responsible for straw degradation,how straw return affects Si bioavailability,its uptake,and rice yield remains ***,we investigate the change of soil Si fractions and microbial community in a 39-year-old paddy field amended by a long-term straw *** show that rice straw return significantly increased soil bioavailable Si and rice yield from 29.9%to 61.6%and from 14.5%to 23.6%,respectively,when compared to NPK fertilization *** return significantly altered soil microbial community *** was positively and significantly related to amorphous Si,while Rokubacteria at phylum level,Deltaproteobacteria,and Holophagae at class level was negatively and significantly related to organic matter adsorbed and Fe/Mn-oxide-combined Si in *** analysis of their correlations further demonstrated that Si status significantly explained 12%of soil bacterial community *** findings suggest that soil bacteria community and diversity interact with Si mobility by altering its transformation,thus resulting in the balance of various nutrient sources to drive biological Si cycle in agroecosystem.

关键词： Bacterial community Long-term Silicon fractions Straw returning Silicon cycle

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新一代无创产前筛查技术NIPT2.0临床应用策略专家共识

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中华医学遗传学杂志 2024年第10期41卷 1155-1163页

作者：中国妇幼保健协会生育保健分会徐晨明阴赪宏尹爱华刘珊玲蒋宇林罗琼王华黄荷凤不详复旦大学附属妇产科医院遗传中心上海200011 首都医科大学附属北京妇产医院/北京妇幼保健院产前诊断中心北京100026 广东省妇幼保健院医学遗传中心广州510010 四川大学华西第二医院医学遗传科/产前诊断中心成都610041 北京协和医院产科北京100730 浙江大学医学院附属妇产科医院妇产科杭州310006 湖南省儿童医院医学遗传科国家卫健委出生缺陷研究与预防重点实验室长沙410021 复旦大学生殖与发育研究院上海200433

新一代无创产前筛查技术(NIPT2.0)是近年来基于高通量测序成功实现的对胎儿染色体非整倍体、微缺失/微重复综合征和显性单基因遗传病进行同步筛查的新型无创产前检测方法。NIPT2.0弥补了上一代无创产前筛查技术(NIPT和NIPT Plus)无法检... 详细信息

新一代无创产前筛查技术(NIPT2.0)是近年来基于高通量测序成功实现的对胎儿染色体非整倍体、微缺失/微重复综合征和显性单基因遗传病进行同步筛查的新型无创产前检测方法。NIPT2.0弥补了上一代无创产前筛查技术(NIPT和NIPT Plus)无法检测胎儿单基因遗传病、对部分染色体异常(尤其是13三体、性染色体异常和部分微缺失/微重复综合征)检测不够准确、阳性预测值较低的缺陷。如何合理、规范地应用NIPT2.0,最大限度地发挥其临床价值,已成为亟待明确的问题。鉴于此,中国妇幼保健协会生育保健分会组织专家对上述问题进行了充分的讨论,共同起草了本共识,对NIPT2.0的临床应用策略,包括适用范围、目标疾病、检测前咨询、临床应用路径、检测后遗传咨询和干预、质量控制、局限性等方面提出建议,供国内同行参考,以规范其应用,更好地为临床服务。

关键词：无创产前筛查染色体异常显性单基因遗传病专家共识

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Transmission of Carbapenem Resistance Between Human and Animal NDM-Positive Escherichia coli Strains

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Engineering 2022年第8期8卷 24-33页

作者： Yingbo Shen Fupin Hu Yongqiang wang Dandan Yin Lu Yang Yiqiang Chen Chunyan Xu Jiyun Li Junyao Jiang Xueyang wang yulin Fu Dongyan Shao Dejun Liu Tengfei Ma Chang Cai Zhangqi Shen Shaolin wang Juan Li Rong Zhang Yuebin Ke Congming Wu Jianzhong Shen Timothy R.Walsh Yang wang beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China institute of Antibiotics&Key Laboratory of Clinical Pharmacology of Antibiotics(MoH) Huashan HospitalFudan UniversityShanghai 200040China Department of Preventive Veterinary Medicine College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China College of Animal Science and Technology College of Veterinary MedicineZhejiang A and F UniversityHangzhou 311300China State Key Laboratory for Infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention(CDC)Beijing 102206China The Second Affiliated Hospital of Zhejiang University Zhejiang UniversityHangzhou 310009China Key Laboratory of Genetics&Molecular Medicine of Shenzhen Shenzhen Center for Disease Control and PreventionShenzhen 518055China Department of Zoology University of OxfordOxford OX13SZUK

Although carbapenem use is prohibited in animals in China,carbapenem-resistant Escherichia coli(CREC),especially New Delhi metallo-β-lactamase(NDM)-producing strains,are widely prevalent in foodproducing *** present,the impact of livestock-associated CREC strains on human populations at the national level is ***,we conduct a retrospective cross-sectional study to investigate the prevalence of CREC from clinical settings across 22 chinese provinces or municipalities and analyze anthropogenic factors associated with their *** also ascertain the blaNDMand blaKPCabundance among pig and chicken farms and present a detailed genomic framework for CREC of animal and human ***,631/29799(2.1%)clinical Escherichia coli(***)isolates were identified as *** analysis revealed that being male,an age below 1,an age between 13 and 18,provinces with greater chicken production,and provinces with higher pig production were associated with higher odds of CREC *** general,73.8%(n=4./61)of pig farms and 62.2%(n=28/4.)of chicken farms had a blaNDMabundance of 1×10^(-5)to 1×10^(-3)and 1×10^(-3)to 1×10^(-2),*** all the chinese NDM-positive ***(n=4.3)available at the National Center for Biotechnology Information(NCBI),the genomic analysis revealed that blaNDM-5and Inc X3 were the predominant carbapenemase gene-plasmid combination,while a highly homogeneous relationship between NDM-positive isolates from humans and animals was demonstrated at the plasmid and core genome *** the findings suggest frequent CREC transmission between humans and animals,indicating that further discussions on the use of antibiotics in animals and humans are needed,both in China and across the globe.

关键词： Carbapenem resistance Escherichia coli blaNDM-5 One Health Antimicrobial resistance transmission

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Haplotype-resolved and chromosome-level genome assembly of Colorado potato beetle

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Journal of Genetics and Genomics 2023年第7期50卷 532-535页

作者： Ziqi Ye Ruirui Lu Chao Li Doudou Yang Zhuozhen Zeng Weichao Lin Jie Cheng Zhongmin Yang Li wang yulin Gao Sanwen Huang Xingtan Zhang Suhua Li Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsChinese Academy of Agricultural SciencesShenzhenGuangdong 518000China Key Laboratory of Prevention and Control of Invasive Alien Species in Agriculture&Forestry of the North-western Desert Oasis Ministry of Agriculture and Rural AffairsCollege of AgronomyXinjiang Agricultural UniversityUrumqiXinjiang Uygur Autonomous Region 830052China School of Life sciences Henan UniversityKaifengHenan 475004China Shenzhen Research institute of Henan University ShenzhenGuangdong 518000China College of Horticulture Xinjiang Agricultural UniversityUrumuqiXinjiang Uygur Autonomous Region 830052China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China chinese academy of Tropical Agricultural sciences HaikouHainan 571101China

As the most important non-cereal food crop,potatoes are a staple food for 1.3 billion people(Stokstad,2019).However,these cultivated potatoes are challenged with multiple biotic stresses(i.e.,pathogens and pests),some of which can evade host resistance,leading to a serious dampening of potato *** of these pests is the Colorado potato beetle(hereafter referred to as CPB,Leptinotarsa decemlineata Say).CPB is a member of the order Coleoptera,and originated in the southwestern United States and Mexico(Alyokhin et al.,2008).

关键词： originated hereafter

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对二甲苯吸附剂的结构与组成分析

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石化技术 2004年第2期11卷 45-50页

作者：王玉林张春启中国石油化工股份有限公司北京燕山分公司研究院北京102500

研究了用于二甲苯分离的分子筛,有选择性地考察了分子筛的物化参数如分子筛的晶胞参数、化学硅铝比与结构硅铝比、分子筛含水量等,以及这些参数之间的相互影响,并与国外同类产品的结构特点进行了详细对比。

关键词：对二甲苯分子筛晶胞吸附剂扩孔剂 X-光能量色散法 EDS 氧化钡

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