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The First Crested Duck Genome Reveals Clues to Genetic Compensation and Crest Cushion Formation

Genomics, Proteomics & Bioinformatics 2023年第3期21卷 483-500页

作者： Guobin Chang Xiaoya Yuan Qixin Guo Hao Bai Xiaofang Cao Meng Liu Zhixiu wang Bichun Li Shasha wang Yong Jiang Zhiquan wang Yang Zhang Qi Xu Qianqian Song Rui Pan Lingling Qiu Tiantian Gu Xinsheng Wu yulin Bi Zhengfeng Cao Yu Zhang Yang Chen Hong Li Jianfeng Liu wangcheng Dai Guohong Chen Key Laboratory of Animal Genetics and Breeding and Molecular Design of Jiangsu Province College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety Ministry of EducationInstitutes of Agricultural Science and Technology DevelopmentYangzhou UniversityYangzhou 225009China Novogene Bioinformatics institute Beijing 100080China Department of Agricultural Foodand Nutritional SciencesUniversity of AlbertaEdmontonAB T6G 2R3Canada College of Animal Science and Technology China Agricultural UniversityBeijing 100091China Zhenjiang Tiancheng Agricultural Science and Technology Co. LtdZhenjiang 210034China

The chinese crested(CC)duck is a unique indigenous waterfowl breed,which has a crest cushion that affects its survival ***,the CC duck is an ideal model to investigate the genetic compensation response to maintain genetic *** the present study,we first generated a chromosome-level genome of CC *** genomics revealed that genes related to tissue repair,immune function,and tumors were under strong positive selection,indicating that these adaptive changes might enhance cancer resistance and immune response to maintain the genetic stability of CC *** also assembled a chinese spot-billed(Csp-b)duck genome,and detected the structural variations(SVs)in the genome assemblies of three ducks(i.e.,CC duck,Csp-b duck,and Peking duck).Functional analysis revealed that several SVs were related to the immune system of CC ducks,further strongly suggesting that genetic compensation in the anti-tumor and immune systems supports the survival of CC ***,we confirmed that the CC duck originated from the mallard ***,we revealed the physiological and genetic basis of crest traits and identified a causative mutation in TAS2.40 that leads to crest ***,the findings of this study provide new insights into the role of genetic compensation in adaptive evolution.

关键词： Genetic compensation Genome assembly chinese crested duck Crest cushion Genome adaptive evolution

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膳食纤维和阿魏酸对面团醒发过程中麦谷蛋白大聚体聚集态的影响及其分子间相互作用

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中国食品学报 2023年第6期23卷 92-102页

作者：冯钰琳张慧娟王静北京工商大学食品与健康学院中国-加拿大食品营养与健康联合实验室(北京)、国家市场监管食品特殊监管技术重点实验室北京100048

本文通过测定蛋白质粒径分布、分子质量分布及亚基变化探究膳食纤维(DF)与阿魏酸(FA)在面团醒发过程中对麦谷蛋白大聚体(GMP)聚集态的影响;同时通过荧光光谱、紫外光谱及游离氨基含量的测定探究膳食纤维与阿魏酸与GMP蛋白质分子之间的... 详细信息

本文通过测定蛋白质粒径分布、分子质量分布及亚基变化探究膳食纤维(DF)与阿魏酸(FA)在面团醒发过程中对麦谷蛋白大聚体(GMP)聚集态的影响;同时通过荧光光谱、紫外光谱及游离氨基含量的测定探究膳食纤维与阿魏酸与GMP蛋白质分子之间的相互作用。结果表明,在面团醒发过程中GMP由小粒径(11μm)聚集为大粒径(>50μm)。FA会使较高分子质量范围的谷蛋白亚基发生解聚,DF+FA可以降低这种解聚作用对GMP分子质量分布的影响,将亚基比值维持在0.2.。荧光光谱与紫外光谱表明,FA使含有色氨酸与酪氨酸残基的蛋白结构段暴露在极性更强的水相环境中。DF与FA与GMP之间可能通过共价交联作用使蛋白质分子中游离氨基含量分别显著下降(P2..48%与17.38%(面团醒发90min时),导致蛋白质结构发生变化。结论 :DF与FA的添加会对GMP蛋白质的分子聚集产生影响,并且会与GMP蛋白质之间产生分子间相互作用,使GMP的结构产生变化。

关键词：膳食纤维阿魏酸麦谷蛋白大聚体分子聚集相互作用

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A model for anticancer surveillance was pharmacologically developed to evaluate vitality principle in breast cancer rats

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Journal of Traditional chinese Medicine 2018年第6期38卷 823-833页

作者： Liu Jinyu Zhang Mengyang Zhao Xin Ge Shasha Li Shuang Peng Lin Mu Yuxue Chen Chen Li Xiaoya Zhang Rui Feng Xuanye Deng Bo Jia Liqun Lin yulin wang Yueqi Cheng Zhiqiang TaeHoo Yi Cai Dayong Research Center for Pharmcology and Toxicology Institute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100193China College of Basic Medicine Beijing University of Chinese MedicineBeijing 100029China Oncology Department of chinese Medicine China-Japan Friendship HospitalBeijing 100029China College of Life sciences Kyung Hee UniversityYongin-siGyeonggi-do 17104Republic of Korea

OBJECTIVE: To evaluate vitality principle in breast cancer rats by pharmacologically developing a model for anticancer ***: The breast cancer in rats was replicated with 7,12.Dimethylbenz[a]anthracene(DMBA, i.g.,100 mg/kg) at d_(001). The anticancer surveillance was defined as the intervals between the primary sensitization and the first challenge stirred with complete Freund's adjuvant(CFA), the various intervals(k = 0.80) were dominated from d_(02.)(600.00 h) to d_(095)(2.88.82.h). The optimal surveillant status was confirmed with the median effective interval(EI_(50))from tumor volume regressive curve, for developing the pharmacodynamic model. The tumor and tumor infiltrating lymphocyte histopathology was used to confirm the immune surveillance being affected with CFA in breast cancer *** availability of this model was confirmed with Shugan Liangxue prescription(SLP), from the vitality principle, and assured further from interleukin-12.***: The regressive curve was set up between the intervals and tumor volumes, the EI_(50) in SLP-treated rats(1475.00 h, Y_(SLP)= 0.102. +0.8780/[1 + 10^(2..142.-8.565x)]) was postponed, which was 1.87 multiple of the EI_(50) in CFA rats(791.40 h, y =-0.052. + 0.9452.[1 + 10^(30.4870-10.52.)], so did prepone the curve between the intervals and the immunological biomarker, serum interleukin-12.levels, the EI_(50) in SLP-treated rats(744.90 h, Y_(SLP)=-0.0145 + 0.7455/[1 + 10^(52.09636-18.13x)]) be 0.78 multiple of the EI_(50) in CFA rats(960.10 h, Y_(CFA)= 0.2.60 + 0.72.0/[1 + 10^(-67.1546 +2..52.)]), this immunological action being mediated the anticancer prognosis. Tumor histology was confirmed the more tumor infiltrating lymphocytes activated in SLP rats with CFA stirred immunity than rats only received ***: The model for anticancer surveillance was pharmacologically established as the optimal interval(791.40 h) between the primary sensitization and the first challenge stirred

关键词： Breast cancer Pharmacology Drug screening assays,antitumor Freund's adjuvant Shugan Liangxue prespriction

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Stretchable graded multichannel self-powered respiratory sensor inspired by shark gill

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Fundamental Research 2022年第4期2卷 619-628页

作者： Yang Zou Yansong Gai Puchuan Tan Dongjie Jiang Xuecheng Qu Jiangtao Xue Han Ouyang Bojing Shi Linlin Li Dan Luo yulin Deng Zhou Li Zhong Lin wang School of Life Science Institute of Enginering MedicinBejing Institute of TechnologyBejing 10oo81China CAs Center for Excellence in Nanoscience Bejing Key Laboratory of Micro-Nano Energy and SensorBejing Instute of Nanoenergy and NanosystemsChinese Acadermy of SciencesBeijing 101400China Center on Nanoenergy Research School of Chemistry and Chemical Engineering School of Physical Science and TechnologyGuangxi UniversiyNanning 53004China Key Laboratory for Biomechanics and Mechanobiology of chinese Education Ministry Bejing Advanced Inovation Centre for Biomedical Engieering School of Biological Science and Medical EngineringBeihang UniversityBejing 100083China School of Nanoscience and Technology Universiy of Chinese Academy of ScienesBejing 100049China

Respiratory sensing provides a simple,non-invasive,and efficient way for medical diagnosis and health monitoring,but it relies on sensors that are conformal,accurate,durable,and sustainable ***,a stretchgll structure can convert transverse elastic deformation into longitudinal elastic deformation during ***,multichannel respiratory sensor inspired by the structure of shark gill cleftis *** bionic shark Combining the optimized bionic shark gll structure with the piezoelectric and the triboelectric effect,the bionic shark gill respiratory sensor(BSG-RS)can produce a graded electrical response to different tensile *** on this feature,BSG-RS can simultaneously monitor the breathing rate and breathing depth of the human body accurately,and realize the effective recognition of the different human body's breathing state under the supporting software,With good stretchability,wearabilit,acuracy,and long-term stability(50,0oo cycles),BSG-RS is expected to be applied as self-powered smart wearables for mobile medical diagnostic analysis in the future.

关键词： Bionic Sharkgill Graded Multichannel Respiratory sensing

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A unified deep-learning network to accurately segment insulin granules of different animal models imaged under different electron microscopy methodologies

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Protein & Cell 2019年第4期10卷 306-311页

作者： Xiaoya Zhang Xiaohong Peng Chengsheng Han Wenzhen Zhu Lisi Wei yulin Zhang Yi wang Xiuqin Zhang Hao Tang Jianshe Zhang Xiaojun Xu Fengping Feng Yanhong Xue Erlin Yao Guangming Tan Tao Xu Liangyi Chen State Key Laboratory of Membrane Biology Beijing Key Laboratory of Cardiometabolic Molecular Medicine Institute of Molecular Medicine Peking University Beijing 100871 China. Drug Discovery Center Key Laboratory of Chemical Genomics Peking University Shenzhen Graduate School Shenzhen 518055 China. University of chinese Academy of sciences Beijing 100049 China. Marine Science College of Zhejiang Ocean University National Engineering Research Center of Marine Facilities Aquaculture Zhoushan 316022 China. National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China. National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China. xueyanhong@***. University of chinese Academy of sciences Beijing 100049 China. yaoerlin@***.

Insulin is important for body metabolism regulation and glucose homeostasis,and its dysregulation often leads to metabolic syndrome(MS)and *** is normally stored in large dense-core vesicles(LDCVs)in pancreatic beta cells,and significant reductions in the number,size,gray level and density of insulin granules confer diabetes both in mice(Xue et al.,2.12.and humans(Masini et al.,2.12..

关键词： deep-learning network animal

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中国先进研究堆应用及未来发展

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原子能科学技术 2020年第S1期54卷 213-217页

作者：王玉林朱吉印甄建霄中国原子能科学研究院反应堆工程技术研究部北京102413

中国先进研究堆(CARR)是我国2.世纪建成的高性能的多用途研究堆,是开展中子物理基础研究与应用、反应堆燃料与材料辐照性能研究以及放射性同位素辐照研发的重要科学研究和实验应用平台。CARR采用反中子阱型结构设计,以提供充分的空间进... 详细信息

中国先进研究堆(CARR)是我国2.世纪建成的高性能的多用途研究堆,是开展中子物理基础研究与应用、反应堆燃料与材料辐照性能研究以及放射性同位素辐照研发的重要科学研究和实验应用平台。CARR采用反中子阱型结构设计,以提供充分的空间进行水平中子束流孔道和垂直辐照孔道布置,提高了实验研究和辐照考验综合能力,满足多用途的需要。本文概要介绍CARR实验应用设施、主要用途、辐照与实验应用能力,以及这一科学研究平台的综合利用能力提升规划与未来发展。

关键词：中国先进研究堆实验应用辐照试验未来发展

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Insulating materials for realising carbon neutrality:Opportunities,remaining issues and challenges

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High Voltage 2022年第4期7卷 610-632页

作者： Chuanyang Li Yang Yang Guoqiang Xu Yao Zhou Mengshuo Jia Shaolong Zhong Yu Gao Chanyeop Park Qiang Liu Yalin wang Shakeel Akram Xiaoliang Zeng Yi Li Fangwei Liang Bin Cui Junpeng Fang Lingling Tang yulin Zeng Xingtao Hu Jiachen Gao Giovanni Mazzanti Jinliang He Jianxiao wang Davide Fabiani Gilbert Teyssedre Yang Cao Feipeng wang Yunlong Zi The State Key Laboratory of Power System Department of Electrical EngineeringTsinghua UniversityBeijingChina Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong KongChina Simpson Querrey institute Northwestern UniversityEvanstonIllinoisUSA Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA Department of Information Technology and Electrical Engineering ETH ZürichZürichSwitzerland School of Electrical and Information Engineering Tianjin UniversityTianjinChina Department of Electrical and Computer Engineering Mississippi State UniversityMississippi StateMississippiUSA Electrical and Electronic Engineering The University of ManchesterManchesterUK Department of Electrical Engineering School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghaiChina Key Laboratory of Control of Power Transmission and Conversion(SJTU) Ministry of EducationShanghaiChina College of Electrical Engineering Sichuan UniversityChengduChina Shenzhen institute of Advanced Technology Chinese Academy of Sciences ShenzhenShenzhenChina School of Electrical Engineering Wuhan UniversityWuhanChina School of Integrated Circuits Tsinghua UniversityBeijingChina Jiangsu Jinxin Electric Appliance Co.Ltd. YangzhouChina Tai'an Tiancheng Safety Evaluation Co. Ltd.Tai'anChina Department Electrical Electronic and Information EngineeringUniversity of BolognaBolognaItaly National Engineering Laboratory for Big Data Analysis and Applications Peking UniversityBeijingChina Laplace Paul Sabatier Universityand CNRSToulouseFrance Electrical and Computer Engineering University of ConnecticutStorrsConnecticutUSA State Key Laboratory of Power Transmission Equipment&System Security and New Technology School of Electrical EngineeringChongqing UniversityChongqingChina Thrust of Sustainable Energy and Environment The Hong Kong University of Science and Technology(Guangzhou)GuangzhouChina De

The 2.50 carbon-neutral vision spawns a novel energy structure revolution,and the construction of the future energy structure is based on equipment *** material,as the core of electrical power equipment and electrified transportation asset,faces unprecedented challenges and *** goal of carbon neutral and the urgent need for innovation in electric power equipment and electrification assets are first *** engineering challenges constrained by the insulation system in future electric power equipment/devices and electrified transportation assets are *** materials,including intelligent insulating material,high thermal conductivity insulating material,high energy storage density insulating material,extreme environment resistant insulating material,and environmental-friendly insulating material,are cat-egorised with their scientific issues,opportunities and challenges under the goal of carbon neutrality being *** the context of carbon neutrality,not only improves the understanding of the insulation problems from a macro level,that is,electrical power equipment and electrified transportation asset,but also offers opportunities,remaining issues and challenges from the insulating material *** is hoped that this paper en-visions the challenges regarding design and reliability of insulations in electrical equipment and electric vehicles in the context of policies towards carbon neutrality *** authors also hope that this paper can be helpful in future development and research of novel insulating materials,which promote the realisation of the carbon-neutral vision.

关键词： neutral insulation extreme

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Modes of genetic adaptations underlying functional innovations in the rumen

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Science china(Life sciences) 2021年第1期64卷 1-21页

作者： Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini wang Yu wang Chen Zhao Yong wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang yulin Chen Xihong wang Qiang Qiu Brian PDalrymple Wen wang Yu Jiang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling712100China School of Ecology and Environment Northwestern Polytechnical UniversityXi’an710072China Section for Computational and RNA Biology Department of BiologyUniversity of CopenhagenCopenhagenDK-2100Denmark University of chinese Academy of sciences Beijing100049China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming650223China CEMS NCMISMDISAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing100080China Marine Mammal and Marine Bioacoustics Laboratory Institute of Deep-sea Science and EngineeringChinese Academy of SciencesSanya572000China College of Life sciences Shihezi UniversityShihezi832003China State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of Animal Science and TechnologyGuangxi UniversityNanning530005China College of Animal Science and Technology Yangzhou UniversityYangzhou225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of china Yangzhou UniversityYangzhou225009China Key Laboratory for Major Obstetric Diseases of Guangdong Province The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150China School of Life Science and Technology Shanghai Tech UniversityShanghai201210China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing210095China College of Veterinary Medicine Shaanxi Centre of Stem Cells Engineering&TechnologyNorthwest A&F UniversityYangling712100China Department of Special Economic Animal Nutrition and Feed Science Institute of Special Animal and Plant SciencesChinese Academy of Agricultural SciencesChangchun130112China Section for Ecology and Evolution Department of BiologyUniversity of CopenhagenCopenhagenDK-2100Denmark china National GeneBank BGI-ShenzhenShen

The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant *** analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional *** identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other *** genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen *** modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory *** validated that the key ketogenesis rate-limiting gene(HMGCS2.with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other *** newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community ***,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene *** results greatly improve our understanding of rumen evolution and organ evo-devo in general.

关键词： rumen innovations comparative transcriptomics comparative genomics evo-devo evolution of organs

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桂南花岗岩残积土边坡稳定性分析及坡率优化建议

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路基工程 2024年第2期 107-110页

作者：王豪中铁第五勘察设计院集团有限公司北京100162

基于桂南地区岑溪—大新公路信宜至玉林(广西段)高速公路地质勘察资料,统计分析花岗岩残积土室内试验指标的规律及变异性,结合现场调查情况开展非饱和渗流应力耦合花岗岩残积土边坡稳定性数值模拟,研究降雨条件下不同边坡坡率与稳定系... 详细信息

基于桂南地区岑溪—大新公路信宜至玉林(广西段)高速公路地质勘察资料,统计分析花岗岩残积土室内试验指标的规律及变异性,结合现场调查情况开展非饱和渗流应力耦合花岗岩残积土边坡稳定性数值模拟,研究降雨条件下不同边坡坡率与稳定系数的关系。结果表明:花岗岩残积土物理力学指标具有明显的变异性,黏聚力指标变异性最大;花岗岩残积土边坡坡率较缓时增加了降雨入渗及冲刷,但过陡又容易引起边坡失稳;边坡坡率为1∶0.75时可充分利用花岗岩残积土自身强度。建议边坡设计时设置合理坡率,可采用上缓下陡、分级开挖方案,单级边坡坡率取1∶0.75~1∶1.50(上部边坡坡率可适当放缓)。

关键词：花岗岩残积土参数统计流固耦合边坡稳定性坡率建议

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Submicrometer optical frequency combs based on SPPs metallic multi-ring resonators

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Photonics Research 2023年第12期11卷 2105-2112页

作者： ZHITAO HUANG FANGYUAN MA KEQIAN DONG SHIZHONG YUE CHAO LI yulin WU JUNHUI HUANG XU HAN JIAQIAN SUN ZHAOFENG LI KONG LIU ZHIJIE wang YONG LEI SHENGCHUN QU ZHANGUO wang Key Laboratory of Semiconductor Materials Science Beijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesInstitute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Integrated Circuits and Electronics MIIT Key Laboratory for Low-Dimensional Quantum Structure and DevicesBeijing Institute of TechnologyBeijing 100081China Engineering Research Center for Semiconductor Integrated Technology Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Fachgebiet Angewandte Nanophysik Institut für Physik&IMN MacroNanoTechnische UniversitätIlmenauIlmenau 98693Germany

Optical frequency combs(OFCs)have great potential in communications,especially in dense wavelength-division ***,the size of traditional OFCs based on conventional optical microcavities or dispersion fibers is at least tens of micrometers,far larger than that of nanoscale electronic ***,reducing the size of OFCs to match electronic chips is of ***,for the first time to our knowledge,we introduce surface plasmon polaritons(SPPs)to the construction of OFCs to realize a miniature *** thickness of our device is reduced below 1μ*** the presence of SPPs may induce ohmic and scattering loss,the threshold of the device is obtained as 9μW,comparable to the conventional ***,the response time is 13.2.ps,much faster than the optical *** work provides a feasible strategy for the miniaturization of OFCs.

关键词： metallic faster feasible

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